RGD Reference Report - A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C. - Rat Genome Database

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A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.

Authors: Li, D  Wang, F  Lai, M  Chen, Y  Zhang, JF 
Citation: Li D, etal., J Neurosci. 2005 Feb 23;25(8):1914-23.
RGD ID: 8554004
Pubmed: PMID:15728831   (View Abstract at PubMed)
PMCID: PMC6726054   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.4790-04.2005   (Journal Full-text)

Phosphorylation and dephosphorylation are primary means for rapid regulation of a variety of neuronal functions, such as membrane excitability, neurotransmitter release, and gene expression. Voltage-gated Ca2+ channels are targets for phosphorylation by a variety of second messengers through activation of different types of protein kinases (PKs). Protein phosphatases (PPs), like PKs, are equally important in regulating Ca2+ channels in neurons. However, much less is understood about whether and how a particular type of PP contributes to regulating neuronal Ca2+ channel activities. This is primarily because of the lack of specific inhibitors/activators for different types of PPs, particularly the PP2c family. The functional roles of PP2c and its substrates in the brain remain virtually unknown. During our yeast two-hybrid screening, PP2calpha was pulled out by both N- and P/Q-type Ca2+ channel C termini. This raised the possibility that PP2calpha might be associated with voltage-gated Ca2+ channels for regulation of the Ca(2+) channel activity. Biochemical studies show that PP2calpha binds directly to neuronal Ca2+ channels forming a functional protein complex in vivo. PP2calpha, unlike PP1, PP2a and PP2b, is more effective in dephosphorylation of neuronal Ca2+ channels after their phosphorylation by PKC. In hippocampal neurons, disruption of the PP2calpha-Ca2+ channel interaction significantly enhances the response of Ca2+ channels to modulation by PKC. Thus, the PP2calpha-Ca2+ channel complex is responsible for rapid dephosphorylation of Ca2+ channels and may contribute to regulation of synaptic transmission in neurons.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ppp2caRatnegative regulation of calcium ion transmembrane transporter activity  IMP  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ppm1aRatneuron projection located_inIDA PMID:15728831UniProt 
Ppp2caRatterminal bouton  IDA  RGD 

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Cacna1b  (calcium voltage-gated channel subunit alpha1 B)
Ppm1a  (protein phosphatase, Mg2+/Mn2+ dependent, 1A)
Ppp2ca  (protein phosphatase 2 catalytic subunit alpha)


Additional Information