Jak2 (Janus kinase 2) - Rat Genome Database

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Gene: Jak2 (Janus kinase 2) Mus musculus
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Symbol: Jak2
Name: Janus kinase 2
RGD ID: 10823
MGI Page MGI
Description: Enables interleukin-12 receptor binding activity and protein tyrosine kinase activity. Involved in several processes, including hemopoiesis; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to dexamethasone stimulus; and regulation of apoptotic process. Located in caveola and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and musculoskeletal system. Used to study essential thrombocythemia; myelofibrosis; myeloproliferative neoplasm; and polycythemia vera. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI504024; C81284; Fd17; JAK-2; tyrosine-protein kinase JAK2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,229,006 - 29,290,495 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1929,229,228 - 29,290,480 (+)EnsemblGRCm39 Ensembl
GRCm381929,251,803 - 29,313,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,251,828 - 29,313,080 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,326,318 - 29,387,570 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361929,318,452 - 29,377,979 (+)NCBIMGSCv36mm8
Celera1930,028,576 - 30,089,642 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP)
Acute Lymphoblastic Leukemia, with Lymphomatous Features  (ISO)
acute myeloid leukemia  (ISO)
adrenocortical carcinoma  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (IMP)
anemia  (IMP)
ankylosing spondylitis  (ISO)
atherosclerosis  (ISO)
bacterial gastritis  (ISO)
Brain Injuries  (ISO)
Budd-Chiari syndrome  (ISO)
Cachexia  (IEP)
calcinosis  (ISO)
Cancer Pain  (ISO)
chromosome 9p deletion syndrome  (ISO)
chronic myelogenous leukemia, BCR-ABL1 positive  (ISO)
chronic myeloid leukemia  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (ISO)
colorectal carcinoma  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
Diabetic Nephropathies  (ISO)
esophageal carcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
essential thrombocythemia  (IAGP,ISO)
Experimental Arthritis  (IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Colitis  (ISO)
Experimental Liver Cirrhosis  (IDA,ISO)
Experimental Liver Neoplasms  (ISO)
familial erythrocytosis 1  (ISO)
familial erythrocytosis 2  (IMP)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
glucose intolerance  (IMP)
Growth Disorders  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
hepatocellular carcinoma  (IEP,IMP,ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hyperalgesia  (IMP,ISO)
hyperuricemia  (ISO)
Inflammation  (ISO)
Intestinal Reperfusion Injury  (ISO)
leukemia  (ISO)
limited scleroderma  (ISO)
liver cancer  (IEP,IMP)
liver cirrhosis  (IEP)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
lung carcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
mesenteric vascular occlusion  (ISO)
metabolic dysfunction-associated steatohepatitis  (IMP)
metabolic dysfunction-associated steatotic liver disease  (ISO)
myelofibrosis  (IAGP,ISO)
myeloid neoplasm  (ISO)
myeloproliferative neoplasm  (IAGP)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrotic syndrome  (IMP)
Niemann-Pick disease type C1  (IDA)
obesity  (ISO)
polycythemia  (IMP,ISO)
polycythemia vera  (IAGP,ISO)
portal hypertension  (IMP)
Pregnancy Complications  (ISO)
primary biliary cholangitis  (ISO)
primary ovarian insufficiency  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (IMP)
retinal detachment  (ISO)
rheumatoid arthritis  (IMP)
scrapie  (IEP)
Sepsis  (ISO)
Sepsis-Associated Encephalopathy  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
Spontaneous Abortions  (ISO)
steatotic liver disease  (IMP)
stomach cancer  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (IMP)
Thrombocythemia 3  (ISO)
thrombocytosis  (IAGP,ISO)
Thromboembolism  (ISO)
thrombosis  (IAGP)
transient cerebral ischemia  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-ethoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,8-dihydroxycoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
abamectin  (ISO)
acetamide  (ISO)
acetic acid  (ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
aluminium hydroxide  (EXP)
amitrole  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
angiotensin II  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
arecoline  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
auranofin  (ISO)
baicalin  (EXP)
Bardoxolone methyl  (EXP)
baricitinib  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-Elemonic acid  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calciol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
capillarisin  (ISO)
carbon nanotube  (EXP)
ceruletide  (EXP)
chelerythrine  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP)
Cirsimarin  (EXP)
cisplatin  (EXP,ISO)
clomiphene  (ISO)
clothianidin  (ISO)
clozapine  (ISO)
cocaine  (EXP)
coniferyl aldehyde  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (EXP)
corticosterone  (ISO)
coumermycin A1  (EXP)
crocin-1  (ISO)
cucurbitacin I  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
dapagliflozin  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
delphinidin  (ISO)
deoxynivalenol  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (EXP)
divanadium pentaoxide  (ISO)
doxorubicin  (EXP,ISO)
emodin  (ISO)
eriocitrin  (ISO)
erlotinib hydrochloride  (ISO)
estrone  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
fraxetin  (ISO)
fructose  (ISO)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
galaxolide  (ISO)
Ganoderic acid A  (EXP)
genistein  (ISO)
Gingerenone A  (ISO)
Ginkgoic acid  (ISO)
glucose  (ISO)
glutathione  (EXP)
Goe 6976  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
hesperetin  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (ISO)
hexestrol  (ISO)
hispidulin  (ISO)
hydrogen peroxide  (EXP,ISO)
ivermectin  (ISO)
kainic acid  (ISO)
ketamine  (ISO)
L-arginine  (EXP)
lactucin  (EXP)
lapatinib  (ISO)
limonin  (EXP)
linagliptin  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
loliolide  (ISO)
losartan  (ISO)
LY294002  (EXP)
melittin  (ISO)
melphalan  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
mestranol  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP)
Methylthiouracil  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (EXP,ISO)
mitoxantrone  (ISO)
Monobutylphthalate  (EXP)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (EXP)
Nonylphenol  (EXP)
okadaic acid  (ISO)
olanzapine  (ISO)
oleic acid  (ISO)
ozone  (EXP)
pantoprazole  (EXP)
paracetamol  (EXP)
paroxetine  (ISO)
PD123319  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylpropanolamine  (ISO)
PhIP  (ISO)
phosphane  (ISO)
phosphatidic acid  (EXP)
pipoxolan  (EXP)
pirinixic acid  (EXP)
platycodin D  (ISO)
PNU-282987  (ISO)
ponatinib  (ISO)
Ponicidin  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
PRIM-O-GLUCOSYLCIMIFUGIN  (EXP)
progesterone  (ISO)
propofol  (ISO)
pterostilbene  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Rhynchophylline  (ISO)
rotenone  (ISO)
rutin  (ISO)
ruxolitinib  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
S3I-201  (ISO)
Salinomycin  (ISO)
selumetinib  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
Sinomenine  (ISO)
sodium arsenite  (ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (ISO)
stattic  (EXP)
streptozocin  (ISO)
succimer  (EXP)
sulfadimethoxine  (ISO)
sulfasalazine  (EXP)
sulforaphane  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
theobromine  (ISO)
thymoquinone  (EXP,ISO)
Tiron  (ISO)
titanium dioxide  (EXP)
tofacitinib  (ISO)
toosendanin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
tropisetron  (ISO)
tyrphostin B42  (EXP,ISO)
umbelliferone  (ISO)
urethane  (EXP,ISO)
valproic acid  (ISO)
valsartan  (ISO)
verteporfin  (EXP)
vinclozolin  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (IDA)
adaptive immune response  (IEA)
axon regeneration  (ISO,ISS)
cell adhesion  (ISO)
cell differentiation  (IMP)
cell surface receptor signaling pathway via JAK-STAT  (IBA,IDA,IGI,IMP,ISO)
cellular response to dexamethasone stimulus  (IDA)
cellular response to interleukin-3  (IDA)
cellular response to lipopolysaccharide  (IDA)
chromatin remodeling  (IEA)
collagen-activated signaling pathway  (IEA,ISO)
cytokine-mediated signaling pathway  (IBA,IGI,IMP,ISO,TAS)
enzyme-linked receptor protein signaling pathway  (IDA)
erythrocyte differentiation  (IBA,IMP)
erythropoietin-mediated signaling pathway  (IEA)
extrinsic apoptotic signaling pathway  (IDA)
G protein-coupled receptor signaling pathway  (ISO,ISS)
granulocyte-macrophage colony-stimulating factor signaling pathway  (IEA,ISO)
growth hormone receptor signaling pathway  (ISO,ISS)
growth hormone receptor signaling pathway via JAK-STAT  (IBA,IDA,IMP,ISO)
hormone-mediated signaling pathway  (ISO,ISS)
immune response  (NAS)
interleukin-12-mediated signaling pathway  (ISO,ISS)
interleukin-23-mediated signaling pathway  (IEA)
interleukin-3-mediated signaling pathway  (IEA,ISO)
interleukin-5-mediated signaling pathway  (IEA,ISO)
intracellular signal transduction  (IBA,IDA)
intrinsic apoptotic signaling pathway in response to oxidative stress  (ISO,ISS)
mammary gland epithelium development  (IMP)
microglial cell activation  (IGI)
modulation of chemical synaptic transmission  (IEA,ISO)
myeloid cell differentiation  (IMP)
negative regulation of apoptotic process  (IDA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of cell-cell adhesion  (ISO,ISS)
negative regulation of neuron apoptotic process  (IEA,ISO)
nuclear receptor-mediated mineralocorticoid signaling pathway  (ISO,ISS)
peptidyl-tyrosine phosphorylation  (IDA)
platelet-derived growth factor receptor signaling pathway  (ISO,ISS)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (IMP)
positive regulation of cell activation  (ISO,ISS)
positive regulation of cell differentiation  (ISO,ISS)
positive regulation of cell migration  (ISO,ISS)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of cell-substrate adhesion  (ISO,ISS)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of cytosolic calcium ion concentration  (ISO,ISS)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of epithelial cell apoptotic process  (IEA,ISO)
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation  (IEA,ISO)
positive regulation of growth hormone receptor signaling pathway  (IMP)
positive regulation of insulin secretion  (ISO,ISS)
positive regulation of interleukin-1 beta production  (IGI,ISO,ISS)
positive regulation of interleukin-17 production  (NAS)
positive regulation of leukocyte proliferation  (ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of MHC class II biosynthetic process  (IGI)
positive regulation of natural killer cell proliferation  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO,ISS)
positive regulation of nitric-oxide synthase biosynthetic process  (IDA,IGI,ISO)
positive regulation of NK T cell proliferation  (ISO,NAS)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
positive regulation of platelet activation  (IEA,ISO)
positive regulation of platelet aggregation  (IEA,ISO)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of signaling receptor activity  (IGI)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of T cell proliferation  (IDA,ISO)
positive regulation of T-helper 17 type immune response  (NAS)
positive regulation of transcription by RNA polymerase II  (IGI)
positive regulation of tumor necrosis factor production  (IDA,IGI)
positive regulation of type II interferon production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
post-embryonic hemopoiesis  (IMP)
post-translational protein modification  (ISO,ISS)
protein autophosphorylation  (IDA,ISO)
regulation of apoptotic process  (IBA)
regulation of inflammatory response  (ISO,ISS)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of postsynapse to nucleus signaling pathway  (IEA,ISO)
response to amine  (IEA,ISO)
response to antibiotic  (ISO)
response to granulocyte macrophage colony-stimulating factor  (NAS)
response to hydroperoxide  (ISO,ISS)
response to interleukin-12  (ISO,ISS)
response to lipopolysaccharide  (IDA)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO,ISS)
response to tumor necrosis factor  (ISO,ISS)
signal transduction  (IMP)
symbiont-induced defense-related programmed cell death  (IDA)
thrombopoietin-mediated signaling pathway  (ISO)
transcription by RNA polymerase II  (IGI)
tumor necrosis factor-mediated signaling pathway  (ISO,ISS)
type II interferon-mediated signaling pathway  (ISO,ISS)
tyrosine phosphorylation of STAT protein  (IDA,IMP,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood coagulation  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal cell physiology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal embryonic erythropoiesis  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal granulocyte differentiation  (IAGP)
abnormal hematopoietic system physiology  (IAGP)
abnormal iron homeostasis  (IAGP)
abnormal mammary gland development  (IAGP)
abnormal mammary gland growth during lactation  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal megakaryocyte differentiation  (IAGP)
abnormal megakaryocyte morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal protein level  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
abnormal thrombosis  (IAGP)
absent common myeloid progenitor cells  (IAGP)
anemia  (IAGP)
anisocytosis  (IAGP)
decreased B cell number  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating iron level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased corpora lutea number  (IAGP)
decreased embryo size  (IAGP)
decreased erythroblast number  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hematocrit  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased litter size  (IAGP)
decreased mean corpuscular hemoglobin  (IAGP)
decreased mean corpuscular volume  (IAGP)
decreased ovary weight  (IAGP)
decreased ovulation rate  (IAGP)
decreased spleen white pulp amount  (IAGP)
delayed estrous cycle  (IAGP)
delayed female fertility  (IAGP)
delayed sexual maturation  (IAGP)
delayed vaginal opening  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enhanced megakaryocyte emperipolesis  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
giant platelets  (IAGP)
hypochromic microcytic anemia  (IAGP)
impaired hematopoiesis  (IAGP)
increased chronic myelocytic leukemia incidence  (IAGP)
increased erythrocyte cell number  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased granulocyte number  (IAGP)
increased heart rate  (IAGP)
increased hematocrit  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased hemoglobin content  (IAGP)
increased hemolymphoid system tumor incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased lymphocyte cell number  (IAGP)
increased mean platelet volume  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased megakaryocyte progenitor cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased spleen red pulp amount  (IAGP)
increased spleen weight  (IAGP)
lactation failure  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
limb paralysis  (IAGP)
microcytosis  (IAGP)
myelofibrosis  (IAGP)
myeloid hyperplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
pallor  (IAGP)
poikilocytosis  (IAGP)
polychromatophilia  (IAGP)
polycythemia  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prolonged diestrus  (IAGP)
prolonged metestrus  (IAGP)
reduced female fertility  (IAGP)
reticulocytosis  (IAGP)
short proestrus  (IAGP)
small liver  (IAGP)
spleen fibrosis  (IAGP)
tachypnea  (IAGP)
thrombocytosis  (IAGP)
References

References - curated
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98. JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury. Yang Y, etal., J Pineal Res. 2013 Oct;55(3):275-86. doi: 10.1111/jpi.12070. Epub 2013 Jun 25.
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102. JAK2 inhibitor TG101348 overcomes erlotinib-resistance in non-small cell lung carcinoma cells with mutated EGF receptor. Zhang FQ, etal., Oncotarget. 2015 Jun 10;6(16):14329-43. doi: 10.18632/oncotarget.3685.
103. Inhibition of JAK2/STAT3 signaling pathway protects mice from the DDP-induced acute kidney injury in lung cancer. Zhang L, etal., Inflamm Res. 2019 Sep;68(9):751-760. doi: 10.1007/s00011-019-01258-4. Epub 2019 Jun 26.
104. Oxymatrine protects against myocardial injury via inhibition of JAK2/STAT3 signaling in rat septic shock. Zhang M, etal., Mol Med Rep. 2013 Apr;7(4):1293-9. doi: 10.3892/mmr.2013.1315. Epub 2013 Feb 8.
105. Amyloid-beta induces hepatic insulin resistance in vivo via JAK2. Zhang Y, etal., Diabetes. 2013 Apr;62(4):1159-66. doi: 10.2337/db12-0670. Epub 2012 Dec 6.
106. Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats. Zhao JB, etal., Neurosci Lett. 2011 Jul 8;498(2):147-52. Epub 2011 May 10.
107. [Effects of puerarin on expressions of leptin receptor mRNA, phosphorylated Janus kinase 2/phosphorylated signal transducers and activators of transcription 3 proteins in the liver of rats with non-alcoholic fatty liver]. Zheng PY, etal., Zhong Xi Yi Jie He Xue Bao. 2008 Sep;6(9):921-7.
108. Recombinant human erythropoietin attenuates neuronal apoptosis and cognitive defects via JAK2/STAT3 signaling in experimental endotoxemia. Zhou TF and Yu JG, J Surg Res. 2013 Jul;183(1):304-12. doi: 10.1016/j.jss.2012.11.035. Epub 2012 Dec 6.
109. Elevated retinol binding protein 4 levels are associated with atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway. Zhou W, etal., World J Diabetes. 2021 Apr 15;12(4):466-479. doi: 10.4239/wjd.v12.i4.466.
110. SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. Zhu H, etal., Eur J Pharmacol. 2013 Aug 15;714(1-3):23-31. doi: 10.1016/j.ejphar.2013.05.043. Epub 2013 Jun 11.
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