Inpp4b (inositol polyphosphate-4-phosphatase type II B) - Rat Genome Database

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Gene: Inpp4b (inositol polyphosphate-4-phosphatase type II B) Rattus norvegicus
Analyze
Symbol: Inpp4b
Name: inositol polyphosphate-4-phosphatase type II B
RGD ID: 620470
Description: Enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Acts upstream of or within phosphatidylinositol dephosphorylation. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human INPP4B (inositol polyphosphate-4-phosphatase type II B); PARTICIPATES IN inositol phosphate metabolic pathway; phosphoinositide metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inositol polyphosphate 4-phosphatase type II; inositol polyphosphate-4-phosphatase type II 105kD; inositol polyphosphate-4-phosphatase, type II; inositol polyphosphate-4-phosphatase, type II, 105kD; type II inositol 3,4-bisphosphate 4-phosphatase; type II inositol-3,4-bisphosphate 4-phosphatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Inpp4bTn(sb-T2/Bart3)2.143Mcwi   Inpp4bTn(sb-T2/Bart3)2.232Mcwi  
Genetic Models: F344-Inpp4bTn(sb-T2/Bart3)2.143Mcwi F344-Inpp4bTn(sb-T2/Bart3)2.232Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81942,824,710 - 43,575,039 (-)NCBIGRCr8
mRatBN7.21925,920,189 - 26,670,085 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1925,925,358 - 26,280,634 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1932,773,840 - 33,511,367 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01933,427,933 - 34,165,436 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01935,664,080 - 36,411,093 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01929,592,889 - 30,341,528 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1929,597,905 - 29,968,424 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01940,508,684 - 41,132,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41927,722,430 - 28,363,639 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11927,727,256 - 28,484,803 (-)NCBI
Celera1925,451,220 - 26,189,580 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
daunorubicin  (ISO)
Dibutyl phosphate  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
folpet  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
isotretinoin  (ISO)
maneb  (ISO)
methoxychlor  (EXP)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
O-methyleugenol  (ISO)
panobinostat  (ISO)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. Norris FA, etal., J Biol Chem 1997 Sep 19;272(38):23859-64.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:16631325   PMID:21982707   PMID:23078915  


Genomics

Comparative Map Data
Inpp4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81942,824,710 - 43,575,039 (-)NCBIGRCr8
mRatBN7.21925,920,189 - 26,670,085 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1925,925,358 - 26,280,634 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1932,773,840 - 33,511,367 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01933,427,933 - 34,165,436 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01935,664,080 - 36,411,093 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01929,592,889 - 30,341,528 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1929,597,905 - 29,968,424 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01940,508,684 - 41,132,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41927,722,430 - 28,363,639 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11927,727,256 - 28,484,803 (-)NCBI
Celera1925,451,220 - 26,189,580 (-)NCBICelera
Cytogenetic Map19q11NCBI
INPP4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384142,023,160 - 142,846,535 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4142,023,160 - 142,847,432 (-)EnsemblGRCh38hg38GRCh38
GRCh374142,944,313 - 143,767,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364143,168,631 - 143,987,054 (-)NCBINCBI36Build 36hg18NCBI36
Build 344143,307,498 - 143,710,137NCBI
Celera4140,279,978 - 141,098,274 (-)NCBICelera
Cytogenetic Map4q31.21NCBI
HuRef4138,678,404 - 139,496,966 (-)NCBIHuRef
CHM1_14142,926,560 - 143,744,866 (-)NCBICHM1_1
T2T-CHM13v2.04145,340,544 - 146,163,746 (-)NCBIT2T-CHM13v2.0
Inpp4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39882,068,895 - 82,865,553 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl882,069,185 - 82,854,543 (+)EnsemblGRCm39 Ensembl
GRCm38881,342,266 - 82,134,312 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl881,342,556 - 82,127,914 (+)EnsemblGRCm38mm10GRCm38
