(+)-artemisinic acid multiple interactions ISO RGD:731579 6480464 [[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA] which results in decreased chemical synthesis of Cholesterol, [artemisic acid results in decreased expression of HMGCR protein] which results in decreased chemical synthesis of Cholesterol CTD PMID:23063590 (+)-artemisinic acid decreases expression ISO RGD:731579 6480464 [artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA more ... CTD PMID:23063590 (-)-epigallocatechin 3-gallate increases expression ISO RGD:731579 6480464 epigallocatechin gallate results in increased expression of HMGCR mRNA CTD PMID:32512070 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:731580 6480464 epigallocatechin gallate inhibits the reaction [1 more ... CTD PMID:30092300 (24S)-24-hydroxycholesterol decreases activity ISO RGD:731579 6480464 24-hydroxycholesterol results in decreased activity of HMGCR protein CTD PMID:7751816 (25R)-cholest-5-ene-3beta,26-diol decreases activity ISO RGD:731579 6480464 27-hydroxycholesterol metabolite results in decreased activity of HMGCR protein, 27-hydroxycholesterol results in decreased activity of HMGCR protein CTD PMID:18024962 more ... (25R)-cholest-5-ene-3beta,26-diol decreases expression EXP 6480464 27-hydroxycholesterol results in decreased expression of HMGCR mRNA, 27-hydroxycholesterol results in decreased expression of HMGCR protein CTD PMID:28167099 (25R)-cholest-5-ene-3beta,26-diol decreases activity EXP 6480464 27-hydroxycholesterol results in decreased activity of HMGCR protein CTD PMID:7749852 , PMID:7788503 (25R)-cholest-5-ene-3beta,26-diol multiple interactions ISO RGD:731579 6480464 [[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein more ... CTD PMID:11408283 , PMID:9059514 (R,R,R)-alpha-tocopherol multiple interactions EXP 6480464 [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in increased activity of HMGCR protein], [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] CTD PMID:19595682 , PMID:21535577 (S)-nicotine increases expression ISO RGD:731579 6480464 Nicotine results in increased expression of HMGCR mRNA CTD PMID:23416264 (S)-nicotine affects expression EXP 6480464 Nicotine affects the expression of HMGCR mRNA CTD PMID:31972234 1,2,3-trilinolenoylglycerol increases expression ISO RGD:731580 6480464 trilinolenin results in increased expression of HMGCR mRNA CTD PMID:18356535 1,2,3-trilinoleoylglycerol increases expression ISO RGD:731580 6480464 trilinolein results in increased expression of HMGCR mRNA CTD PMID:18356535 1,2,4-trimethylbenzene decreases expression EXP 6480464 pseudocumene results in decreased expression of HMGCR protein CTD PMID:17337753 1,2-dimethylhydrazine increases expression ISO RGD:731580 6480464 1, 2-Dimethylhydrazine results in increased expression of HMGCR mRNA CTD PMID:22206623 1,3,5-trinitro-1,3,5-triazinane increases expression EXP 6480464 cyclonite results in increased expression of HMGCR mRNA CTD PMID:25559034 1,3-dichloropropan-2-ol increases expression ISO RGD:731580 6480464 1 more ... CTD PMID:24333398 , PMID:30092300 1,3-dichloropropan-2-ol multiple interactions ISO RGD:731580 6480464 epigallocatechin gallate inhibits the reaction [1 more ... CTD PMID:30092300 1,3-dichloropropan-2-ol multiple interactions ISO RGD:731579 6480464 alliin inhibits the reaction [1 more ... CTD PMID:29305303 1,3-dichloropropan-2-ol increases expression ISO RGD:731579 6480464 1 more ... CTD PMID:29305303 1,8-cineole decreases expression ISO RGD:731579 6480464 Eucalyptol results in decreased expression of HMGCR protein CTD PMID:24613879 1-(3-(trifluoromethyl)phenyl)piperazine increases expression EXP 6480464 1-(3-trifluoromethylphenyl)piperazine results in increased expression of HMGCR mRNA CTD PMID:26821219 1-benzylpiperazine increases expression EXP 6480464 N-benzylpiperazine results in increased expression of HMGCR mRNA CTD PMID:26821219 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of HMGCR mRNA CTD PMID:25380136 , PMID:30723492 17alpha-ethynylestradiol increases activity EXP 6480464 Ethinyl Estradiol results in increased activity of HMGCR protein CTD PMID:11473529 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expression ISO RGD:731579 6480464 Metribolone results in increased expression of HMGCR mRNA, Metribolone results in increased expression of HMGCR protein CTD PMID:16751804 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:731579 6480464 Dihydrotestosterone results in increased expression of HMGCR mRNA CTD PMID:29581250 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO RGD:731580 6480464 Dihydrotestosterone results in decreased expression of HMGCR mRNA CTD PMID:29367455 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:731580 6480464 [Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:23756648 , PMID:30722647 2,2',4,4',5,5'-hexachlorobiphenyl increases expression ISO RGD:731579 6480464 2 more ... CTD PMID:34627992 2,2',4,4',5,5'-hexachlorobiphenyl decreases expression ISO RGD:731580 6480464 2 more ... CTD PMID:20005886 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:27291303 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO RGD:731580 6480464 2 more ... CTD PMID:30294300 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO RGD:731579 6480464 2 more ... CTD PMID:31173147 2,2'-Dihydroxy-4-methoxybenzophenone increases expression ISO RGD:731579 6480464 dioxybenzone results in increased expression of HMGCR mRNA CTD PMID:32407875 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:731580 6480464 Tetrachlorodibenzodioxin results in increased expression of HMGCR mRNA CTD PMID:19770486 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731580 6480464 [Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:23756648 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:731580 6480464 Tetrachlorodibenzodioxin results in decreased expression of HMGCR mRNA CTD PMID:20005886 , PMID:22977169 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:731579 6480464 Tetrachlorodibenzodioxin results in decreased expression of HMGCR mRNA, Tetrachlorodibenzodioxin results in decreased expression of HMGCR protein CTD PMID:17101203 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of HMGCR mRNA CTD PMID:21215274 more ... 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:731580 6480464 Trinitrobenzenesulfonic Acid results in increased expression of HMGCR mRNA CTD PMID:17982090 2,4-D decreases expression ISO RGD:731580 6480464 2, 4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCR CTD PMID:26838045 2,4-dibromophenol increases expression ISO RGD:731579 6480464 2, 4-dibromophenol results in increased expression of HMGCR mRNA CTD PMID:17447562 2,6-di-tert-butyl-4-methylphenol increases activity EXP 6480464 Butylated Hydroxytoluene results in increased activity of HMGCR protein CTD PMID:9199277 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of HMGCR mRNA CTD PMID:21346803 2-acetamidofluorene multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA, beta-ionone promotes the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA] CTD PMID:20435455 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions ISO RGD:731579 6480464 [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of geranylgeranyl pyrophosphate CTD PMID:17208200 2-trans,6-trans-farnesyl diphosphate multiple interactions ISO RGD:731579 6480464 [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate CTD PMID:17208200 22-Hydroxycholesterol decreases expression ISO RGD:731579 6480464 22-hydroxycholesterol results in decreased expression of HMGCR mRNA CTD PMID:19426978 24,25-dihydrolanosterol decreases activity ISO RGD:731579 6480464 lanostenol results in decreased activity of HMGCR protein CTD PMID:18024962 25-hydroxycholesterol multiple interactions ISO RGD:731579 6480464 [25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein more ... CTD PMID:12477733 more ... 25-hydroxycholesterol decreases expression ISO RGD:731579 6480464 25-hydroxycholesterol results in decreased expression of HMGCR protein CTD PMID:27447558 25-hydroxycholesterol decreases activity ISO RGD:731579 6480464 25-hydroxycholesterol metabolite results in decreased activity of HMGCR protein, 25-hydroxycholesterol results in decreased activity of HMGCR protein CTD PMID:18024962 more ... 25-hydroxycholesterol decreases expression ISO RGD:731580 6480464 25-hydroxycholesterol results in decreased expression of HMGCR mRNA, 25-hydroxycholesterol results in decreased expression of HMGCR protein CTD PMID:19260826 25-hydroxycholesterol decreases activity EXP 6480464 25-hydroxycholesterol results in decreased activity of HMGCR protein CTD PMID:7749852 26-hydroxycholesterol decreases activity ISO RGD:731579 6480464 27-hydroxycholesterol metabolite results in decreased activity of HMGCR protein, 27-hydroxycholesterol results in decreased activity of HMGCR protein CTD PMID:18024962 more ... 26-hydroxycholesterol decreases expression EXP 6480464 27-hydroxycholesterol results in decreased expression of HMGCR mRNA, 27-hydroxycholesterol results in decreased expression of HMGCR protein CTD PMID:28167099 26-hydroxycholesterol decreases activity EXP 6480464 27-hydroxycholesterol results in decreased activity of HMGCR protein CTD PMID:7749852 , PMID:7788503 26-hydroxycholesterol multiple interactions ISO RGD:731579 6480464 [[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein more ... CTD PMID:11408283 , PMID:9059514 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases activity EXP 6480464 Puromycin Aminonucleoside results in increased activity of HMGCR protein CTD PMID:3794548 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:731579 6480464 3 more ... CTD PMID:20574914 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 3-chloropropane-1,2-diol multiple interactions ISO RGD:731579 6480464 [Coconut Oil co-treated with alpha-Chlorohydrin analog] results in increased expression of HMGCR mRNA CTD PMID:30878531 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:731580 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of HMGCR mRNA CTD PMID:16054899 3-methylcholanthrene decreases expression ISO RGD:731580 6480464 Methylcholanthrene results in decreased expression of HMGCR mRNA CTD PMID:35487396 3beta-hydroxy-5alpha-cholest-8(14)-en-15-one decreases activity ISO RGD:731579 6480464 cholest-8(14)-en-3-ol-15-one results in decreased activity of HMGCR protein CTD PMID:7751816 3beta-hydroxylanost-8-en-32-al decreases activity ISO RGD:731580 6480464 lanosten-3-ol-32-al results in decreased activity of HMGCR protein CTD PMID:12617470 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of HMGCR mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of HMGCR mRNA CTD PMID:25380136 4,4'-sulfonyldiphenol decreases expression ISO RGD:731580 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of HMGCR mRNA CTD PMID:33297965 4,4'-sulfonyldiphenol affects methylation ISO RGD:731580 6480464 