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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:50686
Term: atorvastatin calcium
Definition: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.
Chemical ID: MESH:D000069059
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcraffects bindingEXP 6480464CTDAtorvastatin binds to HMGCR proteinPMID:30273964
Hmgcrincreases activityEXP 6480464CTDAtorvastatin results in increased activity of HMGCR proteinPMID:12056585 PMID:12065722
Hmgcrincreases expressionEXP 6480464CTDAtorvastatin results in increased expression of HMGCR mRNAPMID:12056585 PMID:12065722
Hmgcrmultiple interactionsEXP 6480464CTDAtorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA]; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of HMGCR protein]; Atorvastatin inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]; Atorvastatin results in increased expression of and results in increased activity of HMGCR protein; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of HMGCR protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of HMGCR mRNA]PMID:12056585 PMID:30273964 PMID:32048413 PMID:9512650
Hmgcrincreases expressionISOHMGCR (Homo sapiens)6480464CTDAtorvastatin results in increased expression of HMGCR mRNAPMID:10357840 PMID:12612140 PMID:9512650
Hmgcrmultiple interactionsISOHMGCR (Homo sapiens)6480464CTDAtorvastatin results in increased expression of and results in increased activity of HMGCR proteinPMID:9512650
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