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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3380
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppp2ca
Name: protein phosphatase 2 catalytic subunit alpha
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp2caincreases activityEXP 6480464CTDEthanol results in increased activity of PPP2CA proteinPMID:20224005
Ppp2camultiple interactionsEXP 6480464CTDfumonisin B1 inhibits the reaction [Ethanol results in increased activity of PPP2CA protein]; Imipramine inhibits the reaction [Ethanol results in increased activity of PPP2CA protein]PMID:20224005
Ppp2cadecreases methylationISOPpp2ca (Mus musculus)6480464CTDEthanol results in decreased methylation of PPP2CA proteinPMID:32492475
Ppp2camultiple interactionsISOPPP2CA (Homo sapiens)6480464CTDPPP2CA protein affects the reaction [Ethanol affects the localization of CTNNB1 protein]; PPP2CA protein affects the reaction [Ethanol results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; PPP2CA protein affects the reaction [Ethanol results in increased expression of CYP2E1 protein]PMID:30567741
Ppp2camultiple interactionsISOPpp2ca (Mus musculus)6480464CTDBetaine inhibits the reaction [Ethanol results in decreased methylation of PPP2CA protein]; Ethanol affects the expression of and affects the splicing of PPP2CA mRNA; PPP2CA protein inhibits the reaction [Ethanol results in increased phosphorylation of FOXO1 protein]PMID:30319688 PMID:32492475
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