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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3380
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppp2ca
Name: protein phosphatase 2 catalytic subunit alpha
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp2cadecreases expressionISOPpp2ca (Mus musculus)6480464CTDStreptozocin results in decreased expression of PPP2CA protein modified formPMID:34428446
Ppp2cadecreases methylationISOPpp2ca (Mus musculus)6480464CTDStreptozocin results in decreased methylation of PPP2CA proteinPMID:28422052
Ppp2camultiple interactionsISOPpp2ca (Mus musculus)6480464CTD5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of PPP2CA protein modified form]; Folic Acid deficiency promotes the reaction [Streptozocin results in decreased methylation of PPP2CA protein]; Folic Acid inhibits the reaction [Streptozocin results in decreased methylation of PPP2CA protein]; INS1 protein affects the reaction [Streptozocin results in decreased methylation of PPP2CA protein]; Tadalafil inhibits the reaction [Streptozocin results in decreased expression of PPP2CA protein modified form]PMID:28422052 PMID:34428446
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