Mylk3 (myosin light chain kinase 3)

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Gene: Mylk3 (myosin light chain kinase 3) Rattus norvegicus

Analyze

Symbol:

Mylk3

Name:

myosin light chain kinase 3

RGD ID:

1305801

Description:

Enables calmodulin-dependent protein kinase activity and myosin light chain kinase activity. Involved in myofibril assembly and positive regulation of sarcomere organization. Located in cytosol. Orthologous to human MYLK3 (myosin light chain kinase 3); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cardiac-MLCK; cardiac-MyBP-C-associated Ca/CaM kinase; LOC291926; MLCK; putative myosin light chain kinase 3; RGD1305801; similar to Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2)

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MYLK3 (myosin light chain kinase 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Mylk3 (myosin light chain kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mylk3 (myosin light chain kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MYLK3 (myosin light chain kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MYLK3 (myosin light chain kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mylk3 (myosin light chain kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MYLK3 (myosin light chain kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MYLK3 (myosin light chain kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mylk3 (myosin light chain kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TRAV22 (T cell receptor alpha variable 22)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Mylk3 (myosin light chain kinase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MYLK3 (myosin light chain kinase 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mylk3 (myosin light chain kinase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	sqa	Alliance	DIOPT (OrthoFinder\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RCK2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	mylk3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	21,685,085 - 21,743,587 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	21,691,929 - 21,742,954 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	23,398,906 - 23,432,675 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	28,593,424 - 28,627,193 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	31,556,254 - 31,590,023 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	27,388,163 - 27,442,451 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	27,404,712 - 27,441,536 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	38,356,781 - 38,408,247 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	23,068,059 - 23,101,629 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	23,072,884 - 23,120,712 (+)	NCBI
Celera	19	21,568,596 - 21,602,349 (+)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

glycogen storage disease IXb (ISO)

Parkinson's disease 17 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

amosite asbestos (ISO)

aristolochic acid A (ISO)

benzalkonium chloride (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

cantharidin (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

crocidolite asbestos (ISO)

D-mannitol (ISO)

diazinon (ISO)

dioxygen (ISO)

diquat (ISO)

dorsomorphin (ISO)

gentamycin (EXP)

lidocaine (EXP)

manganese(II) chloride (EXP)

mercury dichloride (EXP)

methapyrilene (ISO)

microcystin-LR (ISO)

mifepristone (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

ozone (ISO)

paracetamol (EXP)

phenylephrine (ISO)

phenylmercury acetate (ISO)

potassium bromate (EXP)

progesterone (ISO)

SB 431542 (ISO)

serpentine asbestos (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

testosterone (EXP)

triclosan (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cardiac myofibril assembly (IBA,IMP)

cellular response to interleukin-1 (ISO)

positive regulation of sarcomere organization (IDA)

regulation of vascular permeability involved in acute inflammatory response (ISO)

sarcomere organization (IBA,IMP,ISO)

sarcomerogenesis (IMP)

Cellular Component

actin cytoskeleton (IBA,ISO)

cytoplasm (IBA,ISO)

cytosol (IDA)

Molecular Function

ATP binding (IEA)

calmodulin-dependent protein kinase activity (IDA,ISO)

myosin light chain kinase activity (IBA,IMP,ISO)

protein kinase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium/calcium-mediated signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Identification of cardiac-specific myosin light chain kinase.	Chan JY, etal., Circ Res. 2008 Mar 14;102(5):571-80. doi: 10.1161/CIRCRESAHA.107.161687. Epub 2008 Jan 17.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.	Seguchi O, etal., J Clin Invest. 2007 Oct;117(10):2812-24.

