GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmgcr | decreases activity | ISO | HMGCR (Homo sapiens) | 6480464 | CTD | geranylgeraniol results in decreased activity of HMGCR protein | PMID:12477733 | Hmgcr | multiple interactions | ISO | HMGCR (Homo sapiens) | 6480464 | CTD | [geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of HMGCR protein; [MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to geranylgeraniol; MVK gene mutant form promotes the reaction [geranylgeraniol results in decreased activity of HMGCR protein] | PMID:12477733 PMID:19819230 | |
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