Akt1 (AKT serine/threonine kinase 1) - Rat Genome Database

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Gene: Akt1 (AKT serine/threonine kinase 1) Rattus norvegicus
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Symbol: Akt1
Name: AKT serine/threonine kinase 1
RGD ID: 2081
Description: Enables several functions, including ATP binding activity; GTPase activating protein binding activity; and enzyme binding activity. Involved in several processes, including cellular response to mechanical stimulus; glycogen biosynthetic process; and insulin receptor signaling pathway. Acts upstream of or within several processes, including cellular response to insulin stimulus; negative regulation of cell size; and positive regulation of sodium ion transport. Located in nucleus. Used to study autosomal recessive polycystic kidney disease; hypertension; impotence; myocardial infarction; and type 2 diabetes mellitus. Biomarker of several diseases, including brain ischemia; diabetic retinopathy; gastrointestinal system cancer (multiple); type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); colorectal cancer (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; adenosine signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-taxifolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Akt; AKT1 kinase; Murine thymoma viral (v-akt) oncogene homolog 1; PKB; PKB alpha; protein kinase B; protein kinase B alpha; RAC protein kinase alpha RAC-PK alpha; RAC protein kinase alpha, RAC-PK alpha; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; thymoma viral proto-oncogene; thymoma viral proto-oncogene 1; v-akt murine thymoma viral oncogene homolog 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Akt1em1Soar  
Genetic Models: SD-Akt1em1Soar
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,534,810 - 137,555,131 (-)NCBIGRCr8
mRatBN7.26131,713,716 - 131,735,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,713,720 - 131,733,921 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6131,883,770 - 131,900,905 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,180,876 - 132,197,963 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,543,341 - 131,560,403 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,218,398 - 137,239,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,218,376 - 137,236,258 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,225,955 - 146,247,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,640,482 - 137,657,552 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,646,668 - 137,663,739 (-)NCBI
Celera6129,262,032 - 129,279,096 (-)NCBICelera
RH 3.4 Map6782.49RGD
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
amyotrophic lateral sclerosis  (ISO)
Animal Disease Models  (ISO)
atherosclerosis  (ISO)
autosomal recessive polycystic kidney disease  (IDA)
bipolar disorder  (ISO)
bone osteosarcoma  (ISO)
Brain Injuries  (IEP)
brain ischemia  (IEP)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
Calcification of Aortic Valve  (ISO)
cannabis abuse  (ISO)
Carcinogenesis  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Charcot-Marie-Tooth disease axonal type 2O  (ISO)
chronic myeloid leukemia  (ISO)
colon cancer  (IEP,ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
coronary artery disease  (ISO)
Cowden syndrome 6  (ISO)
Diabetic Cardiomyopathies  (ISO)
diabetic retinopathy  (IEP)
Endometrioid Carcinomas  (ISO)
Endotoxemia  (IEP)
epilepsy  (ISO)
esophageal cancer  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (IDA)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IDA,IEP)
Experimental Mammary Neoplasms  (ISO)
familial adenomatous polyposis  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis 5  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Hepatomegaly  (ISO)
Hyperplasia  (ISO)
hypertension  (IDA)
Hypertriglyceridemia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
impotence  (IDA)
in situ carcinoma  (ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
Intervertebral Disc Displacement  (ISO)
invasive ductal carcinoma  (ISO)
Kidney Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Macrocephaly Mesodermal Hamartoma Spectrum  (ISO)
malignant astrocytoma  (ISO)
melanoma  (ISO)
Memory Disorders  (ISO)
Meningeal Neoplasms  (ISO)
meningioma  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (IDA,ISO)
Myocardial Reperfusion Injury  (IDA)
Neointima  (ISO)
obesity  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatic intraductal papillary-mucinous neoplasm  (ISO)
paraplegia  (IEP)
Parkinson's disease  (ISO)
pre-malignant neoplasm  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Proteus syndrome  (ISO,ISS)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Right Ventricular Hypertrophy  (IDA)
schizophrenia  (ISO,ISS)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
Staphylococcal Pneumonia  (ISO)
steatotic liver disease  (ISO)
Stroke  (ISO)
substance-induced psychosis  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (IDA,IEP,ISO)
ureteral obstruction  (IEP)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Ventilator-Induced Lung Injury  (ISO)
vulva cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-Eudesmin  (ISO)
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-Arctigenin  (ISO)
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(-)-selegiline  (EXP)
(-)-trans-epsilon-viniferin  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(R)-adrenaline  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP)
(R)-salsolinol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dichloropropan-2-ol  (ISO)
1,3-Dinitropyrene  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1,8-Dinitropyrene  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-monopalmitoylglycerol  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
14,15-EET  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
16,16-dimethylprostaglandin E2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-chloroethanol  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
20-hydroxyecdysone  (EXP)
26-hydroxycholesterol  (ISO)
28-Homobrassinolide  (EXP)
3',5'-cyclic GMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-hydroxyisovaleric acid  (EXP)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-methylglutaric acid  (EXP)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-aminophenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-Hydroxycapric acid  (EXP)
5-methoxypsoralen  (EXP,ISO)
6,7-dimethoxy-2-phenylquinoxaline  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP,ISO)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7-ketocholesterol  (EXP)
8-(4-chlorophenylthio)-cAMP  (EXP)
8-Br-cAMP  (ISO)
9,10-anthraquinone  (ISO)
9-cis-retinoic acid  (EXP,ISO)
[6]-Shogaol  (ISO)
abamectin  (ISO)
ABT-737  (ISO)
acadesine  (ISO)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
afatinib  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
agmatine  (ISO)
AH23848  (ISO)
AICA ribonucleotide  (ISO)
alachlor  (ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allethrin  (EXP,ISO)
alloxan  (EXP,ISO)
allyl isothiocyanate  (ISO)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (EXP)
alpha-phellandrene  (ISO)
aluminium hydroxide  (ISO)
alvocidib  (ISO)
AM-251  (ISO)
amidotrizoic acid  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amoxicillin  (ISO)
amphetamine  (ISO)
anethole  (ISO)
angelicin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antigen  (ISO)
ANTIMYCIN  (ISO)
antimycin A  (ISO)
Antrocin  (ISO)
apigenin  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
arecoline  (EXP,ISO)
Arg-Gly-Asp  (EXP)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (ISO)
arotinoid acid  (ISO)
ARS-1620  (ISO)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
astaxanthin  (ISO)
astilbin  (ISO)
astragaloside IV  (EXP)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
Atpenin A5  (ISO)
atrazine  (ISO)
aucubin  (ISO)
aureusidin  (EXP)
Auriculasin  (ISO)
avermectin  (ISO)
azathioprine  (ISO)
AZD4547  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
BAPTA  (EXP)
Bardoxolone methyl  (ISO)
Bavachinin  (ISO)
bazedoxifene  (ISO)
belinostat  (ISO)
benomyl  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzophenanthridine  (ISO)
benzyl isothiocyanate  (ISO)
berberine  (EXP,ISO)
beta-carotene  (ISO)
beta-cyclodextrin  (ISO)
beta-D-glucosamine  (ISO)
betalain  (ISO)
Betanin  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
biliverdin  (ISO)
biotin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
BMS-754807  (ISO)
boric acid  (ISO)
bortezomib  (ISO)
bosutinib  (ISO)
brefeldin A  (EXP)
bufalin  (ISO)
butan-1-ol  (EXP,ISO)
butein  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
Cacalol  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcidiol  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calix[6]arene  (ISO)
calyculin a  (ISO)
camptothecin  (ISO)
candesartan  (EXP)
cannabidiol  (ISO)
cannabigerol  (ISO)
cantharidin  (ISO)
capecitabine  (ISO)
capivasertib  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
captan  (ISO)
carbamazepine  (ISO)
CARBENOXOLONE  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (ISO)
carmustine  (EXP,ISO)
carnosic acid  (ISO)
carnosine  (EXP)
carrageenan  (ISO)
carvedilol  (EXP,ISO)
casticin  (ISO)
CEDRELONE  (ISO)
celastrol  (EXP,ISO)
celecoxib  (EXP,ISO)
ceric oxide  (ISO)
ceritinib  (ISO)
ceruletide  (ISO)
chaetoglobosin A  (EXP)
chicoric acid  (EXP)
CHIR 99021  (ISO)
chitosan  (EXP,ISO)
chlordecone  (ISO)
chloroethene  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chloroquine  (EXP,ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
cholic acid  (ISO)
chromium atom  (EXP,ISO)
chromium(6+)  (EXP,ISO)
chromones  (ISO)
chrysin  (ISO)
chrysophanol  (ISO)
cilostazol  (EXP,ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
Citreoviridin  (EXP,ISO)
clenbuterol  (EXP)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (EXP)
colistin  (EXP,ISO)
copanlisib  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(I) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
coptisine  (ISO)
cordycepin  (EXP,ISO)
corilagin  (EXP,ISO)
corticosterone  (EXP)
cortisol  (EXP)
coumarin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
Cruentaren A  (ISO)
cucurbitacin E  (ISO)
curcumin  (EXP,ISO)
cyclizine  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
Cyclosporin H  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
cypermethrin  (EXP,ISO)
D-aspartic acid  (EXP,ISO)
D-glucose  (EXP,ISO)
dactolisib  (EXP,ISO)
dapagliflozin  (EXP)
DAPT  (ISO)
daunorubicin  (ISO)
deferiprone  (EXP)
deguelin  (ISO)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
diazoxide  (EXP)
dibenziodolium  (ISO)
dibenzoylmethane  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (ISO)
dichlorine  (EXP)
dichloromethane  (ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
Dicyclohexyl phthalate  (EXP)
Didymin  (ISO)
dieckol  (ISO)
diethylstilbestrol  (ISO)
dihydro-beta-erythroidine  (ISO)
dihydrolipoamide  (EXP)
dihydrolipoic acid  (EXP)
Dihydrotanshinone I  (ISO)
dimethylarsinic acid  (EXP,ISO)
Dinitramine  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
diprotium oxide  (ISO)
diquat  (ISO)
disodium cromoglycate  (EXP)
disodium selenite  (EXP,ISO)
dithionite(2-)  (EXP)
divinyl sulfone  (ISO)
dobutamine  (EXP,ISO)
dodecanoic acid  (ISO)
Doramectin  (EXP)
dorsomorphin  (ISO)
doxazosin  (EXP)
doxepin  (EXP)
doxorubicin  (EXP,ISO)
eckol  (ISO)
edaravone  (EXP)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
embelin  (ISO)
emodin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
equol  (ISO)
ergothioneine  (EXP)
erlotinib hydrochloride  (ISO)
Erucin  (ISO)
esculetin  (ISO)
estrogen  (EXP)
estrone  (ISO)
ethanol  (EXP,ISO)
ethyl trans-caffeate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
etoposide  (ISO)
etoxazole  (ISO)
everolimus  (ISO)
Evodiamine  (ISO)
excitatory amino acid agonist  (EXP)
farnesyl diphosphate  (ISO)
fasudil  (EXP)
fenpyroximate  (ISO)
fenvalerate  (ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (EXP)
ferulic acid  (EXP)
filipin III  (EXP,ISO)
finasteride  (EXP)
fingolimod hydrochloride  (ISO)
fisetin  (EXP,ISO)
flavokawain B  (ISO)
flufenoxuron  (ISO)
fluorometholone  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP,ISO)
fluvastatin  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formononetin  (ISO)
FR900359  (ISO)
fraxetin  (ISO)
frenolicin B  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
furazolidone  (ISO)
furosemide  (EXP)
Fusaric acid  (ISO)
gadodiamide hydrate  (ISO)
galangin  (ISO)
gallein  (EXP)
gallic acid  (ISO)
gallocatechin  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
Garcinol  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
gemfibrozil  (ISO)
Genipin  (ISO)
Geniposide  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
Geraniin  (ISO)
GGTI-2133  (EXP)
Gingerenone A  (EXP,ISO)
gingerol  (ISO)
ginkgolide B  (ISO)
ginsenoside Rb1  (ISO)
ginsenoside Rd  (ISO)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP,ISO)
ginsenoside Rg2  (EXP)
Ginsenoside Rh4  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (EXP)
glycerol  (ISO)
glycerol 2-phosphate  (ISO)
glycidol  (EXP)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK690693  (ISO)
gypenoside LXXV  (ISO)
haloperidol  (EXP)
hellebrigenin  (ISO)
hemin  (ISO)
heparin  (EXP)
hesperetin  (EXP)
hesperidin  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
high-density lipoprotein cholesterol  (ISO)
Hispolon  (ISO)
homocysteine  (ISO)
hyaluronic acid  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP,ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxyflutamide  (EXP)
hydroxytyrosol  (ISO)
IC-87114  (ISO)
icariin  (EXP,ISO)
icariside II  (ISO)
idelalisib  (ISO)
imiquimod  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
insulin  (ISO)
iodixanol  (ISO)
ionomycin  (ISO)
irbesartan  (ISO)
iron atom  (EXP)
iron dextran  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoflurane  (EXP,ISO)
Isoliensinine  (ISO)
isoliquiritigenin  (ISO)
isoorientin  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
ivermectin  (ISO)
JTE-013  (EXP)
kaempferol  (EXP,ISO)
kahweol  (ISO)
Kalafungin  (ISO)
ketanserin  (ISO)
Kirenol  (ISO)
KN-93  (EXP,ISO)
kojic acid  (ISO)
KT 5720  (EXP)
Ku-0063794  (ISO)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (EXP)
L-gamma-glutamyl-L-cysteine  (EXP)
L-glutamic acid  (ISO)
L-methionine  (EXP)
L-threonine  (ISO)
lactacystin  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leptomycin B  (ISO)
letrozole  (EXP)
leukotriene B4  (ISO)
leupeptin  (ISO)
leuprolide  (ISO)
Licochalcone A  (ISO)
licoricidin  (ISO)
Liensinine  (ISO)
linalool  (ISO)
linsidomine  (EXP,ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
liraglutide  (ISO)
lithium atom  (ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (ISO)
LM-1685  (ISO)
loliolide  (ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
lovastatin  (EXP,ISO)
Lupalbigenin  (ISO)
lupeol  (EXP)
Lupiwighteone  (ISO)
luteolin  (EXP,ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY 117018  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
magnesium atom  (EXP)
Magnolol  (EXP)
malonaldehyde  (ISO)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
manumycin A  (EXP)
masoprocol  (ISO)
Mecamylamine  (ISO)
Medermycin  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
meloxicam  (ISO)
menaquinone  (EXP)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl caffeate  (ISO)
methyl pyruvate  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
metoprolol  (EXP)
mevalonic acid  (ISO)
mevinphos  (EXP)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
mirabegron  (EXP)
mirtazapine  (EXP)
mitomycin C  (ISO)
MK-2206  (EXP,ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (EXP,ISO)
morin  (EXP,ISO)
morphine  (ISO)
morpholines  (ISO)
morusin  (ISO)
Mumbaistatin  (ISO)
mycophenolic acid  (ISO)
myo-inositol hexakisphosphate  (ISO)
myrtenal  (EXP)
Myrtucommulone A  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N-phosphocreatine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N-Vinyl-2-pyrrolidone  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
Naftopidil  (ISO)
naloxone  (ISO)
naphthalene  (ISO)
naringin  (EXP,ISO)
Neferine  (EXP,ISO)
neoastilbin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nifedipine  (ISO)
nilutamide  (ISO)
Nitidine  (ISO)
nitric oxide  (EXP)
nitroprusside  (EXP,ISO)
nobiletin  (EXP,ISO)
Nonylphenol  (EXP,ISO)
Nookatone  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
nordihydroguaiaretic acid  (EXP)
notoginsenoside R1  (ISO)
novobiocin  (ISO)
NSC 23766  (ISO)
nystatin  (ISO)
o-anisidine  (ISO)
o-cresol  (EXP)
Obacunone  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
Octicizer  (ISO)
okadaic acid  (EXP,ISO)
olanzapine  (ISO)
olaparib  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (EXP,ISO)
oleuropein  (ISO)
oligopeptide  (ISO)
olmesartan  (EXP)
Olprinone hydrochloride  (EXP)
omacetaxine mepesuccinate  (ISO)
omipalisib  (ISO)
Ophiopogonin D  (ISO)
organoselenium compound  (EXP,ISO)
orlistat  (ISO)
orotic acid  (ISO)
osimertinib  (ISO)
osthole  (ISO)
OSU-03012  (ISO)
oxaliplatin  (ISO)
oxidopamine  (EXP,ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Paeonol  (EXP,ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
Parthenin  (ISO)
patulin  (ISO)
paxilline  (ISO)
PD 0325901  (ISO)
PD 168393  (EXP)
pentetrazol  (EXP)
pentobarbital  (EXP)
pepstatin A  (ISO)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
perfluoroundecanoic acid  (EXP)
perifosine  (ISO)
permethrin  (ISO)
peroxynitrous acid  (EXP)
PHA-665752  (ISO)
phenanthrene  (ISO)
phenethyl caffeate  (ISO)
phenformin  (ISO)
phenobarbital  (EXP)
phenol red  (ISO)
phentermine  (ISO)
phenylephrine  (EXP,ISO)
PhIP  (ISO)
phloretin  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (EXP,ISO)
phosphonoformic acid  (ISO)
phosphoramidon  (ISO)
phylloquinone  (EXP)
phytoestrogen  (EXP)
piclamilast  (EXP)
picoxystrobin  (ISO)
picropodophyllotoxin  (ISO)
piperine  (ISO)
pipoxolan  (ISO)
pirinixic acid  (EXP)
Plantamajoside  (EXP,ISO)
platycodin D  (EXP,ISO)
plerixafor  (EXP,ISO)
plitidepsin  (ISO)
plumbagin  (EXP,ISO)
Polygodial  (EXP)
ponatinib  (ISO)
potassium bromate  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (EXP)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prilocaine  (ISO)
procaine  (ISO)
procyanidin B1  (ISO)
procyanidin B2  (ISO)
progesterone  (EXP,ISO)
promegestone  (EXP)
propazine  (ISO)
propiconazole  (EXP)
propofol  (EXP,ISO)
propranolol  (ISO)
prostaglandin E2  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (ISO)
PX-866  (ISO)
pyocyanine  (ISO)
pyrethrins  (ISO)
pyrithione  (EXP)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (ISO)
quartz  (ISO)
quercetagetin  (EXP)
quercetin  (EXP,ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
