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Interleukin-10 (Il-10) is a prominent member of the interleukin 10 family of cytokines which also includes interleukin 28A, 28B and 29 known as interferon type III or lambda. In addition to the mammalian proteins, several viral homologues are also known. The many biological actions of Il-10 impinge upon the release of immune mediators and antigen presentation with an overall anti-inflammatory effect; interestingly it is Il-10 and not the other members of the family that appear to promote such ef

Pathway Diagram:

Ariadne Genomics Inc. P-Tyr1 P-Tyr2 Jak1 Stat3 Jak-Stat signaling pathway Stat1 Il10ra ---- Stat1 Il10 P-Tyr2 ---- Stat3 Il10ra Il10 ---- Il10ra Il10rb --+> Tyk2 Tyk2 Il10ra --+> Jak1 Tyk2 ---> Il10ra Il10ra ---- Jak1 Il10 --+> Stat3 Jak1 ---> Il10ra Il10 --+> Stat1 Th1 cell: Th2 cell responses; anti-inflammatory effects Il10 ---> Th1 cell: Th2 cell responses; anti-inflammatory effects Il10 ---- Il10rb Il10rb Il10rb ---- Tyk2

Genes in Pathway:

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Interleukin-10 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1580494
G Il10ra interleukin 10 receptor subunit alpha JBrowse link 8 49,558,062 49,573,891 RGD:5688379
G Il10rb interleukin 10 receptor subunit beta JBrowse link 11 31,560,301 31,582,457 RGD:5688379
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:5688379
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:5688379
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:5688379
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:5688379

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the Interleukin-10 signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayStat3
allograft rejection pathwayIl10
angiotensin II signaling pathway via AT1 receptorTyk2
asthma disease pathwayIl10
autoimmune thyroid disease pathwayIl10
ceramide signaling pathwayJak1 , Stat1 , Stat3
chemokine mediated signaling pathwayStat1 , Stat3
cytokine mediated signaling pathwayIl10 , Il10ra , Il10rb
Entamoeba histolyca infection pathwayIl10
epidermal growth factor/neuregulin signaling pathwayStat1 , Stat3
erythropoietin signaling pathwayStat1
fibroblast growth factor signaling pathwayStat1
granulocyte-macrophage colony-stimulating factor signaling pathwayStat1 , Stat3
hepatitis C virus infection pathwayJak1 , Stat1 , Stat3
influenza A virus infection pathwayJak1 , Stat1
Interleukin-10 signaling pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1 , Stat3 , Tyk2
interleukin-12 signaling pathwayStat1 , Stat3 , Tyk2
interleukin-2 signaling pathwayJak1 , Stat1 , Stat3
interleukin-23 signaling pathwayStat1 , Stat3 , Tyk2
interleukin-27 signaling pathwayJak1 , Stat1 , Stat3 , Tyk2
interleukin-4 signaling pathwayIl10 , Jak1
interleukin-6 signaling pathwayJak1 , Stat1 , Stat3 , Tyk2
Jak-Stat signaling pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1 , Stat3 , Tyk2
Leishmania infection pathwayIl10 , Jak1 , Stat1
leptin system pathwayStat3
measles infection pathwayJak1 , Stat1 , Stat3
Mycobacterium tuberculosis infection pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1
Non-Stat, Jak dependent pathwayJak1 , Tyk2
pancreatic cancer pathwayJak1 , Stat1 , Stat3
Plasmodium infection pathwayIl10
platelet-derived growth factor signaling pathwayJak1 , Stat1 , Stat3
Staphylococcus aureus infection pathwayIl10
systemic lupus erythematosus pathwayIl10
T cell receptor signaling pathwayIl10
Toll-like receptor signaling pathwayStat1
Toxoplasma gondii infection pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1 , Stat3
Trypanosoma brucei infection pathwayIl10
Trypanosoma cruzi infection pathwayIl10
tumor necrosis factor mediated signaling pathwayStat1
type II interferon signaling pathwayJak1 , Stat1 , Stat3

References Associated with the Interleukin-10 signaling pathway:

Ontology Path Diagram:

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