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Gene: TYK2 (tyrosine kinase 2) Homo sapiens
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Symbol: TYK2
Name: tyrosine kinase 2
Description: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IMD35; JTK1; non-receptor tyrosine-protein kinase TYK2
Orthologs:
Mus musculus (house mouse) : Tyk2 (tyrosine kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tyk2 (tyrosine kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyk2 (tyrosine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TYK2 (tyrosine kinase 2)
Canis lupus familiaris (dog) : TYK2 (tyrosine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyk2 (tyrosine kinase 2)
Sus scrofa (pig) : TYK2 (tyrosine kinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,350,528 - 10,380,572 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,461,204 - 10,491,248 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,322,209 - 10,352,211 (-)NCBINCBI36hg18NCBI36
Build 341910,322,208 - 10,352,211NCBI
Celera1910,356,496 - 10,385,954 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,041,213 - 10,071,290 (-)NCBIHuRef
CHM1_11910,461,760 - 10,491,969 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on TYK2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316192
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.