Pkn1 (protein kinase N1) - Rat Genome Database

Name: Pkn1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Pkn1 (protein kinase N1) Rattus norvegicus

Analyze

Symbol:

Pkn1

Name:

protein kinase N1

RGD ID:

69308

Description:

Enables protein kinase activity. Predicted to be involved in several processes, including epithelial cell migration; intracellular signal transduction; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including negative regulation of B cell proliferation; regulation of germinal center formation; and spleen development. Predicted to be located in several cellular components, including cleavage furrow; endosome; and midbody. Predicted to be part of protein-containing complex. Orthologous to human PKN1 (protein kinase N1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

PAK-1; Prkcl1; protease-activated kinase 1; protein kinase C-like 1; protein kinase C-like PKN; protein kinase PKN; protein-kinase C-related kinase 1; serine-threonine protein kinase N; serine/threonine-protein kinase N1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PKN1 (protein kinase N1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Pkn1 (protein kinase N1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pkn1 (protein kinase N1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PKN1 (protein kinase N1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PKN1 (protein kinase N1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pkn1 (protein kinase N1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PKN1 (protein kinase N1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PKN1 (protein kinase N1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pkn1 (protein kinase N1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PKN2 (protein kinase N2)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Pkn1 (protein kinase N1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PKN1 (protein kinase N1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pkn1a (protein kinase N1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pkn1b (protein kinase N1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PKC1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Pkn	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pkn-1	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	24,442,130 - 24,470,107 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	24,442,122 - 24,470,107 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	31,263,238 - 31,291,231 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	31,917,654 - 31,945,652 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	34,140,489 - 34,168,479 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	24,803,524 - 24,832,305 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	24,803,524 - 24,831,500 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	35,782,679 - 35,810,655 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	26,132,497 - 26,160,471 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	26,137,378 - 26,165,287 (+)	NCBI
Celera	19	23,985,369 - 24,013,043 (+)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Neointima (IMP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3-Nitrobenzanthrone (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

caffeine (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cobalt dichloride (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

folic acid (ISO)

fulvestrant (ISO)

gentamycin (EXP)

ivermectin (ISO)

methimazole (EXP)

methylphenidate (ISO)

N-methyl-4-phenylpyridinium (ISO)

O-methyleugenol (ISO)

ozone (ISO)

perfluorononanoic acid (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

quercetin (ISO)

rotenone (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

tamibarotene (ISO)

tetrachloromethane (ISO)

valproic acid (ISO)

vanadium atom (ISO)

vanadium(0) (ISO)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell apoptotic process (IEA,ISO)

B cell homeostasis (IEA,ISO)

chromatin remodeling (IEA)

epithelial cell migration (IEA,ISO,ISS)

hyperosmotic response (IEA,ISO)

intracellular signal transduction (IBA)

negative regulation of B cell proliferation (IEA,ISO)

negative regulation of protein phosphorylation (IEA,ISO)

phosphorylation (IEA)

positive regulation of DNA-templated transcription (IEA)

post-translational protein modification (IEA,ISO,ISS)

protein phosphorylation (IDA)

regulation of cell motility (IEA,ISO,ISS)

regulation of germinal center formation (IEA,ISO)

regulation of immunoglobulin production (IEA,ISO)

regulation of transcription by RNA polymerase II (IEA,ISO,ISS)

renal system process (IEA,ISO)

signal transduction (IEA)

spleen development (IEA,ISO)

Cellular Component

cleavage furrow (IEA,ISO,ISS)

cytoplasm (IEA,ISO,ISS)

cytoplasmic vesicle (ISO)

endosome (IEA,ISO,ISS)

midbody (IEA,ISO,ISS)

nucleus (IEA,ISO,ISS)

protein-containing complex (IEA)

Molecular Function

ATP binding (IEA)

chromatin binding (IEA,ISO,ISS)

diacylglycerol-dependent serine/threonine kinase activity (ISO)

histone binding (IEA,ISO,ISS)

histone deacetylase binding (IEA,ISO,ISS)

histone H3T11 kinase activity (IEA,ISO,ISS)

nuclear androgen receptor binding (IEA,ISO,ISS)

nuclear receptor coactivator activity (IEA,ISO,ISS)

protein binding (ISO)

protein kinase activity (IDA,ISO)

protein kinase C binding (IEA,ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IEA,ISO,ISS)

