Tyk2 (tyrosine kinase 2) - Rat Genome Database

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Gene: Tyk2 (tyrosine kinase 2) Rattus norvegicus
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Symbol: Tyk2
Name: tyrosine kinase 2
RGD ID: 2320469
Description: Enables type 1 angiotensin receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of lymphocyte proliferation; and positive regulation of type II interferon production. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human TYK2 (tyrosine kinase 2); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; Interleukin-10 signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH (+)-schisandrin B; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100361294; LOC298706; non-receptor tyrosine-protein kinase TYK2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,641,881 - 19,667,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,641,884 - 19,667,044 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,661,293 - 23,682,384 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0821,959,148 - 21,980,237 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0819,871,547 - 19,892,652 (-)NCBIRnor_WKY
Rnor_6.0822,118,224 - 22,149,807 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,124,560 - 22,150,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,180,760 - 22,205,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,096,969 - 20,149,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,128,873 - 20,148,992 (-)NCBI
Celera821,036,299 - 21,057,402 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. Jones SA, etal., J Clin Invest. 2011 Sep 1;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.
3. Signaling through the JAK/STAT pathway, recent advances and future challenges. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
4. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart. Pan J, etal., Circ Res. 1997 Oct;81(4):611-7.
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Biology of interleukin-10. Sabat R, etal., Cytokine Growth Factor Rev. 2010 Oct;21(5):331-44. doi: 10.1016/j.cytogfr.2010.09.002. Epub 2010 Nov 5.
11. Jak family of kinases in cancer. Verma A, etal., Cancer Metastasis Rev 2003 Dec;22(4):423-34.
Additional References at PubMed
PMID:1386289   PMID:8232552   PMID:10502458   PMID:20458337   PMID:27235399  


Genomics

Comparative Map Data
Tyk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,641,881 - 19,667,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,641,884 - 19,667,044 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,661,293 - 23,682,384 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0821,959,148 - 21,980,237 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0819,871,547 - 19,892,652 (-)NCBIRnor_WKY
Rnor_6.0822,118,224 - 22,149,807 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,124,560 - 22,150,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,180,760 - 22,205,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,096,969 - 20,149,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,128,873 - 20,148,992 (-)NCBI
Celera821,036,299 - 21,057,402 (-)NCBICelera
Cytogenetic Map8q13NCBI
TYK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,350,533 - 10,380,572 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1910,350,533 - 10,380,608 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,461,209 - 10,491,248 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,322,209 - 10,352,211 (-)NCBINCBI36Build 36hg18NCBI36
Build 341910,322,208 - 10,352,211NCBI
Celera1910,356,496 - 10,385,954 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,041,213 - 10,071,290 (-)NCBIHuRef
CHM1_11910,461,760 - 10,491,969 (-)NCBICHM1_1
T2T-CHM13v2.01910,476,657 - 10,506,988 (-)NCBIT2T-CHM13v2.0
Tyk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,015,364 - 21,042,689 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,015,364 - 21,042,539 (-)EnsemblGRCm39 Ensembl
GRCm38921,104,068 - 21,131,393 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,104,068 - 21,131,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,908,512 - 20,935,719 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,854,476 - 20,881,612 (-)NCBIMGSCv36mm8
Celera918,372,782 - 18,399,989 (-)NCBICelera
Cytogenetic Map9A3NCBI
Tyk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,617,999 - 1,636,068 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,618,099 - 1,637,996 (-)NCBIChiLan1.0ChiLan1.0
TYK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11910,565,490 - 10,596,647 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,565,490 - 10,594,541 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0199,901,612 - 9,932,623 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TYK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,747,145 - 50,770,008 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,748,329 - 50,769,216 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,617,718 - 50,639,776 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,269,592 - 51,291,659 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,269,646 - 51,291,659 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,475,504 - 50,497,770 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,904,500 - 50,926,568 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,145,386 - 51,167,670 (+)NCBIUU_Cfam_GSD_1.0
Tyk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,650,169 - 209,673,217 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659681,310 - 702,962 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936659681,463 - 704,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TYK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,157,811 - 69,183,456 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,157,774 - 69,183,555 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,492,135 - 69,517,888 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TYK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,399,945 - 9,420,054 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,399,775 - 9,417,630 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,583,417 - 10,634,844 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tyk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,500,339 - 2,517,694 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,499,811 - 2,518,817 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tyk2
68 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:438
Count of miRNA genes:231
Interacting mature miRNAs:283
Transcripts:ENSRNOT00000041678
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 18 46 37 19 37 42 29 32 11
Low 25 11 4 4 8 11 32 6 9 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000041678   ⟹   ENSRNOP00000048018
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,641,884 - 19,667,044 (-)Ensembl
Rnor_6.0 Ensembl822,124,560 - 22,150,005 (-)Ensembl
RefSeq Acc Id: NM_001257347   ⟹   NP_001244276
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,641,881 - 19,662,982 (-)NCBI
Rnor_6.0822,124,586 - 22,145,687 (-)NCBI
Rnor_5.0822,180,760 - 22,205,979 (-)NCBI
Celera821,036,299 - 21,057,402 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242585   ⟹   XP_006242647
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,641,881 - 19,667,155 (-)NCBI
Rnor_6.0822,124,586 - 22,149,807 (-)NCBI
Rnor_5.0822,180,760 - 22,205,979 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242586   ⟹   XP_006242648
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,641,881 - 19,667,155 (-)NCBI
Rnor_6.0822,124,586 - 22,149,807 (-)NCBI
Rnor_5.0822,180,760 - 22,205,979 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080645   ⟹   XP_038936573
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,641,881 - 19,666,805 (-)NCBI
RefSeq Acc Id: XM_039080646   ⟹   XP_038936574
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,649,750 - 19,667,157 (-)NCBI
RefSeq Acc Id: XR_001839127
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,641,881 - 19,667,156 (-)NCBI
Rnor_6.0822,128,471 - 22,149,807 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005487734
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,649,366 - 19,667,156 (-)NCBI
RefSeq Acc Id: XR_005487735
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,649,749 - 19,667,156 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001244276   ⟸   NM_001257347
- UniProtKB: D3ZD03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242648   ⟸   XM_006242586
- Peptide Label: isoform X1
- UniProtKB: D3ZD03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242647   ⟸   XM_006242585
- Peptide Label: isoform X1
- UniProtKB: D3ZD03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000048018   ⟸   ENSRNOT00000041678
RefSeq Acc Id: XP_038936573   ⟸   XM_039080645
- Peptide Label: isoform X1
- UniProtKB: D3ZD03 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936574   ⟸   XM_039080646
- Peptide Label: isoform X2
Protein Domains
FERM   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZD03-F1-model_v2 AlphaFold D3ZD03 1-1186 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2320469 AgrOrtholog
BioCyc Gene G2FUF-31438 BioCyc
Ensembl Genes ENSRNOG00000032948 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000048018 ENTREZGENE
  ENSRNOP00000048018.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041678 ENTREZGENE
  ENSRNOT00000041678.6 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_F1 UniProtKB/TrEMBL
  FERM_F2 UniProtKB/TrEMBL
  Jak1_PHL_dom UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak/Tyk2 UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_TYK2_N UniProtKB/TrEMBL
  Tyr_Pkinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:100361294 UniProtKB/TrEMBL
NCBI Gene 100361294 ENTREZGENE
Pfam FERM_F1 UniProtKB/TrEMBL
  FERM_F2 UniProtKB/TrEMBL
  Jak1_Phl UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Tyk2 PhenoGen
PIRSF TyrPK_Jak UniProtKB/TrEMBL
PRINTS JANUSKINASE UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
  YKINASETYK2 UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP FERM_3-hlx UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt D3ZD03 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-03 LOC100361294  tyrosine kinase 2  Tyk2  tyrosine kinase 2  Data Merged 737654 APPROVED
2012-02-03 Tyk2    LOC100361294  tyrosine kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100361294  tyrosine kinase 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Tyk2  tyrosine kinase 2   Tyk2_predicted  tyrosine kinase 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tyk2_predicted  tyrosine kinase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED