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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:2596
Term: alliin
Definition: An L-alanine derivative in which one of the methyl hydrogens of L-alanine has been replaced by an (S)-allylsulfinyl group.
Chemical ID: MESH:C006453
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcrmultiple interactionsEXP 6480464CTDalliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]PMID:16640830
Hmgcrmultiple interactionsISOHMGCR (Homo sapiens)6480464CTDalliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein]PMID:29305303
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