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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:63749
Term: (+)-artemisinic acid
Definition: A monocarboxylic acid that is prop-2-enoic acid which is substituted at position 2 by a 4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl group (the 1S,4R,4aS,8aR diastereoisomer). It is a sesquiterpenoid precursor of artemisinin, obtained from sweet wormwood, Artemisia annua.
Chemical ID: MESH:C047721
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcrdecreases expressionISORGD:7315796480464CTD[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA artemisic acid results in decreased expression of HMGCR mRNA artemisic acid results in decreased expression of HMGCR protein

PMID:23063590
Hmgcrmultiple interactionsISORGD:7315796480464CTD[[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA] which results in decreased chemical synthesis of Cholesterol [artemisic acid results in decreased expression of HMGCR protein] which results in decreased chemical synthesis of Cholesterol

PMID:23063590
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