HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) - Rat Genome Database

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Gene: HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) Chlorocebus sabaeus
Analyze
Symbol: HMGCR
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
RGD ID: 18438138
Description: ENCODES a protein that exhibits identical protein binding (ortholog); protein phosphatase 2A binding (ortholog); INVOLVED IN bile acid signaling pathway (ortholog); cholesterol biosynthetic process (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; bile acid signaling pathway; cholesterol biosynthetic pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1469,664,784 - 69,690,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl469,665,417 - 69,688,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604918,450,156 - 18,475,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HMGCR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1469,664,784 - 69,690,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl469,665,417 - 69,688,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604918,450,156 - 18,475,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
HMGCR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38575,336,529 - 75,362,116 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl575,336,329 - 75,364,001 (+)EnsemblGRCh38hg38GRCh38
GRCh37574,632,993 - 74,657,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36574,668,855 - 74,693,681 (+)NCBINCBI36Build 36hg18NCBI36
Build 34574,668,854 - 74,693,681NCBI
Celera570,526,169 - 70,551,102 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef569,838,165 - 69,863,098 (+)NCBIHuRef
CHM1_1574,065,715 - 74,090,648 (+)NCBICHM1_1
T2T-CHM13v2.0575,817,189 - 75,843,009 (+)NCBIT2T-CHM13v2.0
Hmgcr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391396,785,470 - 96,807,444 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1396,785,475 - 96,807,444 (-)EnsemblGRCm39 Ensembl
GRCm381396,648,962 - 96,670,936 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1396,648,967 - 96,670,936 (-)EnsemblGRCm38mm10GRCm38
MGSCv371397,418,917 - 97,440,891 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361397,750,033 - 97,771,547 (-)NCBIMGSCv36mm8
Celera13100,288,206 - 100,310,264 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.65NCBI
Hmgcr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8229,732,163 - 29,754,276 (-)NCBIGRCr8
mRatBN7.2227,997,523 - 28,018,983 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl227,997,525 - 28,019,703 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx235,045,191 - 35,066,504 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0233,145,271 - 33,166,584 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0227,959,454 - 27,980,761 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0227,480,224 - 27,500,654 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,480,226 - 27,500,654 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0246,592,881 - 46,614,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4227,127,504 - 27,149,580 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1227,047,872 - 27,069,949 (-)NCBI
Celera224,043,814 - 24,065,183 (-)NCBICelera
RH 3.4 Map213.3RGD
Cytogenetic Map2q12NCBI
Hmgcr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542525,359,884 - 25,380,745 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542525,362,165 - 25,380,611 (-)NCBIChiLan1.0ChiLan1.0
HMGCR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2439,937,829 - 39,962,461 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1538,091,460 - 38,116,092 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0539,936,630 - 39,961,519 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1540,548,919 - 40,573,785 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl540,548,919 - 40,573,785 (-)Ensemblpanpan1.1panPan2
HMGCR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1330,970,037 - 30,988,987 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl330,970,037 - 30,990,294 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha332,211,759 - 32,233,728 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0330,898,455 - 30,920,631 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl330,898,248 - 30,921,069 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1330,828,548 - 30,850,686 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0330,798,860 - 30,820,987 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0331,177,224 - 31,199,407 (-)NCBIUU_Cfam_GSD_1.0
Hmgcr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213189,458,452 - 189,480,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365491,378,736 - 1,400,532 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365491,378,536 - 1,400,501 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGCR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl284,380,224 - 84,402,957 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1284,380,245 - 84,401,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2285,967,367 - 85,988,242 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q22NCBI
Hmgcr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624951682,178 - 711,474 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624951681,559 - 711,476 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 5 60
Low 15
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000013509   ⟹   ENSCSAP00000011506
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl469,665,417 - 69,688,686 (+)Ensembl
RefSeq Acc Id: XM_007975643   ⟹   XP_007973834
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1469,665,385 - 69,690,343 (+)NCBI
Vero_WHO_p1.0NW_02366604918,450,156 - 18,475,169 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007973834 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000011506
  ENSCSAP00000011506.1
Reference Protein Sequences
RefSeq Acc Id: XP_007973834   ⟸   XM_007975643
- UniProtKB: A0A0D9RSB7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000011506   ⟸   ENSCSAT00000013509


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015420 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013509.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3270.10 UniProtKB/TrEMBL
  3.30.70.420 UniProtKB/TrEMBL
InterPro HMG_CoA_Rdtase UniProtKB/TrEMBL
  HMG_CoA_Rdtase_cat_sf UniProtKB/TrEMBL
  HMG_CoA_Rdtase_CS UniProtKB/TrEMBL
  HMG_CoA_Rdtase_eu_arc UniProtKB/TrEMBL
  HMG_CoA_Rdtase_metazoan UniProtKB/TrEMBL
  HMG_CoA_Rdtase_N UniProtKB/TrEMBL
  HMG_CoA_Rdtase_NAD(P)-bd_sf UniProtKB/TrEMBL
  HMG_CoA_Rdtase_sub-bd_dom_sf UniProtKB/TrEMBL
  SSD UniProtKB/TrEMBL
NCBI Gene HMGCR ENTREZGENE
PANTHER 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE UniProtKB/TrEMBL
  PTHR10572 UniProtKB/TrEMBL
Pfam HMG-CoA_red UniProtKB/TrEMBL
  Sterol-sensing UniProtKB/TrEMBL
PRINTS HMGCOARDTASE UniProtKB/TrEMBL
PROSITE HMG_COA_REDUCTASE_1 UniProtKB/TrEMBL
  HMG_COA_REDUCTASE_2 UniProtKB/TrEMBL
  HMG_COA_REDUCTASE_3 UniProtKB/TrEMBL
  HMG_COA_REDUCTASE_4 UniProtKB/TrEMBL
  SSD UniProtKB/TrEMBL
Superfamily-SCOP Multidrug efflux transporter AcrB transmembrane domain UniProtKB/TrEMBL
  SSF55035 UniProtKB/TrEMBL
  SSF56542 UniProtKB/TrEMBL
UniProt A0A0D9RSB7 ENTREZGENE, UniProtKB/TrEMBL