quizartinib  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
raffinose  (EXP,ISO)
raloxifene  (EXP,ISO)
razoxane  (EXP)
reparixin  (ISO)
reserpine  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
riboflavin  (ISO)
rimonabant  (EXP,ISO)
ritonavir  (ISO)
rivastigmine  (EXP)
roflumilast  (EXP)
rolipram  (EXP)
romidepsin  (ISO)
rosuvastatin calcium  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rubimaillin  (ISO)
Rutamarin  (ISO)
ruthenium atom  (ISO)
ruthenium red  (ISO)
rutin  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
Salidroside  (EXP)
salubrinal  (EXP)
salvianolic acid B  (EXP)
sarpogrelate  (ISO)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
sclareol  (ISO)
scoparone  (ISO)
selenium atom  (EXP,ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sertraline  (EXP)
sevoflurane  (EXP)
Shikonin  (ISO)
sildenafil citrate  (EXP)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
simazine  (ISO)
simvastatin  (EXP,ISO)
Sinomenine  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
sodium nitrite  (EXP)
solasodine  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
squalene  (EXP)
SR 144528  (ISO)
stattic  (ISO)
staurosporine  (EXP,ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (EXP,ISO)
sulindac  (EXP,ISO)
sulindac sulfone  (EXP,ISO)
swainsonine  (ISO)
syringic acid  (ISO)
T-2 toxin  (EXP)
tadalafil  (EXP)
taiwanin C  (ISO)
tamarixetin  (ISO)
tamoxifen  (ISO)
tanespimycin  (EXP,ISO)
Tanshinone I  (EXP)
taraxasterol  (ISO)
taurine  (EXP,ISO)
taurocholic acid  (EXP)
taurolithocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
tephrosin  (ISO)
terbutylazine  (ISO)
Terfenadine  (ISO)
teriflunomide  (ISO)
terpinolene  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP,ISO)
Tetrachlorobisphenol A  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
theobromine  (EXP)
thiamine(1+) chloride  (EXP,ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
Thiorphan  (ISO)
thymoquinone  (ISO)
thyroxine  (EXP)
tipifarnib  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
topiramate  (EXP)
trametinib  (ISO)
trans-anethole  (ISO)
triadimefon  (EXP)
triamcinolone  (EXP)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triciribine  (ISO)
triclosan  (EXP,ISO)
trifluoperazine  (EXP,ISO)
triphenylstannane  (EXP,ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
Tryptanthrine  (ISO)
tunicamycin  (EXP,ISO)
Tylophorine  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
Ursonic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vandetanib  (ISO)
vanillic acid  (ISO)
veliparib  (ISO)
vemurafenib  (ISO)
venlafaxine hydrochloride  (EXP)
verapamil  (EXP)
vildagliptin  (EXP)
vinclozolin  (ISO)
vincristine  (EXP,ISO)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
VX nerve agent  (EXP)
warfarin  (EXP)
water  (ISO)
WIN 55212-2  (EXP,ISO)
withaferin A  (EXP)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
xanthosine  (EXP)
Y-27632  (ISO)
zalcitabine  (EXP)
zearalenone  (EXP,ISO)
zerumbone  (ISO)
zidovudine  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (ISO)
ziram  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation-induced cell death of T cells  (IEA,ISO)
apoptotic mitochondrial changes  (IEA,ISO)
behavioral response to pain  (IEA,ISO)
canonical NF-kappaB signal transduction  (IEA,ISO)
cell migration involved in sprouting angiogenesis  (IEA,ISO)
cell projection organization  (IDA)
cellular response to cadmium ion  (IEA,ISO)
cellular response to decreased oxygen levels  (IEA,ISO)
cellular response to epidermal growth factor stimulus  (IEA,ISO,ISS)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (IEA,ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hypoxia  (IDA)
cellular response to insulin stimulus  (IMP,ISO,ISS)
cellular response to mechanical stimulus  (IDA)
cellular response to nerve growth factor stimulus  (IDA,IEA,IEP,ISO)
cellular response to organic cyclic compound  (IDA)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA,ISO)
cellular response to peptide  (ISO)
cellular response to prostaglandin E stimulus  (IEA,ISO)
cellular response to reactive oxygen species  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to vascular endothelial growth factor stimulus  (IEA,ISO)
DNA damage response  (IDA)
epidermal growth factor receptor signaling pathway  (IEA,ISO)
establishment of protein localization to mitochondrion  (IEA,ISO)
execution phase of apoptosis  (IEA,ISO)
gene expression  (IEA,ISO)
germ cell development  (ISO)
glucose homeostasis  (IEA,ISO)
glucose metabolic process  (IEA,ISO)
glycogen biosynthetic process  (IEA,IMP)
glycogen cell differentiation involved in embryonic placenta development  (IEA,ISO)
glycogen metabolic process  (IEA,ISO)
inflammatory response  (IEA,ISO)
insulin receptor signaling pathway  (IDA,IEA,IMP,ISO,ISS)
insulin-like growth factor receptor signaling pathway  (IEA,ISO,ISS)
interleukin-18-mediated signaling pathway  (IEA,ISO)
intracellular signal transduction  (IBA,ISO)
labyrinthine layer blood vessel development  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
maintenance of protein location in mitochondrion  (IEA,ISO)
mammalian oogenesis stage  (IEA,ISO)
maternal placenta development  (IEA,ISO)
negative regulation of apoptotic process  (ISO,TAS)
negative regulation of autophagy  (IEA,ISO)
negative regulation of calcium import into the mitochondrion  (IMP)
negative regulation of cell size  (IDA)
negative regulation of cGAS/STING signaling pathway  (IEA,ISO)
negative regulation of cilium assembly  (IEA,ISO,ISS)
negative regulation of fatty acid beta-oxidation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of JNK cascade  (IDA)
negative regulation of leukocyte cell-cell adhesion  (IEA,ISO)
negative regulation of long-chain fatty acid import across plasma membrane  (IEA,ISO)
negative regulation of lymphocyte migration  (IEA,ISO)
negative regulation of protein localization to lysosome  (IEA,ISO,ISS)
negative regulation of protein ubiquitination  (IEA,ISO)
negative regulation of proteolysis  (IEA,ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA,ISO,ISS)
negative regulation of superoxide anion generation  (IMP)
non-canonical NF-kappaB signal transduction  (IEA,ISO)
organic substance transport  (IEA)
osteoblast differentiation  (IEA,ISO)
