STAT3 (signal transducer and activator of transcription 3) - Rat Genome Database

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Gene: STAT3 (signal transducer and activator of transcription 3) Homo sapiens
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Symbol: STAT3
Name: signal transducer and activator of transcription 3
RGD ID: 737517
HGNC Page HGNC
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II repressing transcription factor binding activity; and nucleic acid binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of erythrocyte differentiation; and positive regulation of macromolecule metabolic process. Localizes to chromatin; cytosol; and nucleus. Implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including Churg-Strauss syndrome; cervix uteri carcinoma in situ; chronic lymphocytic leukemia; kidney cancer (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acute-phase response factor; ADMIO; ADMIO1; APRF; DNA-binding protein APRF; FLJ20882; HIES; MGC16063; signal transducer and activator of transcription 3 (acute-phase response factor)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1742,313,324 - 42,388,540 (-)EnsemblGRCh38hg38GRCh38
GRCh381742,313,324 - 42,388,502 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,465,342 - 40,540,460 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,718,869 - 37,794,039 (-)NCBINCBI36hg18NCBI36
Build 341737,718,868 - 37,794,039NCBI
Celera1737,120,227 - 37,194,843 (-)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1736,230,024 - 36,304,785 (-)NCBIHuRef
CHM1_11740,701,045 - 40,776,137 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (EXP)
adenocarcinoma  (EXP)
adenoid cystic carcinoma  (IAGP)
adult T-cell leukemia  (EXP)
Alzheimer's disease  (IDA,ISO)
anaplastic large cell lymphoma  (EXP)
angiomyolipoma  (IEP)
angiosarcoma  (IDA)
Animal Disease Models  (EXP)
Animal Mammary Neoplasms  (EXP)
atherosclerosis  (EXP)
Atrophy  (EXP)
autistic disorder  (ISO)
autoimmune disease  (EXP)
B-lymphoblastic leukemia/lymphoma  (EXP)
bacterial pneumonia  (ISO)
Behcet's disease  (IAGP)
Brain Injuries  (ISO)
brain ischemia  (EXP)
breast cancer  (IAGP,IDA,IMP)
Breast Neoplasms  (EXP)
carcinoma  (EXP)
Cardiomegaly  (EXP)
cardiomyopathy  (EXP,ISO)
cervix uteri carcinoma in situ  (IEP)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis  (EXP)
Chronic Hepatitis C  (IEP)
chronic lymphocytic leukemia  (IEP)
Churg-Strauss syndrome  (IEP)
colon adenocarcinoma  (IEP)
colon cancer  (ISO)
Colonic Neoplasms  (EXP)
colorectal cancer  (ISS)
colorectal carcinoma  (ISO)
congenital diaphragmatic hernia  (EXP)
Copper-Overload Cirrhosis  (EXP)
Crohn's disease  (IAGP)
Diabetic Nephropathies  (ISO)
duodenal ulcer  (ISO)
Endometrial Neoplasms  (IEP)
Epidermal Hyperplasia  (ISO)
Experimental Arthritis  (EXP,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (EXP)
Experimental Neoplasms  (EXP)
Fever  (EXP)
Fibrosis  (EXP)
genetic disease  (IAGP)
head and neck squamous cell carcinoma  (EXP,IMP)
heart disease  (ISO)
hyper IgE recurrent infection syndrome 1  (IAGP)
hyper IgE syndrome  (EXP,IAGP)
Hyperalgesia  (ISO)
hyperuricemia  (ISO)
idiopathic pulmonary fibrosis  (EXP,IEP)
Inflammation  (EXP)
inflammatory bowel disease  (ISS)
irritant dermatitis  (ISO)
juvenile rheumatoid arthritis  (EXP)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (EXP)
lung non-small cell carcinoma  (EXP)
lymphangioleiomyomatosis  (IEP)
Lymphatic Metastasis  (EXP)
lymphoproliferative syndrome  (IAGP)
Mammary Neoplasms, Experimental  (EXP,ISO)
medulloblastoma  (EXP)
Memory Disorders  (EXP)
mental depression  (ISO)
middle cerebral artery infarction  (EXP)
Multisystem Autoimmune Disease, Infantile-Onset, 1  (IAGP)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (IDA)
Neoplasm Metastasis  (EXP,IDA,IEP,IMP)
Neoplastic Cell Transformation  (EXP)
nephroblastoma  (IEP)
neutropenia  (ISO)
Niemann-Pick disease type C1  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
ovarian cancer  (IMP)
Ovarian Neoplasms  (EXP,IEP)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (EXP)
periodontitis  (ISO)
peripartum cardiomyopathy  (ISS)
pre-malignant neoplasm  (EXP,ISO)
primary immunodeficiency disease  (IAGP)
prostate cancer  (IMP)
prostate carcinoma  (IDA,IMP)
Prostatic Neoplasms  (EXP,ISO)
psoriasis  (EXP,IMP,ISO)
psoriatic arthritis  (IAGP)
pulmonary fibrosis  (EXP,ISO)
Pyogenic Granuloma  (IDA)
renal cell carcinoma  (IAGP,IEP)
Reperfusion Injury  (EXP)
Retina Reperfusion Injury  (ISO)
rheumatoid arthritis  (IAGP)
scrapie  (ISO)
Sepsis  (ISO)
Sepsis-Associated Encephalopathy  (ISO)
skin melanoma  (IEP)
Skin Neoplasms  (ISO)
squamous cell carcinoma  (EXP,IDA)
stomach cancer  (IEP)
Stomach Neoplasms  (EXP)
Subarachnoid Hemorrhage  (ISO)
T-cell lymphoblastic leukemia/lymphoma  (EXP)
T-Cell Lymphoma  (EXP)
Tongue Neoplasms  (IDA,IEP)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (EXP)
type 2 diabetes mellitus  (IDA)
ulcerative colitis  (EXP,IAGP)
Uterine Cervical Neoplasms  (EXP,IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(-)-Arctigenin  (EXP,ISO)
(-)-cotinine  (EXP)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-lobeline  (EXP)
(20R)-protopanaxadiol  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(R)-lipoic acid  (EXP)
(R)-mevalonic acid  (EXP,ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1'-azobis(N,N-dimethylformamide)  (EXP)