bis(4-hydroxyphenyl)sulfone affects the methylation of HMGCR gene CTD PMID:31683443 4,4'-sulfonyldiphenol increases expression ISO RGD:731580 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of HMGCR mRNA CTD PMID:34850234 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of HMGCR mRNA CTD PMID:21346803 4-hydroxy-TEMPO multiple interactions ISO RGD:731579 6480464 tempol inhibits the reaction [Asbestos more ... CTD PMID:21257924 5-aza-2'-deoxycytidine affects expression ISO RGD:731579 6480464 Decitabine affects the expression of HMGCR mRNA CTD PMID:23300844 5-bromo-2'-deoxyuridine multiple interactions ISO RGD:731580 6480464 [Bromodeoxyuridine co-treated with furan] affects the expression of HMGCR mRNA CTD PMID:24910943 5-bromo-2'-deoxyuridine increases expression ISO RGD:731580 6480464 Bromodeoxyuridine results in increased expression of HMGCR mRNA CTD PMID:24910943 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime multiple interactions ISO RGD:731579 6480464 [6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:30611723 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions EXP 6480464 [6-chloro-2 more ... CTD PMID:21212096 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of HMGCR mRNA CTD PMID:24780913 7-ketocholesterol decreases activity ISO RGD:731579 6480464 7-ketocholesterol results in decreased activity of HMGCR protein CTD PMID:7751816 7-ketocholesterol increases expression ISO RGD:731579 6480464 7-ketocholesterol results in increased expression of HMGCR mRNA CTD PMID:23454145 7-ketocholesterol multiple interactions ISO RGD:731579 6480464 [7-ketocholesterol co-treated with KNG1 protein modified form] results in decreased expression of HMGCR mRNA more ... CTD PMID:23454145 7alpha-hydroxycholesterol decreases activity EXP 6480464 cholest-5-en-3 beta, 7 alpha-diol results in decreased activity of HMGCR protein CTD PMID:9199277 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of HMGCR mRNA CTD PMID:31881176 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of HMGCR mRNA CTD PMID:28959563 acrylamide increases expression ISO RGD:731580 6480464 Acrylamide results in increased expression of HMGCR mRNA CTD PMID:34896238 acrylamide multiple interactions ISO RGD:731580 6480464 Acrylamide inhibits the reaction [Streptozocin results in increased expression of HMGCR mRNA] CTD PMID:34896238 Actein affects expression EXP 6480464 actein affects the expression of HMGCR mRNA CTD PMID:19527300 aflatoxin B1 decreases expression ISO RGD:731580 6480464 Aflatoxin B1 results in decreased expression of HMGCR mRNA CTD PMID:19770486 aflatoxin B1 decreases expression ISO RGD:731579 6480464 Aflatoxin B1 results in decreased expression of HMGCR mRNA CTD PMID:21641981 , PMID:27153756 aflatoxin B1 decreases methylation ISO RGD:731579 6480464 Aflatoxin B1 results in decreased methylation of HMGCR gene CTD PMID:27153756 all-trans-retinoic acid increases expression ISO RGD:731579 6480464 Tretinoin results in increased expression of HMGCR mRNA CTD PMID:33167477 allethrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in decreased expression of HMGCR mRNA, [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of HMGCR mRNA CTD PMID:33051911 , PMID:33396045 alliin multiple interactions EXP 6480464 alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] CTD PMID:16640830 alliin multiple interactions ISO RGD:731579 6480464 alliin inhibits the reaction [1 more ... CTD PMID:29305303 alpha-naphthoflavone multiple interactions EXP 6480464 alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA], alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein] CTD PMID:19931295 amiodarone increases expression ISO RGD:731580 6480464 Amiodarone results in increased expression of HMGCR mRNA CTD PMID:24489787 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HMGCR mRNA CTD PMID:16483693 amphotericin B multiple interactions ISO RGD:731580 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA], [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA CTD PMID:36464106 ampicillin multiple interactions ISO RGD:731580 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA], [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA CTD PMID:36464106 arachidonic acid decreases expression ISO RGD:731579 6480464 Arachidonic Acid results in decreased expression of HMGCR mRNA CTD PMID:16704987 Archazolid B increases expression ISO RGD:731579 6480464 archazolid B results in increased expression of HMGCR mRNA CTD PMID:25218289 Aroclor 1254 increases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of HMGCR mRNA CTD PMID:18178546 Aroclor 1254 decreases expression ISO RGD:731580 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of HMGCR mRNA CTD PMID:23650126 atorvastatin calcium multiple interactions ISO RGD:731579 6480464 Atorvastatin results in increased expression of and results in increased activity of HMGCR protein CTD PMID:9512650 atorvastatin calcium affects binding EXP 6480464 Atorvastatin binds to HMGCR protein CTD PMID:30273964 atorvastatin calcium multiple interactions EXP 6480464 Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA] more ... CTD PMID:12056585 more ... atorvastatin calcium increases expression EXP 6480464 Atorvastatin results in increased expression of HMGCR mRNA CTD PMID:12056585 , PMID:12065722 atorvastatin calcium increases activity EXP 6480464 Atorvastatin results in increased activity of HMGCR protein CTD PMID:12056585 , PMID:12065722 atorvastatin calcium increases expression ISO RGD:731579 6480464 Atorvastatin results in increased expression of HMGCR mRNA CTD PMID:10357840 more ... avobenzone increases expression ISO RGD:731579 6480464 avobenzone results in increased expression of HMGCR mRNA CTD PMID:31016361 , PMID:32407875 Azaspiracid increases expression ISO RGD:731579 6480464 azaspiracid results in increased expression of HMGCR mRNA CTD PMID:28939011 azathioprine decreases expression ISO RGD:731579 6480464 Azathioprine results in decreased expression of HMGCR mRNA CTD PMID:22623647 benzalkonium chloride increases expression ISO RGD:731579 6480464 Benzalkonium Compounds results in increased expression of HMGCR mRNA CTD PMID:26919959 benzalkonium chloride increases expression ISO RGD:731580 6480464 Benzalkonium Compounds results in increased expression of HMGCR mRNA CTD PMID:31199489 benzene affects expression EXP 6480464 Benzene affects the expression of HMGCR mRNA CTD PMID:15878777 benzene increases expression ISO RGD:731579 6480464 Benzene results in increased expression of HMGCR mRNA CTD PMID:19162166 benzo[a]pyrene multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA] more ... CTD PMID:19931295 benzo[a]pyrene decreases expression ISO RGD:731579 6480464 Benzo(a)pyrene results in decreased expression of HMGCR mRNA CTD PMID:16269432 more ... benzo[a]pyrene multiple interactions ISO RGD:731579 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:17690111 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of HMGCR mRNA, Benzo(a)pyrene results in decreased expression of HMGCR protein CTD PMID:19931295 benzo[a]pyrene increases expression ISO RGD:731580 6480464 Benzo(a)pyrene results in increased expression of HMGCR mRNA CTD PMID:19770486 , PMID:21569818 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:731579 6480464 7 more ... CTD PMID:19150397 benzo[b]fluoranthene decreases expression ISO RGD:731579 6480464 benzo(b)fluoranthene results in decreased expression of HMGCR mRNA CTD PMID:16269432 benzo[b]fluoranthene multiple interactions ISO RGD:731579 6480464 [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of HMGCR mRNA CTD PMID:17690111 benzofurans increases expression ISO RGD:731579 6480464 Benzofurans results in increased expression of HMGCR mRNA CTD PMID:17447562 beta-ionone multiple interactions EXP 6480464 beta-ionone promotes the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA] CTD PMID:20435455 beta-naphthoflavone multiple interactions ISO RGD:731579 6480464 AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HMGCR mRNA] CTD PMID:22234961 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HMGCR mRNA CTD PMID:18164116 beta-naphthoflavone multiple interactions ISO RGD:731580 6480464 AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HMGCR mRNA] CTD PMID:22234961 beta-naphthoflavone decreases expression ISO RGD:731579 6480464 beta-Naphthoflavone results in decreased expression of HMGCR mRNA CTD PMID:22234961 , PMID:31225620 beta-naphthoflavone decreases expression ISO RGD:731580 6480464 beta-Naphthoflavone results in decreased expression of HMGCR mRNA CTD PMID:22234961 betulin decreases expression ISO RGD:731579 6480464 betulin results in decreased expression of HMGCR mRNA, betulin results in decreased expression of HMGCR protein CTD PMID:27378817 , PMID:27447558 bezafibrate decreases activity EXP 6480464 Bezafibrate results in decreased activity of HMGCR protein CTD PMID:2044640 , PMID:2907502 bezafibrate increases activity ISO RGD:731579 6480464 Bezafibrate results in increased activity of HMGCR protein CTD PMID:2044640 bilirubin IXalpha multiple interactions EXP 6480464 [Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein CTD PMID:12700418 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:731580 6480464 [Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:19850644 more ... bis(2-ethylhexyl) phthalate decreases expression ISO RGD:731580 6480464 Diethylhexyl Phthalate results in decreased expression of HMGCR mRNA CTD PMID:25975992 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of HMGCR mRNA CTD PMID:33983380 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Clofibrate co-treated with Diethylhexyl Phthalate] results in decreased expression of HMGCR mRNA CTD PMID:9207284 bis(2-ethylhexyl) phthalate increases expression ISO RGD:731580 6480464 Diethylhexyl Phthalate results in increased expression of HMGCR mRNA CTD PMID:19850644 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of HMGCR mRNA, bisphenol A results in increased expression of HMGCR protein CTD PMID:24768697 more ... bisphenol A affects expression ISO RGD:731579 6480464 bisphenol A affects the expression of HMGCR mRNA CTD PMID:30903817 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of HMGCR mRNA CTD PMID:30903817 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of HMGCR mRNA CTD PMID:30816183 more ... bisphenol A multiple interactions ISO RGD:731579 6480464 bisphenol A results in increased expression of and results in increased activity of HMGCR protein, SREBF2 protein affects the reaction [bisphenol A results in increased expression of and results in increased activity of HMGCR protein] CTD PMID:31270304 bisphenol A decreases methylation ISO RGD:731580 6480464 bisphenol A results in decreased methylation of HMGCR promoter CTD PMID:27502578 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of HMGCR gene CTD PMID:28505145 bisphenol A affects methylation ISO RGD:731580 6480464 bisphenol A affects the methylation of HMGCR promoter CTD PMID:27334623 bisphenol A multiple interactions ISO RGD:731580 6480464 [Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:23756648 , PMID:30722647 bisphenol A increases expression ISO RGD:731580 6480464 bisphenol A results in increased expression of HMGCR mRNA, bisphenol A results in increased expression of HMGCR protein CTD PMID:21932408 more ... bisphenol F increases methylation ISO RGD:731579 6480464 bisphenol F results in increased methylation of HMGCR gene CTD PMID:31601247 bucladesine multiple interactions ISO RGD:731579 6480464 fluorene-9-bisphenol inhibits the reaction [Bucladesine results in increased expression of HMGCR mRNA] CTD PMID:35987080 bucladesine increases expression ISO RGD:731579 6480464 Bucladesine results in increased expression of HMGCR mRNA CTD PMID:35987080 butan-1-ol multiple interactions ISO RGD:731579 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of HMGCR mRNA CTD PMID:29432896 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of HMGCR mRNA CTD PMID:17066326 cadmium atom multiple interactions EXP 6480464 [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in increased activity of HMGCR protein] more ... CTD PMID:21535577 , PMID:25240712 cadmium atom increases activity EXP 6480464 Cadmium results in increased activity of HMGCR protein CTD PMID:21535577 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of HMGCR mRNA CTD PMID:17066326 , PMID:19010381 cadmium dichloride decreases expression ISO RGD:731579 6480464 Cadmium Chloride results in decreased expression of HMGCR mRNA CTD PMID:24527689 cadmium sulfate multiple interactions ISO RGD:731579 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of HMGCR mRNA CTD PMID:18654764 caffeine increases expression EXP 6480464 Caffeine results in increased expression of HMGCR mRNA, Caffeine results in increased expression of HMGCR protein CTD PMID:29800656 more ... caffeine decreases phosphorylation ISO RGD:731579 6480464 Caffeine results in decreased phosphorylation of HMGCR protein CTD PMID:35688186 caffeine increases expression ISO RGD:731579 6480464 Caffeine results in increased expression of HMGCR mRNA, Caffeine results in increased expression of HMGCR protein CTD PMID:30825513 caffeine multiple interactions ISO RGD:731579 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA] more ... CTD PMID:30825513 caffeine multiple interactions EXP 6480464 [Dietary Fats co-treated with Caffeine] results in decreased expression of HMGCR mRNA, Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of HMGCR mRNA] CTD PMID:29800656 , PMID:29958987 carbamazepine decreases expression ISO RGD:731579 6480464 Carbamazepine results in decreased expression of HMGCR mRNA CTD PMID:19566492 carbon nanotube affects expression ISO RGD:731580 6480464 Nanotubes, Carbon affects the expression of HMGCR mRNA CTD PMID:23845593 carbon nanotube increases expression ISO RGD:731580 6480464 Nanotubes, Carbon results in increased expression of HMGCR mRNA CTD PMID:25554681 carbon nanotube decreases expression ISO RGD:731580 6480464 Nanotubes more ... CTD PMID:25620056 CGS-21680 multiple interactions ISO RGD:731579 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA] CTD PMID:30825513 chenodeoxycholic acid decreases response to substance ISO RGD:731579 6480464 HMGCR protein results in decreased susceptibility to Chenodeoxycholic Acid CTD PMID:7461467 chenodeoxycholic acid multiple interactions ISO RGD:731579 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of HMGCR mRNA, [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine] results in decreased expression of HMGCR mRNA CTD PMID:33819548 chenodeoxycholic acid decreases activity EXP 6480464 Chenodeoxycholic Acid results in decreased activity of HMGCR protein CTD PMID:6832710 chitosan multiple interactions EXP 6480464 [Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA], Chitosan inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA] CTD PMID:28987369 chlorogenic acid decreases expression ISO RGD:731580 6480464 Chlorogenic Acid results in decreased expression of HMGCR mRNA CTD PMID:21870829 chlorogenic acid multiple interactions EXP 6480464 [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein], Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein] CTD PMID:20696151 chlorpromazine increases expression ISO RGD:731579 6480464 Chlorpromazine results in increased expression of HMGCR mRNA CTD PMID:17052361 cholesterol multiple interactions EXP 6480464 [Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA more ... CTD PMID:16581047 more ... cholesterol decreases expression EXP 15045610 cholesterol decreases expression of Hmgcr mRNA in liver RGD cholesterol decreases expression EXP 6480464 Cholesterol results in decreased expression of HMGCR mRNA CTD PMID:16581047 cholesterol multiple interactions ISO RGD:731579 6480464 [25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein more ... CTD PMID:11408283 more ... cholesterol decreases expression ISO RGD:731579 6480464 Cholesterol results in decreased expression of HMGCR mRNA CTD PMID:17516993 cholesterol decreases activity ISO RGD:731579 6480464 Cholesterol results in decreased activity of HMGCR protein CTD PMID:18024962 cholic acid multiple interactions EXP 6480464 [Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA more ... CTD PMID:30273964 choline multiple interactions ISO RGD:731580 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HMGCR mRNA more ... CTD PMID:18952117 , PMID:20938992 chromium atom decreases expression ISO RGD:731579 6480464 Chromium results in decreased expression of HMGCR mRNA CTD PMID:17547211 chromium(6+) affects expression ISO RGD:731580 6480464 chromium hexavalent ion affects the expression of HMGCR mRNA CTD PMID:28472532 ciguatoxin CTX1B affects expression ISO RGD:731580 6480464 Ciguatoxins affects the expression of HMGCR mRNA CTD PMID:18353800 cis-caffeic acid decreases expression ISO RGD:731580 6480464 caffeic acid results in decreased expression of HMGCR mRNA CTD PMID:21870829 cisplatin affects expression ISO RGD:731579 6480464 Cisplatin affects the expression of HMGCR mRNA CTD PMID:23300844 cisplatin multiple interactions ISO RGD:731579 6480464 [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of HMGCR mRNA CTD PMID:30871063 cisplatin decreases expression ISO RGD:731579 6480464 Cisplatin results in decreased expression of HMGCR mRNA CTD PMID:27594783 clobetasol increases expression ISO RGD:731580 6480464 Clobetasol results in increased expression of HMGCR mRNA CTD PMID:27462272 clofibrate decreases activity ISO RGD:731580 6480464 Clofibrate results in decreased activity of HMGCR protein CTD PMID:18611391 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of HMGCR mRNA CTD PMID:12518023 more ... clofibrate decreases expression ISO RGD:731580 6480464 Clofibrate results in decreased expression of HMGCR mRNA, Clofibrate results in decreased expression of HMGCR protein CTD PMID:20573577 , PMID:23811191 clofibrate multiple interactions EXP 6480464 [Clofibrate co-treated with Diethylhexyl Phthalate] results in decreased expression of HMGCR mRNA, Mevalonic Acid inhibits the reaction [Clofibrate results in decreased expression of HMGCR mRNA] CTD PMID:12518023 , PMID:9207284 clofibrate decreases activity EXP 6480464 Clofibrate results in decreased activity of HMGCR protein CTD PMID:1327145 clofibrate decreases expression ISO RGD:731579 6480464 Clofibrate results in decreased expression of HMGCR CTD PMID:16502264 clozapine multiple interactions ISO RGD:731579 6480464 [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol, [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides CTD PMID:16027736 clozapine increases expression ISO RGD:731579 6480464 Clozapine results in increased expression of HMGCR mRNA CTD PMID:16027736 , PMID:17052361 clozapine increases activity ISO RGD:731579 6480464 Clozapine results in increased activity of HMGCR protein CTD PMID:16027736 cobalt dichloride multiple interactions ISO RGD:731579 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of HMGCR mRNA CTD PMID:18654764 cobalt dichloride increases expression ISO RGD:731579 6480464 cobaltous chloride results in increased expression of HMGCR mRNA CTD PMID:19376846 colesevelam hydrochloride increases expression ISO RGD:731580 6480464 Colesevelam Hydrochloride results in increased expression of HMGCR mRNA CTD PMID:22120639 colesevelam hydrochloride multiple interactions ISO RGD:731580 6480464 Colesevelam Hydrochloride promotes the reaction [Simvastatin results in increased expression of HMGCR mRNA] CTD PMID:22120639 colforsin daropate hydrochloride multiple interactions ISO RGD:731579 6480464 [Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA more ... CTD PMID:16751804 more ... colforsin daropate hydrochloride affects expression ISO RGD:731579 6480464 Colforsin affects the expression of HMGCR mRNA CTD PMID:20726872 colforsin daropate hydrochloride increases expression ISO RGD:731579 6480464 Colforsin results in increased expression of HMGCR mRNA CTD PMID:16751804 , PMID:16935330 copper atom increases expression EXP 6480464 Copper results in increased expression of HMGCR mRNA CTD PMID:22465980 copper atom decreases expression ISO RGD:731580 6480464 Copper results in decreased expression of HMGCR mRNA CTD PMID:17205981 copper(0) increases expression EXP 6480464 Copper results in increased expression of HMGCR mRNA CTD PMID:22465980 copper(0) decreases expression ISO RGD:731580 6480464 Copper results in decreased expression of HMGCR mRNA CTD PMID:17205981 copper(II) chloride decreases expression ISO RGD:731579 6480464 cupric chloride results in decreased expression of HMGCR mRNA CTD PMID:34921933 copper(II) sulfate decreases expression ISO RGD:731579 6480464 Copper Sulfate results in decreased expression of HMGCR mRNA CTD PMID:19549813 copper(II) sulfate increases expression ISO RGD:731579 6480464 Copper Sulfate results in increased expression of HMGCR mRNA CTD PMID:12860252 corilagin multiple interactions EXP 6480464 corilagin inhibits the reaction [Doxorubicin results in increased activity of HMGCR protein] CTD PMID:34605098 cortisol multiple interactions ISO RGD:731579 6480464 IGF1 protein inhibits the reaction [Hydrocortisone results in decreased expression of HMGCR mRNA], Mifepristone inhibits the reaction [Hydrocortisone results in decreased expression of HMGCR mRNA] CTD PMID:31075344 cortisol decreases expression ISO RGD:731579 6480464 Hydrocortisone results in decreased expression of HMGCR mRNA CTD PMID:31075344 coumarin increases expression EXP 6480464 coumarin results in increased expression of HMGCR mRNA CTD PMID:18480146 crizotinib increases expression ISO RGD:731579 6480464 crizotinib results in increased expression of HMGCR mRNA CTD PMID:23707608 crocidolite asbestos decreases activity ISO RGD:731579 6480464 Asbestos, Crocidolite results in decreased activity of HMGCR protein CTD PMID:21257924 crocidolite