peripheral nervous system myelin maintenance  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of cell growth  (IDA,IEA,ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (IEA,ISO,ISS)
positive regulation of fat cell differentiation  (IEA,ISO)
positive regulation of fibroblast migration  (IEA,ISO)
positive regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glucose import  (IEA,ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (IEA,ISO)
positive regulation of I-kappaB phosphorylation  (IEA,ISO)
positive regulation of lipid biosynthetic process  (IEA,ISO,ISS)
positive regulation of mitochondrial membrane potential  (IMP)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of organ growth  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
positive regulation of protein localization to cell surface  (IEA,ISO)
positive regulation of protein localization to endoplasmic reticulum  (IEA,ISO)
positive regulation of protein localization to nucleus  (IEA,ISO)
positive regulation of protein localization to plasma membrane  (IEA,ISO)
positive regulation of protein metabolic process  (IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of sodium ion transport  (IEA,IMP,ISO)
positive regulation of TORC1 signaling  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of vasoconstriction  (IMP)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO)
protein catabolic process  (ISO)
protein import into nucleus  (IEA,ISO)
protein phosphorylation  (IDA)
protein ubiquitination  (IEA,ISO)
regulation of aerobic respiration  (IMP)
regulation of apoptotic process  (ISO,ISS)
regulation of cell migration  (IMP,ISO)
regulation of glycogen biosynthetic process  (ISO)
regulation of myelination  (IEA,ISO)
regulation of neuron projection development  (IEA,ISO,ISS)
regulation of postsynapse organization  (IEA,ISO)
regulation of protein localization  (IMP,ISO)
regulation of translation  (IEA)
regulation of tRNA methylation  (IEA,ISO)
response to fluid shear stress  (IEA,ISO)
response to food  (IEA,ISO)
response to growth factor  (ISO)
response to growth hormone  (ISS)
response to heat  (IEA,ISO)
response to hormone  (ISO)
response to insulin-like growth factor stimulus  (ISS)
response to ischemia  (IEP)
response to organic substance  (ISO)
response to oxidative stress  (ISS)
response to UV-A  (IEA,ISO)
sphingosine-1-phosphate receptor signaling pathway  (IEA,ISO)
spinal cord development  (IDA)
striated muscle cell differentiation  (IEA,ISO)
translation  (IMP)

Cellular Component
cell-cell junction  (IEA,ISO)
ciliary basal body  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO,TAS)
glutamatergic synapse  (IEA,ISO)
membrane  (ISO)
microtubule cytoskeleton  (ISO)
mitochondrion  (IEA,ISO)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IDA,IEA,ISO,ISS)
plasma membrane  (IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)
spindle  (IEA,ISO)
vesicle  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
adenosine signaling pathway  (ISO)
altered phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA,ISO)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway  (IEA)
E-cadherin signaling pathway  (ISO)
eicosanoid signaling pathway   (ISO)
endometrial cancer pathway  (IEA)
endothelin signaling pathway   (ISO)
epidermal growth factor/neuregulin signaling pathway   (IEA)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
Fc gamma receptor mediated signaling pathway  (IEA)
fibroblast growth factor signaling pathway  (ISO)
forkhead class A signaling pathway  (ISO)
glioma pathway   (IEA)
Hedgehog signaling pathway  (ISO)
hepatitis C pathway   (IEA)
hypoxia inducible factor pathway  (ISO)
influenza A pathway   (IEA)
insulin responsive facilitative sugar transporter mediated glucose transport pathway   (IMP,ISO)
insulin signaling pathway  (IEA,ISO)
insulin-like growth factor signaling pathway  (ISO)
interleukin-4 signaling pathway   (ISO)
interleukin-6 signaling pathway   (ISO)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway   (IEA)
mitogen activated protein kinase signaling pathway   (IEA)
mTOR signaling pathway  (IEA,ISO)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA,ISO)
p53 signaling pathway   (ISO)
pancreatic cancer pathway   (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway   (IMP,ISO)
prostate cancer pathway   (IEA)
Reelin signaling pathway   (ISO)
renal cell carcinoma pathway  (IEA)
small cell lung carcinoma pathway  (IEA)
sphingosine 1-phosphate signaling pathway  (ISO)
T cell receptor signaling pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway  (IEA)
tuberculosis pathway  (IEA)
type II interferon signaling pathway   (ISO)
vascular endothelial growth factor signaling pathway  (IEA,ISO)

References

References - curated
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77. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Majewski N, etal., Mol Cell 2004 Dec 3;16(5):819-30.
78. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Maroulakou IG, etal., Cancer Res. 2007 Jan 1;67(1):167-77.
79. Akt/protein kinase B overexpression as an accurate prognostic marker in adult diffuse astrocytoma. Matsutani T, etal., Acta Neurochir (Wien). 2009 Mar;151(3):263-8; discussion 268. Epub 2009 Feb 25.
80. GADD45a is a novel candidate gene in inflammatory lung injury via influences on Akt signaling. Meyer NJ, etal., FASEB J. 2009 May;23(5):1325-37. Epub 2009 Jan 5.
81. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
82. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
83. Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice. Ng SS, etal., Clin Cancer Res. 2001 Oct;7(10):3269-75.
84. Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Nicodemus KK, etal., Arch Gen Psychiatry. 2010 Oct;67(10):991-1001.
85. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
86. A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Pallafacchina G, etal., Proc Natl Acad Sci U S A 2002 Jul 9;99(14):9213-8.
87. New driver mutations in non-small-cell lung cancer. Pao W and Girard N, Lancet Oncol. 2011 Feb;12(2):175-80.
88. Vitis labruscana leaf extract ameliorates scopolamine-induced impairments with activation of Akt, ERK and CREB in mice. Pariyar R, etal., Phytomedicine. 2017 Dec 1;36:8-17. doi: 10.1016/j.phymed.2017.09.008. Epub 2017 Sep 23.
