Tyk2 (tyrosine kinase 2) - Rat Genome Database

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Gene: Tyk2 (tyrosine kinase 2) Mus musculus
Analyze
Symbol: Tyk2
Name: tyrosine kinase 2
RGD ID: 1316193
MGI Page MGI
Description: Predicted to enable growth hormone receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and type 1 angiotensin receptor binding activity. Involved in cell population proliferation and positive regulation of T cell proliferation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Used to study obesity. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human TYK2 (tyrosine kinase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: JTK1; non-receptor tyrosine-protein kinase TYK2; tyrosine kinase TYK2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,015,364 - 21,042,689 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,015,364 - 21,042,539 (-)EnsemblGRCm39 Ensembl
GRCm38921,104,068 - 21,131,393 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,104,068 - 21,131,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,908,512 - 20,935,719 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,854,476 - 20,881,612 (-)NCBIMGSCv36mm8
Celera918,372,782 - 18,399,989 (-)NCBICelera
Cytogenetic Map9A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal body temperature homeostasis  (IAGP)
abnormal brown adipose tissue morphology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal fat cell differentiation  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal nitric oxide homeostasis  (IAGP)
abnormal ovary morphology  (IEA)
abnormal pancreas morphology  (IEA)
abnormal response to infection  (IAGP)
abnormal seminal vesicle morphology  (IEA)
abnormal splenocyte physiology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
decreased CD8-positive, CD25-positive alpha-beta T cell number  (IEA)
decreased energy expenditure  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased macrophage nitric oxide production  (IAGP)
decreased plasmacytoid dendritic cell number  (IEA)
decreased susceptibility to induced arthritis  (IAGP)
disorganized mitochondrial cristae  (IAGP)
enlarged spleen  (IEA)
enlarged thymus  (IEA)
impaired adaptive thermogenesis  (IAGP)
impaired glucose tolerance  (IAGP)
increased body weight  (IAGP)
increased cholesterol level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interleukin-12 level  (IAGP)
increased susceptibility to Herpesvirales infection  (IAGP)
increased susceptibility to Herpesvirales infection induced morbidity/mortality  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to Picornaviridae infection induced morbidity/mortality  (IAGP)
increased susceptibility to Riboviria infection  (IAGP)
increased susceptibility to Riboviria infection induced morbidity/mortality  (IAGP)
increased susceptibility to viral infection induced morbidity/mortality  (IAGP)
long tibia  (IEA)
obese  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. Jones SA, etal., J Clin Invest. 2011 Sep 1;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart. Pan J, etal., Circ Res. 1997 Oct;81(4):611-7.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Biology of interleukin-10. Sabat R, etal., Cytokine Growth Factor Rev. 2010 Oct;21(5):331-44. doi: 10.1016/j.cytogfr.2010.09.002. Epub 2010 Nov 5.
Additional References at PubMed
PMID:7893599   PMID:8943050   PMID:9038232   PMID:10330148   PMID:10349636   PMID:11042159   PMID:11070173   PMID:11070174   PMID:11076861   PMID:11114383   PMID:11217851   PMID:11313413  
PMID:11313414   PMID:11437454   PMID:11877284   PMID:12023369   PMID:12391177   PMID:12477932   PMID:12517976   PMID:12554654   PMID:12594853   PMID:12679810   PMID:14500783   PMID:14610273  
PMID:14617019   PMID:14662340   PMID:14768057   PMID:15226272   PMID:15254900   PMID:15488705   PMID:15489334   PMID:15491990   PMID:15578097   PMID:15781341   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:16148148   PMID:16482511   PMID:16601124   PMID:16602821   PMID:16751369   PMID:16982690   PMID:17048270   PMID:17078929   PMID:17372006   PMID:17395783   PMID:17785781  
PMID:17967808   PMID:18082134   PMID:18086385   PMID:18424713   PMID:18593942   PMID:18641345   PMID:18845149   PMID:19088061   PMID:19118004   PMID:19494301   PMID:19502390   PMID:19680139  
PMID:19917699   PMID:20080754   PMID:20338026   PMID:20713887   PMID:21267068   PMID:21408089   PMID:21471442   PMID:21606247   PMID:21757742   PMID:21765170   PMID:21787891   PMID:21864028  
PMID:21873635   PMID:21878673   PMID:22723949   PMID:22995073   PMID:23217260   PMID:23653476   PMID:23836059   PMID:23990909   PMID:24069548   PMID:24345760   PMID:24604832   PMID:24696087  
PMID:24729620   PMID:25057888   PMID:25109392   PMID:25156366   PMID:25849081   PMID:26432894   PMID:26824662   PMID:27802075   PMID:27807284   PMID:28378742   PMID:28668884   PMID:29016674  
PMID:30131584   PMID:30718299   PMID:30740104   PMID:31042082   PMID:32149730   PMID:32929218   PMID:35821088  


Genomics

Comparative Map Data
Tyk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,015,364 - 21,042,689 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,015,364 - 21,042,539 (-)EnsemblGRCm39 Ensembl
GRCm38921,104,068 - 21,131,393 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,104,068 - 21,131,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,908,512 - 20,935,719 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,854,476 - 20,881,612 (-)NCBIMGSCv36mm8
Celera918,372,782 - 18,399,989 (-)NCBICelera
Cytogenetic Map9A3NCBI
TYK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,350,533 - 10,380,572 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1910,350,533 - 10,380,608 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,461,209 - 10,491,248 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,322,209 - 10,352,211 (-)NCBINCBI36Build 36hg18NCBI36
Build 341910,322,208 - 10,352,211NCBI
Celera1910,356,496 - 10,385,954 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,041,213 - 10,071,290 (-)NCBIHuRef
CHM1_11910,461,760 - 10,491,969 (-)NCBICHM1_1
T2T-CHM13v2.01910,476,657 - 10,506,988 (-)NCBIT2T-CHM13v2.0
Tyk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,641,881 - 19,667,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,641,884 - 19,667,044 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,661,293 - 23,682,384 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0821,959,148 - 21,980,237 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0819,871,547 - 19,892,652 (-)NCBIRnor_WKY
Rnor_6.0822,118,224 - 22,149,807 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,124,560 - 22,150,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,180,760 - 22,205,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,096,969 - 20,149,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,128,873 - 20,148,992 (-)NCBI
Celera821,036,299 - 21,057,402 (-)NCBICelera
Cytogenetic Map8q13NCBI
Tyk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,617,999 - 1,636,068 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,618,099 - 1,637,996 (-)NCBIChiLan1.0ChiLan1.0
TYK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11910,565,490 - 10,596,647 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,565,490 - 10,594,541 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0199,901,612 - 9,932,623 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TYK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,747,145 - 50,770,008 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,748,329 - 50,769,216 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,617,718 - 50,639,776 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,269,592 - 51,291,659 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,269,646 - 51,291,659 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,475,504 - 50,497,770 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,904,500 - 50,926,568 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,145,386 - 51,167,670 (+)NCBIUU_Cfam_GSD_1.0
Tyk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,650,169 - 209,673,217 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659681,310 - 702,962 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936659681,463 - 704,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TYK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,157,811 - 69,183,456 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,157,774 - 69,183,555 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,492,135 - 69,517,888 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TYK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,399,945 - 9,420,054 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,399,775 - 9,417,630 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,583,417 - 10,634,844 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tyk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,500,339 - 2,517,694 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,499,811 - 2,518,817 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:397
Count of miRNA genes:303
Interacting mature miRNAs:348
Transcripts:ENSMUST00000001036
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000122211296Mouse
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756237306370Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse

Markers in Region
D9Mit361  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,128,961 - 21,129,069UniSTSGRCm38
MGSCv37920,933,405 - 20,933,513UniSTSGRCm37
Celera918,397,675 - 18,397,783UniSTS
Cytogenetic Map9A3UniSTS
cM Map98.0UniSTS
Whitehead_YAC9 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001205312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_018793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001778942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC163637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF052607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF173032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY902350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000001036   ⟹   ENSMUSP00000001036
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,015,365 - 21,038,642 (-)Ensembl
GRCm38.p6 Ensembl921,104,069 - 21,127,346 (-)Ensembl
RefSeq Acc Id: ENSMUST00000213717
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,015,364 - 21,042,476 (-)Ensembl
GRCm38.p6 Ensembl921,104,068 - 21,131,180 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214454   ⟹   ENSMUSP00000150214
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,015,366 - 21,042,539 (-)Ensembl
GRCm38.p6 Ensembl921,104,070 - 21,131,243 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214615
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,038,736 - 21,042,484 (-)Ensembl
GRCm38.p6 Ensembl921,127,440 - 21,131,188 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214864   ⟹   ENSMUSP00000151194
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,034,755 - 21,042,539 (-)Ensembl
GRCm38.p6 Ensembl921,123,459 - 21,131,243 (-)Ensembl
RefSeq Acc Id: ENSMUST00000216874   ⟹   ENSMUSP00000150354
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,015,366 - 21,042,528 (-)Ensembl
GRCm38.p6 Ensembl921,104,070 - 21,131,232 (-)Ensembl
RefSeq Acc Id: NM_001205312   ⟹   NP_001192241
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,015,364 - 21,042,571 (-)NCBI
GRCm38921,104,068 - 21,131,275 (-)ENTREZGENE
Celera918,372,782 - 18,399,989 (-)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_018793   ⟹   NP_061263
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,015,364 - 21,042,571 (-)NCBI
GRCm38921,104,068 - 21,131,275 (-)ENTREZGENE
MGSCv37920,908,512 - 20,935,719 (-)RGD
Celera918,372,782 - 18,399,989 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510492   ⟹   XP_006510555
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,015,364 - 21,042,556 (-)NCBI
GRCm38921,104,068 - 21,131,260 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006510494   ⟹   XP_006510557
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,022,683 - 21,042,689 (-)NCBI
GRCm38921,111,387 - 21,131,393 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242579   ⟹   XP_011240881
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,015,364 - 21,042,451 (-)NCBI
GRCm38921,104,068 - 21,131,161 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244455   ⟹   XP_030100315
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,015,364 - 21,042,574 (-)NCBI
GRCm38921,104,068 - 21,131,278 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244456   ⟹   XP_030100316
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,015,364 - 21,042,556 (-)NCBI
GRCm38921,104,068 - 21,131,260 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001778942
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,015,364 - 21,042,689 (-)NCBI
GRCm38921,104,068 - 21,131,393 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_061263   ⟸   NM_018793
- Peptide Label: isoform 2
- UniProtKB: Q8VE41 (UniProtKB/Swiss-Prot),   Q9R117 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001192241   ⟸   NM_001205312
- Peptide Label: isoform 1
- UniProtKB: E9QJS1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510555   ⟸   XM_006510492
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006510557   ⟸   XM_006510494
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011240881   ⟸   XM_011242579
- Peptide Label: isoform X1
- UniProtKB: Q8VE41 (UniProtKB/Swiss-Prot),   Q9R117 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030100315   ⟸   XM_030244455
- Peptide Label: isoform X3
RefSeq Acc Id: XP_030100316   ⟸   XM_030244456
- Peptide Label: isoform X4
RefSeq Acc Id: ENSMUSP00000150354   ⟸   ENSMUST00000216874
RefSeq Acc Id: ENSMUSP00000001036   ⟸   ENSMUST00000001036
RefSeq Acc Id: ENSMUSP00000150214   ⟸   ENSMUST00000214454
RefSeq Acc Id: ENSMUSP00000151194   ⟸   ENSMUST00000214864
Protein Domains
FERM   Protein kinase   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R117-F1-model_v2 AlphaFold Q9R117 1-1184 view protein structure

Promoters
RGD ID:6848502
Promoter ID:MM_ACW:49754
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:TYK2.HSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36920,912,051 - 20,912,551 (-)MPROMDB
RGD ID:6848503
Promoter ID:MM_ACW:49755
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:TYK2.ISEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36920,920,236 - 20,920,736 (-)MPROMDB
RGD ID:6845294
Promoter ID:MM_KWN:56548
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000001036,   NM_018793,   UC009OKF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36920,935,576 - 20,936,076 (-)MPROMDB
RGD ID:8668922
Promoter ID:EPDNEW_M12492
Type:initiation region
Name:Tyk2_1
Description:Mus musculus tyrosine kinase 2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38921,131,240 - 21,131,300EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929470 AgrOrtholog
Ensembl Genes ENSMUSG00000032175 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000001036.11 UniProtKB/TrEMBL
  ENSMUSP00000150214 ENTREZGENE
  ENSMUSP00000150214.2 UniProtKB/Swiss-Prot
  ENSMUSP00000150354 ENTREZGENE
  ENSMUSP00000150354.2 UniProtKB/TrEMBL
  ENSMUSP00000151194.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000001036.11 UniProtKB/TrEMBL
  ENSMUST00000213717 ENTREZGENE
  ENSMUST00000214454 ENTREZGENE
  ENSMUST00000214454.2 UniProtKB/Swiss-Prot
  ENSMUST00000214864.2 UniProtKB/TrEMBL
  ENSMUST00000216874 ENTREZGENE
  ENSMUST00000216874.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jak1_PHL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak/Tyk2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_TYK2_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54721 UniProtKB/Swiss-Prot
MGD MGI:1929470 ENTREZGENE
NCBI Gene 54721 ENTREZGENE
PANTHER NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE HOPSCOTCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FERM_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jak1_Phl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tyk2 PhenoGen
PIRSF TyrPK_Jak UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS JANUSKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YKINASETYK2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART B41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SVI6_MOUSE UniProtKB/TrEMBL
  E9QJS1 ENTREZGENE, UniProtKB/TrEMBL
  Q2M4G5_MOUSE UniProtKB/TrEMBL
  Q3TDN4_MOUSE UniProtKB/TrEMBL
  Q3TIS9_MOUSE UniProtKB/TrEMBL
  Q3U447_MOUSE UniProtKB/TrEMBL
  Q8VE41 ENTREZGENE
  Q9R117 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O88431 UniProtKB/Swiss-Prot
  Q3TXE3 UniProtKB/Swiss-Prot
  Q52KQ2 UniProtKB/Swiss-Prot
  Q8VE41 UniProtKB/Swiss-Prot