MGSCv37884,239,099 - 84,646,460 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36884,610,947 - 85,018,308 (+)NCBIMGSCv36mm8
Celera886,003,317 - 86,422,617 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map839.02NCBI
Inpp4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955471938,005 - 1,291,695 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955471938,005 - 1,291,695 (+)NCBIChiLan1.0ChiLan1.0
INPP4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23139,915,448 - 140,728,958 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14140,308,554 - 141,448,389 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04134,405,934 - 135,213,851 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14145,707,005 - 146,513,611 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4145,706,307 - 146,141,029 (-)Ensemblpanpan1.1panPan2
INPP4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.119826,711 - 1,192,340 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl19850,784 - 1,186,498 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha191,074,484 - 1,439,447 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.019847,593 - 1,213,382 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl19872,222 - 1,211,381 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.119829,445 - 1,194,997 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0191,190,522 - 1,556,374 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0191,544,331 - 1,910,402 (+)NCBIUU_Cfam_GSD_1.0
Inpp4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530147,989,723 - 48,731,310 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365355,794,135 - 6,171,072 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365355,427,131 - 6,168,622 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INPP4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl885,084,133 - 85,514,516 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1884,812,041 - 85,555,200 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2890,440,950 - 90,810,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
INPP4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1788,929,249 - 89,732,375 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl788,979,493 - 89,461,475 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603768,478,295 - 69,289,053 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inpp4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248531,355,384 - 1,868,812 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248531,350,577 - 2,147,616 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Inpp4b
5026 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:388
Count of miRNA genes:208
Interacting mature miRNAs:253
Transcripts:ENSRNOT00000024981, ENSRNOT00000025013
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192481604133061905Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat

Markers in Region
D15Mit4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25138,497,366 - 138,497,449 (+)MAPPERmRatBN7.2
mRatBN7.25138,493,166 - 138,493,249 (+)MAPPERmRatBN7.2
mRatBN7.21926,052,677 - 26,052,794 (+)MAPPERmRatBN7.2
mRatBN7.25138,501,566 - 138,501,649 (+)MAPPERmRatBN7.2
mRatBN7.25138,505,766 - 138,505,849 (+)MAPPERmRatBN7.2
Rnor_6.01929,725,257 - 29,725,373NCBIRnor6.0
Rnor_6.05144,227,288 - 144,227,370NCBIRnor6.0
Rnor_5.01940,635,255 - 40,635,371UniSTSRnor5.0
Rnor_5.05147,995,326 - 147,995,408UniSTSRnor5.0
RGSC_v3.45145,575,830 - 145,575,912UniSTSRGSC3.4
RGSC_v3.41927,849,593 - 27,849,709UniSTSRGSC3.4
RGSC_v3.11927,854,418 - 27,854,535RGD
Celera1925,576,861 - 25,576,977UniSTS
Celera5137,003,287 - 137,003,369UniSTS
Cytogenetic Map19q11UniSTS
D19Rat41  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21926,296,511 - 26,296,662 (+)MAPPERmRatBN7.2
Rnor_6.01929,966,560 - 29,966,710NCBIRnor6.0
Rnor_5.01940,875,102 - 40,875,252UniSTSRnor5.0
RGSC_v3.41928,102,830 - 28,102,981RGDRGSC3.4
RGSC_v3.41928,102,831 - 28,102,981UniSTSRGSC3.4
RGSC_v3.11928,107,656 - 28,107,807RGD
Celera1925,818,951 - 25,819,101UniSTS
SHRSP x BN Map1920.2599RGD
SHRSP x BN Map1920.2599UniSTS
Cytogenetic Map19q11UniSTS
D19Rat120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21926,182,615 - 26,182,815 (+)MAPPERmRatBN7.2
Rnor_6.01929,855,156 - 29,855,355NCBIRnor6.0
Rnor_5.01940,765,631 - 40,765,830UniSTSRnor5.0
RGSC_v3.41927,980,182 - 27,980,382RGDRGSC3.4
RGSC_v3.41927,980,183 - 27,980,382UniSTSRGSC3.4