89. Neuromuscular dysfunction in the mutant superoxide dismutase mouse model of amyotrophic lateral sclerosis. Parkhouse WS, etal., Amyotroph Lateral Scler. 2008;9(1):24-34.
90. Akt/PKB isoforms expression in the human lumbar herniated disc: correlation with clinical and MRI findings. Pasku D, etal., Eur Spine J. 2011 Oct;20(10):1676-83. Epub 2011 May 18.
91. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
92. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
93. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
94. Genetic studies of the protein kinase AKT1 in Parkinson's disease. Ran C, etal., Neurosci Lett. 2011 Aug 21;501(1):41-4. Epub 2011 Jun 29.
95. Activation of the PI3K/mTOR pathway is involved in cystic proliferation of cholangiocytes of the PCK rat. Ren XS, etal., PLoS One. 2014 Jan 30;9(1):e87660. doi: 10.1371/journal.pone.0087660. eCollection 2014.
96. Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes. Resjo S, etal., Cell Signal. 2002 Mar;14(3):231-8.
97. GOA pipeline RGD automated data pipeline
98. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
99. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
100. Knockdown of Akt isoforms by RNA silencing suppresses the growth of human prostate cancer cells in vitro and in vivo. Sasaki T, etal., Biochem Biophys Res Commun. 2010 Aug 13;399(1):79-83. doi: 10.1016/j.bbrc.2010.07.045. Epub 2010 Jul 16.
101. Redox-sensitive prosurvival and proapoptotic protein expression in the myocardial remodeling post-infarction in rats. Schenkel PC, etal., Mol Cell Biochem. 2010 Aug;341(1-2):1-8. doi: 10.1007/s11010-010-0431-8. Epub 2010 Mar 30.
102. The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B. Schmidlin M, etal., EMBO J. 2004 Dec 8;23(24):4760-9. Epub 2004 Nov 11.
103. Oncopreventive effects of theanine and theobromine on dimethylhydrazine-induced colon cancer model. Shojaei-Zarghani S, etal., Biomed Pharmacother. 2021 Feb;134:111140. doi: 10.1016/j.biopha.2020.111140. Epub 2020 Dec 24.
104. Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase. Simone S, etal., Diabetes. 2008 Oct;57(10):2626-36. doi: 10.2337/db07-1579. Epub 2008 Jul 3.
105. Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. Song K, etal., EMBO J. 2006 Jan 11;25(1):58-69. Epub 2005 Dec 15.
106. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Storozhuk Y, etal., Br J Cancer. 2013 May 28;108(10):2021-32. doi: 10.1038/bjc.2013.187. Epub 2013 Apr 30.
107. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling. Sunters A, etal., J Biol Chem. 2010 Mar 19;285(12):8743-58. doi: 10.1074/jbc.M109.027086. Epub 2009 Dec 30.
108. Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1). Takata M, etal., J Biol Chem. 1999 Jul 16;274(29):20611-8.
109. Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Tavazoie SF, etal., Nat Neurosci. 2005 Dec;8(12):1727-34. Epub 2005 Nov 6.
110. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
111. AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families. Thiselton DL, etal., Biol Psychiatry. 2008 Mar 1;63(5):449-57. Epub 2007 Sep 6.
112. Akt signal transduction dysfunction in Parkinson's disease. Timmons S, etal., Neurosci Lett. 2009 Dec 18;467(1):30-5. Epub 2009 Oct 1.
113. Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: study with insulin and exercise. Turinsky J and Damrau-Abney A, Am J Physiol. 1999 Jan;276(1 Pt 2):R277-82.
114. Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Ugi S, etal., Mol Cell Biol 2002 Apr;22(7):2375-87.
115. Increased phosphorylation of Akt in triple-negative breast cancers. Umemura S, etal., Cancer Sci. 2007 Dec;98(12):1889-92. Epub 2007 Sep 24.
116. Akt-mediated GSK-3beta inhibition prevents migration of polyamine-depleted intestinal epithelial cells via Rac1. Vaidya RJ, etal., Cell Mol Life Sci. 2006 Dec;63(23):2871-9.
117. MicroRNA-31/184 is involved in transforming growth factor-β-induced apoptosis in A549 human alveolar adenocarcinoma cells. Wang CJ, etal., Life Sci. 2020 Feb 1;242:117205. doi: 10.1016/j.lfs.2019.117205. Epub 2019 Dec 23.
118. Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. Wang R, etal., J Neurochem. 2006 Dec;99(6):1543-54. Epub 2006 Oct 25.
119. LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis. Wang S, etal., Aging (Albany NY). 2022 Aug 30;14(16):6809-6828. doi: 10.18632/aging.204256. Epub 2022 Aug 30.
120. [Effect of recombinant human erythropoietin on hippocampal p-Akt and caspase-9 expressions in rats with status epilepticus and the mechanism]. Wang WP, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jan;30(1):64-9.
121. AKT1 polymorphisms are associated with tuberculosis in the Chinese population. Wang X, etal., Int J Immunogenet. 2010 Apr;37(2):97-101. doi: 10.1111/j.1744-313X.2010.00897.x. Epub 2010 Feb 5.
122. SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells. Wang X, etal., J Biol Chem 2004 Jan 2;279(1):133-41. Epub 2003 Oct 16.
123. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
124. Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function. Wobser H, etal., Diabetologia. 2006 Mar;49(3):519-26. doi: 10.1007/s00125-005-0119-x. Epub 2006 Jan 27.
125. Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan. Wong CK, etal., Mol Cancer Res. 2020 Mar;18(3):414-423. doi: 10.1158/1541-7786.MCR-19-0525. Epub 2020 Jan 13.
126. Recent advances in the protein kinase B signaling pathway. Woodgett JR Curr Opin Cell Biol. 2005 Apr;17(2):150-7.
127. MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer. Wu YR, etal., Tumour Biol. 2016 Sep;37(9):12061-12070. doi: 10.1007/s13277-016-5074-2. Epub 2016 May 17.
128. PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways. Xiong X, etal., Neurobiol Dis. 2014 Jun;66:43-52. doi: 10.1016/j.nbd.2014.02.006. Epub 2014 Feb 27.