Additional References at PubMed

PMID:18390750	PMID:25451385	PMID:26316108	PMID:26809094	PMID:28300565

Genomics

Comparative Map Data

Mylk3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	21,685,085 - 21,743,587 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	21,691,929 - 21,742,954 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	23,398,906 - 23,432,675 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	28,593,424 - 28,627,193 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	31,556,254 - 31,590,023 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	27,388,163 - 27,442,451 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	27,404,712 - 27,441,536 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	38,356,781 - 38,408,247 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	23,068,059 - 23,101,629 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	23,072,884 - 23,120,712 (+)	NCBI
Celera	19	21,568,596 - 21,602,349 (+)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

MYLK3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	46,702,282 - 46,763,246 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	46,702,282 - 46,790,407 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	46,736,194 - 46,797,158 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	45,293,695 - 45,339,722 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	31,244,379 - 31,290,436 (-)	NCBI		Celera
Cytogenetic Map	16	q11.2	NCBI
HuRef	16	32,625,650 - 32,671,687 (-)	NCBI		HuRef
CHM1_1	16	48,143,152 - 48,189,182 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	52,499,182 - 52,560,128 (-)	NCBI		T2T-CHM13v2.0

Mylk3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	86,050,933 - 86,112,969 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	86,050,932 - 86,112,974 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	85,324,928 - 85,386,340 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	85,324,303 - 85,386,345 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	87,848,828 - 87,889,223 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	85,030,905 - 85,070,828 (-)	NCBI		MGSCv36	mm8
MGSCv36	8	88,215,034 - 88,255,429 (-)	NCBI		MGSCv36	mm8
Celera	8	89,618,765 - 89,675,102 (-)	NCBI		Celera
Cytogenetic Map	8	C3	NCBI
cM Map	8	41.61	NCBI

Mylk3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955448	255,119 - 287,712 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955448	254,280 - 287,451 (-)	NCBI	ChiLan1.0	ChiLan1.0

MYLK3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	16	62,065,765 - 62,129,712 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	26,966,653 - 27,029,413 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	45,858,723 - 45,919,859 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	45,863,863 - 45,905,082 (-)	Ensembl	panpan1.1		panPan2

MYLK3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	8,382,436 - 8,416,740 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	8,381,854 - 8,416,368 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	8,535,870 - 8,570,561 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	8,498,390 - 8,533,075 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	8,498,832 - 8,531,004 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	8,327,588 - 8,362,127 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	8,408,586 - 8,443,037 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	8,424,303 - 8,458,844 (+)	NCBI		UU_Cfam_GSD_1.0

Mylk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	59,441,555 - 59,499,618 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	89,570 - 126,025 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936475	89,717 - 137,866 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MYLK3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	37,850,754 - 37,920,754 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	37,850,117 - 37,920,862 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MYLK3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	32,553,897 - 32,593,968 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	32,553,602 - 32,593,638 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	43,993,073 - 44,049,954 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mylk3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624914	198,803 - 239,427 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624914	200,914 - 251,699 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mylk3
130 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	37
Count of miRNA genes:	34
Interacting mature miRNAs:	36
Transcripts:	ENSRNOT00000023657
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411590	Foco7	Food consumption QTL 7	6.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	19	1	24688055	Rat
10054132	Srcrt9	Stress Responsive Cort QTL 9	2.87	0.0017	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	27355345	Rat
631678	Cm9	Cardiac mass QTL 9	4.27	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	19	1	28982497	Rat
631681	Cm12	Cardiac mass QTL 12	3.33	0.00053	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	19	1	28982497	Rat
1549847	Bss8	Bone structure and strength QTL 8	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	19	1	31963836	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	1	36824771	Rat
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	1	36824771	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	36824771	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	1	36824771	Rat
9589102	Slep13	Serum leptin concentration QTL 13	4.63	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	19	569374	45569374	Rat
8694186	Bw152	Body weight QTL 152	3.34	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	569374	45569374	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2187927	46708701	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	2316121	47316121	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	3204777	48204777	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	7457249	42983518	Rat
724565	Tcas5	Tongue tumor susceptibility QTL 5	10.04		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	19	9977753	39654489	Rat
631840	Niddm38	Non-insulin dependent diabetes mellitus QTL 38	3.86		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	19	10323180	23069265	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10827970	43544039	Rat
61407	Scl12	Serum cholesterol level QTL 12		0.001	blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	19	13926401	30303727	Rat
1558656	Prcs1	Prostate cancer susceptibility QTL 1	5		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	19	15114598	34521833	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	15605023	46559041	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat

Markers in Region

RH138801

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	21,742,767 - 21,742,891 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	27,441,632 - 27,441,755	NCBI	Rnor6.0
Rnor_5.0	19	38,407,428 - 38,407,551	UniSTS	Rnor5.0
RGSC_v3.4	19	23,101,789 - 23,101,912	UniSTS	RGSC3.4
Celera	19	21,602,509 - 21,602,632	UniSTS
Cytogenetic Map	19	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		43			2							1
Low			46	34	17	34	8	8	18	32	36	10	8
Below cutoff	2		11	7		7		2	42	3	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001110810	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006255355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097579	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	EU236721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000023657 ⟹ ENSRNOP00000023657

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	21,708,776 - 21,742,608 (+)	Ensembl
Rnor_6.0 Ensembl	19	27,404,712 - 27,441,536 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000100814 ⟹ ENSRNOP00000083206

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	21,691,929 - 21,742,608 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119434 ⟹ ENSRNOP00000090047

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	21,708,776 - 21,742,954 (+)	Ensembl

RefSeq Acc Id:

NM_001110810 ⟹ NP_001104280

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	21,708,776 - 21,742,608 (+)	NCBI
Rnor_6.0	19	27,404,667 - 27,441,472 (+)	NCBI
Rnor_5.0	19	38,356,781 - 38,408,247 (+)	NCBI
RGSC_v3.4	19	23,068,059 - 23,101,629 (+)	RGD
Celera	19	21,568,596 - 21,602,349 (+)	RGD

Sequence:

