Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase) - Rat Genome Database

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Gene: Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase) Rattus norvegicus
Analyze
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
RGD ID: 2803
Description: Enables identical protein binding activity and protein phosphatase 2A binding activity. Involved in several processes, including lipid homeostasis; positive regulation of MAPK cascade; and regulation of striated muscle cell apoptotic process. Located in intracellular membrane-bounded organelle. Used to study Wilson disease; drug-induced hepatitis; end stage renal disease; pulmonary hypertension; and type 2 diabetes mellitus. Biomarker of chronic kidney disease; non-alcoholic fatty liver disease; and premature menopause. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase); PARTICIPATES IN bile acid signaling pathway; metabolic syndrome X pathway; alendronate pharmacodynamics pathway; INTERACTS WITH (+)-alpha-tocopherol; (25R)-cholest-5-ene-3beta,26-diol; (R)-mevalonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMG-CoA reductase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2227,997,523 - 28,018,983 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl227,997,525 - 28,019,703 (-)Ensembl
Rnor_6.0227,480,224 - 27,500,654 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,480,226 - 27,500,654 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0246,592,881 - 46,614,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4227,127,504 - 27,149,580 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1227,047,872 - 27,069,949 (-)NCBI
Celera224,043,814 - 24,065,183 (-)NCBICelera
RH 3.4 Map213.3RGD
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(R)-mevalonic acid  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP,ISO)
1,2,3-trilinolenoylglycerol  (ISO)
1,2,3-trilinoleoylglycerol  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1,3-dichloropropan-2-ol  (ISO)
1,8-cineole  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,4-dibromophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
24,25-dihydrolanosterol  (ISO)
25-hydroxycholesterol  (EXP,ISO)
26-hydroxycholesterol  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3beta-hydroxy-5alpha-cholest-8(14)-en-15-one  (ISO)
3beta-hydroxylanost-8-en-32-al  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
7alpha-hydroxycholesterol  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
Actein  (EXP)
aflatoxin B1  (ISO)
allethrin  (EXP)
alliin  (EXP,ISO)
alpha-naphthoflavone  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
Aroclor 1254  (EXP,ISO)
atorvastatin calcium  (EXP,ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzofurans  (ISO)
beta-ionone  (EXP)
beta-naphthoflavone  (EXP,ISO)
betulin  (ISO)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chitosan  (EXP)
chlorogenic acid  (EXP,ISO)
chlorpromazine  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colesevelam hydrochloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumarin  (EXP)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
D-gluconic acid  (EXP)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (ISO)
desmosterol  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP)
difenoconazole  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
disodium selenite  (EXP)
dorsomorphin  (ISO)
elemental selenium  (EXP)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
enniatin  (ISO)
entinostat  (ISO)
Epomediol  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
ezetimibe  (ISO)
farnesol  (EXP,ISO)
farnesyl diphosphate  (ISO)
fenarimol  (EXP)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
ferulic acid  (ISO)
fingolimod hydrochloride  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
furan  (EXP,ISO)
Ganoderic acid A  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
geranyl diphosphate  (ISO)
geranylgeraniol  (ISO)
glafenine  (EXP)
glutathione  (EXP)
Glycidyl stearate  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
haloperidol  (ISO)
Heptachlor epoxide  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (ISO)
HT-2 toxin  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
imidacloprid  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ketamine  (EXP)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lanost-8-ene-3beta,30-diol  (ISO)
lead diacetate  (EXP)
lead nitrate  (EXP,ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
lead(II) chloride  (ISO)
leflunomide  (EXP)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
losartan  (EXP)
lovastatin  (ISO)
m-xylene  (EXP)
magnesium atom  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
menadione  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
myricetin  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
naringin  (EXP,ISO)
nefazodone  (EXP)
nickel dichloride  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nimesulide  (EXP)
obeticholic acid  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP,ISO)
oleic acid  (ISO)
orlistat  (EXP)
oxybenzone  (ISO)
paracetamol  (EXP,ISO)
perflubron  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenformin  (EXP)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
phosphatidylcholine  (EXP)
phytosterols  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
piperine  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
proanthocyanidin  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
puerarin  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (EXP,ISO)
risperidone  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (EXP)
silibinin  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium cholate  (ISO)
Soman  (EXP)
soybean oil  (EXP)
stigmasterol  (ISO)
streptozocin  (EXP)
sucrose  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (EXP)
tetrahydrocurcumin  (EXP)
thapsigargin  (ISO)
thiazolidinediones  (ISO)
thioacetamide  (EXP)
thiourea  (EXP)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
trans-cinnamic acid  (ISO)
triacsin C  (ISO)
triadimefon  (EXP,ISO)
tributyl phosphate  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
trimellitic anhydride  (ISO)
triolein  (ISO)
triphenyl phosphate  (EXP,ISO)
triphenylstannane  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
umbelliferone  (EXP)
undecane  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
warfarin  (EXP)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zingerone  (EXP)
ziprasidone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Abe M, etal., Drug Metab Pharmacokinet. 2010;25(3):274-82.
2. Chen CW and Cheng HH, J Nutr. 2006 Jun;136(6):1472-6.
3. Chen XR, etal., J Pharmacol Exp Ther. 2008 Sep;326(3):966-74. Epub 2008 Jun 18.
4. Cheng XW, etal., J Hypertens. 2011 Mar;29(3):542-52.
5. Chmielewski M, etal., Mol Cell Biochem 2003 Apr;246(1-2):187-91.
6. Cho K, etal., J Med Food. 2009 Dec;12(6):1293-301.
7. Côté I, etal., Br J Nutr. 2014 Nov 28;112(10):1592-600. doi: 10.1017/S0007114514002517. Epub 2014 Sep 29.
8. Côté I, etal., Eur J Nutr. 2013 Aug;52(5):1523-32. doi: 10.1007/s00394-012-0459-5. Epub 2012 Nov 2.
9. Dobreanu M, etal., Rom J Intern Med. 2007;45(2):193-9.
10. Edwards PA, etal., J Biol Chem. 1985 Aug 25;260(18):10278-82.
11. Ferri N, etal., Mol Pharmacol. 2008 Jul;74(1):144-53. Epub 2008 Apr 15.
12. Floris S, etal., Brain. 2004 Mar;127(Pt 3):616-27. Epub 2003 Dec 22.
13. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Gegg ME, etal., J Immunol. 2005 Feb 15;174(4):2327-35.
15. Girgis RE, etal., Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H938-45. Epub 2003 May 15.
16. GOA data from the GO Consortium
17. Gupta SD, etal., J Lipid Res. 1999 Sep;40(9):1572-84.
18. Gustavsson C, etal., Retina. 2008 Apr;28(4):645-52.
19. Karadeniz Cakmak G, etal., J Gastrointest Surg. 2009 Sep;13(9):1707-16. Epub 2009 Jul 4.
20. KEGG
21. Kilic U, etal., Neuroscience. 2005;134(3):901-6.
22. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
23. Levy E, etal., Life Sci. 2007 Mar 27;80(16):1472-83. Epub 2007 Jan 20.
24. Li G, etal., Neurology. 2007 Aug 28;69(9):878-85.
25. Liappis AP, etal., Clin Infect Dis. 2001 Oct 15;33(8):1352-7. Epub 2001 Sep 20.
26. Mammen AL, etal., Arthritis Rheum. 2011 Mar;63(3):713-21. doi: 10.1002/art.30156.
27. Marmugi A, etal., Toxicology. 2014 Nov 5;325:133-43. doi: 10.1016/j.tox.2014.08.006. Epub 2014 Aug 26.
28. Martini C, etal., J Cell Physiol. 2009 Aug;220(2):524-30.
29. McPherson R, etal., Clin Ther. 1992 Mar-Apr;14(2):276-91.
30. MGD data from the GO Consortium
31. Mix E, etal., J Autoimmun. 2006 Dec;27(4):251-65. Epub 2006 Nov 3.
32. Miyahara S, etal., Am J Pathol. 2004 May;164(5):1697-706.
33. Mizukawa M, etal., Hypertens Res. 2009 Jul;32(7):617-24. Epub 2009 May 22.
34. NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. Neuvonen PJ, etal., Clin Pharmacokinet. 2008;47(7):463-74.
36. Ngo Sock ET, etal., Horm Metab Res. 2014 Jul;46(8):550-5. doi: 10.1055/s-0034-1370910. Epub 2014 Mar 11.
37. Nishiguchi T, etal., J Pharm Pharmacol. 2009 Jun;61(6):781-8.
38. OMIM Disease Annotation Pipeline
39. Ostroukhova M, etal., Ann Allergy Asthma Immunol. 2009 Dec;103(6):463-8.
40. Pallottini V, etal., J Hepatol. 2006 Feb;44(2):368-74. Epub 2005 Jul 11.
41. Pallottini V, etal., Mech Ageing Dev. 2004 Sep;125(9):633-9.
42. Pallottini V, etal., Mech Ageing Dev. 2007 Nov-Dec;128(11-12):688-95. Epub 2007 Oct 16.
43. Perovic M, etal., Biogerontology. 2009 Mar 7.
44. Pipeline to import KEGG annotations from KEGG into RGD
45. Pipeline to import SMPDB annotations from SMPDB into RGD
46. Prasad GV, etal., Am J Transplant. 2004 Nov;4(11):1897-903.
47. RGD automated data pipeline
48. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. RGD automated import pipeline for gene-chemical interactions
50. Rombouts K, etal., J Hepatol. 2003 May;38(5):564-72.
51. Rung E, etal., Biol Reprod. 2005 Mar;72(3):538-45. Epub 2004 Sep 22.
52. Sarkey JP, etal., J Neurochem. 2007 Mar;100(5):1265-77. Epub 2006 Dec 22.
53. Stewart RA, etal., Circulation. 2005 Apr 12;111(14):1756-62. Epub 2005 Apr 4.
54. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
55. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
56. Torrens C, etal., Hypertension. 2009 Apr;53(4):661-7. Epub 2009 Feb 16.
57. Trapani L, etal., J Cell Biochem. 2010 May 15;110(2):392-8.
58. Tristano AG, etal., Biochem Biophys Res Commun. 2007 Feb 2;353(1):11-7. Epub 2006 Nov 17.
59. Ucak A, etal., Ann Vasc Surg. 2011 Jul;25(5):686-95.
60. Valenza M, etal., Neurobiol Dis. 2007 Oct;28(1):133-42. Epub 2007 Jul 10.
61. Visavadiya NP and Narasimhacharya AV, Clin Exp Pharmacol Physiol. 2007 Mar;34(3):244-9.
62. Waehre T, etal., J Am Coll Cardiol. 2003 May 7;41(9):1460-7.
63. Wahner AD, etal., Neurology. 2008 Apr 15;70(16 Pt 2):1418-22. Epub 2008 Jan 9.
64. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
65. Wolozin B, etal., BMC Med. 2007 Jul 19;5:20.
66. Wong DH, etal., Fertil Steril. 2011 Sep 9.
67. Xie Z, etal., Metabolism. 2010 Apr;59(4):554-60. Epub 2009 Nov 14.
68. Xu J, etal., J Pharm Pharmacol. 2009 Apr;61(4):503-10.
69. Yamagata T, etal., Rheumatol Int. 2007 May;27(7):631-9. Epub 2006 Nov 21.
70. Yamazaki H, etal., J Atheroscler Thromb. 2006 Dec;13(6):295-307.
71. Yao HW, etal., Clin Exp Pharmacol Physiol. 2006 Sep;33(9):793-7.
72. Yasuda H, etal., Kidney Int. 2006 May;69(9):1535-42.
73. Ying S, etal., Biochem Biophys Res Commun. 2007 Nov 16;363(2):395-8. Epub 2007 Sep 10.
74. Yu Y, etal., J Am Coll Cardiol. 2004 Aug 18;44(4):904-13.
75. Zhang L, etal., Circulation. 2005 Nov 29;112(22):3486-94.
Additional References at PubMed
PMID:1352323   PMID:1628744   PMID:2369897   PMID:2991281   PMID:7798939   PMID:8647961   PMID:9186920   PMID:10698924   PMID:11792727   PMID:12114517   PMID:12409258   PMID:12920113  
PMID:15090540   PMID:15337832   PMID:15489334   PMID:15845870   PMID:15919082   PMID:16100574   PMID:16636304   PMID:16741953   PMID:17180682   PMID:17327468   PMID:19470373   PMID:19895880  
PMID:20435455   PMID:20876579   PMID:22405826   PMID:22871113   PMID:23063590   PMID:23280554   PMID:23617777   PMID:24319730   PMID:24694611   PMID:28938515   PMID:33412161  


Genomics

Comparative Map Data
Hmgcr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2227,997,523 - 28,018,983 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl227,997,525 - 28,019,703 (-)Ensembl
Rnor_6.0227,480,224 - 27,500,654 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,480,226 - 27,500,654 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0246,592,881 - 46,614,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4227,127,504 - 27,149,580 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1227,047,872 - 27,069,949 (-)NCBI
Celera224,043,814 - 24,065,183 (-)NCBICelera
RH 3.4 Map213.3RGD
Cytogenetic Map2q12NCBI
HMGCR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl575,336,329 - 75,364,001 (+)EnsemblGRCh38hg38GRCh38
GRCh38575,336,334 - 75,362,116 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37574,632,993 - 74,657,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36574,668,855 - 74,693,681 (+)NCBINCBI36hg18NCBI36
Build 34574,668,854 - 74,693,681NCBI
Celera570,526,169 - 70,551,102 (+)NCBI
Cytogenetic Map5q13.3NCBI
HuRef569,838,165 - 69,863,098 (+)NCBIHuRef
CHM1_1574,065,715 - 74,090,648 (+)NCBICHM1_1
Hmgcr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391396,785,470 - 96,807,444 (-)NCBIGRCm39mm39
GRCm39 Ensembl1396,785,475 - 96,807,444 (-)Ensembl
GRCm381396,648,962 - 96,670,936 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1396,648,967 - 96,670,936 (-)EnsemblGRCm38mm10GRCm38
MGSCv371397,418,917 - 97,440,891 (-)NCBIGRCm37mm9NCBIm37
MGSCv361397,750,033 - 97,771,547 (-)NCBImm8
Celera13100,288,206 - 100,310,264 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.65NCBI
Hmgcr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542525,359,884 - 25,380,745 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542525,362,165 - 25,380,611 (-)NCBIChiLan1.0ChiLan1.0
HMGCR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1540,548,919 - 40,573,785 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl540,548,919 - 40,573,785 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0539,936,630 - 39,961,519 (-)NCBIMhudiblu_PPA_v0panPan3
HMGCR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1330,970,037 - 30,988,987 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl330,970,037 - 30,990,294 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha332,211,759 - 32,233,728 (-)NCBI
ROS_Cfam_1.0330,898,455 - 30,920,631 (-)NCBI
UMICH_Zoey_3.1330,828,548 - 30,850,686 (-)NCBI
UNSW_CanFamBas_1.0330,798,860 - 30,820,987 (-)NCBI
UU_Cfam_GSD_1.0331,177,224 - 31,199,407 (-)NCBI
Hmgcr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213189,458,452 - 189,480,240 (+)NCBI
SpeTri2.0NW_0049365491,378,536 - 1,400,501 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGCR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl284,380,225 - 84,402,956 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1284,380,245 - 84,401,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2285,967,367 - 85,988,242 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q22NCBI