129. Association between AKT1 gene and Parkinson's disease: a protective haplotype. Xiromerisiou G, etal., Neurosci Lett. 2008 May 9;436(2):232-4. Epub 2008 Mar 15.
130. Akt1-mediated regulation of macrophage polarization in a murine model of Staphylococcus aureus pulmonary infection. Xu F, etal., J Infect Dis. 2013 Aug 1;208(3):528-38. doi: 10.1093/infdis/jit177. Epub 2013 Apr 23.
131. Impaired Epithelial Wound Healing and EGFR Signaling Pathways in the Corneas of Diabetic Rats. Xu K and Yu FS, Invest Ophthalmol Vis Sci. 2011 Feb 17.
132. The mechanisms of EGFR in the regulation of axon regeneration. Xu MF, etal., Cell Biochem Funct. 2014 Jan;32(1):101-5. doi: 10.1002/cbf.2977. Epub 2013 May 17.
133. Inhibitory effects of Chanling Gao on the proliferation and liver metastasis of transplanted colorectal cancer in nude mice. Yang B, etal., PLoS One. 2019 Feb 21;14(2):e0201504. doi: 10.1371/journal.pone.0201504. eCollection 2019.
134. Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer. Yu X, etal., J Exp Clin Cancer Res. 2020 Apr 10;39(1):62. doi: 10.1186/s13046-020-01566-2.
135. Ras GTPase-activating protein binds to Akt and is required for its activation. Yue Y, etal., J Biol Chem. 2004 Mar 26;279(13):12883-9. Epub 2004 Jan 5.
136. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
137. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
138. Chromium-containing traditional Chinese medicine, Tianmai Xiaoke Tablet improves blood glucose through activating insulin-signaling pathway and inhibiting PTP1B and PCK2 in diabetic rats. Zhang Q, etal., J Integr Med. 2014 May;12(3):162-70. doi: 10.1016/S2095-4964(14)60020-0.
139. Increased phosphorylation of protein kinase B and related substrates after traumatic brain injury in humans and rats. Zhang X, etal., J Cereb Blood Flow Metab. 2006 Jul;26(7):915-26. Epub 2005 Oct 19.
140. Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation. Zhu LH, etal., Clin Sci (Lond). 2015 Jul;129(2):129-45. doi: 10.1042/CS20140679.
Additional References at PubMed
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Genomics

Comparative Map Data
Akt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,534,810 - 137,555,131 (-)NCBIGRCr8
mRatBN7.26131,713,716 - 131,735,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,713,720 - 131,733,921 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6131,883,770 - 131,900,905 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,180,876 - 132,197,963 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,543,341 - 131,560,403 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,218,398 - 137,239,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,218,376 - 137,236,258 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,225,955 - 146,247,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,640,482 - 137,657,552 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,646,668 - 137,663,739 (-)NCBI
Celera6129,262,032 - 129,279,096 (-)NCBICelera
RH 3.4 Map6782.49RGD
Cytogenetic Map6q32NCBI
AKT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814104,769,349 - 104,795,748 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14104,769,349 - 104,795,751 (-)EnsemblGRCh38hg38GRCh38
GRCh3714105,235,686 - 105,262,085 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,306,731 - 104,333,125 (-)NCBINCBI36Build 36hg18NCBI36
Build 3414104,306,752 - 104,330,608NCBI
Celera1485,290,760 - 85,317,154 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,432,617 - 85,464,212 (-)NCBIHuRef
CHM1_114105,173,739 - 105,200,089 (-)NCBICHM1_1
T2T-CHM13v2.01499,012,235 - 99,038,624 (-)NCBIT2T-CHM13v2.0
Akt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,620,260 - 112,641,266 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,620,255 - 112,641,318 (-)EnsemblGRCm39 Ensembl
GRCm3812112,653,821 - 112,674,884 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,653,821 - 112,674,884 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712113,892,032 - 113,912,487 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,101,629 - 113,121,998 (-)NCBIMGSCv36mm8
Celera12113,867,449 - 113,888,183 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.2NCBI
Akt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,208,710 - 3,229,904 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555383,208,711 - 3,224,386 (-)NCBIChiLan1.0ChiLan1.0
AKT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215105,950,803 - 105,978,465 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,167,305 - 105,194,960 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,417,229 - 85,444,722 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,211,645 - 105,236,756 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,208,128 - 105,236,756 (-)Ensemblpanpan1.1panPan2
AKT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,317,399 - 72,335,686 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,317,869 - 72,335,193 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha871,823,163 - 71,843,039 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0872,592,378 - 72,612,252 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,592,384 - 72,609,857 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,275,001 - 72,294,850 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,318,256 - 72,338,331 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,717,834 - 72,737,716 (-)NCBIUU_Cfam_GSD_1.0
Akt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,791,300 - 1,810,158 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621620,074 - 639,093 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936621620,163 - 639,115 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKT1
(Sus scrofa - pig)
No map positions available.