small GTPase binding (IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	A novel protein kinase with leucine zipper-like sequences: its catalytic domain is highly homologous to that of protein kinase C.	Mukai H and Ono Y, Biochem Biophys Res Commun 1994 Mar 15;199(2):897-904.
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Phosphorylation events associated with different states of activation of a hepatic cardiolipin/protease-activated protein kinase. Structural identity to the protein kinase N-type protein kinases.	Peng B, etal., J Biol Chem 1996 Dec 13;271(50):32233-40.
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling.	Singh NK, etal., J Biol Chem. 2012 Oct 19;287(43):36291-304. doi: 10.1074/jbc.M112.361220. Epub 2012 Aug 13.
12.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:8051089	PMID:9478917	PMID:10619026	PMID:11054541	PMID:12514133	PMID:12783890	PMID:16427251	PMID:17332740	PMID:17687038	PMID:18006505	PMID:18066052	PMID:20188095
PMID:20228790	PMID:21754995	PMID:23223530	PMID:29045568	PMID:36897022

Genomics

Comparative Map Data

Pkn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	24,442,130 - 24,470,107 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	24,442,122 - 24,470,107 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	31,263,238 - 31,291,231 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	31,917,654 - 31,945,652 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	34,140,489 - 34,168,479 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	24,803,524 - 24,832,305 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	24,803,524 - 24,831,500 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	35,782,679 - 35,810,655 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	26,132,497 - 26,160,471 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	26,137,378 - 26,165,287 (+)	NCBI
Celera	19	23,985,369 - 24,013,043 (+)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

PKN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	14,433,306 - 14,471,859 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	14,433,053 - 14,471,867 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	14,544,118 - 14,582,671 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	14,405,166 - 14,443,679 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	14,405,165 - 14,443,678	NCBI
Celera	19	14,438,283 - 14,476,800 (+)	NCBI		Celera
Cytogenetic Map	19	p13.12	NCBI
HuRef	19	14,121,160 - 14,152,794 (+)	NCBI		HuRef
CHM1_1	19	14,544,156 - 14,582,658 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	14,559,936 - 14,598,492 (+)	NCBI		T2T-CHM13v2.0

Pkn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	84,393,162 - 84,425,819 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	84,393,165 - 84,425,808 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	83,666,533 - 83,699,181 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	83,666,536 - 83,699,179 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	86,193,995 - 86,223,025 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	86,560,201 - 86,589,231 (-)	NCBI		MGSCv36	mm8
Celera	8	87,960,887 - 87,989,891 (-)	NCBI		Celera
Cytogenetic Map	8	C2	NCBI
cM Map	8	40.22	NCBI

Pkn1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	33,043,918 - 33,063,567 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	33,040,868 - 33,062,753 (+)	NCBI	ChiLan1.0	ChiLan1.0

PKN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	19	18,365,105 - 18,403,896 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	13,996,454 - 14,035,272 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	14,838,478 - 14,879,205 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	14,846,463 - 14,879,205 (+)	Ensembl	panpan1.1		panPan2

PKN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	48,160,480 - 48,184,346 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	48,160,529 - 48,184,751 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	48,036,227 - 48,059,971 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	48,679,041 - 48,702,797 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	48,679,045 - 48,703,317 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	47,890,581 - 47,914,314 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	48,316,854 - 48,340,898 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	48,559,780 - 48,583,516 (-)	NCBI		UU_Cfam_GSD_1.0

Pkn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	207,340,155 - 207,365,294 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936659	2,990,937 - 3,014,485 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936659	2,990,905 - 3,014,553 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PKN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	64,800,721 - 64,824,957 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	64,800,718 - 64,824,952 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	65,194,139 - 65,211,437 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PKN1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	13,088,060 - 13,130,848 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	13,082,132 - 13,130,897 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	6,525,087 - 6,570,118 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pkn1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624901	1,582,790 - 1,605,279 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pkn1
157 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	95
Count of miRNA genes:	78
Interacting mature miRNAs:	84
Transcripts:	ENSRNOT00000005770
Prediction methods:	Microtar, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411590	Foco7	Food consumption QTL 7	6.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	19	1	24688055	Rat
10054132	Srcrt9	Stress Responsive Cort QTL 9	2.87	0.0017	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	27355345	Rat
631678	Cm9	Cardiac mass QTL 9	4.27	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	19	1	28982497	Rat
631681	Cm12	Cardiac mass QTL 12	3.33	0.00053	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	19	1	28982497	Rat
1549847	Bss8	Bone structure and strength QTL 8	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	19	1	31963836	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	1	36824771	Rat
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	1	36824771	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	36824771	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	1	36824771	Rat
9589102	Slep13	Serum leptin concentration QTL 13	4.63	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	19	569374	45569374	Rat
8694186	Bw152	Body weight QTL 152	3.34	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	569374	45569374	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2187927	46708701	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	2316121	47316121	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	3204777	48204777	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	7457249	42983518	Rat
724565	Tcas5	Tongue tumor susceptibility QTL 5	10.04		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	19	9977753	39654489	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10827970	43544039	Rat
61407	Scl12	Serum cholesterol level QTL 12		0.001	blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	19	13926401	30303727	Rat
1558656	Prcs1	Prostate cancer susceptibility QTL 1	5		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	19	15114598	34521833	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	15605023	46559041	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat

Markers in Region

D19Rat74

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	24,448,251 - 24,448,377 (-)	MAPPER	mRatBN7.2
Rnor_6.0	19	24,825,253 - 24,825,378	NCBI	Rnor6.0
Rnor_5.0	19	35,804,408 - 35,804,533	UniSTS	Rnor5.0
RGSC_v3.4	19	26,138,615 - 26,138,741	RGD	RGSC3.4
RGSC_v3.4	19	26,138,616 - 26,138,741	UniSTS	RGSC3.4
RGSC_v3.1	19	26,143,441 - 26,143,567	RGD
Celera	19	23,991,193 - 23,991,316	UniSTS
SHRSP x BN Map	19	16.8698	RGD
SHRSP x BN Map	19	16.8698	UniSTS
Cytogenetic Map	19	q11	UniSTS

RH94446

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	24,470,261 - 24,470,430 (-)	MAPPER	mRatBN7.2
Rnor_6.0	19	24,803,201 - 24,803,369	NCBI	Rnor6.0
Rnor_5.0	19	35,782,356 - 35,782,524	UniSTS	Rnor5.0
Celera	19	24,013,198 - 24,013,366	UniSTS
Cytogenetic Map	19	q11	UniSTS

RH137957

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	24,467,582 - 24,467,784 (-)	MAPPER	mRatBN7.2
Rnor_6.0	19	24,805,847 - 24,806,048	NCBI	Rnor6.0
Rnor_5.0	19	35,785,002 - 35,785,203	UniSTS	Rnor5.0
RGSC_v3.4	19	26,157,947 - 26,158,148	UniSTS	RGSC3.4
Celera	19	24,010,519 - 24,010,720	UniSTS
Cytogenetic Map	19	q11	UniSTS

RH140664

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	24,470,489 - 24,470,678 (-)	MAPPER	mRatBN7.2
Rnor_6.0	19	24,802,953 - 24,803,141	NCBI	Rnor6.0
Rnor_5.0	19	35,782,108 - 35,782,296	UniSTS	Rnor5.0
RGSC_v3.4	19	26,160,748 - 26,160,936	UniSTS	RGSC3.4
Celera	19	24,013,426 - 24,013,614	UniSTS
Cytogenetic Map	19	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	51	35	19	35	8	11	74	35	41	11	8
Low			6	6		6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006255245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601249	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097675	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061836	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB608722	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D26180	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV774518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L35634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000005770 ⟹ ENSRNOP00000005770

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	24,442,130 - 24,470,107 (+)	Ensembl
Rnor_6.0 Ensembl	19	24,803,524 - 24,831,500 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000106468 ⟹ ENSRNOP00000086181

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	24,448,413 - 24,470,107 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000116583 ⟹ ENSRNOP00000082261

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	24,442,122 - 24,470,107 (+)	Ensembl

RefSeq Acc Id:

NM_017175 ⟹ NP_058871

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	24,442,130 - 24,470,107 (+)	NCBI
Rnor_6.0	19	24,803,524 - 24,831,500 (-)	NCBI
Rnor_5.0	19	35,782,679 - 35,810,655 (-)	NCBI
RGSC_v3.4	19	26,132,497 - 26,160,471 (+)	RGD
Celera	19	23,985,369 - 24,013,043 (+)	RGD

Sequence:

show sequence

ATCCTGCAGCCGCTGGGGCCCGAGGGCGCAGCTCGGCGGAGGCCTGGCCAGGCCGGGCCGAGCG
CAGCAGGCCGGATCGCGCAGCGCGCCAGGGAAGGTCTGGGCTCCGCGCTTCCCGCCCCACACGC
CGACGCGCTCGCAAGCCCTCCCTCGGCGCTGGGACCCCTGGCGGACATGGCCGGCGACGCCGTG
CAGAGTGAACCTCGCAGCTGGTCACTGCTGGAGCAGCTGGGTCTGGCTGGGGCAGACCTGGCAG
CCCCTGGGGTGCAGCAGCAGCTGGAGTTAGAGCGAGAGCGGCTGAAGCGGGAAATCCGAAAAGA
GCTGAAGCTGAAGGAGGGCGCTGAGAACCTGAGGCGGGCCACCACTGACCTGGGCCGCAGCTTG
GCCCCTGTGGAACTGCTGCTGAGGGGCTCCGCTAGACGGCTTGACTTGCTGCACCAGCAGCTGC
AGGAGCTGCATGCACATGTGGTGCTGCCCGACCCTACAGCGGGGAGTGATGCTCCCCAATCCCT
TGCAGAGGGCAGCCCTGTCTGCTCATCCACCAACCTGAGCCGAGTGGCTGGCCTGGAGAAGCAG
CTGGCCATTGAGCTCAAGGTCAAACAGGGGGCAGAAAACATGATCCAGACCTACAGCAATGGCA
GCACCAAGGACCGGAAGCTGCTGTTGACGGCCCAACAGATGCTGCAGGATAGTAAGACCAAGAT
TGACATCATCCGCATGCAGCTTCGCCGGGCGCTACAAGCACTCCAGGCTGGCCAGCTGGAGAGT
CAGGCAGCTCCTGATGAGGCCCACGGAGATCCAGACCTGGGAGCCGTAGAGCTACGCATTGAGG
AGCTACGACACCATTTTCGAGTAGAGCATGCAGTGGCAGAAGGCGCCAAGAATGTCCTGCGTCT
GCTCAGTGCTGCAAAGGCCCCAGACCGCAAAGCAGTCAGCGAGGCTCAGGAGAAATTGACTGAG
TCCAACCAGAAGCTGGGCTTGCTGCGGGAGTCACTGGAGAGGCGCTTGGGGGAACTGCCTGCTG
ATCACCCCAAGGGACGCCTGCTTCGGGAGGAGCTCACTGCGGCCTCATCGGCAGCCTTCAGTGC
AATACTGCCTGGGCCCTTCCCTGCCACTCACTACAGCACCTTGAGCAAGCCTGCACCACTCACA
GGGACCCTGGAAGTACGAGTGGTGGGCTGCAAAAACCTTCCCGAGACCATCCCTTGGAGCCCTC
CCCCCTCAGTCGGGGCATCTGGGACCCCCGACAGCCGCACTCCTTTCCTGAGTCGTCCAGCTCG
GGGCCTTTACAACCGAAGTGGAAGCCTTAGTGGACGGAGCAGCCTCAAGGGGGAGGCAGAGAAT
TCCACTGAGGTCAGCACCGTGCTCAAGCTGGACAACACTGTGGTGGGGCAAACAGCCTGGAAGC
CATGCGGCCCCAATGCCTGGGACCAGAGCTTCACCCTGGAGCTGGAGAGGGCTCGGGAGCTGGA
GTTGGCTGTGTTCTGGCGTGACCAGAGGGGTCTGTGTGCTCTCAAATTTCTGAAGTTGGAAGAC
TTCTTGGACAATGAGAGGCATGAGGTGCAGCTGGACATGGAACCCCAGGGCTGCCTGGTGGCTG
AGGTCACCTTCCGTAACCCCATCATCGAGCGGATCCCTAGGCTCCAAAGGCAGAAAAAAATTTT
CTCCAAGCAGCAAGGGCAGACATTTCAGCGTGCCAGACAGATGAACATCGATGTGGCCACCTGG
GTGCGGCTGCTCCGGAGACTCATCCCGAACGCCGTGGCCACTGGCTCCTTCAGCCCCAATGCAT
CTCCAGGCTCTGAGATCCGGAGCACTGGAGACATATCCATGGAGAAATTGAATCTCGGTGCTGA
CTCAGACAGCTCGTCCCAGAAGAGCCCCGCAGGGCTGCCCTCCACCTCATGTAGCCTGAGTTCT
CCAACCCACGAATCCACCACCTCTCCAGAGCTGCCTTCAGAGACCCAGGAGACCCCAGGCCCTG
GCCTGTGCAGTCCCCTGAGGAAGTCGCCCCTGACGCTTGAGGACTTCAAGTTCCTGGCAGTGCT
TGGTCGGGGTCACTTTGGAAAGGTGCTGCTGTCTGAATTCCACTCCAGTGGGGAGCTCTTTGCC
ATTAAAGCCTTGAAGAAAGGTGACATTGTAGCCCGGGATGAGGTTGAGAGCCTGATGTGTGAGA
AGCGGATTTTGGCGACCGTGACCAGGGCAGGACATCCCTTCCTGGTGAACCTTTTCGGCTGTTT
CCAGACCCCAGAGCATGTGTGCTTTGTGATGGAGTACTCAGCCGGTGGGGACTTGATGCTGCAT
ATCCACAGCGACGTGTTCTCAGAGCCTCGGGCTGTCTTCTATTCGGCCTGTGTGGTGCTGGGAC
TGCAGTTCCTCCATGAACACAAGATTGTCTACAGGGACCTGAAGTTGGACAATTTGCTCCTGGA
TACTGAGGGCTACGTCAAGATCGCAGACTTTGGCCTCTGCAAGGAGGGGATGGGCTATGGGGAC
CGGACCAGCACATTCTGCGGAACTCCGGAGTTCCTGGCGCCGGAAGTGCTCACAGACACATCCT
ACACTCGAGCCGTGGACTGGTGGGGACTGGGTGTATTGCTCTATGAGATGCTGGTTGGAGAGTC
TCCGTTCCCTGGGGACGACGAGGAGGAAGTATTTGACAGCATCGTCAATGATGAGGTTCGTTAT
CCCCGCTTCCTGTCTGCGGAGGCCATCGGCATCATGAGAAGGCTACTGCGGAGGAACCCAGAGC
GGAGGTTGGGATCCACTGAGCGTGATGCAGAAGATGTGAAAAAACAGCCTTTCTTCAGGACTCT
GGACTGGGATGCCCTGCTGGCCCGTCGCCTGCCTCCACCCTTCGTGCCTACACTTTCGGGGCGC
ACAGACGTCAGCAACTTCGATGAGGAGTTCACTGGGGAGGCCCCCACACTGAGCCCTCCCCGGG
ATGCACGGCCCCTGACAGCTGCGGAGCAGGCGGCCTTCCGGGATTTCGACTTTGTGGCAGGAGG
CTATTAGCCCTAAGCCCCTGCCTTGCCCAAGAGTTCTTGGTTTTTAAAAAAGCCTTTGGGGTTT
ACTCCATACATGCAT