asbestos increases expression ISO RGD:731580 6480464 Asbestos, Crocidolite results in increased expression of HMGCR mRNA CTD PMID:29279043 crocidolite asbestos multiple interactions ISO RGD:731579 6480464 manganese protoporphyrin inhibits the reaction [Asbestos more ... CTD PMID:21257924 curcumin increases expression ISO RGD:731579 6480464 Curcumin results in increased expression of HMGCR mRNA CTD PMID:16713233 curcumin decreases expression EXP 6480464 Curcumin results in decreased expression of HMGCR mRNA CTD PMID:27208389 curcumin affects expression ISO RGD:731580 6480464 Curcumin affects the expression of HMGCR mRNA, Curcumin affects the expression of HMGCR protein CTD PMID:27208389 cyclosporin A increases expression ISO RGD:731579 6480464 Cyclosporine results in increased expression of HMGCR mRNA CTD PMID:17516993 cyclosporin A multiple interactions ISO RGD:731579 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine] results in decreased expression of HMGCR mRNA CTD PMID:33819548 cyclosporin A decreases expression ISO RGD:731579 6480464 Cyclosporine results in decreased expression of HMGCR mRNA CTD PMID:20106945 more ... cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of HMGCR mRNA CTD PMID:19224547 cyhalothrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in decreased expression of HMGCR mRNA, [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of HMGCR mRNA CTD PMID:33051911 , PMID:33396045 cypermethrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in decreased expression of HMGCR mRNA, [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of HMGCR mRNA CTD PMID:33051911 , PMID:33396045 cyproconazole affects expression ISO RGD:731580 6480464 cyproconazole affects the expression of HMGCR mRNA CTD PMID:22045034 D-gluconic acid multiple interactions EXP 6480464 [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA] CTD PMID:30031400 dehydroepiandrosterone multiple interactions ISO RGD:731579 6480464 Dehydroepiandrosterone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein], Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein] CTD PMID:9059514 deoxycholic acid multiple interactions ISO RGD:731579 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of HMGCR mRNA, [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine] results in decreased expression of HMGCR mRNA CTD PMID:33819548 deoxynivalenol decreases expression ISO RGD:731579 6480464 deoxynivalenol results in decreased expression of HMGCR mRNA CTD PMID:22982764 desmosterol decreases expression ISO RGD:731580 6480464 Desmosterol results in decreased expression of HMGCR protein CTD PMID:19260826 dexamethasone multiple interactions ISO RGD:731580 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of HMGCR mRNA CTD PMID:16054899 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of HMGCR mRNA, Dexamethasone results in decreased expression of HMGCR protein CTD PMID:32234517 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of HMGCR mRNA CTD PMID:16962226 Di-n-hexyl phthalate decreases expression EXP 6480464 di-n-hexyl phthalate results in decreased expression of HMGCR mRNA CTD PMID:26934186 , PMID:33983380 dibenz[a,h]anthracene decreases expression ISO RGD:731579 6480464 1 more ... CTD PMID:16269432 dibenz[a,h]anthracene multiple interactions ISO RGD:731579 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:17690111 dibenzo[a,l]pyrene decreases expression ISO RGD:731579 6480464 dibenzo(a, l)pyrene results in decreased expression of HMGCR mRNA CTD PMID:16269432 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of HMGCR mRNA CTD PMID:17379624 more ... dicrotophos decreases expression ISO RGD:731579 6480464 dicrotophos results in decreased expression of HMGCR mRNA CTD PMID:28302478 Dicyclohexyl phthalate decreases expression EXP 6480464 dicyclohexyl phthalate results in decreased expression of HMGCR mRNA CTD PMID:33983380 diethyl phthalate increases expression EXP 6480464 diethyl phthalate results in increased expression of HMGCR mRNA CTD PMID:33983380 difenoconazole increases expression EXP 6480464 difenoconazole results in increased expression of HMGCR mRNA CTD PMID:28263823 diisobutyl phthalate decreases expression EXP 6480464 diisobutyl phthalate results in decreased expression of HMGCR mRNA CTD PMID:28655647 , PMID:33983380 diisononyl phthalate decreases expression EXP 6480464 diisononyl phthalate results in decreased expression of HMGCR mRNA CTD PMID:33983380 dinophysistoxin 1 decreases expression ISO RGD:731579 6480464 dinophysistoxin 1 results in decreased expression of HMGCR mRNA CTD PMID:28939011 dioxygen multiple interactions ISO RGD:731580 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of HMGCR mRNA CTD PMID:30529165 dipentyl phthalate decreases expression EXP 6480464 di-n-pentyl phthalate results in decreased expression of HMGCR mRNA CTD PMID:33983380 disodium selenite multiple interactions EXP 6480464 [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA] CTD PMID:30031400 disodium selenite multiple interactions ISO RGD:731580 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA] CTD PMID:36464106 dorsomorphin multiple interactions ISO RGD:731579 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HMGCR mRNA CTD PMID:27188386 doxorubicin multiple interactions EXP 6480464 corilagin inhibits the reaction [Doxorubicin results in increased activity of HMGCR protein] CTD PMID:34605098 doxorubicin increases activity EXP 6480464 Doxorubicin results in increased activity of HMGCR protein CTD PMID:34605098 elemental selenium multiple interactions EXP 6480464 [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA], Selenium promotes the reaction [Cholesterol results in decreased expression of HMGCR mRNA] CTD PMID:16581047 , PMID:30031400 elemental selenium multiple interactions ISO RGD:731580 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA] CTD PMID:36464106 endosulfan affects expression EXP 6480464 Endosulfan affects the expression of HMGCR mRNA CTD PMID:29391264 endosulfan increases expression ISO RGD:731580 6480464 Endosulfan results in increased expression of HMGCR mRNA CTD PMID:30502743 enilconazole affects expression ISO RGD:731580 6480464 enilconazole affects the expression of HMGCR mRNA CTD PMID:30853599 enniatin decreases expression ISO RGD:731579 6480464 enniatins results in decreased expression of HMGCR mRNA CTD PMID:25625232 entinostat decreases expression ISO RGD:731579 6480464 entinostat results in decreased expression of HMGCR mRNA CTD PMID:27188386 Epomediol increases activity EXP 6480464 epomediol results in increased activity of HMGCR protein CTD PMID:10961725 , PMID:11473529 epoxiconazole decreases expression ISO RGD:731580 6480464 epoxiconazole results in decreased expression of HMGCR mRNA CTD PMID:35436446 ethanol increases expression ISO RGD:731580 6480464 Ethanol results in increased expression of HMGCR mRNA CTD PMID:19167417 ethanol affects expression ISO RGD:731580 6480464 Ethanol affects the expression of HMGCR mRNA CTD PMID:30319688 ethanol affects expression EXP 6480464 Ethanol affects the expression of HMGCR mRNA, Ethanol affects the expression of HMGCR protein CTD PMID:31075344 , PMID:32535229 ethanol multiple interactions ISO RGD:731579 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of HMGCR mRNA CTD PMID:29432896 ethanol multiple interactions EXP 6480464 zingerone inhibits the reaction [Ethanol results in increased activity of HMGCR protein] CTD PMID:28442378 ethanol increases activity EXP 6480464 Ethanol results in increased activity of HMGCR protein CTD PMID:28442378 ethanol decreases activity ISO RGD:731579 6480464 Ethanol results in decreased activity of HMGCR protein CTD PMID:22841563 ethyl methanesulfonate decreases expression ISO RGD:731579 6480464 Ethyl Methanesulfonate results in decreased expression of HMGCR mRNA CTD PMID:23649840 eugenol decreases expression ISO RGD:731580 6480464 Eugenol results in decreased expression of HMGCR mRNA CTD PMID:21870829 ezetimibe multiple interactions ISO RGD:731579 6480464 [Simvastatin co-treated with Ezetimibe] results in increased expression of HMGCR mRNA CTD PMID:17980884 ezetimibe increases activity ISO RGD:731579 6480464 Ezetimibe results in increased activity of HMGCR protein CTD PMID:17980884 farnesol multiple interactions ISO RGD:731579 6480464 [Farnesol analog co-treated with Oleic Acid] results in increased expression of HMGCR mRNA CTD PMID:30611723 farnesol decreases activity ISO RGD:731579 6480464 Farnesol results in decreased activity of HMGCR protein CTD PMID:12477733 farnesol increases expression EXP 6480464 Farnesol results in increased expression of HMGCR protein CTD PMID:16332721 farnesyl diphosphate multiple interactions ISO RGD:731579 6480464 [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate CTD PMID:17208200 fenarimol increases expression EXP 6480464 fenarimol results in increased expression of HMGCR mRNA CTD PMID:28970091 fenofibrate decreases expression EXP 6480464 Fenofibrate results in decreased expression of HMGCR mRNA CTD PMID:16595124 fenofibrate multiple interactions ISO RGD:731580 6480464 NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA], NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA] CTD PMID:23063693 fenofibrate increases expression ISO RGD:731580 6480464 Fenofibrate results in increased expression of HMGCR mRNA CTD PMID:23063693 fenvalerate multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in decreased expression of HMGCR mRNA, [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of HMGCR mRNA CTD PMID:33051911 , PMID:33396045 ferulic acid decreases expression ISO RGD:731580 6480464 ferulic acid results in decreased expression of HMGCR mRNA CTD PMID:21870829 fingolimod hydrochloride increases expression ISO RGD:731579 6480464 Fingolimod Hydrochloride results in increased expression of HMGCR mRNA CTD PMID:24356939 fluoranthene decreases expression ISO RGD:731580 6480464 fluoranthene results in decreased expression of HMGCR mRNA CTD PMID:28329830 fluoranthene multiple interactions ISO RGD:731580 6480464 [1-methylanthracene co-treated with fluoranthene] results in decreased expression of HMGCR mRNA CTD PMID:28329830 flusilazole affects expression ISO RGD:731580 6480464 flusilazole affects the expression of HMGCR mRNA CTD PMID:22634333 flutamide increases expression EXP 6480464 Flutamide results in increased expression of HMGCR mRNA CTD PMID:24136188 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of HMGCR mRNA CTD PMID:24793618 fluvastatin multiple interactions ISO RGD:731579 6480464 [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin CTD PMID:19773416 fluvastatin decreases activity ISO RGD:731579 6480464 fluvastatin results in decreased activity of HMGCR protein CTD PMID:8593127 folic acid multiple interactions ISO RGD:731580 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HMGCR mRNA, Folic Acid inhibits the reaction [Dietary Fats results in increased activity of and results in decreased phosphorylation of HMGCR protein] CTD PMID:20938992 , PMID:26400185 folic acid decreases expression ISO RGD:731580 6480464 Folic Acid results in decreased expression of HMGCR mRNA CTD PMID:25629700 formaldehyde decreases expression ISO RGD:731579 6480464 Formaldehyde results in decreased expression of HMGCR mRNA CTD PMID:23649840 fructose multiple interactions EXP 6480464 [6-chloro-2 more ... CTD PMID:19193814 , PMID:21212096 fructose increases expression EXP 6480464 Fructose results in increased expression of HMGCR mRNA CTD PMID:19193814 , PMID:21212096 fucoxanthin decreases activity ISO RGD:731580 6480464 fucoxanthin results in decreased activity of HMGCR protein CTD PMID:20519145 furan multiple interactions ISO RGD:731580 6480464 [Bromodeoxyuridine co-treated with furan] affects the expression of HMGCR mRNA CTD PMID:24910943 furan increases expression ISO RGD:731580 6480464 furan results in increased expression of HMGCR mRNA CTD PMID:24183702 furan increases methylation EXP 6480464 furan results in increased methylation of HMGCR gene CTD PMID:22079235 Ganoderic acid A decreases expression ISO RGD:731579 6480464 ganoderic acid A results in decreased expression of HMGCR mRNA CTD PMID:29852127 Ganoderic acid A multiple interactions ISO RGD:731580 6480464 [Dietary Fats co-treated with ganoderic acid A] affects the expression of HMGCR mRNA CTD PMID:29852127 genistein multiple interactions ISO RGD:731580 6480464 [Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of HMGCR mRNA CTD PMID:27181934 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of HMGCR mRNA CTD PMID:22061828 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of HMGCR mRNA CTD PMID:33387578 geraniol increases expression ISO RGD:731580 6480464 geraniol results in increased expression of HMGCR mRNA CTD PMID:26141755 geraniol decreases expression ISO RGD:731579 6480464 geraniol results in decreased expression of HMGCR protein CTD PMID:23668785 , PMID:24875281 geraniol decreases expression ISO RGD:731580 6480464 geraniol results in decreased expression of HMGCR protein CTD PMID:24875281 , PMID:26141755 geraniol decreases activity ISO RGD:731579 6480464 geraniol results in decreased activity of HMGCR protein CTD PMID:12477733 more ... geraniol affects expression ISO RGD:731579 6480464 geraniol affects the expression of HMGCR mRNA CTD PMID:23668785 geranyl diphosphate multiple interactions ISO RGD:731579 6480464 [geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of HMGCR protein, Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate] CTD PMID:19819230 , PMID:19856009 geranyl diphosphate increases abundance ISO RGD:731579 6480464 HMGCR protein results in increased abundance of geranyl diphosphate CTD PMID:19856009 geranylgeraniol multiple interactions ISO RGD:731579 6480464 [geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of HMGCR protein more ... CTD PMID:12477733 , PMID:19819230 geranylgeraniol decreases activity ISO RGD:731579 6480464 geranylgeraniol results in decreased activity of HMGCR protein CTD PMID:12477733 glafenine increases expression EXP 6480464 Glafenine results in increased expression of HMGCR mRNA CTD PMID:24136188 glutathione increases expression EXP 6480464 Glutathione deficiency results in increased expression of HMGCR mRNA CTD PMID:15345336 Glycidyl stearate multiple interactions ISO RGD:731579 6480464 [Coconut Oil co-treated with glycidyl stearate] results in increased expression of HMGCR mRNA CTD PMID:30878531 glycochenodeoxycholic acid multiple interactions ISO RGD:731579 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of HMGCR mRNA, [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine] results in decreased expression of HMGCR mRNA CTD PMID:33819548 glycocholic acid multiple interactions ISO RGD:731579 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of HMGCR mRNA, [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine] results in decreased expression of HMGCR mRNA CTD PMID:33819548 glycodeoxycholic acid multiple interactions ISO RGD:731579 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of HMGCR mRNA, [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine] results in decreased expression of HMGCR mRNA CTD PMID:33819548 glyphosate increases expression ISO RGD:731580 6480464 glyphosate results in increased expression of HMGCR mRNA CTD PMID:31374489 GW 4064 increases expression ISO RGD:731579 6480464 GW 4064 results in increased expression of HMGCR mRNA CTD PMID:30611723 GW 7647 multiple interactions ISO RGD:731579 6480464 [GW 7647 co-treated with Oleic Acid] results in increased expression of HMGCR mRNA CTD PMID:30611723 haloperidol increases activity ISO RGD:731579 6480464 Haloperidol results in increased activity of HMGCR protein CTD PMID:16027736 haloperidol increases expression ISO RGD:731579 6480464 Haloperidol results in increased expression of HMGCR mRNA CTD PMID:16027736 , PMID:17052361 haloperidol multiple interactions ISO RGD:731579 6480464 [Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol, [Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides CTD PMID:16027736 Heptachlor epoxide increases expression ISO RGD:731580 6480464 Heptachlor Epoxide results in increased expression of HMGCR mRNA CTD PMID:25270620 hesperidin multiple interactions ISO RGD:731580 6480464 Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein] CTD PMID:16427799 hexadecanoic acid multiple interactions ISO RGD:731580 6480464 [[Palmitic Acid co-treated with Oleic Acid] co-treated with IFNA2 protein alternative form] results in decreased expression of HMGCR protein CTD PMID:31299271 HT-2 toxin decreases expression ISO RGD:731579 6480464 HT-2 toxin results in decreased expression of HMGCR mRNA CTD PMID:22982764 hydrogen peroxide increases expression ISO RGD:731579 6480464 Hydrogen Peroxide results in increased expression of HMGCR mRNA CTD PMID:12414654 hydrogen peroxide multiple interactions ISO RGD:731579 6480464 [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCR mRNA CTD PMID:18032389 hydroxychloroquine affects expression ISO RGD:731579 6480464 Hydroxychloroquine affects the expression of HMGCR mRNA CTD PMID:28975700 hydroxychloroquine multiple interactions ISO RGD:731579 6480464 Simvastatin affects the reaction [Hydroxychloroquine affects the expression of HMGCR mRNA] CTD PMID:28975700 imidacloprid decreases expression ISO RGD:731580 6480464 imidacloprid results in decreased expression of HMGCR mRNA CTD PMID:31780179 isobutanol multiple interactions ISO RGD:731579 6480464 [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of HMGCR mRNA CTD PMID:29432896 isoprenaline multiple interactions EXP 6480464 7-hydroxycoumarin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] more ... CTD PMID:16640830 more ... isoprenaline increases activity EXP 6480464 Isoproterenol results in increased activity of HMGCR protein CTD PMID:16640830 more ... isotretinoin decreases expression ISO RGD:731579 6480464 Isotretinoin results in decreased expression of HMGCR mRNA CTD PMID:20436886 ketamine decreases expression EXP 6480464 Ketamine results in decreased expression of HMGCR mRNA CTD PMID:20080153 ketoconazole increases activity EXP 6480464 Ketoconazole results in increased activity of HMGCR protein CTD PMID:9199277 ketoconazole increases expression EXP 6480464 Ketoconazole results in increased expression of HMGCR mRNA CTD PMID:28263823 ketoconazole decreases expression ISO RGD:731579 6480464 Ketoconazole results in decreased expression of HMGCR mRNA CTD PMID:16935330 ketoconazole decreases activity EXP 6480464 Ketoconazole results in decreased activity of HMGCR protein CTD PMID:12617470 ketoconazole multiple interactions ISO RGD:731579 6480464 [Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA CTD PMID:16935330 L-ascorbic acid increases expression ISO RGD:731580 6480464 Ascorbic Acid results in increased expression of HMGCR mRNA CTD PMID:32913121 L-methionine multiple interactions ISO RGD:731580 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HMGCR mRNA more ... CTD PMID:18952117 , PMID:20938992 lanost-8-ene-3beta,30-diol decreases activity ISO RGD:731580 6480464 32-hydroxy-24, 25-dihydrolanosterol results in decreased activity of HMGCR protein CTD PMID:12617470 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of HMGCR mRNA, lead acetate results in decreased expression of HMGCR protein CTD PMID:29908845 lead diacetate multiple interactions ISO RGD:731579 6480464 SRT1720 inhibits the reaction [lead acetate results in increased expression of HMGCR protein] CTD PMID:34842334 lead nitrate increases expression ISO RGD:731580 6480464 lead nitrate results in increased expression of HMGCR mRNA CTD PMID:22293356 lead nitrate increases expression EXP 6480464 lead nitrate results in increased expression of HMGCR mRNA CTD PMID:15475176 , PMID:16705668 lead nitrate multiple interactions ISO RGD:731580 6480464 [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA] CTD PMID:22293356 lead(0) multiple interactions EXP 6480464 puerarin affects the reaction [Lead affects the expression of HMGCR] CTD PMID:22001170 lead(0) affects expression EXP 6480464 Lead affects the expression of HMGCR CTD PMID:22001170 lead(2+) multiple interactions EXP 6480464 puerarin affects the reaction [Lead affects the expression of HMGCR] CTD PMID:22001170 lead(2+) affects expression EXP 6480464 Lead affects the expression of HMGCR CTD PMID:22001170 lead(II) chloride multiple interactions ISO RGD:731579 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of HMGCR mRNA CTD PMID:18654764 leflunomide increases expression EXP 6480464 leflunomide results in increased expression of HMGCR mRNA CTD PMID:24136188 linalool decreases expression ISO RGD:731580 6480464 linalool results in decreased expression of HMGCR mRNA, linalool results in decreased expression of HMGCR protein CTD PMID:21944868 linalool decreases expression ISO RGD:731579 6480464 linalool results in decreased expression of HMGCR mRNA, linalool results in decreased expression of HMGCR protein CTD PMID:21944868 , PMID:24613879 linalool multiple interactions ISO RGD:731579 6480464 linalool inhibits the reaction [KAT2B protein binds to HMGCR promoter] more ... CTD PMID:21944868 lipopolysaccharide increases expression ISO RGD:731579 6480464 Lipopolysaccharides results in increased expression of HMGCR mRNA, Lipopolysaccharides results in increased expression of HMGCR protein CTD PMID:33677747 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of HMGCR mRNA, Lipopolysaccharides results in increased expression of HMGCR protein CTD PMID:29958987 , PMID:33677747 lipopolysaccharide multiple interactions EXP 6480464 Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of HMGCR mRNA] more ... CTD PMID:29958987 , PMID:33677747 lipopolysaccharide multiple interactions ISO RGD:731579 6480464 [NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of HMGCR mRNA more ... CTD PMID:33677747 , PMID:35877022 lithocholic acid multiple interactions ISO RGD:731580 6480464 [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of HMGCR mRNA CTD PMID:20359477 loperamide increases expression ISO RGD:731580 6480464 Loperamide results in increased expression of HMGCR mRNA CTD PMID:35926757 losartan multiple interactions EXP 6480464 Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA] CTD PMID:19109942 lovastatin multiple interactions ISO RGD:731579 6480464 [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate more ... CTD PMID:17208200 , PMID:19856009 lovastatin multiple interactions ISO RGD:731580 6480464 [Dietary Fats co-treated with Lovastatin] affects the expression of HMGCR mRNA CTD PMID:29852127 lovastatin affects expression ISO RGD:731580 6480464 Lovastatin affects the expression of HMGCR mRNA CTD PMID:27208389 lovastatin decreases activity ISO RGD:731579 6480464 Lovastatin results in decreased activity of HMGCR protein CTD PMID:17208200 more ... lovastatin increases expression ISO RGD:731579 6480464 Lovastatin results in increased expression of HMGCR mRNA CTD PMID:19260826 , PMID:8517861 lovastatin increases expression ISO RGD:731580 6480464 Lovastatin results in increased expression of HMGCR mRNA CTD PMID:19260826 m-xylene decreases expression EXP 6480464 3-xylene results in decreased expression of HMGCR mRNA CTD PMID:12815608 magnesium atom multiple interactions EXP 6480464 [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA] CTD PMID:30031400 manganese atom multiple interactions EXP 6480464 [Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein CTD PMID:12700418 manganese atom increases activity EXP 6480464 Manganese results in increased activity of HMGCR protein CTD PMID:12700418 manganese(0) multiple interactions EXP 6480464 [Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein CTD PMID:12700418 manganese(0) increases activity EXP 6480464 Manganese results in increased activity of HMGCR protein CTD PMID:12700418 menadione increases expression ISO RGD:731579 6480464 Vitamin K 3 results in increased expression of HMGCR mRNA CTD PMID:12414654 menadione multiple interactions ISO RGD:731579 6480464 manganese protoporphyrin inhibits the reaction [Vitamin K 3 results in decreased activity of HMGCR protein], tempol inhibits the reaction [Vitamin K 3 results in decreased activity of HMGCR protein] CTD PMID:21257924 menadione decreases activity ISO RGD:731579 6480464 Vitamin K 3 results in decreased activity of HMGCR protein CTD PMID:21257924 mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of HMGCR mRNA CTD PMID:16507785 metformin decreases expression ISO RGD:731580 6480464 Metformin results in decreased expression of HMGCR mRNA CTD PMID:21870829 metformin increases expression EXP 6480464 Metformin results in increased expression of HMGCR mRNA CTD PMID:31324951 metformin multiple interactions ISO RGD:731580 6480464 Metformin inhibits the reaction [AGT protein results in increased activity of and results in increased phosphorylation of HMGCR protein] CTD PMID:29499335 methimazole multiple interactions ISO RGD:731579 6480464 IGF1 protein inhibits the reaction [Methimazole results in decreased expression of HMGCR mRNA], Methimazole inhibits the reaction [IGF1 protein results in increased expression of HMGCR mRNA] CTD PMID:29990518 methimazole decreases expression ISO RGD:731579 6480464 Methimazole results in decreased expression of HMGCR mRNA CTD PMID:29990518 methimazole decreases expression ISO RGD:731580 6480464 Methimazole results in decreased expression of HMGCR mRNA CTD PMID:29990518 methyl methanesulfonate decreases expression ISO RGD:731579 6480464 Methyl Methanesulfonate results in decreased expression of HMGCR mRNA CTD PMID:23649840 metronidazole multiple interactions ISO RGD:731580 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA], [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA CTD PMID:36464106 mevalonic acid decreases activity ISO RGD:731579 6480464 Mevalonic Acid results in decreased activity of HMGCR protein CTD PMID:12477733 mevalonic acid multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of HMGCR protein] more ... CTD PMID:12056585 , PMID:12518023 mevalonic acid multiple interactions ISO RGD:731579 6480464 [25-hydroxycholesterol co-treated with Mevalonic Acid] results in increased ubiquitination of HMGCR protein CTD PMID:21944868 mevalonolactone decreases activity ISO RGD:731579 6480464 mevalonolactone results in decreased activity of HMGCR protein CTD PMID:12477733 , PMID:3042028 miconazole increases expression ISO RGD:731580 6480464 Miconazole results in increased expression of HMGCR mRNA CTD PMID:27462272 microcystin-LR increases expression ISO RGD:731580 6480464 cyanoginosin LR results in increased expression of HMGCR mRNA CTD PMID:25497113 mifepristone multiple interactions ISO RGD:731579 6480464 Mifepristone inhibits the reaction [Hydrocortisone results in decreased expression of HMGCR mRNA] CTD PMID:31075344 mono(2-ethylhexyl) phthalate increases expression ISO RGD:731579 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of HMGCR mRNA CTD PMID:23118965 mono(2-ethylhexyl) phthalate multiple interactions ISO RGD:731580 6480464 [Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of HMGCR mRNA CTD PMID:27181934 monocrotophos increases expression EXP 6480464 Monocrotophos results in increased expression of HMGCR mRNA CTD PMID:32267039 myricetin multiple interactions EXP 6480464 myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased activity of HMGCR protein] CTD PMID:25240712 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA] CTD PMID:19931295 N-methylformamide affects expression ISO RGD:731580 6480464 methylformamide affects the expression of HMGCR mRNA, methylformamide analog affects the expression of HMGCR mRNA CTD PMID:17040096 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA more ... CTD PMID:18164116 more ... N-nitrosodiethylamine increases expression ISO RGD:731580 6480464 Diethylnitrosamine results in increased expression of HMGCR mRNA CTD PMID:24535843 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of HMGCR mRNA CTD PMID:25380136 N-nitrosodimethylamine decreases expression ISO RGD:731579 6480464 Dimethylnitrosamine results in decreased expression of HMGCR mRNA CTD PMID:17547211 naringin multiple interactions EXP 6480464 naringin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] CTD PMID:16906524 naringin multiple interactions ISO RGD:731580 6480464 naringin affects the reaction [LEPR protein affects the activity of HMGCR protein] CTD PMID:16427799 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of HMGCR mRNA CTD PMID:24136188 neomycin multiple interactions ISO RGD:731580 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA], [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA CTD PMID:36464106 nickel dichloride decreases expression ISO RGD:731579 6480464 nickel chloride results in decreased expression of HMGCR mRNA CTD PMID:17312168 nicotinamide multiple interactions EXP 6480464 [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA] more ... CTD PMID:20696151 , PMID:21212096 nicotine increases expression ISO RGD:731579 6480464 Nicotine results in increased expression of HMGCR mRNA CTD PMID:23416264 nicotine affects expression EXP 6480464 Nicotine affects the expression of HMGCR mRNA CTD PMID:31972234 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of HMGCR mRNA CTD PMID:24136188 obeticholic acid decreases expression ISO RGD:731579 6480464 obeticholic acid results in decreased expression of HMGCR mRNA CTD PMID:27939613 octocrylene increases expression ISO RGD:731579 6480464 octocrylene results in increased expression of HMGCR mRNA CTD PMID:34864131 okadaic acid decreases expression ISO RGD:731579 6480464 Okadaic Acid results in decreased expression of HMGCR mRNA CTD PMID:28939011 olanzapine increases expression ISO RGD:731579 6480464 olanzapine results in increased expression of HMGCR mRNA CTD PMID:17052361 olanzapine multiple interactions EXP 6480464 1-(carboxymethylthio)tetradecane promotes the reaction [olanzapine results in decreased expression of HMGCR mRNA], olanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of HMGCR mRNA] CTD PMID:23226405 olanzapine decreases expression EXP 6480464 olanzapine results in decreased expression of HMGCR mRNA CTD PMID:23226405 oleic acid multiple interactions ISO RGD:731579 6480464 [6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:30611723 oleic acid multiple interactions ISO RGD:731580 6480464 [[Palmitic Acid co-treated with Oleic Acid] co-treated with IFNA2 protein alternative form] results in decreased expression of HMGCR protein CTD PMID:31299271 orlistat multiple interactions EXP 6480464 orlistat inhibits the reaction [Dietary Fats results in increased expression of HMGCR protein] CTD PMID:25087745 oxybenzone increases expression ISO RGD:731579 6480464 oxybenzone results in increased expression of HMGCR mRNA CTD PMID:32407875 paracetamol affects expression ISO RGD:731580 6480464 Acetaminophen affects the expression of HMGCR mRNA CTD PMID:15030884 , PMID:17562736 paracetamol multiple interactions ISO RGD:731579 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of HMGCR mRNA CTD PMID:33819548 paracetamol decreases expression ISO RGD:731579 6480464 Acetaminophen results in decreased expression of HMGCR mRNA CTD PMID:29067470 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of HMGCR mRNA CTD PMID:18246545 , PMID:33387578 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of HMGCR mRNA CTD PMID:17202762 parathion increases expression ISO RGD:731580 6480464 Parathion results in increased expression of HMGCR mRNA CTD PMID:34813904 perflubron increases expression ISO RGD:731579 6480464 perflubron results in increased expression of HMGCR mRNA CTD PMID:25871633 perfluorohexanesulfonic acid increases expression ISO RGD:731580 6480464 perfluorohexanesulfonic acid results in increased expression of HMGCR mRNA CTD PMID:21705711 perfluorononanoic acid decreases expression ISO RGD:731579 6480464 perfluoro-n-nonanoic acid results in decreased expression of HMGCR mRNA CTD PMID:21641976 , PMID:32588087 perfluorooctane-1-sulfonic acid decreases activity EXP 6480464 perfluorooctane sulfonic acid results in decreased activity of HMGCR protein CTD PMID:1327145 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:731579 6480464 perfluorooctane sulfonic acid results in decreased expression of HMGCR mRNA CTD PMID:32253466 , PMID:32588087 perfluorooctane-1-sulfonic acid increases expression ISO RGD:731579 6480464 perfluorooctane sulfonic acid results in increased expression of HMGCR mRNA CTD PMID:23074026 perfluorooctane-1-sulfonic acid increases expression ISO RGD:731580 6480464 perfluorooctane sulfonic acid results in increased expression of HMGCR mRNA CTD PMID:19429403 , PMID:20936131 perfluorooctanoic acid decreases activity EXP 6480464 perfluorooctanoic acid results in decreased activity of HMGCR protein CTD PMID:1327145 perfluorooctanoic acid decreases expression ISO RGD:731579 6480464 perfluorooctanoic acid results in decreased expression of HMGCR mRNA CTD PMID:32068100 more ... perfluorooctanoic acid decreases expression ISO RGD:731580 6480464 perfluorooctanoic acid results in decreased expression of HMGCR mRNA CTD PMID:26942110 more ... perfluorooctanoic acid increases expression ISO RGD:731579 6480464 perfluorooctanoic acid results in increased expression of HMGCR mRNA CTD PMID:23978341 perfluorooctanoic acid multiple interactions ISO RGD:731580 6480464 PPARA gene mutant form inhibits the reaction [perfluorooctanoic acid results in decreased expression of HMGCR mRNA] CTD PMID:32822737 perfluorooctanoic acid increases expression ISO RGD:731580 6480464 perfluorooctanoic acid results in increased expression of HMGCR mRNA CTD PMID:19429403 , PMID:25092180 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of HMGCR mRNA CTD PMID:19162173 permethrin decreases expression ISO RGD:731580 6480464 Permethrin analog results in decreased expression of HMGCR mRNA CTD PMID:21745691 phenformin decreases expression EXP 6480464 Phenformin results in decreased expression of HMGCR mRNA CTD PMID:31324951 phenylmercury acetate decreases expression ISO RGD:731579 6480464 Phenylmercuric Acetate results in decreased expression of HMGCR mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:731579 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HMGCR mRNA CTD PMID:27188386 phenylpropanolamine increases expression ISO RGD:731579 6480464 Phenylpropanolamine results in increased expression of HMGCR mRNA CTD PMID:27756839 phorbol 13-acetate 12-myristate increases expression ISO RGD:731579 6480464 Tetradecanoylphorbol Acetate results in increased expression of HMGCR mRNA CTD PMID:12044893 phorone affects expression EXP 6480464 phorone affects the expression of HMGCR mRNA CTD PMID:18198479 phosphatidylcholine increases activity EXP 6480464 Phosphatidylcholines results in increased activity of HMGCR protein CTD PMID:12559476 phytosterols multiple interactions ISO RGD:731580 6480464 APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HMGCR mRNA] CTD PMID:18155511 picoxystrobin increases expression ISO RGD:731579 6480464 picoxystrobin results in increased expression of HMGCR mRNA CTD PMID:33512557 pioglitazone increases expression ISO RGD:731579 6480464 pioglitazone results in increased expression of HMGCR mRNA CTD PMID:12044893 pioglitazone decreases expression ISO RGD:731580 6480464 pioglitazone results in decreased expression of HMGCR mRNA CTD PMID:20503262 piperine multiple interactions EXP 6480464 piperine inhibits the reaction [Dietary Fats results in increased expression of HMGCR protein] CTD PMID:25087745 pirinixic acid multiple interactions ISO RGD:731580 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HMGCR mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO RGD:731580 6480464 pirinixic acid results in decreased expression of HMGCR mRNA CTD PMID:15777286 more ... pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of HMGCR mRNA CTD PMID:17126302 piroxicam decreases expression ISO RGD:731579 6480464 Piroxicam results in decreased expression of HMGCR mRNA CTD PMID:21858171 potassium chromate decreases expression ISO RGD:731579 6480464 potassium chromate(VI) results in decreased expression of HMGCR mRNA CTD PMID:22714537 potassium dichromate decreases expression ISO RGD:731579 6480464 Potassium Dichromate results in decreased expression of HMGCR mRNA CTD PMID:17547211 potassium dichromate increases expression ISO RGD:731580 6480464 Potassium Dichromate results in increased expression of HMGCR mRNA CTD PMID:23608068 potassium dichromate increases expression ISO RGD:731579 6480464 Potassium Dichromate results in increased expression of HMGCR mRNA CTD PMID:23718831 pravastatin decreases response to substance ISO RGD:731579 6480464 HMGCR gene SNP results in decreased susceptibility to Pravastatin CTD PMID:15199031 pravastatin increases expression EXP 6480464 Pravastatin results in increased expression of HMGCR mRNA CTD PMID:27225895 pravastatin increases expression ISO RGD:731580 6480464 Pravastatin results in increased expression of HMGCR mRNA CTD PMID:27225895 pravastatin decreases activity ISO RGD:731579 6480464 Pravastatin results in decreased activity of HMGCR protein CTD PMID:29969672 , PMID:8593127 pravastatin affects expression ISO RGD:731579 6480464 Pravastatin affects the expression of HMGCR mRNA CTD PMID:8517861 pregnenolone multiple interactions ISO RGD:731579 6480464 Pregnenolone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein], Pregnenolone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein] CTD PMID:9059514 pregnenolone 16alpha-carbonitrile multiple interactions ISO RGD:731580 6480464 [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of HMGCR mRNA, NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of HMGCR mRNA] CTD PMID:20359477 , PMID:22698814 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:731580 6480464 Pregnenolone Carbonitrile results in increased expression of HMGCR mRNA CTD PMID:20359477 , PMID:22698814 proanthocyanidin affects binding EXP 6480464 Proanthocyanidins binds to HMGCR protein CTD PMID:30273964 proanthocyanidin multiple interactions EXP 6480464 Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA], Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of HMGCR protein] CTD PMID:30273964 progesterone increases expression ISO RGD:731579 6480464 Progesterone results in increased expression of HMGCR mRNA CTD PMID:18070364 propiconazole increases expression EXP 6480464 propiconazole results in increased expression of HMGCR mRNA CTD PMID:28970091 puerarin multiple interactions EXP 6480464 puerarin affects the reaction [Lead affects the expression of HMGCR] CTD PMID:22001170 quercetin multiple interactions EXP 6480464 [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in increased activity of HMGCR protein], [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] CTD PMID:19595682 , PMID:21535577 quercetin decreases expression ISO RGD:731579 6480464 Quercetin results in decreased expression of HMGCR mRNA CTD PMID:21632981 quercetin 3-O-beta-D-glucofuranoside multiple interactions ISO RGD:731579 6480464 [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCR mRNA CTD PMID:18032389 quercetin 3-O-beta-D-glucopyranoside multiple interactions ISO RGD:731579 6480464 [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCR mRNA CTD PMID:18032389 quinolin-8-ol decreases expression ISO RGD:731579 6480464 Oxyquinoline results in decreased expression of HMGCR mRNA CTD PMID:21632981 resveratrol increases expression ISO RGD:731579 6480464 resveratrol results in increased expression of HMGCR mRNA CTD PMID:22153697 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of HMGCR mRNA CTD PMID:21907337 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA] more ... CTD PMID:21907337 resveratrol multiple interactions ISO RGD:731579 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of HMGCR mRNA more ... CTD PMID:23386644 more ... resveratrol decreases activity ISO RGD:731579 6480464 resveratrol results in decreased activity of HMGCR protein CTD PMID:23386644 resveratrol decreases expression ISO RGD:731579 6480464 resveratrol results in decreased expression of HMGCR mRNA CTD PMID:23386644 resveratrol decreases activity ISO RGD:731580 6480464 resveratrol results in decreased activity of HMGCR protein CTD PMID:18611391 risperidone increases expression ISO RGD:731579 6480464 Risperidone results in increased expression of HMGCR mRNA CTD PMID:17052361 rotenone multiple interactions EXP 6480464 Rotenone inhibits the reaction [Fructose results in increased expression of HMGCR mRNA] CTD PMID:21212096 rotenone increases expression ISO RGD:731579 6480464 Rotenone results in increased expression of HMGCR mRNA CTD PMID:33512557 rotenone affects expression EXP 6480464 Rotenone affects the expression of HMGCR mRNA CTD PMID:28374803 rotenone multiple interactions ISO RGD:731579 6480464 [7-ketocholesterol co-treated with Rotenone] results in decreased expression of HMGCR mRNA, [Stigmasterol co-treated with Rotenone] results in decreased expression of HMGCR mRNA CTD PMID:23454145 SB 431542 multiple interactions ISO RGD:731579 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HMGCR mRNA CTD PMID:27188386 selenium atom multiple interactions EXP 6480464 [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA], Selenium promotes the reaction [Cholesterol results in decreased expression of HMGCR mRNA] CTD PMID:16581047 , PMID:30031400 selenium atom multiple interactions ISO RGD:731580 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA] CTD PMID:36464106 senecionine decreases expression ISO RGD:731580 6480464 senecionine results in decreased expression of HMGCR protein CTD PMID:35357534 silibinin decreases expression ISO RGD:731579 6480464 Silybin results in decreased expression of HMGCR protein CTD PMID:25294820 simvastatin increases expression EXP 6480464 Simvastatin results in increased expression of HMGCR mRNA, Simvastatin results in increased expression of HMGCR protein CTD PMID:12056585 more ... simvastatin increases expression ISO RGD:731579 6480464 Simvastatin results in increased expression of HMGCR mRNA, Simvastatin results in increased expression of HMGCR protein CTD PMID:10357840 more ... simvastatin increases activity EXP 6480464 Simvastatin results in increased activity of HMGCR protein CTD PMID:12056585 , PMID:1627634 simvastatin affects response to substance ISO RGD:731579 6480464 HMGCR intron polymorphism affects the susceptibility to Simvastatin, HMGCR polymorphism affects the susceptibility to Simvastatin CTD PMID:17870053 more ... simvastatin decreases response to substance ISO RGD:731579 6480464 HMGCR exon alternative form results in decreased susceptibility to Simvastatin CTD PMID:18559695 simvastatin multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of HMGCR protein] more ... CTD PMID:12056585 more ... simvastatin increases expression ISO RGD:731580 6480464 Simvastatin results in increased expression of HMGCR mRNA CTD PMID:16282522 , PMID:22120639 simvastatin multiple interactions ISO RGD:731580 6480464 Colesevelam Hydrochloride promotes the reaction [Simvastatin results in increased expression of HMGCR mRNA] CTD PMID:22120639 simvastatin multiple interactions ISO RGD:731579 6480464 [HMGCR intron polymorphism affects the expression of HMGCR exon alternative form] which results in decreased susceptibility to Simvastatin more ... CTD PMID:12477733 more ... simvastatin increases activity ISO RGD:731579 6480464 Simvastatin results in increased activity of HMGCR protein CTD PMID:1627634 simvastatin decreases activity ISO RGD:731579 6480464 Simvastatin results in decreased activity of HMGCR protein CTD PMID:17980884 more ... sirolimus increases expression