Ces2g (carboxylesterase 2G) - Rat Genome Database

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Gene: Ces2g (carboxylesterase 2G) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ces2g
Name: carboxylesterase 2G
RGD ID: 1308358
Description: Predicted to enable carboxylic ester hydrolase activity. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human CES2 (carboxylesterase 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: carboxylesterase 2-like; Ces2l; hypothetical protein LOC291952; LOC291952; RGD1308358; similar to 2210023G05Rik protein
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81949,856,670 - 49,865,034 (+)NCBIGRCr8
mRatBN7.21932,946,748 - 32,954,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1932,946,748 - 32,954,337 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1939,761,709 - 39,769,294 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01940,415,613 - 40,423,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01942,704,596 - 42,712,141 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,025,379 - 37,034,611 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,025,375 - 37,034,285 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01947,890,553 - 47,910,285 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41934,883,453 - 34,891,042 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11934,888,380 - 34,895,173 (+)NCBI
Celera1932,375,982 - 32,383,571 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Ces2g
34 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:371
Count of miRNA genes:204
Interacting mature miRNAs:233
Transcripts:ENSRNOT00000048385
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192481604133061905Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 24 47 81 79 49 24 49 6 173 70 27 37 37 30

Sequence


Ensembl Acc Id: ENSRNOT00000048385   ⟹   ENSRNOP00000044478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1948,626 - 56,118 (-)Ensembl
Rnor_6.0 Ensembl1937,025,375 - 37,034,285 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079722   ⟹   ENSRNOP00000071384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1932,946,748 - 32,954,337 (+)Ensembl
RefSeq Acc Id: NM_001106175   ⟹   NP_001099645
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81949,856,670 - 49,864,261 (+)NCBI
mRatBN7.21932,946,748 - 32,954,337 (+)NCBI
Rnor_6.01937,025,379 - 37,032,968 (+)NCBI
Rnor_5.01947,890,553 - 47,910,285 (+)NCBI
RGSC_v3.41934,883,453 - 34,891,042 (+)RGD
Celera1932,375,982 - 32,383,571 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255448   ⟹   XP_006255510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81949,856,670 - 49,865,034 (+)NCBI
mRatBN7.21932,946,748 - 32,953,587 (+)NCBI
Rnor_6.01937,025,420 - 37,034,611 (+)NCBI
Rnor_5.01947,890,553 - 47,910,285 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099645 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255510 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92342 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071384.2
RefSeq Acc Id: NP_001099645   ⟸   NM_001106175
- Peptide Label: precursor
- UniProtKB: A0A0G2K0C1 (UniProtKB/TrEMBL),   A6IYL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255510   ⟸   XM_006255448
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000044478   ⟸   ENSRNOT00000048385
Ensembl Acc Id: ENSRNOP00000071384   ⟸   ENSRNOT00000079722
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXQ0-F1-model_v2 AlphaFold D3ZXQ0 1-560 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701061
Promoter ID:EPDNEW_R11585
Type:multiple initiation site
Name:Ces2g_1
Description:carboxylesterase 2G
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01937,025,360 - 37,025,420EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308358 AgrOrtholog
BioCyc Gene G2FUF-5863 BioCyc
BioCyc Pathway PWY-6857 [retinol biosynthesis] BioCyc
BioCyc Pathway Image PWY-6857 BioCyc
Ensembl Genes ENSRNOG00000013808 Ensembl
  ENSRNOG00000070043 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079722.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/TrEMBL
  Type-B_Carboxylest/Lipase UniProtKB/TrEMBL
KEGG Report rno:291952 UniProtKB/TrEMBL
NCBI Gene 291952 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/TrEMBL
  COCAINE ESTERASE UniProtKB/TrEMBL
Pfam COesterase UniProtKB/TrEMBL
PhenoGen Ces2g PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013808 RatGTEx
  ENSRNOG00000070043 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A0G2K0C1 ENTREZGENE, UniProtKB/TrEMBL
  A6IYL4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-18 Ces2g  carboxylesterase 2G  RGD1308358  similar to 2210023G05Rik protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1308358  similar to 2210023G05Rik protein   RGD1308358_predicted  similar to 2210023G05Rik protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1308358_predicted  similar to 2210023G05Rik protein (predicted)  LOC291952_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC291952_predicted  similar to 2210023G05Rik protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL