Hhip (Hedgehog-interacting protein) - Rat Genome Database

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Gene: Hhip (Hedgehog-interacting protein) Rattus norvegicus
Analyze
Symbol: Hhip
Name: Hedgehog-interacting protein
RGD ID: 1564108
Description: Predicted to enable hedgehog family protein binding activity and zinc ion binding activity. Involved in negative regulation of apoptotic process. Predicted to be located in cell surface and plasma membrane. Biomarker of diabetic neuropathy and primary biliary cholangitis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human HHIP (hedgehog interacting protein); PARTICIPATES IN Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Hedgehog-interacting protein-like; LOC291936; RGD1564108; similar to hedgehog-interacting protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81944,768,038 - 44,856,878 (+)NCBIGRCr8
mRatBN7.21927,863,684 - 27,952,528 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1927,863,213 - 27,952,528 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1934,712,650 - 34,808,109 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01935,366,712 - 35,462,195 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01937,595,871 - 37,684,377 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01931,525,134 - 31,614,487 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1931,524,671 - 31,614,246 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01942,430,120 - 42,518,700 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41929,752,595 - 29,840,439 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1927,371,896 - 27,460,078 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium dichloride  (EXP)
calciol  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
deguelin  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
folic acid  (ISO)
fonofos  (ISO)
genistein  (ISO)
hydrogen peroxide  (EXP)
indole-3-methanol  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
panobinostat  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
thifluzamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vismodegib  (ISO)
vorinostat  (ISO)
XL147  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The role of hedgehog-interacting protein in maintaining cavernous nerve integrity and adult penile morphology. Angeloni NL, etal., J Sex Med. 2009 Sep;6(9):2480-93. doi: 10.1111/j.1743-6109.2009.01349.x. Epub 2009 Jun 9.
2. Interactions between Hedgehog proteins and their binding partners come into view. Beachy PA, etal., Genes Dev. 2010 Sep 15;24(18):2001-12.
3. Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Choi SS, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Dec;297(6):G1093-106. doi: 10.1152/ajpgi.00292.2009. Epub 2009 Oct 8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Lao T, etal., Genome Med. 2015 Feb 14;7(1):12. doi: 10.1186/s13073-015-0137-3. eCollection 2015.
6. The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. Omenetti A, etal., Gut. 2008 Sep;57(9):1275-82. doi: 10.1136/gut.2008.148619. Epub 2008 Mar 28.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study. Van Durme YM, etal., Eur Respir J. 2010 Jul;36(1):89-95. doi: 10.1183/09031936.00129509. Epub 2009 Dec 8.
13. Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein. Vogt A, etal., J Exp Med. 2004 Mar 15;199(6):753-61.
14. Gene susceptibility identification in a longitudinal study confirms new loci in the development of chronic obstructive pulmonary disease and influences lung function decline. Xie J, etal., Respir Res. 2015 Apr 18;16:49. doi: 10.1186/s12931-015-0209-3.
Additional References at PubMed
PMID:10050855   PMID:12569124   PMID:12917290   PMID:15294024   PMID:15576403   PMID:19561609   PMID:19561611  


Genomics

Comparative Map Data
Hhip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81944,768,038 - 44,856,878 (+)NCBIGRCr8
mRatBN7.21927,863,684 - 27,952,528 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1927,863,213 - 27,952,528 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1934,712,650 - 34,808,109 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01935,366,712 - 35,462,195 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01937,595,871 - 37,684,377 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01931,525,134 - 31,614,487 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1931,524,671 - 31,614,246 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01942,430,120 - 42,518,700 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41929,752,595 - 29,840,439 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1927,371,896 - 27,460,078 (+)NCBICelera
Cytogenetic Map19q11NCBI
HHIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384144,646,156 - 144,745,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4144,646,156 - 144,745,271 (+)EnsemblGRCh38hg38GRCh38
GRCh374145,567,308 - 145,666,423 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364145,786,623 - 145,879,331 (+)NCBINCBI36Build 36hg18NCBI36
Build 344145,924,777 - 146,017,486NCBI
Celera4142,895,050 - 142,987,336 (+)NCBICelera
Cytogenetic Map4q31.21NCBI
HuRef4141,298,063 - 141,390,789 (+)NCBIHuRef
CHM1_14145,543,638 - 145,636,362 (+)NCBICHM1_1
T2T-CHM13v2.04147,963,548 - 148,062,608 (+)NCBIT2T-CHM13v2.0
Hhip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39880,692,480 - 80,784,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl880,692,480 - 80,784,635 (-)EnsemblGRCm39 Ensembl
GRCm38879,965,850 - 80,058,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl879,965,851 - 80,058,006 (-)EnsemblGRCm38mm10GRCm38
MGSCv37882,489,750 - 82,581,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36882,867,946 - 82,954,065 (-)NCBIMGSCv36mm8
Celera884,241,203 - 84,333,109 (-)NCBICelera
Cytogenetic Map8C2NCBI
cM Map837.95NCBI
Hhip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955428657,900 - 745,250 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955428657,918 - 745,255 (+)NCBIChiLan1.0ChiLan1.0
HHIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23142,524,310 - 142,620,159 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14142,887,844 - 142,985,062 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04136,989,818 - 137,085,407 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14148,651,597 - 148,743,933 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4148,651,597 - 148,744,619 (+)Ensemblpanpan1.1panPan2
HHIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11543,432,464 - 43,525,973 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1543,431,650 - 43,520,861 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1543,824,285 - 43,917,965 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01544,093,271 - 44,162,284 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1544,093,295 - 44,162,122 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11543,369,053 - 43,460,672 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01543,453,081 - 43,546,222 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01543,725,148 - 43,818,741 (+)NCBIUU_Cfam_GSD_1.0
Hhip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530146,766,102 - 46,868,595 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365354,210,305 - 4,305,930 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365354,210,305 - 4,305,930 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HHIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl883,583,739 - 83,679,136 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1883,583,735 - 83,678,368 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2888,870,182 - 88,941,146 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HHIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1791,216,874 - 91,311,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl791,216,955 - 91,310,387 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603770,844,677 - 70,944,651 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hhip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248533,649,967 - 3,735,834 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248533,649,974 - 3,739,344 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hhip
501 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:183
Count of miRNA genes:141
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000024616
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192481604133061905Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat

Markers in Region
BI302228  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21927,900,260 - 27,900,416 (+)MAPPERmRatBN7.2
Rnor_6.01931,561,847 - 31,562,002NCBIRnor6.0
Rnor_5.01942,466,947 - 42,467,102UniSTSRnor5.0
RGSC_v3.41929,790,390 - 29,790,545UniSTSRGSC3.4
Celera1927,408,446 - 27,408,601UniSTS
RH 3.4 Map19249.19UniSTS
Cytogenetic Map19q11UniSTS
RH142844  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21927,952,353 - 27,952,497 (+)MAPPERmRatBN7.2
Rnor_6.01931,614,313 - 31,614,456NCBIRnor6.0
Rnor_5.01942,518,526 - 42,518,669UniSTSRnor5.0
RGSC_v3.41929,840,265 - 29,840,408UniSTSRGSC3.4
Celera1927,459,904 - 27,460,047UniSTS
Cytogenetic Map19q11UniSTS
RH138698  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21927,952,351 - 27,952,496 (+)MAPPERmRatBN7.2
Rnor_6.01931,614,311 - 31,614,455NCBIRnor6.0
Rnor_5.01942,518,524 - 42,518,668UniSTSRnor5.0
RGSC_v3.41929,840,263 - 29,840,407UniSTSRGSC3.4
Celera1927,459,902 - 27,460,046UniSTS
Cytogenetic Map19q11UniSTS
RH141770  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21927,890,373 - 27,890,558 (+)MAPPERmRatBN7.2
Rnor_6.01931,551,948 - 31,552,132NCBIRnor6.0
Rnor_5.01942,457,354 - 42,457,538UniSTSRnor5.0
RGSC_v3.41929,779,393 - 29,779,577UniSTSRGSC3.4
Celera1927,398,583 - 27,398,767UniSTS
Cytogenetic Map19q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 2 5 11
Low 3 4 57 41 8 41 7 7 67 33 23 7
Below cutoff 23 10 1 3 9 1

Sequence


RefSeq Acc Id: ENSRNOT00000024616   ⟹   ENSRNOP00000024616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1927,863,213 - 27,952,528 (+)Ensembl
Rnor_6.0 Ensembl1931,524,671 - 31,614,246 (+)Ensembl
RefSeq Acc Id: NM_001191817   ⟹   NP_001178746
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81944,768,038 - 44,856,878 (+)NCBI
mRatBN7.21927,863,684 - 27,952,528 (+)NCBI
Rnor_6.01931,525,134 - 31,614,487 (+)NCBI
Rnor_5.01942,430,120 - 42,518,700 (+)NCBI
Celera1927,371,896 - 27,460,078 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178746 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92304 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024616
  ENSRNOP00000024616.5
RefSeq Acc Id: NP_001178746   ⟸   NM_001191817
- Peptide Label: precursor
- UniProtKB: D3ZGL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024616   ⟸   ENSRNOT00000024616
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZGL3-F1-model_v2 AlphaFold D3ZGL3 1-700 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701048
Promoter ID:EPDNEW_R11571
Type:multiple initiation site
Name:Hhip_1
Description:Hedgehog-interacting protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01931,524,637 - 31,524,697EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564108 AgrOrtholog
BioCyc Gene G2FUF-5967 BioCyc
Ensembl Genes ENSRNOG00000018268 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024616 ENTREZGENE
  ENSRNOT00000024616.8 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_extracell UniProtKB/TrEMBL
  Folate_rcpt_cons-reg UniProtKB/TrEMBL
  Glc/Sorbosone_DH UniProtKB/TrEMBL
  Quinoprot_gluc/sorb_DH UniProtKB/TrEMBL
KEGG Report rno:291936 UniProtKB/TrEMBL
NCBI Gene 291936 ENTREZGENE
PANTHER HEDGEHOG-INTERACTING PROTEIN UniProtKB/TrEMBL
  HEDGEHOG-INTERACTING PROTEIN UniProtKB/TrEMBL
Pfam EGF_2 UniProtKB/TrEMBL
  Folate_rec UniProtKB/TrEMBL
  GSDH UniProtKB/TrEMBL
PhenoGen Hhip PhenoGen
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018268 RatGTEx
SMART EGF UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Quino_gluc_DH UniProtKB/TrEMBL
UniProt D3ZGL3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Hhip  Hedgehog-interacting protein  LOC100366089  Hedgehog-interacting protein-like  Data merged from RGD:2324369 1643240 APPROVED
2010-05-06 LOC100366089  Hedgehog-interacting protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Hhip  Hedgehog-interacting protein  RGD1564108_predicted  similar to hedgehog-interacting protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564108_predicted  similar to hedgehog-interacting protein (predicted)  LOC291936  similar to hedgehog-interacting protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC291936  similar to hedgehog-interacting protein      Symbol and Name status set to provisional 70820 PROVISIONAL