Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Tyk2 (tyrosine kinase 2) Rattus norvegicus
Analyze
Symbol: Tyk2
Name: tyrosine kinase 2
Description: Exhibits type 1 angiotensin receptor binding activity. Predicted to be involved in intracellular signal transduction and peptidyl-tyrosine phosphorylation. Predicted to localize to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TYK2 (tyrosine kinase 2); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; Interleukin-10 signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH testosterone enanthate; 17alpha-ethynylestradiol (ortholog); 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC100361294; LOC298706; non-receptor tyrosine-protein kinase TYK2
Orthologs:
Homo sapiens (human) : TYK2 (tyrosine kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Tyk2 (tyrosine kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyk2 (tyrosine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TYK2 (tyrosine kinase 2)
Canis lupus familiaris (dog) : TYK2 (tyrosine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyk2 (tyrosine kinase 2)
Sus scrofa (pig) : TYK2 (tyrosine kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0822,118,224 - 22,149,807 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0822,180,760 - 22,205,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,096,969 - 20,149,004 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1820,128,873 - 20,148,992 (-)NCBI
Celera821,036,299 - 21,057,402 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Tyk2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2320469
Created: 2010-05-05
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.