hide sequence

RefSeq Acc Id:

XM_006255245 ⟹ XP_006255307

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	24,445,726 - 24,470,106 (+)	NCBI
Rnor_6.0	19	24,803,525 - 24,827,253 (-)	NCBI
Rnor_5.0	19	35,782,679 - 35,810,655 (-)	NCBI

Sequence:

show sequence

CACACACGCACACACACACGCACGCACGCACGCACGTACGTACGTGCGCATGAGGGTGTGTGAG
TAGCTTCCAGAGGGACTTAAACTAGCACCAATAGCTGTTTGTTCATTAGGGTCTGTGCAGGCAG
GTGTGGGAAGTGTGCAGATTTATGATGCTGTGTCCCACTTCCATGCTGACCCCTGTGGGAGTGC
AATATAAGCGAGACTACTCTGTGCACTCCCGAGCCCGTGTCCCAGACATACACCTGCAGGTGTC
TGTGTGCAAATTAGTATCCCGTGTACACCCTGAGCCAGGCACAGACCTGCACAGCTAGATGCAC
ACACCTTTGGGAAGCTGTGTTCTACCCACACACTCCTGCAGGTGGGGACTGGTCTAGTCTGCCT
TCCGTCGCTGTGATAAAAGACTGACCAAAAGCAACTTGGGGAAGAAAGGGTTTATTTGGTTTTA
TAAATTATAGTTCATCACGGAGTGAAGTCAGGGCTGGGGCTGAAGACAGAAGCGTAAGGCAAAA
CCGCAGAGGAGCACTGCTCACTGTTCCCTCCCTCTGGCTGGCTCAGCTCCTTTTGTACACCCCA
GGCCCACCTGCCCAGGATGGCACTGCCCACAGAGAGCTGAGCCCTCCTACATCACTTAGCAGTC
AAGAAAATATCCCTTAGACAGGCCCACCGGCCAGTCCCACAAGCCAGGCCCACACAGGCCTCCT
CAACTGAGGGGTGCAGATCTCACAGCTGCAAAGCTGGAACTGTGTCTGCACCGTTGAGCCCATG
GCCCCACACATAAGATCCTGCCTGCTATGTAATATCCTGTGCATGTGTCTGCCAGTGTGTCAGG
CACTAAAAACTTTCTCCCTGGCTCACCTCCAGAGAAACAAGCATGGCCATTTAGGGGGTGATGG
GGGAAGAACCTCTTACATGGCCCACACCTACCTGGGATATAGAAGCAGGTAGATATCTGAGTTC
GAAGTCACCCTGTTCTCCATAGTGAATTACAGGTCAACCAGAACTACATAGAGAGACCTGTCTC
AAAAACAAAACAAAATAACTCCTACCCCTAACAACAACAAAAAACTTGCCCTAGAGCTGGCCTG
GCGCAGAGGATGCTGGGAACTGGAAGGAAAGAGGAAGTGGCAGTCCAGAGGCCCTGTCAGGGCT
GAGGTTCAGGAAGAGGGCGTGGCCCTCAGGCCAGACCTAGGACCCAGATGGCAGCTGATCCCCC
TTTGGATTTGGAGCTGGAGAGTGAACCTCGCAGCTGGTCACTGCTGGAGCAGCTGGGTCTGGCT
GGGGCAGACCTGGCAGCCCCTGGGGTGCAGCAGCAGCTGGAGTTAGAGCGAGAGCGGCTGAAGC
GGGAAATCCGAAAAGAGCTGAAGCTGAAGGAGGGCGCTGAGAACCTGAGGCGGGCCACCACTGA
CCTGGGCCGCAGCTTGGCCCCTGTGGAACTGCTGCTGAGGGGCTCCGCTAGACGGCTTGACTTG
CTGCACCAGCAGCTGCAGGAGCTGCATGCACATGTGGTGCTGCCCGACCCTACAGCGGGGAGTG
ATGCTCCCCAATCCCTTGCAGAGGGCAGCCCTGTCTGCTCATCCACCAACCTGAGCCGAGTGGC
TGGCCTGGAGAAGCAGCTGGCCATTGAGCTCAAGGTCAAACAGGGGGCAGAAAACATGATCCAG
ACCTACAGCAATGGCAGCACCAAGGACCGGAAGCTGCTGTTGACGGCCCAACAGATGCTGCAGG
ATAGTAAGACCAAGATTGACATCATCCGCATGCAGCTTCGCCGGGCGCTACAAGCACTCCAGGC
TGGCCAGCTGGAGAGTCAGGCAGCTCCTGATGAGGCCCACGGAGATCCAGACCTGGGAGCCGTA
GAGCTACGCATTGAGGAGCTACGACACCATTTTCGAGTAGAGCATGCAGTGGCAGAAGGCGCCA
AGAATGTCCTGCGTCTGCTCAGTGCTGCAAAGGCCCCAGACCGCAAAGCAGTCAGCGAGGCTCA
GGAGAAATTGACTGAGTCCAACCAGAAGCTGGGCTTGCTGCGGGAGTCACTGGAGAGGCGCTTG
GGGGAACTGCCTGCTGATCACCCCAAGGGACGCCTGCTTCGGGAGGAGCTCACTGCGGCCTCAT
CGGCAGCCTTCAGTGCAATACTGCCTGGGCCCTTCCCTGCCACTCACTACAGCACCTTGAGCAA
GCCTGCACCACTCACAGGGACCCTGGAAGTACGAGTGGTGGGCTGCAAAAACCTTCCCGAGACC
ATCCCTTGGAGCCCTCCCCCCTCAGTCGGGGCATCTGGGACCCCCGACAGCCGCACTCCTTTCC
TGAGTCGTCCAGCTCGGGGCCTTTACAACCGAAGTGGAAGCCTTAGTGGACGGAGCAGCCTCAA
GGGGGAGGCAGAGAATTCCACTGAGGTCAGCACCGTGCTCAAGCTGGACAACACTGTGGTGGGG
CAAACAGCCTGGAAGCCATGCGGCCCCAATGCCTGGGACCAGAGCTTCACCCTGGAGCTGGAGA
GGGCTCGGGAGCTGGAGTTGGCTGTGTTCTGGCGTGACCAGAGGGGTCTGTGTGCTCTCAAATT
TCTGAAGTTGGAAGACTTCTTGGACAATGAGAGGCATGAGGTGCAGCTGGACATGGAACCCCAG
GGCTGCCTGGTGGCTGAGGTCACCTTCCGTAACCCCATCATCGAGCGGATCCCTAGGCTCCAAA
GGCAGAAAAAAATTTTCTCCAAGCAGCAAGGGCAGACATTTCAGCGTGCCAGACAGATGAACAT
CGATGTGGCCACCTGGGTGCGGCTGCTCCGGAGACTCATCCCGAACGCCGTGGCCACTGGCTCC
TTCAGCCCCAATGCATCTCCAGGCTCTGAGATCCGGAGCACTGGAGACATATCCATGGAGAAAT
TGAATCTCGGTGCTGACTCAGACAGCTCGTCCCAGAAGAGCCCCGCAGGGCTGCCCTCCACCTC
ATGTAGCCTGAGTTCTCCAACCCACGAATCCACCACCTCTCCAGAGCTGCCTTCAGAGACCCAG
GAGACCCCAGGCCCTGGCCTGTGCAGTCCCCTGAGGAAGTCGCCCCTGACGCTTGAGGACTTCA
AGTTCCTGGCAGTGCTTGGTCGGGGTCACTTTGGAAAGGTGCTGCTGTCTGAATTCCACTCCAG
TGGGGAGCTCTTTGCCATTAAAGCCTTGAAGAAAGGTGACATTGTAGCCCGGGATGAGGTTGAG
AGCCTGATGTGTGAGAAGCGGATTTTGGCGACCGTGACCAGGGCAGGACATCCCTTCCTGGTGA
ACCTTTTCGGCTGTTTCCAGACCCCAGAGCATGTGTGCTTTGTGATGGAGTACTCAGCCGGTGG
GGACTTGATGCTGCATATCCACAGCGACGTGTTCTCAGAGCCTCGGGCTGTCTTCTATTCGGCC
TGTGTGGTGCTGGGACTGCAGTTCCTCCATGAACACAAGATTGTCTACAGGGACCTGAAGTTGG
ACAATTTGCTCCTGGATACTGAGGGCTACGTCAAGATCGCAGACTTTGGCCTCTGCAAGGAGGG
GATGGGCTATGGGGACCGGACCAGCACATTCTGCGGAACTCCGGAGTTCCTGGCGCCGGAAGTG
CTCACAGACACATCCTACACTCGAGCCGTGGACTGGTGGGGACTGGGTGTATTGCTCTATGAGA
TGCTGGTTGGAGAGTCTCCGTTCCCTGGGGACGACGAGGAGGAAGTATTTGACAGCATCGTCAA
TGATGAGGTTCGTTATCCCCGCTTCCTGTCTGCGGAGGCCATCGGCATCATGAGAAGGCTACTG
CGGAGGAACCCAGAGCGGAGGTTGGGATCCACTGAGCGTGATGCAGAAGATGTGAAAAAACAGC
CTTTCTTCAGGACTCTGGACTGGGATGCCCTGCTGGCCCGTCGCCTGCCTCCACCCTTCGTGCC
TACACTTTCGGGGCGCACAGACGTCAGCAACTTCGATGAGGAGTTCACTGGGGAGGCCCCCACA
CTGAGCCCTCCCCGGGATGCACGGCCCCTGACAGCTGCGGAGCAGGCGGCCTTCCGGGATTTCG
ACTTTGTGGCAGGAGGCTATTAGCCCTAAGCCCCTGCCTTGCCCAAGAGTTCTTGGTTTTTAAA
AAAGCCTTTGGGGTTTACTCCATACATGCA

