Gene: Inpp4b (inositol polyphosphate-4-phosphatase type II B) Rattus norvegicus
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Symbol: Inpp4b
Name: inositol polyphosphate-4-phosphatase type II B
Description: ENCODES a protein that exhibits phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; lipid binding (ortholog); phosphatidylinositol bisphosphate phosphatase activity (ortholog); INVOLVED IN cellular calcium ion homeostasis (ortholog); negative regulation of osteoclast differentiation (ortholog); regulation of bone remodeling (ortholog); PARTICIPATES IN inositol phosphate metabolic pathway; phosphoinositide metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); hepatocellular carcinoma (ortholog); pancreatic carcinoma (ortholog); FOUND IN cytoplasm (ortholog); Golgi apparatus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene
AGR Description: Exhibits phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; predicted to be involved in several processes, including cellular calcium ion homeostasis, negative regulation of osteoclast differentiation, and regulation of bone remodeling; predicted to localize to the Golgi apparatus; orthologous to human INPP4B (inositol polyphosphate-4-phosphatase type II B).
Merged Description: Exhibits phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; predicted to be involved in several processes, including cellular calcium ion homeostasis, negative regulation of osteoclast differentiation, and regulation of bone remodeling; predicted to localize to the Golgi apparatus; orthologous to human INPP4B (inositol polyphosphate-4-phosphatase type II B); PARTICIPATES IN inositol phosphate metabolic pathway; phosphoinositide metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: inositol polyphosphate 4-phosphatase type II; inositol polyphosphate-4-phosphatase type II 105kD; inositol polyphosphate-4-phosphatase, type II; inositol polyphosphate-4-phosphatase, type II, 105kD; type II inositol 3,4-bisphosphate 4-phosphatase; type II inositol-3,4-bisphosphate 4-phosphatase
Orthologs:
Allele / Splice: Inpp4bTn(sb-T2/Bart3)2.143Mcwi   Inpp4bTn(sb-T2/Bart3)2.232Mcwi  
Genetic Models: F344-Inpp4bTn(sb-T2/Bart3)2.232Mcwi F344-Inpp4bTn(sb-T2/Bart3)2.143Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01929,592,889 - 30,341,528 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01940,508,684 - 41,132,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41927,722,430 - 28,363,639 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11927,727,256 - 28,484,803 (-)NCBI
Celera1925,451,220 - 26,189,580 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated
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Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Inpp4b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620470
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.