RGD Reference Report - Biology of interleukin-10. - Rat Genome Database

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Biology of interleukin-10.

Authors: Sabat, Robert  Grütz, Gerald  Warszawska, Katarzyna  Kirsch, Stefan  Witte, Ellen  Wolk, Kerstin  Geginat, Jens 
Citation: Sabat R, etal., Cytokine Growth Factor Rev. 2010 Oct;21(5):331-44. doi: 10.1016/j.cytogfr.2010.09.002. Epub 2010 Nov 5.
RGD ID: 5688379
Pubmed: PMID:21115385   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cytogfr.2010.09.002   (Journal Full-text)

Interleukin (IL)-10 is the most important cytokine with anti-inflammatory properties besides TGF-ß and IL-35. It is produced by activated immune cells, in particular monocytes/macrophages and T cell subsets including Tr1, Treg, and Th1 cells. IL-10 acts through a transmembrane receptor complex, which is composed of IL-10R1 and IL-10R2, and regulates the functions of many different immune cells. In monocytes/macrophages, IL-10 diminishes the production of inflammatory mediators and inhibits antigen presentation, although it enhances their uptake of antigens. Additionally, IL-10 plays an important role in the biology of B cells and T cells. The special physiological relevance of this cytokine lies in the prevention and limitation of over-whelming specific and unspecific immune reactions and, in consequence, of tissue damage. At the same time, IL-10 strengthens the "scavenger"-function and contributes to induced tolerance. This review provides an overview about the cellular sources, molecular mechanisms, effects, and biological role of IL-10.



RGD Manual Annotations

1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
IL10HumanInterleukin-10 signaling pathway   TAS  RGD 
IL10RAHumanInterleukin-10 signaling pathway   TAS  RGD 
IL10RBHumanInterleukin-10 signaling pathway   TAS  RGD 
Il10RatInterleukin-10 signaling pathway   ISOIL10 (Homo sapiens) RGD 
Il10MouseInterleukin-10 signaling pathway   ISOIL10 (Homo sapiens) RGD 
Il10raRatInterleukin-10 signaling pathway   ISOIL10RA (Homo sapiens) RGD 
Il10raMouseInterleukin-10 signaling pathway   ISOIL10RA (Homo sapiens) RGD 
Il10rbMouseInterleukin-10 signaling pathway   ISOIL10RB (Homo sapiens) RGD 
Il10rbRatInterleukin-10 signaling pathway   ISOIL10RB (Homo sapiens) RGD 
JAK1HumanInterleukin-10 signaling pathway   TAS  RGD 
Jak1RatInterleukin-10 signaling pathway   ISOJAK1 (Homo sapiens) RGD 
Jak1MouseInterleukin-10 signaling pathway   ISOJAK1 (Homo sapiens) RGD 
STAT1HumanInterleukin-10 signaling pathway   TAS  RGD 
STAT3HumanInterleukin-10 signaling pathway   TAS  RGD 
Stat1RatInterleukin-10 signaling pathway   ISOSTAT1 (Homo sapiens) RGD 
Stat1MouseInterleukin-10 signaling pathway   ISOSTAT1 (Homo sapiens) RGD 
Stat3RatInterleukin-10 signaling pathway   ISOSTAT3 (Homo sapiens) RGD 
Stat3MouseInterleukin-10 signaling pathway   ISOSTAT3 (Homo sapiens) RGD 
TYK2HumanInterleukin-10 signaling pathway   TAS  RGD 
Tyk2MouseInterleukin-10 signaling pathway   ISOTYK2 (Homo sapiens) RGD 
1 to 20 of 21 rows

Genes (Rattus norvegicus)
Il10  (interleukin 10) Il10ra  (interleukin 10 receptor subunit alpha) Il10rb  (interleukin 10 receptor subunit beta)
Jak1  (Janus kinase 1) Stat1  (signal transducer and activator of transcription 1) Stat3  (signal transducer and activator of transcription 3)
Tyk2  (tyrosine kinase 2)

Genes (Mus musculus)
Il10  (interleukin 10) Il10ra  (interleukin 10 receptor, alpha) Il10rb  (interleukin 10 receptor, beta)
Jak1  (Janus kinase 1) Stat1  (signal transducer and activator of transcription 1) Stat3  (signal transducer and activator of transcription 3)
Tyk2  (tyrosine kinase 2)

Genes (Homo sapiens)
IL10  (interleukin 10) IL10RA  (interleukin 10 receptor subunit alpha) IL10RB  (interleukin 10 receptor subunit beta)
JAK1  (Janus kinase 1) STAT1  (signal transducer and activator of transcription 1) STAT3  (signal transducer and activator of transcription 3)
TYK2  (tyrosine kinase 2)