show sequence

CAAGGGCCTGGGCCAAACTCAGCCTGTCGCTCTCTCAGTGGTTGAGTGGGAGATAGACACAGAG
AACTTGGCCCTCTCCGTCCCCCACACAGTTCAGTCAGGAGGACAGGTTGGTTCCCTGCAGCAAG
GCTCTTAGCAGCGGAGGACAATGGCCTTCCAGACGTTACCACCAAAGTGAGAAGCAGACCCTTC
GTGCTCCAGTTTCCTTGTCTTTGCCCTTACCAAACCAGAATTGGGATGTCAGGAGTTTCAGAGG
AGGATCCAGAGGGTCTGGGCCCCCAGGGTCTGCCAGCGTTGGGCGGAGCCTGCTTAGTCACCGT
GGACAAAAAACTTAATGTGCTGACTGAGAAGGTCGACAGACTCTTGCATTTCCAAGAAGATGTC
ACAGAGAAGCTACAGTGTGTGTGCCAAGGCATGGATCACCTGGAACAAGGTCTGCATCGGCTGG
AGGCCTCCCAGGAGTTGGGTCTGGCAGGGCCCGGCAGCACTTCCCCAGCCGCTGCTCAGGCCGC
ATGGCCTGAGGTCCTGGAGCTGGTGAGGGCCGTGCGGCAGGAGGGTGCCCAGCACGGTGCCAGG
CTCGAAGCCCTCTTCAAGATGGTGGTGGCTGTGGACAGGGCTATTACTTTGGTAGGGTCCACAA
TCCAGAACTCCAAAGTGGATGATTTCATCCTGCAAGGGACCGTGCCCTGGAGGAAAGGCAGTCT
GGCTGATGGCCCTGAGGAGAACAAGGAGCAAGCAGAAGTGGCTGGAGTGAAGCCAAAGCATGTG
CTGAATACAGGAAGTGTGCAAGCTGCCACTTCTAGGGCGCTGTGGGAAGAGAGCCAGAAGCAGG
ACACACCCGTGGGGACAGTGGAGGGGCTGCCTCTCATCATCGATACGTCACTGAAGGGAGCTGA
CCTCACCCAGGCTGGAGCCTCACTGAGGCAGGGAGTTGAAGCTCTTGACCCAGGCCAAGAACCC
CCACCCGCAGAGGCAGAATCCAGGCTTCCTGCACTAGCCAGCGAGGACACTGGGACCACCCTGG
AATTGTCTGTAGCAATTGACAGAATCAGTGAGGTCCTCACTAGCCTCAGGATGTCCCAAAGTGC
TGGCGAAGGAACCTCATCCAGCAAGCCTGACTGTTCAGAGCCTGGCCCTCAGCCCCTAGGGCCA
CTAACTACAGACAGTGACATTCACAGTGATGAAGGACTTCCCAGGATCTCTGTCCGTATGCGAG
AGATGACTACTCCTGAGGAGCTGTTTGAGACCCAAGGTGGCAGCCCCATTGGCTCGGCAGAAGC
TCCAGGCCCTGGAACTGTGTTAGAAGACCAGATCCCTAAAGGAGCCAGACCATTTCCACCCCTG
CCAAAGAGGAGCTGCAACAATGGTGGCGCGAGTGCAGAGGAGGCAACAGGGCCTGGGGCTGAGC
CCATCAGAGGACCAAGCTTGGTCACAAGGGACTGGAGAGATGAACCTGTTGGGACCACAGACCT
GCAGCAAGGCAGAGACCCAGGAGCGGTGAGCCCTGAACCTGGGAAGGACCATGCAGCCCAGGGC
CCAGGGAGAACCGAAGCTGGAAGGAGGGTGTCTTCTGCTGCAGAGGCTGCCATCGTAGTTCTAG
ATGACAGCGCAGCACCCCCAGCCCCTTTTGAACACCGGGTAGTGAGCATCAAAGACACCCTCAT
CTCGACAAGTTACACAGTGTCCCAACACGAAGTCTTGGGAGGGGGCCGGTTTGGCCAGGTGCAC
AGGTGTACAGAGCGGTCCACAGGCCTTGCACTGGCAGCCAAGATCATCAAAGTGAAGAACATAA
AGGACCGGGAGGATGTGAAGAATGAGATCAACATCATGAACCAGCTCAGCCACGTAAACTTGAT
CCAACTTTATGATGCTTTTGAGAGCAAGAACAGCTTCACCCTGATCATGGAGTATGTGGATGGA
GGTGAACTCTTCGACCGGATCACGGATGAGAAGTACCACCTGACCGAGCTGGATGTGGTCTTGT
TCACAAGGCAGATCTGTGAGGGTGTGCATTACCTGCACCAGCACTACATTCTGCACCTGGACCT
CAAGCCAGAGAACATACTGTGTGTCAGCCAGACTGGGCATCAAATTAAGATTATTGACTTTGGG
CTGGCTAGAAGATATAAACCTCGGGAGAAGCTAAAGGTTAACTTTGGTACTCCAGAGTTCCTGG
CTCCAGAAGTTGTTAACTATGAGTTTGTCTCATTCCCAACAGACATGTGGAGTGTGGGAGTTAT
CACCTACATGCTACTCAGTGGTTTGTCCCCATTTCTAGGGGAAACAGATGCAGAGACCATGAAT
TTTATTGTGAACTGCAGCTGGGATTTCGATGCTGATACCTTCAAAGGGCTGTCAGAGGAAGCCA
AGGACTTTGTTTCACGGTTGCTGGTCAAAGAGAAGAGTTGTAGGATGAGCGCCACACAGTGCCT
GAAACATGAGTGGTTAAATCACCTGATTGCCAAAGCCTCAGGCTCCAACGTTCGCCTCAGATCC
CAACTACTGCTGCAGAAATATATGGCTCAGCGTAAATGGAAGAAACATTTCCATGTGGTGACTG
CAGTCAACAGGCTAAGAAAATTTCCAACGTGTCCCTAATCTACAACTGGGCCTGGGAGTTCCTG
AGGCGACACGCAGTGGTAATGTGAAGAGATGACTCAGGATTTTATGGAGTCAGGAGCTTGGCTG
TTATTGATCTTATTTTGCAAAGAATGGTGGAAGGAAGAAAGAGA

hide sequence

RefSeq Acc Id:

XM_006255355 ⟹ XP_006255417

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	21,691,929 - 21,743,587 (+)	NCBI
Rnor_6.0	19	27,388,163 - 27,442,451 (+)	NCBI
Rnor_5.0	19	38,356,781 - 38,408,247 (+)	NCBI

Sequence:

show sequence

ACCCGAGCTCTTCCCTGCCAAGCGGCCCACCTCATTCCCAGGGCTCCACAGAGTTGGGCAGCAT
CCATTTCCAGGCAAAGTAAATAGATCTTGGTCACCGTGGCCAAAGGATGGGAACTCTGTGCCCT
GTCCCAGCTCTGTGCAGGCCCAGCACCCGAGGCCAGCAGCGGGCATCAGATTACGCCCAGATAT
TCACGAACAAGGAGCAAGCAGAAGTGGCTGGAGTGAAGCCAAAGCATGTGCTGAATACAGGAAG
TGTGCAAGCTGCCACTTCTAGGGCGCTGTGGGAAGAGAGCCAGAAGCAGGACACACCCGTGGGG
ACAGTGGAGGGGCTGCCTCTCATCATCGATACGTCACTGAAGGGAGCTGACCTCACCCAGGCTG
GAGCCTCACTGAGGCAGGGAGTTGAAGCTCTTGACCCAGGCCAAGAACCCCCACCCACAGAGGC
AGAATCCAGGCTTCCTGCACTAGCCAGCGAGGACACTGGGACCACCCTGGAATTGTCTGTAGCA
ATTGACAGAATCAGTGAGGTCCTCACTAGCCTCAGGATGTCCCAAAGTGCTGGCGAAGGAACCT
CATCCAGCAAGCCTGACTGTTCAGAGCCTGGCCCTCAGCCCCTAGGGCCACTAACTACAGACAG
TGACATTCACAGTGATGAAGGACTTCCCAGGATCTCTGTCCGTATGCGAGAGATGACTACTCCT
GAGGAGCTGTTTGAGACCCAAGGTGGCAGCCCCATTGGCTCGGCAGAAGCTCCAGGCCCTGGAA
CTGTGTTAGAAGACCAGATCCCTAAAGGAGCCAGACCATTTCCACCCCTGCCAAAGAGGAGCTG
CAACAATGGTGGCGCGAGTGCAGAGGAGGCAACAGGGCCTGGGGCTGAGCCCATCAGAGGACCA
AGCTTGGTCACAAGGGACTGGAGAGATGAACCTGTTGGGACCACAGACCTGCAGCAAGGCAGAG
ACCCAGGAGCGGTGAGCCCTGAACCTGGGAAGGACCATGCAGCCCAGGGCCCAGGGAGAACCGA
AGCTGGAAGGAGGGTGTCTTCTGCTGCAGAGGCTGCCATCGTAGTTCTAGATGACAGCGCAGCA
CCCCCAGCCCCTTTTGAACACCGGGTAGTGAGCATCAAAGACACCCTCATCTCGACAAGTTACA
CAGTGTCCCAACACGAAGTCTTGGGAGGGGGCCGGTTTGGCCAGGTGCACAGGTGTACAGAGCG
GTCCACAGGCCTTGCACTGGCAGCCAAGATCATCAAAGTGAAGAACATAAAGGACCGGGAGGAT
GTGAAGAATGAGATCAACATCATGAACCAGCTCAGCCACGTAAACTTGATCCAACTTTATGATG
CTTTTGAGAGCAAGAACAGCTTCACCCTGATCATGGAGTATGTGGATGGAGGTGAACTCTTCGA
CCGGATCACGGATGAGAAGTACCACCTGACCGAGCTGGATGTGGTCTTGTTCACAAGGCAGATC
TGTGAGGGTGTGCATTACCTGCACCAGCACTACATTCTGCACCTGGACCTCAAGCCAGAGAACA
TACTGTGTGTCAGCCAGACTGGGCATCAAATTAAGATTATTGACTTTGGGCTGGCTAGAAGATA
TAAACCTCGGGAGAAGCTAAAGGTTAACTTTGGTACTCCAGAGTTCCTGGCTCCAGAAGTTGTT
AACTATGAGTTTGTCTCATTCCCAACAGACATGTGGAGTGTGGGAGTTATCACCTACATGCTAC
TCAGTGGTTTGTCCCCATTTCTAGGGGAAACAGATGCAGAGACCATGAATTTTATTGTGAACTG
CAGCTGGGATTTCGATGCTGATACCTTCAAAGGGCTGTCAGAGGAAGCCAAGGACTTTGTTTCA
CGGTTGCTGGTCAAAGAGAAGAGTTGTAGGATGAGCGCCACACAGTGCCTGAAACATGAGTGGT
TAAATCACCTGATTGCCAAAGCCTCAGGCTCCAACGTTCGCCTCAGATCCCAACTACTGCTGCA
GAAATATATGGCTCAGCGTAAATGGAAGAAACATTTCCATGTGGTGACTGCAGTCAACAGGCTA
AGAAAATTTCCAACGTGTCCCTAATCTACAACTGGGCCTGGGAGTTCCTGAGGCGACACGCAGT
GGTAATGTGAAGAGATGACTCAGGATTTTATGGAGTCAGGAGCTTGGCTGTTATTGATCTTATT
TTGCAAAGAATGGTGGAAGGAAGAAAGAGAGAAAGAAAGAAGAAAAGGGAAAAGGAAAGAAGAT
GGCTACGTTGCTGGCCTCCTTGTGGATGAAAGTGTGTTTTTTTAAAGCCCTAGGAAGGTCACCA
GGTCTAATGCTGCCTCCTCCCCAGAGCCCTCTCTTCTGGTAATGAGAGTAGGCACGCTCAGGAA
GGGCAGGGAAATCCTACTTGGCCTTTGGTCAAATTCAATTCTAAACTCGTCATGATTAAAGAAG
CCAGTAGGGAGGGAAGCATGGGACAGGGAGGAATTAGGTCTGACAGTGGGAAGGAACATGATCG
AAACATACTGTATAACATTCTTAAAGAATTAATAAAATGTATTTTTAAAGGAGTCAGTAGGTTC
GAGCTGCTTGCTATTTTAGTGAAAGAAGCTCCTTTTTTTTTTTTTTTCAGTGAGTAATAGTGCA
AAGATTCAGAATTGATCAAAATGCAAACTGCACTCAACTCTGGGTGAGTCAATCCTCCCCCATC
CAAGGCTCAGGGAGCGTCTCAGAACAGGGGACGGAAAGAACGTAAGAGTTGGTAGATGAGGAGG
AGTCCTAGGGGATGTCTTTGAGACATGACATGACTTGTGTTGGCATCAATTTACAATATCTTTG
GCTACCTGCACAAGATCAAGTCGGCCAAAATTCCAGTGAGGATGGGAGGAAACTCCTGAGGCCC
ACCCCTACTGGTGGAGCTACTGGCAATTGTTGGCTGATGAGGCAGGGAGAATTGTTCTTCTTTA
ACCTCTAGCAGTAGTTGTTTATGCCCCAGTAGATGCTACATACCCATGTGCAGATGGGCAGTAC
CAATTAGACTGGGGAGGTTACTGATGGCAAAAAAATAAATAAAAGGAGTACCTGTAGGTAGGAA
GGAGATGGAGTGGAACATTAGGGAGAATTGGGAGCAGGTAGATGGATATGATCGATATGCATTG
TACTAATGTATGGAGTGTTCAAAGAATAAAAAAGTCATTTAAAACAGAA

hide sequence

RefSeq Acc Id:

XM_039097579 ⟹ XP_038953507

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	21,685,085 - 21,743,587 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001104280	(Get FASTA)	NCBI Sequence Viewer
	XP_006255417	(Get FASTA)	NCBI Sequence Viewer
	XP_038953507	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABW96144	(Get FASTA)	NCBI Sequence Viewer
	E9PT87	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001104280 ⟸ NM_001110810

- UniProtKB:

A8WE96 (UniProtKB/Swiss-Prot), E9PT87 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MSGVSEEDPEGLGPQGLPALGGACLVTVDKKLNVLTEKVDRLLHFQEDVTEKLQCVCQGMDHLE
QGLHRLEASQELGLAGPGSTSPAAAQAAWPEVLELVRAVRQEGAQHGARLEALFKMVVAVDRAI
TLVGSTIQNSKVDDFILQGTVPWRKGSLADGPEENKEQAEVAGVKPKHVLNTGSVQAATSRALW
EESQKQDTPVGTVEGLPLIIDTSLKGADLTQAGASLRQGVEALDPGQEPPPAEAESRLPALASE
DTGTTLELSVAIDRISEVLTSLRMSQSAGEGTSSSKPDCSEPGPQPLGPLTTDSDIHSDEGLPR
ISVRMREMTTPEELFETQGGSPIGSAEAPGPGTVLEDQIPKGARPFPPLPKRSCNNGGASAEEA
TGPGAEPIRGPSLVTRDWRDEPVGTTDLQQGRDPGAVSPEPGKDHAAQGPGRTEAGRRVSSAAE
AAIVVLDDSAAPPAPFEHRVVSIKDTLISTSYTVSQHEVLGGGRFGQVHRCTERSTGLALAAKI
IKVKNIKDREDVKNEINIMNQLSHVNLIQLYDAFESKNSFTLIMEYVDGGELFDRITDEKYHLT
ELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVSQTGHQIKIIDFGLARRYKPREKLKVNF
GTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFK
GLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNHLIAKASGSNVRLRSQLLLQKYMAQRKWKK
HFHVVTAVNRLRKFPTCP

hide sequence

RefSeq Acc Id:	XP_006255417 ⟸ XM_006255355
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZYT9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGTLCPVPALCRPSTRGQQRASDYAQIFTNKEQAEVAGVKPKHVLNTGSVQAATSRALWEESQK QDTPVGTVEGLPLIIDTSLKGADLTQAGASLRQGVEALDPGQEPPPTEAESRLPALASEDTGTT LELSVAIDRISEVLTSLRMSQSAGEGTSSSKPDCSEPGPQPLGPLTTDSDIHSDEGLPRISVRM REMTTPEELFETQGGSPIGSAEAPGPGTVLEDQIPKGARPFPPLPKRSCNNGGASAEEATGPGA EPIRGPSLVTRDWRDEPVGTTDLQQGRDPGAVSPEPGKDHAAQGPGRTEAGRRVSSAAEAAIVV LDDSAAPPAPFEHRVVSIKDTLISTSYTVSQHEVLGGGRFGQVHRCTERSTGLALAAKIIKVKN IKDREDVKNEINIMNQLSHVNLIQLYDAFESKNSFTLIMEYVDGGELFDRITDEKYHLTELDVV LFTRQICEGVHYLHQHYILHLDLKPENILCVSQTGHQIKIIDFGLARRYKPREKLKVNFGTPEF LAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFKGLSEE AKDFVSRLLVKEKSCRMSATQCLKHEWLNHLIAKASGSNVRLRSQLLLQKYMAQRKWKKHFHVV TAVNRLRKFPTCP hide sequence

RefSeq Acc Id:

ENSRNOP00000023657 ⟸ ENSRNOT00000023657

RefSeq Acc Id:	XP_038953507 ⟸ XM_039097579
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000090047 ⟸ ENSRNOT00000119434

RefSeq Acc Id:

ENSRNOP00000083206 ⟸ ENSRNOT00000100814

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-E9PT87-F1-model_v2	AlphaFold	E9PT87	1-786	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305801	AgrOrtholog
BioCyc Gene	G2FUF-6202	BioCyc
Ensembl Genes	ENSRNOG00000017546	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000023657	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000083206	ENTREZGENE
	ENSRNOP00000083206.1	UniProtKB/TrEMBL
	ENSRNOP00000090047.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023657	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000100814	ENTREZGENE
	ENSRNOT00000100814.1	UniProtKB/TrEMBL
	ENSRNOT00000119434.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:291926	UniProtKB/Swiss-Prot
NCBI Gene	291926	ENTREZGENE
PANTHER	DEATH-ASSOCIATED PROTEIN KINASE 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE 17	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mylk3	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZYT9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GIK4_RAT	UniProtKB/TrEMBL
	A8WE96	ENTREZGENE
	E9PT87	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	A8WE96	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Mylk3	myosin light chain kinase 3	RGD1305801_predicted	similar to Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1305801_predicted	similar to Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (predicted)	LOC291926_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC291926_predicted	similar to Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)