1,10-phenanthroline  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
1,4-naphthoquinone  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dichloroindophenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-butoxyethanol  (ISO)
2-methoxyethanol  (ISO)
2-methylcholine  (EXP)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP)
5-fluorouracil  (EXP)
5-formyltetrahydrofolic acid  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
aflatoxin B1  (EXP)
Aflatoxin G1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-acitretin  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allopurinol  (ISO)
alpinumisoflavone  (EXP)
alvocidib  (EXP)
AM-251  (EXP,ISO)
amidotrizoic acid  (EXP)
ammonium chloride  (ISO)
amosite asbestos  (ISO)
amphibole asbestos  (ISO)
andrographolide  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antigen  (ISO)
antirheumatic drug  (EXP)
apigenin  (EXP)
aristolochic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
aucubin  (ISO)
auranofin  (EXP)
azathioprine  (EXP)
baicalein  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[e]pyrene  (EXP)
benzoates  (EXP)
benzoic acid  (EXP,ISO)
beraprost  (ISO)
Bergenin  (ISO)
betulinic acid  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
BQ 123  (ISO)
bucladesine  (ISO)
butylated hydroxyanisole  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calyculin a  (EXP)
camostat  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbamazepine  (EXP)
carbofuran  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cefaloridine  (ISO)
celecoxib  (ISO)
ceruletide  (ISO)
cetrorelix  (EXP)
chitin  (EXP)
chloroprene  (ISO)
chromium(6+)  (EXP)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
cladribine  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
columbamine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP,ISO)
corosolic acid  (ISO)
corticosterone  (ISO)
coumestrol  (EXP)
crizotinib  (EXP)
crocin-1  (EXP)
Cryptotanshinone  (EXP)
crystal violet  (EXP)
cucurbitacin B  (ISO)
cucurbitacin I  (EXP,ISO)
curcumin  (EXP,ISO)
cyanidin cation  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytochalasin D  (EXP)
D-glucose  (EXP,ISO)
DDE  (EXP)
DDT  (EXP)
Deguelin  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
diethylstilbestrol  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (EXP)
diisopropyl fluorophosphate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP)
dinitrogen oxide  (EXP,ISO)
dioxygen  (EXP,ISO)
docebenone  (ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (EXP)
emodin  (EXP)
enalapril  (ISO)
endosulfan  (EXP,ISO)
entinostat  (EXP)
enzalutamide  (EXP)
enzyme inhibitor  (ISO)
erlotinib hydrochloride  (EXP)
erythromycin estolate  (ISO)
ethanol  (ISO)
ethosuximide  (ISO)
ethyl methanesulfonate  (EXP)
fisetin  (EXP)
fluorescein 5-isothiocyanate  (ISO)
fluticasone  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
fraxetin  (EXP)
fructose  (ISO)
fulvestrant  (EXP,ISO)
galangin  (EXP)
gefitinib  (EXP,ISO)
gemcitabine  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
Ginkgoic acid  (EXP)
glafenine  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycine betaine  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GSK690693  (EXP)
GW 3965  (ISO)
halothane  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hexadecanoic acid  (EXP)
Hexamethonium  (EXP,ISO)
Honokiol  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroxamic acid  (EXP,ISO)
imiquimod  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (ISO)
Interferon beta-1b  (EXP)
iomeprol  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoliquiritigenin  (ISO)
isoprenaline  (EXP,ISO)
kurarinol  (EXP,ISO)
L-ascorbic acid  (EXP)
L-mimosine  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP)
levofloxacin  (ISO)
linagliptin  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
losartan  (EXP,ISO)
luteolin  (EXP)
LY294002  (EXP)
lycopene  (EXP)
lycorine  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
Manumycin A  (EXP)
maslinic acid  (ISO)
masoprocol  (EXP)
melatonin  (ISO)
melittin  (EXP,ISO)
mercury dichloride  (EXP,ISO)
methapyrilene  (EXP,ISO)
methotrexate  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (EXP)
methylarsonic acid  (EXP)
methyllycaconitine  (EXP,ISO)
methylmercury chloride  (ISO)
Methylthiouracil  (EXP)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
morusin  (EXP)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,IEP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
naringin  (ISO)
nickel atom  (EXP)
niclosamide  (EXP)
nicotine  (EXP,ISO)
nifuroxazide  (ISO)
nitrofen  (ISO)
nitrofurantoin  (EXP,ISO)
nitroglycerin  (ISO)
ochratoxin A  (ISO)
olanzapine  (ISO)
oleanolic acid  (EXP,ISO)
oridonin  (EXP,ISO)
osimertinib  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paroxetine  (EXP)
phenethyl caffeate  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (EXP,ISO)
phenylephrine  (ISO)
phenylpropanolamine  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosphatidic acid  (ISO)
physostigmine  (ISO)
piperine  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP)
platycodin D  (ISO)
poly(I:C)  (ISO)
potassium dichromate  (EXP)
pravastatin  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
propofol  (EXP,ISO)
propranolol  (EXP)
prostaglandin E2  (ISO)
pterostilbene  (EXP,ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
raloxifene  (EXP)
reactive oxygen species  (ISO)