Stat1 (signal transducer and activator of transcription 1) - Rat Genome Database

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Gene: Stat1 (signal transducer and activator of transcription 1) Mus musculus
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Symbol: Stat1
Name: signal transducer and activator of transcription 1
RGD ID: 732185
MGI Page MGI
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in cell population proliferation; cell surface receptor signaling pathway via JAK-STAT; and defense response to other organism. Acts upstream of or within with a positive effect on positive regulation of apoptotic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; negative regulation of macrophage fusion; and response to exogenous dsRNA. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skeletal musculature. Used to study breast cancer and severe acute respiratory syndrome. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast carcinoma; immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2010005J02Rik; AA408197
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,158,588 - 52,201,024 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,158,599 - 52,201,024 (+)EnsemblGRCm39 Ensembl
GRCm38152,119,438 - 52,161,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl152,119,440 - 52,161,865 (+)EnsemblGRCm38mm10GRCm38
MGSCv37152,176,282 - 52,218,707 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36152,064,002 - 52,105,508 (+)NCBIMGSCv36mm8
Celera152,657,880 - 52,700,334 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
angiomyolipoma  (ISO)
Brain Injuries  (ISO)
breast cancer  (IAGP,ISO)
breast carcinoma  (ISO)
bronchiectasis  (ISO)
chronic mucocutaneous candidiasis  (ISO)
Cognitive Dysfunction  (ISO)
colon adenocarcinoma  (ISO)
combined immunodeficiency  (ISO)
combined T cell and B cell immunodeficiency  (ISO)
COVID-19  (ISO)
Cytomegalovirus Infections  (ISO)
Diarrhea 9  (ISO)
Disease Progression  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (IEP)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
Hearing Loss  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Human Influenza  (ISO)
hypothyroidism  (ISO)
immunodeficiency 31A  (ISO)
immunodeficiency 31B  (ISO)
immunodeficiency 31C  (ISO)
Liver Abscess  (ISO)
liver cirrhosis  (ISO)
lupus nephritis  (ISO)
lymphangioleiomyomatosis  (ISO)
lymphocytic choriomeningitis  (IMP)
Mycobacterium Infections  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
Nervous System Trauma  (ISO)
Neurodevelopmental Disorders  (ISO)
Nontuberculous Mycobacterium Infections  (ISO)
pancreatic adenocarcinoma  (ISO)
periodontitis  (IDA)
primary immunodeficiency disease  (ISO)
prostate adenocarcinoma  (ISO)
pulmonary fibrosis  (ISO)
Reoviridae Infections  (IMP)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
scrapie  (IEP)
Sepsis  (ISO)
severe acute respiratory syndrome  (IAGP)
T-cell acute lymphoblastic leukemia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (EXP)
(+)-catechin  (ISO)
(+)-schisandrin B  (ISO)
(+)-taxifolin  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-Arctigenin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(R)-lipoic acid  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-benzoquinone  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dichloroindophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-nitrofluorene  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-tert-Octylphenol  (ISO)
5,6,7-trimethoxyflavone  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
aconitine  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
amantadine  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amorolfine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antigen  (EXP)
antimonite  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
baricitinib  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (ISO)
busulfan  (ISO)
butenafine  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP,ISO)
Cannabinol  (EXP)
capsaicin  (EXP,ISO)
capsazepine  (EXP)
carbamazepine  (ISO)
CARBENOXOLONE  (ISO)
carbon nanotube  (EXP)
carvedilol  (ISO)
cerium  (ISO)
chlorophyllin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cholesterol  (EXP)
choline  (EXP)
chromium(6+)  (EXP,ISO)
ciguatoxin CTX1B  (EXP)
Cirsimarin  (EXP)
cisplatin  (EXP,ISO)
coniferyl aldehyde  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
daidzein  (EXP)
DDT  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dieldrin  (EXP)
diethyl malate  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimemorfan  (ISO)
dimethylarsinous acid  (ISO)
dinitrogen oxide  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
Evodiamine  (EXP)
fingolimod hydrochloride  (EXP)
flavonoids  (ISO)
flutamide  (EXP,ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furfural  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
geraniol  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
herbimycin  (ISO)
hesperetin  (EXP)
hexachlorobenzene  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
ICI D1694  (ISO)
indometacin  (ISO)
Interferon beta-1b  (ISO)
iopamidol  (ISO)
irinotecan  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoprenaline  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
kaempferol  (EXP)
ketoconazole  (ISO)
L-arginine  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
Luliconazole  (ISO)
lycorine  (EXP)
Mecamylamine  (ISO)
melatonin  (EXP)
mercury dichloride  (ISO)
metam  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
Methylthiouracil  (ISO)
mevalonic acid  (EXP,ISO)
MitoTEMPO  (ISO)
monocrotaline  (ISO)
N'-Nitrosonornicotine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (ISO)
nitric oxide  (EXP)
nitrofurantoin  (ISO)
NORCANTHARIDIN  (EXP)
o-anisidine  (ISO)
ochratoxin A  (EXP)
okadaic acid  (EXP)
oridonin  (ISO)
oroxylin A  (EXP)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
PF-956980  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phosphatidic acid  (EXP)
pipoxolan  (EXP)
pirinixic acid  (EXP)
pitavastatin  (EXP)
pitavastatin(1-)  (EXP)
platycodin D  (ISO)
poly(I:C)  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
protein kinase inhibitor  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resiniferatoxin  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
Ro 41-5253  (ISO)
rotenone  (EXP,ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium chloride  (ISO)
Soman  (ISO)
stattic  (EXP)
sulfates  (ISO)
T-2 toxin  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
taurocholic acid  (ISO)
temozolomide  (ISO)
terbinafine  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (ISO)
thiophenes  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
tofacitinib  (EXP,ISO)
Trachelogenin  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
ursodeoxycholic acid  (ISO)
valsartan  (ISO)
vancomycin  (EXP)
verteporfin  (EXP)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vinyl carbamate  (EXP)
vitamin E  (ISO)
withaferin A  (EXP)
zidovudine  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood circulation  (ISO,ISS)
cell population proliferation  (IGI)
cell surface receptor signaling pathway via JAK-STAT  (IBA,IDA,ISO)
cell surface receptor signaling pathway via STAT  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interferon-beta  (ISO)
cellular response to lipopolysaccharide  (IMP)
cellular response to type II interferon  (ISO)
cytokine-mediated signaling pathway  (IDA,IEA)
defense response  (IBA)
defense response to virus  (IMP,ISO,ISS)
DNA-templated transcription  (IMP)
endothelial cell migration  (ISO)
interleukin-27-mediated signaling pathway  (ISO)
interleukin-7-mediated signaling pathway  (ISO)
interleukin-9-mediated signaling pathway  (ISO)
lipopolysaccharide-mediated signaling pathway  (IDA)
macrophage derived foam cell differentiation  (ISO)
metanephric mesenchymal cell differentiation  (ISS)
metanephric mesenchymal cell proliferation involved in metanephros development  (ISS)
negative regulation by virus of viral protein levels in host cell  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of macrophage fusion  (IMP)
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISS)
negative regulation of metanephric nephron tubule epithelial cell differentiation  (ISS)
negative regulation of transcription by RNA polymerase II  (ISS)
positive regulation of apoptotic process  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of defense response to virus by host  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of erythrocyte differentiation  (ISO,ISS)
positive regulation of interferon-alpha production  (ISO,ISS)
positive regulation of mesenchymal cell proliferation  (ISS)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
regulation of cell population proliferation  (IBA)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (IBA,ISO)
renal tubule development  (ISO)
response to bacterium  (IDA)
response to cAMP  (ISO,ISS)
response to cytokine  (ISO,ISS)
response to exogenous dsRNA  (IDA)
response to hydrogen peroxide  (ISO)
response to interferon-beta  (ISO)
response to lipopolysaccharide  (IDA)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to peptide hormone  (IBA,ISO,ISS)
response to type I interferon  (IDA)
response to type II interferon  (IDA,ISO)
response to xenobiotic stimulus  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)
type I interferon-mediated signaling pathway  (IBA,IMP,ISO)
type II interferon-mediated signaling pathway  (IMP,ISO)

Cellular Component
axon  (ISO,ISS)
chromatin  (ISO)
cytoplasm  (IBA,IDA,IEA,ISO)
cytosol  (ISO,TAS)
dendrite  (ISO,ISS)
ISGF3 complex  (IBA,ISO)
nucleolus  (ISO)
nucleoplasm  (ISO,TAS)
nucleus  (IBA,IDA,IEA,ISO)
perinuclear region of cytoplasm  (ISO)
protein-containing complex  (ISO)
RNA polymerase II transcription regulator complex  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive T cell differentiation  (IEA)
abnormal CD8-positive, alpha-beta T cell differentiation  (IEA)
abnormal CD8-positive, naive alpha-beta T cell number  (IEA)
abnormal cell cycle  (IAGP)
abnormal cell physiology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal gait  (IEA)
abnormal inflammatory response  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal MHC II cell surface expression on macrophages  (IAGP)
abnormal nitric oxide homeostasis  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal redox activity  (IAGP)
abnormal response to infection  (IEA)
abnormal susceptibility to infection induced morbidity/mortality  (IAGP)
abnormal T cell activation  (IEA)
abnormal T cell differentiation  (IEA)
abnormal T-helper 2 physiology  (IEA)
abnormal tibia morphology  (IAGP)
ataxia  (IAGP)
bronchiolitis  (IAGP)
colitis  (IAGP)
decreased B cell number  (IEA)
decreased B-1 B cell number  (IEA)
decreased body size  (IAGP)
decreased bone mineral content  (IEA)
decreased CD8-positive, alpha-beta T cell number  (IEA)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased circulating alkaline phosphatase level  (IEA)
decreased circulating interferon-gamma level  (IAGP)
decreased cytotoxic T cell cytolysis  (IEA)
decreased hepatocyte apoptosis  (IAGP)
decreased interferon-gamma secretion  (IEA)
decreased interleukin-1 beta secretion  (IAGP)
decreased level of surface class I molecules  (IAGP)
decreased lymphocyte cell number  (IEA)
decreased mean corpuscular hemoglobin  (IEA)
decreased mean corpuscular volume  (IEA)
decreased NK cell degranulation  (IEA)
decreased NK cell number  (IEA)
decreased sensitivity to induced cell death  (IAGP)
decreased single-positive T cell number  (IEA)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to neuronal excitotoxicity  (IAGP)
decreased tumor latency  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IEA)
impaired natural killer cell mediated cytotoxicity  (IAGP)
impaired righting response  (IEA)
increased activated T cell number  (IAGP)
increased basophil cell number  (IEA)
increased bone mass  (IAGP)
increased bone resorption  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-12b level  (IAGP)
increased compact bone thickness  (IAGP)
increased compact bone volume  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased eosinophil cell number  (IEA)
increased gastrointestinal tumor incidence  (IAGP)
increased IgG level  (IEA)
increased interferon-gamma secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased large unstained cell number  (IEA)
increased leukocyte cell number  (IEA)
increased lymphocyte cell number  (IEA)
increased macrophage nitric oxide production  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased monocyte cell number  (IEA)
increased myocardial infarct size  (IAGP)
increased neutrophil cell number  (IEA)
increased NK T cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to Coronaviridae infection  (IAGP)
increased susceptibility to Coronaviridae infection induced morbidity/mortality  (IAGP)
increased susceptibility to Herpesvirales infection  (IAGP)
increased susceptibility to Riboviria infection  (IAGP)
increased susceptibility to Togaviridae infection  (IAGP)
increased T cell number  (IEA)
increased trabecular bone volume  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
internal hemorrhage  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
liver inflammation  (IAGP)
lung hemorrhage  (IAGP)
lung inflammation  (IAGP)
multifocal hepatic necrosis  (IAGP)
no abnormal phenotype detected  (IAGP)
peritoneal inflammation  (IAGP)
pleuritis  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
pulmonary edema  (IAGP)
pulmonary necrosis  (IAGP)
small intestine hemorrhage  (IAGP)
thymus atrophy  (IAGP)
tremors  (IAGP)
tumor regression  (IAGP)
ulcerated autopod  (IAGP)
References

References - curated
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21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
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24. Mouse MP Annotation Import Pipeline RGD automated import pipeline
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Additional References at PubMed
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PMID:28673932   PMID:28712289   PMID:28713870   PMID:28716119   PMID:28723692   PMID:28723893   PMID:28751937   PMID:28758191   PMID:28763036   PMID:28774347   PMID:28901399   PMID:28904127  
PMID:28924035   PMID:28965604   PMID:28986419   PMID:29016674   PMID:29089636   PMID:29113698   PMID:29118089   PMID:29196213   PMID:29239838   PMID:29242538   PMID:29268096   PMID:29287229  
PMID:29358280   PMID:29364866   PMID:29374078   PMID:29419930   PMID:29562202   PMID:29562203   PMID:29572810   PMID:29581513   PMID:29596938   PMID:29728568   PMID:29746256   PMID:29750958  
PMID:29753791   PMID:29771971   PMID:29907599   PMID:29950673   PMID:29968354   PMID:30018336   PMID:30066904   PMID:30082830   PMID:30131424   PMID:30134157   PMID:30173917   PMID:30196744  
PMID:30209176   PMID:30214448   PMID:30392829   PMID:30403164   PMID:30423296   PMID:30454647   PMID:30487288   PMID:30538296   PMID:30555556   PMID:30574148   PMID:30685387   PMID:30718218  
PMID:30745322   PMID:30759395   PMID:30796216   PMID:30804041   PMID:30811989   PMID:30814285   PMID:30890796   PMID:31085626   PMID:31103381   PMID:31121156   PMID:31123310   PMID:31160588  
PMID:31182817   PMID:31237385   PMID:31315996   PMID:31329638   PMID:31337338   PMID:31346084   PMID:31350176   PMID:31352002   PMID:31358656   PMID:31408005   PMID:31441125   PMID:31467427  
PMID:31603920   PMID:31619669   PMID:31658997   PMID:31702021   PMID:31722208   PMID:31730616   PMID:31759408   PMID:31825834   PMID:31838787   PMID:31867619   PMID:31872076   PMID:31900342  
PMID:31924792   PMID:31943786   PMID:31948748   PMID:32045471   PMID:32075740   PMID:32094187   PMID:32102981   PMID:32123171   PMID:32152071   PMID:32171527   PMID:32175700   PMID:32182218  
PMID:32188878   PMID:32193462   PMID:32205422   PMID:32248017   PMID:32251490   PMID:32253245   PMID:32270034   PMID:32292786   PMID:32295905   PMID:32296043   PMID:32310998   PMID:32325033  
PMID:32373120   PMID:32428860   PMID:32438398   PMID:32444775   PMID:32461239   PMID:32522833   PMID:32544092   PMID:32553273   PMID:32569771   PMID:32607866   PMID:32631901   PMID:32643603  
PMID:32668198   PMID:32673428   PMID:32690660   PMID:32814877   PMID:32820248   PMID:32860934   PMID:32861799   PMID:32893965   PMID:32932915   PMID:32940605   PMID:32941182   PMID:32958258  
PMID:32991625   PMID:32994273   PMID:33042133   PMID:33069812   PMID:33140051   PMID:33153718   PMID:33177207   PMID:33278357   PMID:33283645   PMID:33323395   PMID:33326784   PMID:33377257  
PMID:33448153   PMID:33472080   PMID:33479228   PMID:33529176   PMID:33601053   PMID:33603753   PMID:33705489   PMID:33770504   PMID:33798037   PMID:33893096   PMID:33984198   PMID:33994863  
PMID:34010595   PMID:34077751   PMID:34124936   PMID:34132573   PMID:34161765   PMID:34168143   PMID:34183650   PMID:34299314   PMID:34345994   PMID:34360789   PMID:34361560   PMID:34365659  
PMID:34373574   PMID:34378531   PMID:34449772   PMID:34497340   PMID:34559306   PMID:34569651   PMID:34653236   PMID:34738614   PMID:34750455   PMID:34755542   PMID:34794531   PMID:34795671  
PMID:34825733   PMID:34830340   PMID:34903043   PMID:34929174   PMID:35137688   PMID:35143611   PMID:35148827   PMID:35173036   PMID:35182467   PMID:35196085   PMID:35196494   PMID:35298836  
PMID:35443177   PMID:35456913   PMID:35470850   PMID:35493520   PMID:35523139   PMID:35584177   PMID:35587373   PMID:35605008   PMID:35637282   PMID:35642851   PMID:35748767   PMID:35767701  
PMID:35968944   PMID:35985835   PMID:36067217   PMID:36150390   PMID:36300763   PMID:36321760   PMID:36323311   PMID:36351394   PMID:36374433   PMID:36449607   PMID:36459790   PMID:36541061  
PMID:36715504   PMID:36735791   PMID:36802427   PMID:36868479   PMID:36923955   PMID:36961447   PMID:36997128   PMID:37022164   PMID:37080331   PMID:37083328   PMID:37092726   PMID:37153622  
PMID:37188813   PMID:37211384   PMID:37248241   PMID:37275873   PMID:37277650   PMID:37327784   PMID:37334380   PMID:37360690   PMID:37406138   PMID:37516843   PMID:37524226   PMID:37550517  
PMID:37556887   PMID:37559725   PMID:37611494   PMID:37663126   PMID:37699392   PMID:37749080   PMID:37777550   PMID:37820603   PMID:37824022   PMID:37848036   PMID:37850815   PMID:37935566  
PMID:38113852   PMID:38136633   PMID:38167862   PMID:38172698   PMID:38289252   PMID:38295788   PMID:38351096   PMID:38355793   PMID:38395995   PMID:38509096   PMID:38658806   PMID:38701091  
PMID:38715061   PMID:38718306   PMID:38743761   PMID:38750107   PMID:38812060   PMID:38926347   PMID:38981367   PMID:38992114   PMID:39002130   PMID:39058762   PMID:39134684   PMID:39196893  
PMID:39328932   PMID:39415015   PMID:39419029   PMID:39477971   PMID:39500322   PMID:39521937   PMID:39547518  


Genomics

Comparative Map Data
Stat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,158,588 - 52,201,024 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,158,599 - 52,201,024 (+)EnsemblGRCm39 Ensembl
GRCm38152,119,438 - 52,161,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl152,119,440 - 52,161,865 (+)EnsemblGRCm38mm10GRCm38
MGSCv37152,176,282 - 52,218,707 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36152,064,002 - 52,105,508 (+)NCBIMGSCv36mm8
Celera152,657,880 - 52,700,334 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.81NCBI
STAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,969,149 - 191,014,171 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2190,908,460 - 191,020,960 (-)EnsemblGRCh38hg38GRCh38
GRCh372191,833,875 - 191,878,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,542,121 - 191,587,181 (-)NCBINCBI36Build 36hg18NCBI36
Build 342191,665,769 - 191,704,442NCBI
Celera2185,428,361 - 185,473,577 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2183,693,413 - 183,738,626 (-)NCBIHuRef
CHM1_12191,839,599 - 191,884,801 (-)NCBICHM1_1
T2T-CHM13v2.02191,458,256 - 191,503,284 (-)NCBIT2T-CHM13v2.0
Stat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,911,522 - 56,951,926 (-)NCBIGRCr8
mRatBN7.2949,419,561 - 49,459,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,419,340 - 49,588,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx957,969,129 - 58,009,299 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,091,965 - 63,132,135 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,387,952 - 61,428,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,287,540 - 54,327,958 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,287,541 - 54,484,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0953,998,204 - 54,038,463 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,455,635 - 46,497,560 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,458,584 - 46,495,612 (-)NCBI
Celera947,082,882 - 47,123,002 (-)NCBICelera
Cytogenetic Map9q22NCBI
Stat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,156,660 - 8,194,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,156,660 - 8,192,018 (+)NCBIChiLan1.0ChiLan1.0
STAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21393,651,032 - 93,700,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B93,666,016 - 93,711,687 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B78,270,642 - 78,316,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B196,186,906 - 196,232,280 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,186,906 - 196,232,280 (-)Ensemblpanpan1.1panPan2
STAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,513,438 - 1,549,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,507,219 - 1,550,178 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,461,622 - 2,502,035 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0371,400,933 - 1,441,368 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,395,727 - 1,441,301 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1371,410,525 - 1,450,952 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,378,532 - 1,418,954 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,407,084 - 1,447,502 (-)NCBIUU_Cfam_GSD_1.0
Stat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303149,602,218 - 149,641,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,196,797 - 7,233,756 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,196,860 - 7,235,854 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1595,593,211 - 95,646,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11595,593,201 - 95,646,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
STAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11076,492,859 - 76,537,689 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1076,492,533 - 76,533,393 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040122,939,721 - 122,984,472 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,067,535 - 5,102,106 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248545,067,578 - 5,106,052 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stat1
2475 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:820
Count of miRNA genes:496
Interacting mature miRNAs:585
Transcripts:ENSMUST00000070968
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14086800867270256Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
1301073Orch5_mautoimmune orchitis resistance 5 (mouse)Not determined11906535153065454Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14086800867270256Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14541777372975057Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
12880407V125Dq2_mvitamin D active form serum level QTL 2 (mouse)11933908153339081Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5196402570406589Mouse
12880409V125Dq1_mvitamin D active form serum level QTL 1 (mouse)12603916060039160Mouse
4142433Hbnr1_mHeligmosomoides bakeri nematode resistance 1 (mouse)Not determined2555019158273271Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
12879917Shm3_msperm head morphology 3 (mouse)14418690462946882Mouse
1301240Sluc15_msusceptibility to lung cancer 15 (mouse)Not determined11906535153065454Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
1301756Pgia1_mproteoglycan induced arthritis 1 (mouse)Not determined11906535153065454Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14086800867270256Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse

Markers in Region
RH124684  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38152,155,004 - 52,155,187UniSTSGRCm38
MGSCv37152,211,848 - 52,212,031UniSTSGRCm37
Celera152,693,475 - 52,693,658UniSTS
Cytogenetic Map1C1.1UniSTS
Stat1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38152,155,003 - 52,156,055UniSTSGRCm38
MGSCv37152,211,847 - 52,212,899UniSTSGRCm37
Celera152,693,474 - 52,694,526UniSTS
Cytogenetic Map1C1.1UniSTS
cM Map125.9UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001205313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001205314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003954297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003954298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF349678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX513160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U06924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U80267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000070968   ⟹   ENSMUSP00000066743
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,158,614 - 52,201,024 (+)Ensembl
GRCm38.p6 Ensembl152,119,455 - 52,161,865 (+)Ensembl
Ensembl Acc Id: ENSMUST00000185743
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,158,731 - 52,177,011 (+)Ensembl
GRCm38.p6 Ensembl152,119,572 - 52,137,852 (+)Ensembl
Ensembl Acc Id: ENSMUST00000186057   ⟹   ENSMUSP00000141132
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,158,783 - 52,199,889 (+)Ensembl
GRCm38.p6 Ensembl152,119,624 - 52,160,730 (+)Ensembl
Ensembl Acc Id: ENSMUST00000186186
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,158,718 - 52,159,553 (+)Ensembl
GRCm38.p6 Ensembl152,119,559 - 52,120,394 (+)Ensembl
Ensembl Acc Id: ENSMUST00000186574   ⟹   ENSMUSP00000140518
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,158,599 - 52,194,571 (+)Ensembl
GRCm38.p6 Ensembl152,119,440 - 52,155,412 (+)Ensembl
Ensembl Acc Id: ENSMUST00000186857   ⟹   ENSMUSP00000140875
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,158,651 - 52,200,166 (+)Ensembl
GRCm38.p6 Ensembl152,119,492 - 52,161,007 (+)Ensembl
Ensembl Acc Id: ENSMUST00000188681   ⟹   ENSMUSP00000141144
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,158,657 - 52,171,792 (+)Ensembl
GRCm38.p6 Ensembl152,119,498 - 52,132,633 (+)Ensembl
Ensembl Acc Id: ENSMUST00000189075
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,189,263 - 52,191,558 (+)Ensembl
GRCm38.p6 Ensembl152,150,104 - 52,152,399 (+)Ensembl
Ensembl Acc Id: ENSMUST00000189244   ⟹   ENSMUSP00000140482
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,189,417 - 52,201,022 (+)Ensembl
GRCm38.p6 Ensembl152,150,258 - 52,161,863 (+)Ensembl
Ensembl Acc Id: ENSMUST00000189336   ⟹   ENSMUSP00000140643
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,191,412 - 52,198,719 (+)Ensembl
GRCm38.p6 Ensembl152,152,253 - 52,159,560 (+)Ensembl
Ensembl Acc Id: ENSMUST00000189347   ⟹   ENSMUSP00000141125
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,158,708 - 52,194,490 (+)Ensembl
GRCm38.p6 Ensembl152,119,549 - 52,155,331 (+)Ensembl
Ensembl Acc Id: ENSMUST00000191435   ⟹   ENSMUSP00000139746
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,158,649 - 52,194,571 (+)Ensembl
GRCm38.p6 Ensembl152,119,490 - 52,155,412 (+)Ensembl
RefSeq Acc Id: NM_001205313   ⟹   NP_001192242
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,158,781 - 52,201,024 (+)NCBI
GRCm38152,119,622 - 52,161,865 (+)NCBI
Celera152,657,880 - 52,700,336 (+)ENTREZGENE
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001205314   ⟹   NP_001192243
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,158,597 - 52,201,024 (+)NCBI
GRCm38152,119,438 - 52,161,865 (+)ENTREZGENE
Celera152,657,880 - 52,700,336 (+)ENTREZGENE
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001357627   ⟹   NP_001344556
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,158,597 - 52,201,024 (+)NCBI
GRCm38152,119,438 - 52,161,865 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009283   ⟹   NP_033309
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,158,597 - 52,201,024 (+)NCBI
GRCm38152,119,438 - 52,161,865 (+)ENTREZGENE
MGSCv37152,176,282 - 52,218,707 (+)RGD
Celera152,657,880 - 52,700,336 (+)ENTREZGENE
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017319463   ⟹   XP_017174952
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,158,601 - 52,200,082 (+)NCBI
GRCm38152,119,441 - 52,160,923 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017319464   ⟹   XP_017174953
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,158,781 - 52,200,082 (+)NCBI
GRCm38152,119,617 - 52,160,923 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030252467   ⟹   XP_030108327
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,158,636 - 52,200,082 (+)NCBI
GRCm38152,119,490 - 52,160,923 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036163078   ⟹   XP_036018971
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,158,588 - 52,194,571 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003954297
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,158,588 - 52,194,571 (+)NCBI
GRCm38152,119,442 - 52,155,094 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003954298
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,158,601 - 52,193,040 (+)NCBI
GRCm38152,119,490 - 52,153,881 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001192242 (Get FASTA)   NCBI Sequence Viewer  
  NP_001192243 (Get FASTA)   NCBI Sequence Viewer  
  NP_001344556 (Get FASTA)   NCBI Sequence Viewer  
  NP_033309 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174952 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174953 (Get FASTA)   NCBI Sequence Viewer  
  XP_030108327 (Get FASTA)   NCBI Sequence Viewer  
  XP_036018971 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19454 (Get FASTA)   NCBI Sequence Viewer  
  AAH04808 (Get FASTA)   NCBI Sequence Viewer  
  AAH42551 (Get FASTA)   NCBI Sequence Viewer  
  AAK48844 (Get FASTA)   NCBI Sequence Viewer  
  BAB31265 (Get FASTA)   NCBI Sequence Viewer  
  BAC30355 (Get FASTA)   NCBI Sequence Viewer  
  BAC32766 (Get FASTA)   NCBI Sequence Viewer  
  BAC38579 (Get FASTA)   NCBI Sequence Viewer  
  BAC39293 (Get FASTA)   NCBI Sequence Viewer  
  BAE34017 (Get FASTA)   NCBI Sequence Viewer  
  BAE35456 (Get FASTA)   NCBI Sequence Viewer  
  BAE43313 (Get FASTA)   NCBI Sequence Viewer  
  BAE43314 (Get FASTA)   NCBI Sequence Viewer  
  EDK99964 (Get FASTA)   NCBI Sequence Viewer  
  EDK99965 (Get FASTA)   NCBI Sequence Viewer  
  EDK99966 (Get FASTA)   NCBI Sequence Viewer  
  EDK99967 (Get FASTA)   NCBI Sequence Viewer  
  EDK99968 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000066743
  ENSMUSP00000066743.8
  ENSMUSP00000139746.2
  ENSMUSP00000140482.2
