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Gene: JAK1 (Janus kinase 1) Homo sapiens
Symbol: JAK1
Name: Janus kinase 1
Description: Exhibits protein phosphatase binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including interleukin-2-mediated signaling pathway; positive regulation of homotypic cell-cell adhesion; and positive regulation of sprouting angiogenesis. Localizes to the cytoplasm and nucleus. Implicated in pancreatic adenocarcinoma. Biomarker of pancreatic ductal adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: JAK-1; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); JTK3; tyrosine-protein kinase JAK1
Mus musculus (house mouse) : Jak1 (Janus kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Jak1 (Janus kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jak1 (Janus kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : JAK1 (Janus kinase 1)
Canis lupus familiaris (dog) : JAK1 (Janus kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jak1 (Janus kinase 1)
Sus scrofa (pig) : JAK1 (Janus kinase 1)
Chlorocebus sabaeus (African green monkey) : JAK1 (Janus kinase 1)
Heterocephalus glaber (naked mole-rat) : Jak1 (Janus kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl164,833,229 - 65,067,754 (-)Ensembl
GRCh38164,833,223 - 65,067,746 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37165,298,906 - 65,432,593 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,071,494 - 65,204,775 (-)NCBINCBI36hg18NCBI36
Build 34165,012,228 - 65,064,007NCBI
Celera163,589,792 - 63,723,086 (-)NCBI
Cytogenetic Map1p31.3NCBI
HuRef163,407,815 - 63,541,120 (-)NCBIHuRef
CHM1_1165,415,253 - 65,649,730 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on JAK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69102
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.