INTERLEUKIN-10 SIGNALING PATHWAY (PW:0000515)

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Description

Interleukin-10 (Il-10) is a prominent member of the interleukin 10 family of cytokines which also includes interleukin 28A, 28B and 29 known as interferon type III or lambda. In addition to the mammalian proteins, several viral homologues are also known. The many biological actions of Il-10 impinge upon the release of immune mediators and antigen presentation with an overall anti-inflammatory effect; interestingly it is Il-10 and not the other members of the family that appear to promote such ef

Pathway Diagram:

Ariadne Genomics Inc. P-Tyr1 P-Tyr2 Jak1 Stat3 Jak-Stat signaling pathway Stat1 Il10ra ---- Stat1 Il10 P-Tyr2 ---- Stat3 Il10ra Il10 ---- Il10ra Il10rb --+> Tyk2 Tyk2 Il10ra --+> Jak1 Tyk2 ---> Il10ra Il10ra ---- Jak1 Il10 --+> Stat3 Jak1 ---> Il10ra Il10 --+> Stat1 Th1 cell: Th2 cell responses; anti-inflammatory effects Il10 ---> Th1 cell: Th2 cell responses; anti-inflammatory effects Il10 ---- Il10rb Il10rb Il10rb ---- Tyk2
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Genes in Pathway:

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Interleukin-10 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1580494
RGD:2311043
RGD:5688379
G Il10ra interleukin 10 receptor subunit alpha JBrowse link 8 49,558,062 49,573,891 RGD:5688379
RGD:2311043
G Il10rb interleukin 10 receptor subunit beta JBrowse link 11 31,560,301 31,582,457 RGD:5688379
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:5688379
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:5688379
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:5688379
RGD:2311043
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:5688379

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Interleukin-10 signaling pathway
Disease TermsGene Symbols
acquired immunodeficiency syndromeIl10
acute kidney failureIl10
Acute Lung InjuryIl10
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesJak1
acute myeloid leukemiaIl10 , Jak1 , Stat3
adenocarcinomaStat3
adenoid cystic carcinomaStat3
adult respiratory distress syndromeIl10
adult T-cell leukemiaIl10 , Stat3
Airway ObstructionIl10
allergic conjunctivitisIl10
allergic contact dermatitisIl10
allergic rhinitisIl10
Alveolar Bone LossIl10
Alzheimer's diseaseIl10 , Stat3
anaplastic large cell lymphomaStat3
anemiaIl10
angiomyolipomaStat1 , Stat3
angiosarcomaStat3
Animal Disease ModelsIl10 , Stat3
anti-basement membrane glomerulonephritisIl10
appendicitisIl10
arteriosclerosisIl10
asthenopiaIl10
asthmaIl10
atherosclerosisStat3
atopic dermatitisIl10
AtrophyStat3
autistic disorderIl10 , Stat3
Autoimmune Disease, Multisystem, Infantile-Onset, 1Stat3
Autoimmune DiseasesStat3
autoimmune hemolytic anemiaIl10
autoimmune hepatitisIl10
autoimmune thrombocytopenic purpuraIl10
bacterial infectious diseaseIl10
bacterial pneumoniaStat3
Behcet's diseaseIl10 , Stat3
Brain InjuriesIl10 , Stat1 , Stat3
brain ischemiaIl10rb , Stat3
breast cancerStat1
Breast NeoplasmsStat1 , Stat3
Bronchial HyperreactivityIl10
Bronchitis, ChronicIl10
bronchus carcinomaIl10
BurnsIl10
Candidiasis, Familial, 6Stat1
carcinomaStat3
CardiomegalyStat3
cardiomyopathyStat3
carotid artery diseaseIl10
carotid stenosisIl10
Cell Transformation, NeoplasticStat3
cervix uteri carcinoma in situStat3
Chagas CardiomyopathyIl10
choroid diseaseIl10
Choroidal NeovascularizationIl10 , Stat3
Chronic Lymphocytic Leukemia, B-CellIl10
chronic mucocutaneous candidiasisStat1
chronic myeloid leukemiaIl10
Churg-Strauss syndromeStat3
Cocaine-Related DisordersTyk2
colitisIl10
Colonic NeoplasmsStat3
colorectal cancerStat3
common coldIl10
congestive heart failureIl10
Copper-Overload CirrhosisStat3
coronary artery diseaseIl10
Crohn's diseaseIl10 , Stat3 , Tyk2
cutaneous leishmaniasisIl10
Cytomegalovirus InfectionsStat1
cytomegalovirus retinitisIl10
decubitus ulcerIl10
diabetes mellitusIl10
Diabetic CardiomyopathiesIl10
Diabetic NephropathiesIl10 , Stat3
diabetic retinopathyIl10
diffuse sclerodermaIl10
dilated cardiomyopathyIl10
Disease ProgressionStat1
disseminated intravascular coagulationIl10
drug allergyIl10
dry eye syndromeIl10
duodenal ulcerStat3
Eales DiseaseIl10
Endometrial NeoplasmsIl10 , Stat3
endometriosisIl10
EndotoxemiaIl10
EntamoebiasisIl10
EnterocolitisIl10
Epidermal HyperplasiaStat3
Experimental ArthritisIl10 , Stat1 , Stat3
Experimental Autoimmune EncephalomyelitisIl10 , Il10ra , Stat1 , Stat3
Experimental Autoimmune UveitisIl10 , Stat3
Experimental Autoimmune UveoretinitisIl10 , Stat3
Experimental ColitisIl10
Experimental Diabetes MellitusIl10 , Stat1 , Stat3
Experimental Liver CirrhosisIl10
Eye BurnsIl10
factor VIII deficiencyIl10
Fanconi anemiaIl10
fatty liver diseaseIl10
Femoral FracturesIl10
FeverStat3
FibrosisStat3
Gallbladder NeoplasmsIl10
genetic diseaseIl10rb , Jak1 , Stat1 , Stat3
Genetic Predisposition to DiseaseIl10
gestational diabetesIl10
glomerulonephritisIl10
glucosephosphate dehydrogenase deficiencyIl10
Graft vs Host DiseaseIl10 , Il10rb
Granuloma, PyogenicStat3
Graves OphthalmopathyIl10
Graves' diseaseIl10
head and neck squamous cell carcinomaStat3
Hearing LossIl10 , Stat1
heart diseaseStat3
Heat StrokeIl10
Heparin-induced ThrombocytopeniaIl10
hepatitis BIl10rb
hepatitis CIl10
Hepatitis C, ChronicStat3
Hepatitis, ChronicStat3
hepatocellular carcinomaIl10 , Stat1
Hernias, Diaphragmatic, CongenitalStat3
herpes simplex virus keratitisIl10
herpes zosterIl10
Hodgkin's lymphomaIl10
human immunodeficiency virus infectious diseaseIl10
Human InfluenzaIl10 , Stat1
Hyper-IgE Recurrent Infection Syndrome, Autosomal DominantStat3
HyperalgesiaIl10 , Stat3
Hypersensitivity, ImmediateIl10
hypertensionIl10
hyperthyroidismIl10
hyperuricemiaStat3
hypothyroidismIl10
idiopathic pulmonary fibrosisStat3
ileitisIl10
IMMUNODEFICIENCY 28Il10rb
IMMUNODEFICIENCY 31AStat1
IMMUNODEFICIENCY 31BStat1
IMMUNODEFICIENCY 31CStat1
InflammationIl10 , Stat3
inflammatory bowel diseaseIl10 , Il10ra , Il10rb , Stat3
inflammatory bowel disease 25Il10rb
inflammatory bowel disease 28Il10ra
intermediate uveitisIl10
intestinal obstructionIl10
irritable bowel syndromeIl10
irritant dermatitisStat3
Job's syndromeStat3
juvenile rheumatoid arthritisStat3
Kidney Reperfusion InjuryIl10
leishmaniasisIl10
liver cirrhosisStat1 , Stat3
Liver InjuryStat3
liver neoplasmIl10 , Stat3
Liver Neoplasms, ExperimentalStat3
Liver Reperfusion InjuryIl10
lung diseaseIl10
Lung NeoplasmsIl10
lymphangioleiomyomatosisStat1 , Stat3
Lymphatic MetastasisStat3
lymphomaIl10
lymphoproliferative syndromeStat3
malignant gliomaIl10
Mammary Neoplasms, AnimalStat3
Mammary Neoplasms, ExperimentalIl10 , Stat1 , Stat3
medulloblastomaStat3
Memory DisordersStat3
middle cerebral artery infarctionStat3
mitral valve stenosisIl10
mucositisIl10
multiple myelomaIl10
Multiple Organ FailureIl10
multiple sclerosisIl10 , Tyk2
Multisystem Autoimmune Disease, Infantile-OnsetStat3
Murine Acquired Immunodeficiency SyndromeIl10
Mycobacterium InfectionsStat1
myocardial infarctionIl10
Myocardial Reperfusion InjuryIl10 , Stat1 , Stat3
myocarditisIl10
Nasal PolypsIl10 , Stat3
Neoplasm MetastasisIl10 , Stat1 , Stat3
nephroblastomaStat1 , Stat3
NeuralgiaIl10
neutropeniaStat3
Niemann-Pick disease type C1Stat3
non-small cell lung carcinomaIl10 , Stat3
nonalcoholic fatty liver diseaseStat3
Nontuberculous Mycobacterium InfectionsStat1 , Tyk2
obesityIl10 , Stat3 , Tyk2
obstructive sleep apneaIl10
Ocular TuberculosisIl10
open-angle glaucomaIl10
otitis mediaIl10
Ovarian NeoplasmsIl10 , Stat3
Oxygen-Induced RetinopathyStat3
pancreatic cancerIl10 , Stat3
pancreatitisIl10
Pancreatitis, Experimental, Acute Il10
panuveitisIl10
Paranoid DisordersTyk2
pericardial effusionIl10
perinatal necrotizing enterocolitisIl10 , Il10rb
periodontitisIl10
peripartum cardiomyopathyStat3
plasmacytomaIl10
pleurisyIl10
pneumoniaIl10
Pneumonia, StaphylococcalIl10
polycythemia veraJak1
postpartum depressionIl10
pre-malignant neoplasmStat3
precursor B lymphoblastic lymphoma/leukemiaStat3
precursor lymphoblastic lymphoma/leukemiaIl10
precursor T-lymphoblastic lymphoma/leukemiaStat1 , Tyk2
Pregnancy-associated MalariaIl10
primary biliary cirrhosisTyk2
Primary Graft DysfunctionIl10
Prostatic NeoplasmsIl10 , Jak1 , Stat1 , Stat3
prostatitisIl10
Pseudomonas Aeruginosa KeratitisIl10
psoriasisIl10 , Stat3 , Tyk2
psoriatic arthritisStat3
pulmonary eosinophiliaIl10
pulmonary fibrosisStat1 , Stat3
pulmonary hypertensionIl10
Radiation Injuries, ExperimentalIl10
renal cell carcinomaStat3
Reoviridae InfectionsStat1
Reperfusion InjuryIl10 , Stat1 , Stat3
respiratory allergyIl10
respiratory syncytial virus infectious diseaseIl10
Retina Reperfusion InjuryStat3
retinal artery occlusionIl10
retinal diseaseIl10
retinopathy of prematurityIl10
Retroviridae InfectionsIl10
rheumatic heart diseaseIl10
rheumatoid arthritisIl10 , Stat1 , Stat3 , Tyk2
RhinosinusitisIl10
schizophreniaIl10
sciatic neuropathyIl10
scrapieStat1 , Stat3
Seasonal Allergic RhinitisIl10
SepsisIl10 , Stat1 , Stat3
Sepsis-Associated EncephalopathyStat3
Shock, HemorrhagicIl10
Shwartzman phenomenonIl10
sickle cell anemiaIl10
Sjogren's syndromeIl10
skin diseaseIl10
skin melanomaStat3
Skin NeoplasmsStat3
Smith-Magenis syndromeStat3
SplenomegalyIl10
squamous cell carcinomaStat3
Staphylococcal InfectionsIl10
Stomach NeoplasmsStat3
StrokeIl10
Subarachnoid HemorrhageStat3
systemic lupus erythematosusIl10 , Jak1
T-cell leukemiaStat3
T-Cell LymphomaStat3
thrombocytopeniaIl10
thrombosisIl10
thyrotoxicosisIl10
Tongue NeoplasmsStat3
tongue squamous cell carcinomaIl10
toxic encephalopathyIl10
toxic shock syndromeIl10
Toxoplasma ChorioretinitisIl10
Toxoplasmosis, OcularIl10
trachomaIl10
transient cerebral ischemiaIl10 , Stat3
Transplant RejectionIl10
Trauma, Nervous SystemStat1
trichinosisIl10
type 1 diabetes mellitusIl10 , Stat3 , Tyk2
type 2 diabetes mellitusIl10 , Stat3
Tyrosine Kinase 2 DeficiencyTyk2
ulcerative colitisIl10 , Stat3
Uterine Cervical NeoplasmsIl10 , Stat3
uveitisIl10
vasculitisIl10
Venous ThrombosisIl10
Ventilator-Induced Lung InjuryIl10
viral pneumoniaIl10
visceral leishmaniasisIl10 , Il10ra
Waldenstroem's macroglobulinemiaIl10
Wegener's granulomatosisIl10
Weight LossIl10
Wilson diseaseIl10
Wounds and InjuriesIl10
Wounds, PenetratingIl10
Pathway Annotations Associated with Genes in the Interleukin-10 signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayStat3
allograft rejection pathwayIl10
angiotensin II signaling pathway via AT1 receptorTyk2
asthma pathwayIl10
autoimmune thyroiditis pathwayIl10
ceramide signaling pathwayJak1 , Stat1 , Stat3
Chagas disease pathwayIl10
chemokine mediated signaling pathwayStat1 , Stat3
cytokine mediated signaling pathwayIl10 , Il10ra , Il10rb
Entamoebiasis pathwayIl10
epidermal growth factor/neuregulin signaling pathwayStat1 , Stat3
erythropoietin signaling pathwayStat1
fibroblast growth factor signaling pathwayStat1
granulocyte-macrophage colony-stimulating factor signaling pathwayStat1 , Stat3
hepatitis C pathwayJak1 , Stat1 , Stat3
influenza A pathwayJak1 , Stat1
Interleukin-10 signaling pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1 , Stat3 , Tyk2
interleukin-12 signaling pathwayStat1 , Stat3 , Tyk2
interleukin-2 signaling pathwayJak1 , Stat1 , Stat3
interleukin-23 signaling pathwayStat1 , Stat3 , Tyk2
interleukin-27 signaling pathwayJak1 , Stat1 , Stat3 , Tyk2
interleukin-4 signaling pathwayIl10 , Jak1
interleukin-6 signaling pathwayJak1 , Stat1 , Stat3 , Tyk2
Jak-Stat signaling pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1 , Stat3 , Tyk2
Leishmaniasis pathwayIl10 , Jak1 , Stat1
leptin system pathwayStat3
malaria pathwayIl10
measles pathwayJak1 , Stat1 , Stat3
Non-Stat, Jak dependent pathwayJak1 , Tyk2
pancreatic cancer pathwayJak1 , Stat1 , Stat3
platelet-derived growth factor signaling pathwayJak1 , Stat1 , Stat3
sleeping sickness pathwayIl10
Staphylococcus aureus infection pathwayIl10
systemic lupus erythematosus pathwayIl10
T cell receptor signaling pathwayIl10
Toll-like receptor signaling pathwayStat1
toxoplasmosis pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1 , Stat3
tuberculosis pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1
tumor necrosis factor mediated signaling pathwayStat1
type II interferon signaling pathwayJak1 , Stat1 , Stat3

References Associated with the Interleukin-10 signaling pathway:

Ontology Path Diagram:

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