RGSC_v3.11927,985,008 - 27,985,208RGD
Celera1925,706,606 - 25,706,805UniSTS
SHRSP x BN Map1920.2599RGD
SHRSP x BN Map1920.2599UniSTS
Cytogenetic Map19q11UniSTS
D19Got19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21926,283,898 - 26,284,096 (+)MAPPERmRatBN7.2
Rnor_6.01929,954,758 - 29,954,955NCBIRnor6.0
Rnor_5.01940,863,300 - 40,863,497UniSTSRnor5.0
RGSC_v3.41928,089,765 - 28,089,963RGDRGSC3.4
RGSC_v3.41928,089,766 - 28,089,963UniSTSRGSC3.4
RGSC_v3.11928,094,591 - 28,094,789RGD
Celera1925,806,321 - 25,806,518UniSTS
Cytogenetic Map19q11UniSTS
AU047006  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21926,551,265 - 26,551,402 (+)MAPPERmRatBN7.2
Rnor_6.01930,221,722 - 30,221,858NCBIRnor6.0
Rnor_5.01941,130,850 - 41,130,986UniSTSRnor5.0
RGSC_v3.41928,362,454 - 28,362,590UniSTSRGSC3.4
Celera1926,073,432 - 26,073,568UniSTS
Cytogenetic Map19q11UniSTS
RH138607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21926,236,741 - 26,236,960 (+)MAPPERmRatBN7.2
Rnor_6.01929,908,062 - 29,908,280NCBIRnor6.0
Rnor_5.01940,816,604 - 40,816,822UniSTSRnor5.0
RGSC_v3.41928,041,670 - 28,041,888UniSTSRGSC3.4
Celera1925,759,562 - 25,759,780UniSTS
Cytogenetic Map19q11UniSTS
RH143194  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21926,236,823 - 26,236,947 (+)MAPPERmRatBN7.2
Rnor_6.01929,908,144 - 29,908,267NCBIRnor6.0
Rnor_5.01940,816,686 - 40,816,809UniSTSRnor5.0
RGSC_v3.41928,041,752 - 28,041,875UniSTSRGSC3.4
Celera1925,759,644 - 25,759,767UniSTS
Cytogenetic Map19q11UniSTS
AU029195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21926,161,303 - 26,161,447 (+)MAPPERmRatBN7.2
Rnor_6.01929,833,847 - 29,833,990NCBIRnor6.0
Rnor_5.01940,744,189 - 40,744,332UniSTSRnor5.0
RGSC_v3.41927,958,518 - 27,958,661UniSTSRGSC3.4
Celera1925,685,318 - 25,685,461UniSTS
Cytogenetic Map19q11UniSTS


Genetic Models
This gene Inpp4b is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 8 17 8 8 14 7 8 8
Low 3 35 44 36 2 36 3 52 35 34 3
Below cutoff 5 5 5 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U96920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U96921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000024981   ⟹   ENSRNOP00000024981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1925,925,358 - 26,280,634 (-)Ensembl
Rnor_6.0 Ensembl1929,597,905 - 29,968,424 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000025013   ⟹   ENSRNOP00000025013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1925,925,588 - 26,280,634 (-)Ensembl
Rnor_6.0 Ensembl1929,598,280 - 29,951,493 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097624   ⟹   ENSRNOP00000085379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1925,925,588 - 26,280,634 (-)Ensembl
RefSeq Acc Id: NM_053917   ⟹   NP_446369
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,574,411 (-)NCBI
mRatBN7.21925,925,587 - 26,669,963 (-)NCBI
Rnor_6.01929,598,279 - 30,341,442 (-)NCBI
Rnor_5.01940,508,684 - 41,132,035 (-)NCBI
RGSC_v3.41927,722,430 - 28,363,639 (-)RGD
Celera1925,451,220 - 26,189,580 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772462   ⟹   XP_008770684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,242,638 (-)NCBI
mRatBN7.21925,926,776 - 26,346,238 (-)NCBI
Rnor_6.01929,598,279 - 30,008,667 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601163   ⟹   XP_017456652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,575,036 (-)NCBI
mRatBN7.21925,925,575 - 26,670,084 (-)NCBI
Rnor_6.01929,598,279 - 30,341,527 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601165   ⟹   XP_017456654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,575,039 (-)NCBI
mRatBN7.21925,926,776 - 26,670,085 (-)NCBI
Rnor_6.01929,598,279 - 30,341,528 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097428   ⟹   XP_038953356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,575,036 (-)NCBI
mRatBN7.21925,926,776 - 26,670,084 (-)NCBI
RefSeq Acc Id: XM_039097429   ⟹   XP_038953357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,495,120 (-)NCBI
mRatBN7.21925,926,776 - 26,589,522 (-)NCBI
RefSeq Acc Id: XM_039097430   ⟹   XP_038953358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,575,037 (-)NCBI
mRatBN7.21925,925,575 - 26,670,085 (-)NCBI
RefSeq Acc Id: XM_039097434   ⟹   XP_038953362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,068,527 (-)NCBI
mRatBN7.21925,926,776 - 26,164,030 (-)NCBI
RefSeq Acc Id: XM_039097435   ⟹   XP_038953363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,149,920 (-)NCBI