hide sequence

RefSeq Acc Id:

XM_039097675 ⟹ XP_038953603

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	24,456,600 - 24,470,106 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_058871	(Get FASTA)	NCBI Sequence Viewer
	XP_006255307	(Get FASTA)	NCBI Sequence Viewer
	XP_038953603	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH61836	(Get FASTA)	NCBI Sequence Viewer
	AAL31374	(Get FASTA)	NCBI Sequence Viewer
	BAA05168	(Get FASTA)	NCBI Sequence Viewer
	EDL92260	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005770
	ENSRNOP00000082261
	ENSRNOP00000082261.1
	ENSRNOP00000086181.1
GenBank Protein	Q63433	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_058871 ⟸ NM_017175

- UniProtKB:

Q6P748 (UniProtKB/Swiss-Prot), Q8VIJ2 (UniProtKB/Swiss-Prot), Q63433 (UniProtKB/Swiss-Prot), A6IYD2 (UniProtKB/TrEMBL), A0A8I6GEN7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLKREIRKELKLKEGAENLRRATT
DLGRSLAPVELLLRGSARRLDLLHQQLQELHAHVVLPDPTAGSDAPQSLAEGSPVCSSTNLSRV
AGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQALQ
AGQLESQAAPDEAHGDPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEA
QEKLTESNQKLGLLRESLERRLGELPADHPKGRLLREELTAASSAAFSAILPGPFPATHYSTLS
KPAPLTGTLEVRVVGCKNLPETIPWSPPPSVGASGTPDSRTPFLSRPARGLYNRSGSLSGRSSL
KGEAENSTEVSTVLKLDNTVVGQTAWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALK
FLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPIIERIPRLQRQKKIFSKQQGQTFQRARQMN
IDVATWVRLLRRLIPNAVATGSFSPNASPGSEIRSTGDISMEKLNLGADSDSSSQKSPAGLPST
SCSLSSPTHESTTSPELPSETQETPGPGLCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFHS
SGELFAIKALKKGDIVARDEVESLMCEKRILATVTRAGHPFLVNLFGCFQTPEHVCFVMEYSAG
GDLMLHIHSDVFSEPRAVFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKE
GMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIV
NDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSTERDAEDVKKQPFFRTLDWDALLARRLPPPFV
PTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFRDFDFVAGGY

hide sequence

RefSeq Acc Id:	XP_006255307 ⟸ XM_006255245
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6G981 (UniProtKB/TrEMBL), A0A8I6GEN7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAADPPLDLELESEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLKREIRKELKLKEGAENL RRATTDLGRSLAPVELLLRGSARRLDLLHQQLQELHAHVVLPDPTAGSDAPQSLAEGSPVCSST NLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRA LQALQAGQLESQAAPDEAHGDPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRK AVSEAQEKLTESNQKLGLLRESLERRLGELPADHPKGRLLREELTAASSAAFSAILPGPFPATH YSTLSKPAPLTGTLEVRVVGCKNLPETIPWSPPPSVGASGTPDSRTPFLSRPARGLYNRSGSLS GRSSLKGEAENSTEVSTVLKLDNTVVGQTAWKPCGPNAWDQSFTLELERARELELAVFWRDQRG LCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPIIERIPRLQRQKKIFSKQQGQTFQR ARQMNIDVATWVRLLRRLIPNAVATGSFSPNASPGSEIRSTGDISMEKLNLGADSDSSSQKSPA GLPSTSCSLSSPTHESTTSPELPSETQETPGPGLCSPLRKSPLTLEDFKFLAVLGRGHFGKVLL SEFHSSGELFAIKALKKGDIVARDEVESLMCEKRILATVTRAGHPFLVNLFGCFQTPEHVCFVM EYSAGGDLMLHIHSDVFSEPRAVFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADF GLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEV FDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSTERDAEDVKKQPFFRTLDWDALLARRL PPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFRDFDFVAGGY hide sequence

RefSeq Acc Id:

ENSRNOP00000005770 ⟸ ENSRNOT00000005770

RefSeq Acc Id:	XP_038953603 ⟸ XM_039097675
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000086181 ⟸ ENSRNOT00000106468

RefSeq Acc Id:

ENSRNOP00000082261 ⟸ ENSRNOT00000116583

Protein Domains

AGC-kinase C-terminal C2 Protein kinase REM-1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63433-F1-model_v2	AlphaFold	Q63433	1-946	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701003

Promoter ID:

EPDNEW_R11527

Type:

initiation region

Name:

Pkn1_1

Description:

protein kinase N1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	24,831,500 - 24,831,560	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69308	AgrOrtholog
BioCyc Gene	G2FUF-6022	BioCyc
Ensembl Genes	ENSRNOG00000004131	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005770	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000106468.1	UniProtKB/TrEMBL
	ENSRNOT00000116583	ENTREZGENE
	ENSRNOT00000116583.1	UniProtKB/TrEMBL
Gene3D-CATH	HR1 repeat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5599989	IMAGE-MGC_LOAD
InterPro	AGC-kinase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	C2_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	C2_domain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	C2_PKN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HR1_rho-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HR1_rpt_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pkinase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PKN1_HR1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PKN_HR1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29355	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72497	IMAGE-MGC_LOAD
NCBI Gene	29355	ENTREZGENE
PANTHER	PROTEIN KINASE C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RIBOSOMAL PROTEIN S6 KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	HR1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pkinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pkinase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pkn1	PhenoGen
PROSITE	AGC_KINASE_CTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PS50004	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	REM_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004131	RatGTEx
SMART	Hr1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S_TK_X	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S_TKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46585	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF49562	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC230347
UniProt	A0A8I6G981	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GEN7	ENTREZGENE, UniProtKB/TrEMBL
	A6IYD2	ENTREZGENE, UniProtKB/TrEMBL
	PKN1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6P748	ENTREZGENE
	Q8VIJ2	ENTREZGENE
UniProt Secondary	Q6P748	UniProtKB/Swiss-Prot
	Q8VIJ2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Pkn1	protein kinase N1	Prkcl1	protein kinase C-like 1	Symbol and Name updated	1299863	APPROVED
2002-06-10	Prkcl1	protein kinase C-like 1			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar