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Gene: Stat3 (signal transducer and activator of transcription 3) Mus musculus
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Symbol: Stat3
Name: signal transducer and activator of transcription 3
RGD ID: 69005
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity; and protein kinase binding activity. Involved in several processes, including cellular response to hormone stimulus; neurogenesis; and regulation of nucleobase-containing compound metabolic process. Localizes to several cellular components, including nucleus; plasma membrane; and transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hindlimb long bone. Used to study colorectal cancer; hyper IgE recurrent infection syndrome 1; inflammatory bowel disease; peripartum cardiomyopathy; and psoriasis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1110034C02Rik; A; acute phase response factor; acute-phase response factor; Aprf; AW109958
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,777,632 - 100,830,447 (-)NCBI
GRCm3811100,886,806 - 100,939,594 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,885,098 - 100,939,540 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,748,124 - 100,800,825 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611100,702,900 - 100,755,601 (-)NCBImm8
MGSCv3611101,663,341 - 101,716,042 (-)NCBImm8
Celera11112,235,347 - 112,235,602 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated