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Gene: Jak3 (Janus kinase 3) Mus musculus
Symbol: Jak3
Name: Janus kinase 3
RGD ID: 10824
Description: Exhibits protein tyrosine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; negative regulation of cytokine production; and regulation of apoptotic process. Predicted to localize to cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; adult T-cell leukemia; juvenile myelomonocytic leukemia; and megakaryocytic leukemia. Orthologous to human JAK3 (Janus kinase 3); PARTICIPATES IN altered Jak-Stat signaling pathway; interleukin-2 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: fae; tyrosine-protein kinase JAK3; wil
Homo sapiens (human) : JAK3 (Janus kinase 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Jak3 (Janus kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jak3 (Janus kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : JAK3 (Janus kinase 3)
Canis lupus familiaris (dog) : JAK3 (Janus kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jak3 (Janus kinase 3)
Sus scrofa (pig) : JAK3 (Janus kinase 3)
Chlorocebus sabaeus (African green monkey) : JAK3 (Janus kinase 3)
Heterocephalus glaber (naked mole-rat) : Jak3 (Janus kinase 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39872,129,027 - 72,143,221 (+)NCBI
GRCm38871,676,383 - 71,690,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,676,296 - 71,690,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,200,473 - 74,214,473 (+)NCBIGRCm37mm9NCBIm37
MGSCv36874,605,563 - 74,619,563 (+)NCBImm8
Celera874,191,138 - 74,205,120 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Jak3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10824
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.