Mir23a (microRNA 23a) - Rat Genome Database

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Gene: Mir23a (microRNA 23a) Rattus norvegicus
Symbol: Mir23a
Name: microRNA 23a
RGD ID: 2325395
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including cellular response to estradiol stimulus; negative regulation of gap junction assembly; and positive regulation of cytokine production. Predicted to be located in P-body and extracellular exosome. Predicted to be part of RISC complex. Used to study osteonecrosis. Biomarker of cardiac arrest. Orthologous to human MIR23A (microRNA 23a); INTERACTS WITH 3,7-dihydropurine-6-thione; aflatoxin B1; aristolochic acid A.
Type: ncrna (Ensembl: miRNA)
Previously known as: microRNA mir-23a; rno-mir-23a
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81940,859,769 - 40,859,843 (-)NCBIGRCr8
mRatBN7.21923,954,997 - 23,955,071 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,954,997 - 23,955,071 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,775,857 - 30,775,931 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,430,266 - 31,430,340 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,653,035 - 33,653,109 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,318,582 - 25,318,656 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,318,582 - 25,318,656 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,294,770 - 36,294,844 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1923,503,845 - 23,503,919 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
BMP signaling pathway  (ISO)
cellular response to estradiol stimulus  (IEP)
cellular response to phenylalanine  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of gap junction assembly  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of vascular permeability  (ISO)
ossification  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of Fas signaling pathway  (ISO)
positive regulation of ferroptosis  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 beta production  (IMP)
positive regulation of interleukin-6 production  (IMP)
positive regulation of myelination  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of tumor necrosis factor production  (IMP)
post-embryonic camera-type eye morphogenesis  (ISO)
post-embryonic hindlimb morphogenesis  (ISO)
regulation of gene expression  (ISO)
regulation of semaphorin-plexin signaling pathway  (ISO)
regulation of sprouting angiogenesis  (ISO)
retina vasculature development in camera-type eye  (ISO)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. MicroRNA-23a-3p inhibitor decreases osteonecrosis incidence in a rat model. Dong Y, etal., Mol Med Rep. 2017 Dec;16(6):9331-9336. doi: 10.3892/mmr.2017.7808. Epub 2017 Oct 17.
2. Inhibition of long noncoding RNA growth arrest-specific 5 attenuates cerebral injury induced by deep hypothermic circulatory arrest in rats. Gao S, etal., J Thorac Cardiovasc Surg. 2019 Jan 25:S0022-5223(19)30260-0. doi: 10.1016/j.jtcvs.2019.01.050.
3. MicroRNA-23a-3p promotes the perihematomal edema formation after intracerebral hemorrhage via ZO-1. Hu YL, etal., Eur Rev Med Pharmacol Sci. 2018 May;22(9):2809-2816. doi: 10.26355/eurrev_201805_14980.
4. Acupuncture Ameliorates Neuronal Cell Death, Inflammation, and Ferroptosis and Downregulated miR-23a-3p After Intracerebral Hemorrhage in Rats. Kong Y, etal., J Mol Neurosci. 2021 Sep;71(9):1863-1875. doi: 10.1007/s12031-020-01770-x. Epub 2021 Jan 5.
5. Effect of miR-23 on oxidant-induced injury in human retinal pigment epithelial cells. Lin H, etal., Invest Ophthalmol Vis Sci. 2011 Aug 9;52(9):6308-14. doi: 10.1167/iovs.10-6632.
6. Adipose-derived exosomes deliver miR-23a/b to regulate tumor growth in hepatocellular cancer by targeting the VHL/HIF axis. Liu Y, etal., J Physiol Biochem. 2019 Aug;75(3):391-401. doi: 10.1007/s13105-019-00692-6. Epub 2019 Jul 18.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Role of circulating miRNAs as biomarkers in idiopathic pulmonary arterial hypertension: possible relevance of miR-23a. Sarrion I, etal., Oxid Med Cell Longev. 2015;2015:792846. doi: 10.1155/2015/792846. Epub 2015 Feb 25.
9. Cardiac hypertrophy is positively regulated by MicroRNA miR-23a. Wang K, etal., J Biol Chem. 2012 Jan 2;287(1):589-599. doi: 10.1074/jbc.M111.266940. Epub 2011 Nov 14.
10. MicroRNA-23a participates in estrogen deficiency induced gap junction remodeling of rats by targeting GJA1. Wang N, etal., Int J Biol Sci. 2015 Feb 15;11(4):390-403. doi: 10.7150/ijbs.10930. eCollection 2015.
11. Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer. Yong FL, etal., BMC Cancer. 2013 Jun 8;13:280. doi: 10.1186/1471-2407-13-280.
Additional References at PubMed
PMID:16381832   PMID:16766679   PMID:17604727   PMID:19520079   PMID:20403161   PMID:20937378   PMID:21536891   PMID:21628588   PMID:21698002   PMID:23646144   PMID:23711961   PMID:24101522  
PMID:24269648   PMID:25751060   PMID:25858512   PMID:26553132   PMID:26822703   PMID:27907012   PMID:28125614   PMID:28662151   PMID:29272015   PMID:30081205   PMID:30779059   PMID:32306379  
PMID:32456284   PMID:33197036   PMID:33538509   PMID:33651309   PMID:33779805   PMID:35137264   PMID:35303564   PMID:35921220  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81940,859,769 - 40,859,843 (-)NCBIGRCr8
mRatBN7.21923,954,997 - 23,955,071 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,954,997 - 23,955,071 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,775,857 - 30,775,931 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,430,266 - 31,430,340 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,653,035 - 33,653,109 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,318,582 - 25,318,656 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,318,582 - 25,318,656 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,294,770 - 36,294,844 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1923,503,845 - 23,503,919 (-)NCBICelera
Cytogenetic Map19q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381913,836,587 - 13,836,659 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1913,836,587 - 13,836,659 (-)EnsemblGRCh38hg38GRCh38
GRCh371913,947,401 - 13,947,473 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,808,400 - 13,808,472 (-)NCBINCBI36Build 36hg18NCBI36
Celera1913,841,149 - 13,841,221 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1913,518,969 - 13,519,041 (-)NCBIHuRef
CHM1_11913,947,906 - 13,947,978 (-)NCBICHM1_1
T2T-CHM13v2.01913,962,719 - 13,962,791 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39884,935,147 - 84,935,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,935,147 - 84,935,221 (+)EnsemblGRCm39 Ensembl
GRCm38884,208,518 - 84,208,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,208,518 - 84,208,592 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,732,417 - 86,732,491 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera888,508,624 - 88,508,698 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.58NCBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12048,620,335 - 48,620,386 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,620,323 - 48,620,397 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,494,255 - 48,494,306 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,138,446 - 49,138,497 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,138,434 - 49,138,508 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,348,926 - 48,348,977 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,775,839 - 48,775,890 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,018,907 - 49,018,958 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl265,308,117 - 65,308,186 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,308,117 - 65,308,186 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,581,838 - 65,581,907 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Gad1rno-miR-23a-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Trim63rno-miR-23a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19574461

Predicted Targets
Summary Value
Count of predictions:23345
Count of gene targets:10045
Count of transcripts:10898
Interacting mature miRNAs:rno-miR-23a-3p, rno-miR-23a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,956,224 - 23,956,428 (-)MAPPERmRatBN7.2
Rnor_6.01925,317,225 - 25,317,428NCBIRnor6.0
Rnor_5.01936,293,413 - 36,293,616UniSTSRnor5.0
RGSC_v3.41925,639,971 - 25,640,175RGDRGSC3.4
RGSC_v3.41925,639,972 - 25,640,175UniSTSRGSC3.4
RGSC_v3.11925,644,797 - 25,645,001RGD
Celera1923,505,073 - 23,505,276UniSTS
SHRSP x BN Map1916.8698RGD
SHRSP x BN Map1916.8698UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 2 10 15 1 16 1 7 7 5 6 20 10 7
Below cutoff 1 1 1 1 1 1


Nucleotide Sequences
RefSeq Transcripts NR_031825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000053767
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1923,954,997 - 23,955,071 (-)Ensembl
Rnor_6.0 Ensembl1925,318,582 - 25,318,656 (+)Ensembl
RefSeq Acc Id: NR_031825
Rat AssemblyChrPosition (strand)Source
GRCr81940,859,769 - 40,859,843 (-)NCBI
mRatBN7.21923,954,997 - 23,955,071 (-)NCBI
Rnor_6.01925,318,582 - 25,318,656 (+)NCBI
Rnor_5.01936,294,770 - 36,294,844 (+)NCBI
Celera1923,503,845 - 23,503,919 (-)NCBI

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325395 AgrOrtholog
BioCyc Gene G2FUF-6086 BioCyc
Ensembl Genes ENSRNOG00000035644 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053767 ENTREZGENE
miRBase MI0000852 ENTREZGENE
NCBI Gene 100314228 ENTREZGENE
PhenoGen Mir23a PhenoGen
RatGTEx ENSRNOG00000035644 RatGTEx
RNAcentral URS00005070A9 RNACentral
  URS00005540D2 RNACentral
  URS000075CDA9 RNACentral

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir23a  microRNA 23a  Mir23a  microRNA mir-23a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir23a  microRNA mir-23a      Symbol and Name status set to provisional 70820 PROVISIONAL