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Gene: Tyk2 (tyrosine kinase 2) Rattus norvegicus
Symbol: Tyk2
Name: tyrosine kinase 2
Description: Exhibits type 1 angiotensin receptor binding activity. Predicted to be involved in intracellular signal transduction and peptidyl-tyrosine phosphorylation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TYK2 (tyrosine kinase 2); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; Interleukin-10 signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH (+)-schisandrin B; bisphenol A; testosterone enanthate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC100361294; LOC298706; non-receptor tyrosine-protein kinase TYK2
Homo sapiens (human) : TYK2 (tyrosine kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Tyk2 (tyrosine kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyk2 (tyrosine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TYK2 (tyrosine kinase 2)
Canis lupus familiaris (dog) : TYK2 (tyrosine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyk2 (tyrosine kinase 2)
Sus scrofa (pig) : TYK2 (tyrosine kinase 2)
Chlorocebus sabaeus (African green monkey) : TYK2 (tyrosine kinase 2)
Heterocephalus glaber (naked mole-rat) : Tyk2 (tyrosine kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0822,118,224 - 22,149,807 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,124,560 - 22,150,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,180,760 - 22,205,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,096,969 - 20,149,004 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1820,128,873 - 20,148,992 (-)NCBI
Celera821,036,299 - 21,057,402 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Tyk2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2320469
Created: 2010-05-05
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.