Gene: JAK1 (Janus kinase 1) Homo sapiens
Symbol: JAK1
Name: Janus kinase 1
Description: This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: JAK-1; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); JTK3; OTTHUMP00000010896; tyrosine-protein kinase JAK1
Mus musculus (house mouse) : Jak1 (Janus kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Jak1 (Janus kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jak1 (Janus kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : JAK1 (Janus kinase 1)
Canis lupus familiaris (dog) : JAK1 (Janus kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jak1 (Janus kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38164,833,223 - 65,067,746 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37165,298,906 - 65,432,593 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,071,494 - 65,204,775 (-)NCBINCBI36hg18NCBI36
Build 34165,012,228 - 65,064,007NCBI
Celera163,589,792 - 63,723,086 (-)NCBI
Cytogenetic Map1p31.3NCBI
HuRef163,407,815 - 63,541,120 (-)NCBIHuRef
CHM1_1165,415,253 - 65,649,730 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on JAK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69102
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2018-03-13
Status: ACTIVE