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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:77013
Term: beta-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.
Chemical ID: MESH:D019324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcrmultiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HMGCR mRNAPMID:18164116
Hmgcrdecreases expressionISOHMGCR (Homo sapiens)6480464CTDbeta-Naphthoflavone results in decreased expression of HMGCR mRNAPMID:22234961 PMID:31225620
Hmgcrdecreases expressionISOHmgcr (Mus musculus)6480464CTDbeta-Naphthoflavone results in decreased expression of HMGCR mRNAPMID:22234961
Hmgcrmultiple interactionsISOHMGCR (Homo sapiens)6480464CTDAHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HMGCR mRNA]PMID:22234961
Hmgcrmultiple interactionsISOHmgcr (Mus musculus)6480464CTDAHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HMGCR mRNA]PMID:22234961
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