Akt1 (AKT serine/threonine kinase 1) - Rat Genome Database

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Gene: Akt1 (AKT serine/threonine kinase 1) Rattus norvegicus
Symbol: Akt1
Name: AKT serine/threonine kinase 1
RGD ID: 2081
Description: Enables several functions, including ATP binding activity; GTPase activating protein binding activity; and enzyme binding activity. Involved in several processes, including cellular response to mechanical stimulus; glycogen biosynthetic process; and insulin receptor signaling pathway. Acts upstream of or within several processes, including cellular response to insulin stimulus; negative regulation of cell size; and positive regulation of sodium ion transport. Located in nucleus. Used to study autosomal recessive polycystic kidney disease; hypertension; impotence; myocardial infarction; and type 2 diabetes mellitus. Biomarker of several diseases, including brain ischemia; diabetic retinopathy; gastrointestinal system cancer (multiple); type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); colorectal cancer (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; adenosine signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-taxifolin.
Type: protein-coding
Previously known as: Akt; AKT1 kinase; Murine thymoma viral (v-akt) oncogene homolog 1; PKB; PKB alpha; protein kinase B; protein kinase B alpha; RAC protein kinase alpha RAC-PK alpha; RAC protein kinase alpha, RAC-PK alpha; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; thymoma viral proto-oncogene; thymoma viral proto-oncogene 1; v-akt murine thymoma viral oncogene homolog 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Akt1em1Soar  
Genetic Models: SD-Akt1em1Soar
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.26131,713,716 - 131,735,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,713,720 - 131,733,921 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6131,883,770 - 131,900,905 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,180,876 - 132,197,963 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,543,341 - 131,560,403 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,218,398 - 137,239,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,218,376 - 137,236,258 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,225,955 - 146,247,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,640,482 - 137,657,552 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,646,668 - 137,663,739 (-)NCBI
Celera6129,262,032 - 129,279,096 (-)NCBICelera
RH 3.4 Map6782.49RGD
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)