mRatBN7.21925,926,776 - 26,245,459 (-)NCBI
RefSeq Acc Id: XM_063277734   ⟹   XP_063133804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,575,036 (-)NCBI
RefSeq Acc Id: XM_063277736   ⟹   XP_063133806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,824,710 - 43,242,638 (-)NCBI
RefSeq Acc Id: XM_063277737   ⟹   XP_063133807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,242,638 (-)NCBI
RefSeq Acc Id: XM_063277738   ⟹   XP_063133808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,824,710 - 43,242,638 (-)NCBI
RefSeq Acc Id: XM_063277739   ⟹   XP_063133809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,575,032 (-)NCBI
RefSeq Acc Id: NP_446369   ⟸   NM_053917
- UniProtKB: A6IYG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770684   ⟸   XM_008772462
- Peptide Label: isoform X1
- UniProtKB: A6IYG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456654   ⟸   XM_017601165
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A1I3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456652   ⟸   XM_017601163
- Peptide Label: isoform X1
- UniProtKB: A6IYG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024981   ⟸   ENSRNOT00000024981
RefSeq Acc Id: ENSRNOP00000025013   ⟸   ENSRNOT00000025013
RefSeq Acc Id: XP_038953358   ⟸   XM_039097430
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038953356   ⟸   XM_039097428
- Peptide Label: isoform X1
- UniProtKB: A6IYG6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953357   ⟸   XM_039097429
- Peptide Label: isoform X1
- UniProtKB: A6IYG6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953363   ⟸   XM_039097435
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038953362   ⟸   XM_039097434
- Peptide Label: isoform X7
RefSeq Acc Id: ENSRNOP00000085379   ⟸   ENSRNOT00000097624
RefSeq Acc Id: XP_063133808   ⟸   XM_063277738
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063133806   ⟸   XM_063277736
- Peptide Label: isoform X3
- UniProtKB: Q9QWG5 (UniProtKB/Swiss-Prot),   O35825 (UniProtKB/Swiss-Prot),   A6IYG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133804   ⟸   XM_063277734
- Peptide Label: isoform X1
- UniProtKB: A6IYG6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133809   ⟸   XM_063277739
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063133807   ⟸   XM_063277737
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A1I3 (UniProtKB/TrEMBL)
Protein Domains
C2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QWG5-F1-model_v2 AlphaFold Q9QWG5 1-928 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620470 AgrOrtholog
BioCyc Gene G2FUF-5984 BioCyc
BioCyc Pathway PWY-6368 [3-phosphoinositide degradation] BioCyc
BioCyc Pathway Image PWY-6368 BioCyc
Ensembl Genes ENSRNOG00000018382 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055007963 UniProtKB/Swiss-Prot
  ENSRNOG00060011966 UniProtKB/Swiss-Prot
  ENSRNOG00065010215 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024981.7 UniProtKB/Swiss-Prot
  ENSRNOT00000025013 ENTREZGENE
  ENSRNOT00000025013.5 UniProtKB/Swiss-Prot
  ENSRNOT00000097624.1 UniProtKB/TrEMBL
  ENSRNOT00055013428 UniProtKB/Swiss-Prot
  ENSRNOT00060020295 UniProtKB/Swiss-Prot
  ENSRNOT00065016487 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INPP4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116699 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 116699 ENTREZGENE
PANTHER INOSITOL POLYPHOSPHATE 4-PHOSPHATASE TYPE II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12187 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/TrEMBL
PhenoGen Inpp4b PhenoGen
PROSITE PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018382 RatGTEx
  ENSRNOG00055007963 RatGTEx
  ENSRNOG00060011966 RatGTEx
  ENSRNOG00065010215 RatGTEx
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A1I3 ENTREZGENE, UniProtKB/TrEMBL
  A6IYG5 ENTREZGENE, UniProtKB/TrEMBL
  A6IYG6 ENTREZGENE, UniProtKB/TrEMBL
  A6IYG7_RAT UniProtKB/TrEMBL
  INP4B_RAT UniProtKB/Swiss-Prot
  O35825 ENTREZGENE
  Q9QWG5 ENTREZGENE
UniProt Secondary O35825 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Inpp4b  inositol polyphosphate-4-phosphatase, type II    inositol polyphosphate-4-phosphatase, type II, 105kD  Name updated 1299863 APPROVED
2002-08-07 Inpp4b  inositol polyphosphate-4-phosphatase, type II, 105kD      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in skeletal muscle and heart with some expression in most tissues 633135
gene_protein a 105,257-Da protein 633135