STAT3 (signal transducer and activator of transcription 3) - Rat Genome Database

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Gene: STAT3 (signal transducer and activator of transcription 3) Homo sapiens
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Symbol: STAT3
Name: signal transducer and activator of transcription 3
RGD ID: 737517
HGNC Page HGNC
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and nucleic acid binding activity. Involved in several processes, including cell surface receptor signaling pathway; negative regulation of primary miRNA processing; and regulation of gene expression. Located in chromatin; cytosol; and nucleus. Part of transcription regulator complex. Implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including Churg-Strauss syndrome; cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); kidney cancer (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: acute-phase response factor; ADMIO; ADMIO1; APRF; DNA-binding protein APRF; FLJ20882; HIES; MGC16063; signal transducer and activator of transcription 3 (acute-phase response factor)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,313,324 - 42,388,442 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1742,313,324 - 42,388,540 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,465,342 - 40,540,460 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,718,869 - 37,794,039 (-)NCBINCBI36hg18NCBI36
Build 341737,718,868 - 37,794,039NCBI
Celera1737,120,227 - 37,194,843 (-)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1736,230,024 - 36,304,785 (-)NCBIHuRef
CHM1_11740,701,045 - 40,776,137 (-)NCBICHM1_1
T2T-CHM13v2.01743,169,811 - 43,244,652 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model