Mamtr2 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Mamtr2 (Mammary tumor resistance QTL 2) Rattus norvegicus

Symbol: Mamtr2
Name: Mammary tumor resistance QTL 2
RGD ID: 731166
Previously known as: Mcs1a; Mcs9
Trait: mammary gland integrity trait   (VT:0010552)    
Measurement Type: mammary tumor number   (CMO:0000343)    
LOD Score: Not Available
P Value: 1.0E-4
Variance: Not Available
Inheritance Type: semidominant
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.227,887,772 - 12,654,247RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.025,417,336 - 10,246,458RGD_MAPPER_PIPELINERnor6.0
Rnor_5.025,396,621 - 10,117,085RGDRnor5.0
RGSC_v3.425,601,528 - 10,539,334RGDRGSC3.4
RGSC_v3.125,627,976 - 10,463,527RGD
Cross Type: intercross
Strains Crossed: WF.COP-(D2Mit29-D2Uwm13)/Uwm 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method
necropsy  (IDA)

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Congenic rats reveal three independent Copenhagen alleles within the Mcs1 quantitative trait locus that confer resistance to mammary cancer. Haag JD, etal., Cancer Res 2003 Sep 15;63(18):5808-12.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1305526Arb2aARB2 cotranscriptional regulator A275538738018183Rat
1589456Pou5f2POU domain class 5, transcription factor 2279075047908738Rat
7509688Fam98b-ps2family with sequence similarity 98, member B, pseudogene 2280008068013311Rat
41141624LOC120100651uncharacterized LOC120100651280178818035957Rat
621682Nr2f1nuclear receptor subfamily 2, group F, member 1280403758050123Rat
7645336LOC102549789uncharacterized LOC102549789280530298304831Rat
1583248Slc25a5-ps6solute carrier family 25 member 5, pseudogene 6282198768226468Rat
41088779LOC120101163U6 spliceosomal RNA282619198262025Rat
41008983LOC120101325small nucleolar RNA SNORA17283347328334859Rat
6490176Rpl6-ps14ribosomal protein L6, pseudogene 14286091558611368Rat
7722382LOC102548480low molecular weight phosphotyrosine protein phosphatase-like21001410310014541Rat
40942615Ormdl1-ps16ORMDL sphingolipid biosynthesis regulator 1, pseudogene 1621066856710673066Rat
1596482Rps8-ps1ribosomal protein S8, pseudogene 121098464010985313Rat
1596458Tdg-ps1thymine-DNA glycosylase, pseudogene 121106041111064568Rat
1359478Arrdc3arrestin domain containing 321113746411149978Rat
40974287LOC120100652uncharacterized LOC12010065221113764811139734Rat
1590822Ubxn1-ps1UBX domain protein 1, pseudogene21122513511226004Rat
41118210LOC120100653uncharacterized LOC12010065321124605711288544Rat
1562101Adgrv1adhesion G protein-coupled receptor V121133143411911713Rat
40980043Rnu1-149RNA, U1 small nuclear 14921139192911392087Rat
41391875Ube2l3-ps3ubiquitin-conjugating enzyme E2L 3, pseudogene 321163469611636749Rat
41361600Mrrf-ps1mitochondrial ribosome recycling factor, pseudogene 121168969211690540Rat
1595695Tuba1a-ps3tubulin, alpha 1A, pseudogene 321190356111905006Rat
1593816Rpl17-ps7ribosomal protein L17, pseudogene 721192000311920552Rat
1308805Lysmd3LysM domain containing 321193378711939944Rat
1593792Polr3gRNA polymerase III subunit G21194521511986125Rat
1306703Mblac2metallo-beta-lactamase domain containing 221198607512028882Rat
620249Cetn3centrin 321208902512101828Rat
11506640LOC108349914uncharacterized LOC10834991421215497012204382Rat
41256822LOC120100656uncharacterized LOC12010065621217127812173747Rat
2321913Fbl-ps1fibrillarin, pseudogene 121248019912571223Rat
7496117LOC10254886060S ribosomal protein L19-like21258207912590457Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
33822D2Mit29246278877727888014Ratregion
36912D2Rat117421185206211852238Ratregion
35901D2Rat313621098383410983959Ratregion
39946D2Rat251227286345718634800Ratregion
42284D2Rat36820221185628411856483Ratregion
40786D2Rat18714621125172111251855Ratregion
43462D2Got127521092860710928882Ratregion
67798D2Uwm1414721265410012654247Ratregion
1638815D2Mco49258289223828922640Ratregion
1633195D2Got39220721053378410533991Ratregion
1633560D2Mco4688721089262610893513Ratregion
5026336RH13181619021208706112087251Ratregion
5026458RH13229218321217629912176482Ratregion
5057478AI0305669021210152612101616Ratregion
5050044RH13383021421114951211149726Ratregion
5053183RH14250110821148596611486074Ratregion
5053253RH14254210421128825011288354Ratregion
5047280RH13223718121199390511994086Ratregion
5072024RH13542121121148534411485555Ratregion
5066992AU048029126281667388166864Ratregion
5065780BE109854151280648348064985Ratregion
5066238PMC123630P1650279079927908642Ratregion
5064866BE108652164280642308064394Ratregion
5089663AU04928923721131667111316908Ratregion
5499715UniSTS:23416522921169008511690314Ratregion
5500129UniSTS:23706221521194269711942912Ratregion
5502551RH12526912521122525011225375Ratregion
Position Markers

Flank 1: (D2Mit29)
Rat AssemblyChrPosition (strand)Source
mRatBN7.227,887,772 - 7,888,014 (+)MAPPER
Rnor_6.025,417,336 - 5,417,577NCBI
Rnor_5.025,396,621 - 5,396,862UniSTS
RGSC_v3.425,601,528 - 5,601,770RGD
RGSC_v3.425,601,529 - 5,601,770UniSTS
RGSC_v3.125,627,976 - 5,628,373RGD
Celera24,338,310 - 4,338,555UniSTS
Cytogenetic Map2q11UniSTS
Flank 2: (D2Uwm14)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2212,654,100 - 12,654,247 (+)MAPPER
Rnor_6.0210,246,312 - 10,246,458NCBI
Rnor_5.0210,116,941 - 10,117,085UniSTS
RGSC_v3.4210,539,188 - 10,539,334RGD
RGSC_v3.4210,539,188 - 10,539,334UniSTS
RGSC_v3.1210,463,381 - 10,463,527RGD
Celera28,980,733 - 8,980,879UniSTS
Cytogenetic Map2 RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777212654247Rat
61368Mcs1Mammary carcinoma susceptibility QTL 14.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777223319447Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Mcs9

RGD Curation Notes
Note Type Note Reference
qtl_cross_pair WFxCOP  
qtl_cross_type intercross  
qtl_disease associated with reduction of mammary carcinomas