HMGCR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1469,664,784 - 69,690,343 (+)NCBI
ChlSab1.1 Ensembl469,665,417 - 69,688,686 (+)Ensembl
Vero_WHO_p1.0NW_02366604918,450,156 - 18,475,169 (+)NCBI
Hmgcr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624951681,559 - 711,476 (+)NCBI

Position Markers
RH129199  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2227,997,953 - 27,998,133 (+)MAPPERmRatBN7.2
Rnor_6.0227,480,655 - 27,480,834NCBIRnor6.0
Rnor_5.0246,593,312 - 46,593,491UniSTSRnor5.0
RGSC_v3.4227,127,933 - 27,128,112UniSTSRGSC3.4
Celera224,044,243 - 24,044,422UniSTS
RH 3.4 Map220.1UniSTS
Cytogenetic Map2q12UniSTS
Hmgcr  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2227,998,720 - 27,999,556 (+)MAPPERmRatBN7.2
Rnor_6.0227,481,422 - 27,482,257NCBIRnor6.0
Rnor_5.0246,594,079 - 46,594,914UniSTSRnor5.0
RGSC_v3.4227,128,700 - 27,129,535UniSTSRGSC3.4
Celera224,045,010 - 24,045,845UniSTS
Cytogenetic Map2q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:191
Count of miRNA genes:143
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000022055
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 54 39 18 39 74 29 40 11
Low 17 3 2 1 2 8 11 6 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022055   ⟹   ENSRNOP00000022055
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl227,997,527 - 28,019,012 (-)Ensembl
Rnor_6.0 Ensembl227,480,226 - 27,500,654 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096437   ⟹   ENSRNOP00000097467
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl227,997,525 - 28,019,703 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101787   ⟹   ENSRNOP00000096084
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl227,997,525 - 28,019,056 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112347   ⟹   ENSRNOP00000087297
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl227,997,525 - 28,016,019 (-)Ensembl
RefSeq Acc Id: NM_013134   ⟹   NP_037266
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2227,997,525 - 28,018,983 (-)NCBI
Rnor_6.0227,480,226 - 27,500,654 (-)NCBI
Rnor_5.0246,592,881 - 46,614,276 (-)NCBI
RGSC_v3.4227,127,504 - 27,149,580 (-)RGD
Celera224,043,814 - 24,065,183 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231826   ⟹   XP_006231888
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2227,997,523 - 28,018,943 (-)NCBI
Rnor_6.0227,480,224 - 27,500,616 (-)NCBI
Rnor_5.0246,592,881 - 46,614,276 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037266   ⟸   NM_013134
- UniProtKB: P51639 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006231888   ⟸   XM_006231826
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000022055   ⟸   ENSRNOT00000022055
RefSeq Acc Id: ENSRNOP00000096084   ⟸   ENSRNOT00000101787
RefSeq Acc Id: ENSRNOP00000087297   ⟸   ENSRNOT00000112347
RefSeq Acc Id: ENSRNOP00000097467   ⟸   ENSRNOT00000096437
Protein Domains
SSD

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691084
Promoter ID:EPDNEW_R1609
Type:initiation region
Name:Hmgcr_1
Description:3-hydroxy-3-methylglutaryl-CoA reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0227,500,681 - 27,500,741EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2803 AgrOrtholog
Ensembl Genes ENSRNOG00000016122 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000022055 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022055 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.3270.10 UniProtKB/Swiss-Prot
  3.30.70.420 UniProtKB/Swiss-Prot
  3.90.770.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5600023 IMAGE-MGC_LOAD
InterPro HMG_CoA_Rdtase UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_cat_sf UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_CS UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_eu_arc UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_metazoan UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_N UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_NAD(P)-bd_sf UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_sub-bd_dom_sf UniProtKB/Swiss-Prot
  SSD UniProtKB/Swiss-Prot
KEGG Report rno:25675 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72532 IMAGE-MGC_LOAD
NCBI Gene 25675 ENTREZGENE
PANTHER PTHR10572 UniProtKB/Swiss-Prot
Pfam HMG-CoA_red UniProtKB/Swiss-Prot
  Sterol-sensing UniProtKB/Swiss-Prot
PharmGKB HMGCR RGD
PhenoGen Hmgcr PhenoGen
PRINTS HMGCOARDTASE UniProtKB/Swiss-Prot
PROSITE HMG_COA_REDUCTASE_1 UniProtKB/Swiss-Prot
  HMG_COA_REDUCTASE_2 UniProtKB/Swiss-Prot
  HMG_COA_REDUCTASE_3 UniProtKB/Swiss-Prot
  HMG_COA_REDUCTASE_4 UniProtKB/Swiss-Prot
  SSD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55035 UniProtKB/Swiss-Prot
  SSF56542 UniProtKB/Swiss-Prot
TIGR TC238888
TIGRFAMs 2A060605 UniProtKB/Swiss-Prot
  HMG_CoA_R_NADP UniProtKB/Swiss-Prot
UniProt HMDH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q64601 UniProtKB/Swiss-Prot
  Q6P2A6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Hmgcr  3-hydroxy-3-methylglutaryl-CoA reductase  Hmgcr  3-hydroxy-3-methylglutaryl-Coenzyme A reductase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hmgcr  3-hydroxy-3-methylglutaryl-Coenzyme A reductase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function rate limiting enzyme in the cholesterologenesis pathway 1300058