ISO RGD:731579 6480464 Sirolimus results in increased expression of HMGCR mRNA CTD PMID:17516993 sodium arsenate affects activity EXP 6480464 sodium arsenate affects the activity of HMGCR protein CTD PMID:26044777 sodium arsenite decreases expression ISO RGD:731580 6480464 sodium arsenite results in decreased expression of HMGCR, sodium arsenite results in decreased expression of HMGCR mRNA CTD PMID:22700541 more ... sodium arsenite affects activity EXP 6480464 sodium arsenite affects the activity of HMGCR protein CTD PMID:26044777 sodium cholate multiple interactions ISO RGD:731580 6480464 [Sodium Cholate co-treated with Dietary Fats] results in decreased expression of HMGCR mRNA CTD PMID:23665937 Soman increases expression EXP 6480464 Soman results in increased expression of HMGCR mRNA CTD PMID:19281266 soybean oil increases activity EXP 6480464 Soybean Oil results in increased activity of HMGCR protein CTD PMID:12559476 stigmasterol multiple interactions ISO RGD:731579 6480464 [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of HMGCR mRNA more ... CTD PMID:23454145 stigmasterol increases expression ISO RGD:731579 6480464 Stigmasterol results in increased expression of HMGCR mRNA CTD PMID:23454145 streptozocin multiple interactions EXP 6480464 [Dietary Fats co-treated with Streptozocin] results in increased expression of HMGCR mRNA more ... CTD PMID:20696151 more ... streptozocin increases expression ISO RGD:731580 6480464 Streptozocin results in increased expression of HMGCR mRNA CTD PMID:34896238 streptozocin multiple interactions ISO RGD:731580 6480464 Acrylamide inhibits the reaction [Streptozocin results in increased expression of HMGCR mRNA] CTD PMID:34896238 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of HMGCR mRNA CTD PMID:25905778 sucrose multiple interactions EXP 6480464 [Dietary Fats co-treated with Sucrose] results in increased expression of HMGCR mRNA more ... CTD PMID:31175915 sunitinib increases expression ISO RGD:731579 6480464 Sunitinib results in increased expression of HMGCR mRNA CTD PMID:31533062 T-2 toxin decreases expression ISO RGD:731579 6480464 T-2 Toxin results in decreased expression of HMGCR mRNA CTD PMID:22982764 , PMID:34581912 tamoxifen affects expression ISO RGD:731580 6480464 Tamoxifen affects the expression of HMGCR mRNA CTD PMID:20937368 tamoxifen multiple interactions ISO RGD:731580 6480464 fatostatin inhibits the reaction [Tamoxifen results in increased expression of HMGCR mRNA], fatostatin inhibits the reaction [Tamoxifen results in increased expression of HMGCR protein] CTD PMID:35944649 tamoxifen increases expression ISO RGD:731580 6480464 Tamoxifen results in increased expression of HMGCR mRNA, Tamoxifen results in increased expression of HMGCR protein CTD PMID:35944649 tebuconazole increases expression ISO RGD:731579 6480464 tebuconazole results in increased expression of HMGCR mRNA CTD PMID:30458266 tert-butyl hydroperoxide increases expression ISO RGD:731579 6480464 tert-Butylhydroperoxide results in increased expression of HMGCR mRNA CTD PMID:12414654 Tesaglitazar increases expression EXP 6480464 tesaglitazar results in increased expression of HMGCR mRNA CTD PMID:21515302 testosterone increases expression ISO RGD:731580 6480464 Testosterone results in increased expression of HMGCR mRNA CTD PMID:16579987 testosterone decreases expression ISO RGD:731579 6480464 Testosterone results in decreased expression of HMGCR mRNA CTD PMID:33359661 tetrachloromethane decreases expression ISO RGD:731580 6480464 Carbon Tetrachloride results in decreased expression of HMGCR mRNA CTD PMID:27339419 tetrachloromethane affects expression ISO RGD:731580 6480464 Carbon Tetrachloride affects the expression of HMGCR mRNA CTD PMID:31919559 tetracycline decreases expression EXP 6480464 Tetracycline results in decreased expression of HMGCR mRNA CTD PMID:19224547 tetrahydrocurcumin multiple interactions EXP 6480464 [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein], tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein] CTD PMID:20696151 thapsigargin decreases expression ISO RGD:731579 6480464 Thapsigargin results in decreased expression of HMGCR mRNA CTD PMID:22378314 thapsigargin increases expression EXP 6480464 Thapsigargin results in increased expression of HMGCR protein CTD PMID:35544339 thapsigargin increases expression ISO RGD:731579 6480464 Thapsigargin results in increased expression of HMGCR mRNA CTD PMID:29453283 thiazolidinediones decreases expression ISO RGD:731580 6480464 Thiazolidinediones results in decreased expression of HMGCR mRNA CTD PMID:21870829 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of HMGCR mRNA CTD PMID:23411599 , PMID:34492290 thioacetamide multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of HMGCR mRNA CTD PMID:28943392 thiourea multiple interactions EXP 6480464 Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA], Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein] CTD PMID:19931295 titanium dioxide increases expression ISO RGD:731580 6480464 titanium dioxide results in increased expression of HMGCR mRNA CTD PMID:23557971 , PMID:27760801 trans-caffeic acid decreases expression ISO RGD:731580 6480464 caffeic acid results in decreased expression of HMGCR mRNA CTD PMID:21870829 trans-cinnamic acid decreases expression ISO RGD:731580 6480464 cinnamic acid results in decreased expression of HMGCR mRNA CTD PMID:21870829 triacsin C decreases expression ISO RGD:731579 6480464 triacsin C results in decreased expression of HMGCR mRNA CTD PMID:16704987 triadimefon increases expression ISO RGD:731580 6480464 triadimefon results in increased expression of HMGCR mRNA CTD PMID:19363144 triadimefon increases expression EXP 6480464 triadimefon results in increased expression of HMGCR mRNA CTD PMID:17178689 , PMID:19423681 tributyl phosphate increases expression ISO RGD:731579 6480464 tributyl phosphate results in increased expression of HMGCR mRNA CTD PMID:30966736 trichloroethene decreases expression ISO RGD:731580 6480464 Trichloroethylene results in decreased expression of HMGCR mRNA CTD PMID:25055964 trichostatin A affects expression ISO RGD:731579 6480464 trichostatin A affects the expression of HMGCR mRNA CTD PMID:28542535 triclosan decreases expression EXP 6480464 Triclosan results in decreased expression of HMGCR mRNA CTD PMID:25554385 trimellitic anhydride increases expression ISO RGD:731580 6480464 trimellitic anhydride results in increased expression of HMGCR mRNA CTD PMID:19042947 triolein increases expression ISO RGD:731580 6480464 Triolein results in increased expression of HMGCR mRNA CTD PMID:18356535 triphenyl phosphate increases expression ISO RGD:731579 6480464 triphenyl phosphate results in increased expression of HMGCR mRNA CTD PMID:30966736 triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of HMGCR mRNA CTD PMID:30589522 triphenylstannane decreases expression EXP 6480464 triphenyltin results in decreased expression of HMGCR mRNA CTD PMID:32504733 Triptolide multiple interactions ISO RGD:731579 6480464 [Colforsin co-treated with triptolide] results in decreased expression of HMGCR mRNA CTD PMID:31557376 troglitazone multiple interactions ISO RGD:731579 6480464 [[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased expression of HMGCR mRNA, [troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of HMGCR mRNA CTD PMID:12044893 , PMID:16946405 troglitazone increases expression ISO RGD:731579 6480464 troglitazone results in increased expression of HMGCR mRNA CTD PMID:12044893 troglitazone increases activity ISO RGD:731579 6480464 troglitazone results in increased activity of HMGCR protein CTD PMID:12044893 tunicamycin decreases expression ISO RGD:731579 6480464 Tunicamycin results in decreased expression of HMGCR mRNA CTD PMID:22378314 , PMID:29453283 umbelliferone multiple interactions EXP 6480464 7-hydroxycoumarin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] CTD PMID:26995004 undecane decreases expression EXP 6480464 undecane results in decreased expression of HMGCR protein CTD PMID:17337753 urethane increases expression ISO RGD:731579 6480464 Urethane results in increased expression of HMGCR mRNA CTD PMID:28818685 ursodeoxycholic acid decreases activity EXP 6480464 Ursodeoxycholic Acid results in decreased activity of HMGCR protein CTD PMID:6832710 valproic acid decreases expression ISO RGD:731580 6480464 Valproic Acid results in decreased expression of HMGCR mRNA CTD PMID:22045034 valproic acid affects methylation ISO RGD:731579 6480464 Valproic Acid affects the methylation of HMGCR gene CTD PMID:29501571 valproic acid decreases expression ISO RGD:731579 6480464 Valproic Acid results in decreased expression of HMGCR mRNA CTD PMID:19566492 more ... valproic acid affects expression ISO RGD:731579 6480464 Valproic Acid affects the expression of HMGCR mRNA CTD PMID:25979313 valproic acid decreases methylation ISO RGD:731579 6480464 Valproic Acid results in decreased methylation of HMGCR gene CTD PMID:29154799 valproic acid multiple interactions ISO RGD:731579 6480464 Valproic Acid affects the reaction [Colforsin affects the expression of HMGCR mRNA] CTD PMID:20726872 vancomycin multiple interactions ISO RGD:731580 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA], [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA CTD PMID:36464106 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of HMGCR mRNA CTD PMID:22570695 warfarin multiple interactions EXP 6480464 Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of HMGCR mRNA] CTD PMID:27488359 Yessotoxin increases expression ISO RGD:731579 6480464 yessotoxin analog results in increased expression of HMGCR mRNA CTD PMID:30679557 zaragozic acid A increases expression ISO RGD:731580 6480464 squalestatin 1 results in increased expression of HMGCR mRNA CTD PMID:27225895 zaragozic acid A increases expression EXP 6480464 squalestatin 1 results in increased expression of HMGCR mRNA CTD PMID:27225895 zinc atom affects expression EXP 6480464 Zinc affects the expression of HMGCR mRNA CTD PMID:17181878 zinc atom decreases expression EXP 6480464 Zinc deficiency results in decreased expression of HMGCR mRNA, Zinc results in decreased expression of HMGCR mRNA CTD PMID:15671213 , PMID:17074742 zinc sulfate decreases expression EXP 6480464 Zinc Sulfate results in decreased expression of HMGCR mRNA CTD PMID:17074742 zinc(0) affects expression EXP 6480464 Zinc affects the expression of HMGCR mRNA CTD PMID:17181878 zinc(0) decreases expression EXP 6480464 Zinc deficiency results in decreased expression of HMGCR mRNA, Zinc results in decreased expression of HMGCR mRNA CTD PMID:15671213 , PMID:17074742 zingerone multiple interactions EXP 6480464 zingerone inhibits the reaction [Ethanol results in increased activity of HMGCR protein] CTD PMID:28442378 ziprasidone increases expression ISO RGD:731579 6480464 ziprasidone results in increased expression of HMGCR mRNA CTD PMID:17052361