AKT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,704,087 - 82,730,711 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2482,704,068 - 82,727,698 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605370,125,334 - 70,153,468 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624734509,368 - 525,295 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624734507,880 - 525,295 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Akt1
60 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:61
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000031164
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat

Markers in Region
RH94769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26131,714,470 - 131,714,647 (+)MAPPERmRatBN7.2
Rnor_6.06137,219,153 - 137,219,329NCBIRnor6.0
Rnor_5.06146,226,709 - 146,226,885UniSTSRnor5.0
RGSC_v3.46137,640,504 - 137,640,680UniSTSRGSC3.4
Celera6129,262,054 - 129,262,230UniSTS
Cytogenetic Map6q32UniSTS
RH94504  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26131,714,459 - 131,714,541 (+)MAPPERmRatBN7.2
Rnor_6.06137,219,142 - 137,219,223NCBIRnor6.0
Rnor_5.06146,226,698 - 146,226,779UniSTSRnor5.0
RGSC_v3.46137,640,493 - 137,640,574UniSTSRGSC3.4
Celera6129,262,043 - 129,262,124UniSTS
RH 3.4 Map6782.49UniSTS
Cytogenetic Map6q32UniSTS
BE111601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26131,716,576 - 131,716,887 (+)MAPPERmRatBN7.2
Rnor_6.06137,221,261 - 137,221,571NCBIRnor6.0
Rnor_5.06146,228,817 - 146,229,127UniSTSRnor5.0
RGSC_v3.46137,642,612 - 137,642,922UniSTSRGSC3.4
Celera6129,264,162 - 129,264,472UniSTS
RH 3.4 Map6783.4UniSTS
Cytogenetic Map6q32UniSTS
PMC312770P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26131,718,480 - 131,719,046 (+)MAPPERmRatBN7.2
Rnor_6.06137,223,165 - 137,223,730NCBIRnor6.0
Rnor_5.06146,230,737 - 146,231,302UniSTSRnor5.0
RGSC_v3.46137,644,516 - 137,645,081UniSTSRGSC3.4
Celera6129,266,060 - 129,266,625UniSTS
Cytogenetic Map6q32UniSTS


Genetic Models
This gene Akt1 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000031164   ⟹   ENSRNOP00000038369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,713,725 - 131,722,390 (-)Ensembl
Rnor_6.0 Ensembl6137,218,376 - 137,236,258 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095849   ⟹   ENSRNOP00000097706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,713,725 - 131,722,908 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099722   ⟹   ENSRNOP00000076378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,713,720 - 131,733,921 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110155   ⟹   ENSRNOP00000096272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,714,449 - 131,731,517 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114705   ⟹   ENSRNOP00000090205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,713,725 - 131,720,391 (-)Ensembl
RefSeq Acc Id: NM_033230   ⟹   NP_150233
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,535,542 - 137,552,610 (-)NCBI
mRatBN7.26131,714,449 - 131,731,517 (-)NCBI
Rnor_6.06137,219,131 - 137,236,201 (-)NCBI
Rnor_5.06146,225,955 - 146,247,008 (-)NCBI
RGSC_v3.46137,640,482 - 137,657,552 (-)RGD
Celera6129,262,032 - 129,279,096 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111773   ⟹   XP_038967701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,534,810 - 137,555,131 (-)NCBI
mRatBN7.26131,713,717 - 131,734,163 (-)NCBI
RefSeq Acc Id: XM_063261541   ⟹   XP_063117611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,534,810 - 137,554,837 (-)NCBI
RefSeq Acc Id: NP_150233   ⟸   NM_033230
- UniProtKB: P47196 (UniProtKB/Swiss-Prot),   A6KBV9 (UniProtKB/TrEMBL),   A0A8L2QJ86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038369   ⟸   ENSRNOT00000031164
RefSeq Acc Id: XP_038967701   ⟸   XM_039111773
- Peptide Label: isoform X1
- UniProtKB: P47196 (UniProtKB/Swiss-Prot),   A6KBV9 (UniProtKB/TrEMBL),   A0A8L2QJ86 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000097706   ⟸   ENSRNOT00000095849
RefSeq Acc Id: ENSRNOP00000076378   ⟸   ENSRNOT00000099722
RefSeq Acc Id: ENSRNOP00000096272   ⟸   ENSRNOT00000110155
RefSeq Acc Id: ENSRNOP00000090205   ⟸   ENSRNOT00000114705
RefSeq Acc Id: XP_063117611   ⟸   XM_063261541
- Peptide Label: isoform X1
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47196-F1-model_v2 AlphaFold P47196 1-480 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2081 AgrOrtholog
BioCyc Gene G2FUF-35781 BioCyc
Ensembl Genes ENSRNOG00000028629 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055028853 UniProtKB/Swiss-Prot
  ENSRNOG00060026743 UniProtKB/Swiss-Prot
  ENSRNOG00065028102 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031164.4 UniProtKB/TrEMBL
  ENSRNOT00000095849.1 UniProtKB/TrEMBL
  ENSRNOT00000099722.1 UniProtKB/TrEMBL
  ENSRNOT00000110155 ENTREZGENE
  ENSRNOT00000110155.1 UniProtKB/TrEMBL
  ENSRNOT00000114705.1 UniProtKB/TrEMBL
  ENSRNOT00055050101 UniProtKB/Swiss-Prot
  ENSRNOT00060046687 UniProtKB/Swiss-Prot
  ENSRNOT00065048586 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Akt1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_PKB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24185 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24185 ENTREZGENE
PANTHER PTHR24351:SF200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AKT1 RGD
PhenoGen Akt1 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028629 RatGTEx
  ENSRNOG00055028853 RatGTEx
  ENSRNOG00060026743 RatGTEx
  ENSRNOG00065028102 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204818
UniProt A0A8I5YBI2_RAT UniProtKB/TrEMBL
  A0A8I6AD70_RAT UniProtKB/TrEMBL
  A0A8I6AQF6_RAT UniProtKB/TrEMBL
  A0A8I6ASB8_RAT UniProtKB/TrEMBL
  A0A8L2QJ86 ENTREZGENE, UniProtKB/TrEMBL
  A6KBV9 ENTREZGENE, UniProtKB/TrEMBL
  AKT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Akt1  AKT serine/threonine kinase 1  Akt1  v-akt murine thymoma viral oncogene homolog 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Akt1  v-akt murine thymoma viral oncogene homolog 1  Akt1  thymoma viral proto-oncogene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Akt1  thymoma viral proto-oncogene 1    v-akt murine thymoma viral oncogene homolog 1  Name updated 1299863 APPROVED
2004-12-14 Akt1  v-akt murine thymoma viral oncogene homolog 1      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Akt1  v-akt murine thymoma viral oncogene homolog 1      Name updated 70585 PROVISIONAL
2001-03-05 Akt  Murine thymoma viral (v-akt) oncogene homolog 1      Symbol withdrawn, allele of Akt1 (RGD:2081) 61033 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_domains contains a pleckstrin homology domain 632176
gene_domains contains a protein-serine/threonine kinase catalytic domain 632176
gene_expression expressed in testis and other tissues 632176
gene_process may act as a protein-serine/threonine kinase 632176
gene_process may bind protein kinase C 632176
gene_process inhibits JUN kinase activation and reduces JNK mediated apoptosis 632178
gene_protein protein sequence contains 480 amino acids 632176
gene_regulation activity is induced by insulin 632177