  ENSMUSP00000140518
  ENSMUSP00000140518.2
  ENSMUSP00000140643.2
  ENSMUSP00000140875
  ENSMUSP00000140875.2
  ENSMUSP00000141125.2
  ENSMUSP00000141132
  ENSMUSP00000141132.2
  ENSMUSP00000141144.2
GenBank Protein P42225 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033309   ⟸   NM_009283
- Peptide Label: isoform 2
- UniProtKB: Q8C3V4 (UniProtKB/TrEMBL),   E9QK78 (UniProtKB/TrEMBL),   Q3TW11 (UniProtKB/TrEMBL),   Q9D323 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001192243   ⟸   NM_001205314
- Peptide Label: isoform 2
- UniProtKB: Q8C3V4 (UniProtKB/TrEMBL),   E9QK78 (UniProtKB/TrEMBL),   Q3TW11 (UniProtKB/TrEMBL),   Q9D323 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001192242   ⟸   NM_001205313
- Peptide Label: isoform 1
- UniProtKB: A0A087WSP5 (UniProtKB/TrEMBL),   Q8C8M3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017174953   ⟸   XM_017319464
- Peptide Label: isoform X1
- UniProtKB: Q8C3V4 (UniProtKB/TrEMBL),   E9QK78 (UniProtKB/TrEMBL),   Q3TW11 (UniProtKB/TrEMBL),   Q9D323 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017174952   ⟸   XM_017319463
- Peptide Label: isoform X1
- UniProtKB: Q8C3V4 (UniProtKB/TrEMBL),   E9QK78 (UniProtKB/TrEMBL),   Q3TW11 (UniProtKB/TrEMBL),   Q9D323 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001344556   ⟸   NM_001357627
- Peptide Label: isoform 2
- UniProtKB: E9QK78 (UniProtKB/TrEMBL),   Q8C3V4 (UniProtKB/TrEMBL),   Q3TW11 (UniProtKB/TrEMBL),   Q9D323 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030108327   ⟸   XM_030252467
- Peptide Label: isoform X1
- UniProtKB: E9QK78 (UniProtKB/TrEMBL),   Q8C3V4 (UniProtKB/TrEMBL),   Q3TW11 (UniProtKB/TrEMBL),   Q9D323 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000066743   ⟸   ENSMUST00000070968
Ensembl Acc Id: ENSMUSP00000140518   ⟸   ENSMUST00000186574
Ensembl Acc Id: ENSMUSP00000140875   ⟸   ENSMUST00000186857
Ensembl Acc Id: ENSMUSP00000139746   ⟸   ENSMUST00000191435
Ensembl Acc Id: ENSMUSP00000141132   ⟸   ENSMUST00000186057
Ensembl Acc Id: ENSMUSP00000141144   ⟸   ENSMUST00000188681
Ensembl Acc Id: ENSMUSP00000140482   ⟸   ENSMUST00000189244
Ensembl Acc Id: ENSMUSP00000141125   ⟸   ENSMUST00000189347
Ensembl Acc Id: ENSMUSP00000140643   ⟸   ENSMUST00000189336
RefSeq Acc Id: XP_036018971   ⟸   XM_036163078
- Peptide Label: isoform X2
- UniProtKB: Q99K94 (UniProtKB/TrEMBL),   Q3TW11 (UniProtKB/TrEMBL),   Q8C497 (UniProtKB/TrEMBL),   Q9D323 (UniProtKB/TrEMBL)
Protein Domains
SH2   STAT transcription factor protein interaction

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42225-F1-model_v2 AlphaFold P42225 1-749 view protein structure

Promoters
RGD ID:6873670
Promoter ID:EPDNEW_M286
Type:initiation region
Name:Stat1_1
Description:Mus musculus signal transducer and activator of transcription1 , transcript variant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38152,119,490 - 52,119,550EPDNEW
RGD ID:6818547
Promoter ID:MM_KWN:694
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000070968,   NM_009283,   UC007AXY.1,   UC007AXZ.1,   UC007AYB.1,   UC007AYC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36152,175,446 - 52,176,777 (+)MPROMDB
RGD ID:6848967
Promoter ID:MM_XEF:114
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:NM_001012914,   NM_001079467,   NM_001088787,   NM_001123654,   NM_001124707,   NM_001124746,   NM_001133211,   NM_001141285,   NM_001166203,   NM_007315,   NM_131480,   NM_139266,   NM_213769
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36152,179,446 - 52,180,052 (+)MPROMDB
RGD ID:6818548
Promoter ID:MM_KWN:695
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:UC007AYD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36152,200,099 - 52,200,599 (+)MPROMDB
RGD ID:6818543
Promoter ID:MM_KWN:696
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000087717
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36152,206,346 - 52,207,052 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103063 AgrOrtholog
Ensembl Genes ENSMUSG00000026104 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000070968 ENTREZGENE
  ENSMUST00000070968.14 UniProtKB/TrEMBL
  ENSMUST00000186057 ENTREZGENE
  ENSMUST00000186057.7 UniProtKB/TrEMBL
  ENSMUST00000186574 ENTREZGENE
  ENSMUST00000186574.7 UniProtKB/TrEMBL
  ENSMUST00000186857 ENTREZGENE
  ENSMUST00000186857.7 UniProtKB/TrEMBL
  ENSMUST00000188681.7 UniProtKB/TrEMBL
  ENSMUST00000189244.7 UniProtKB/TrEMBL
  ENSMUST00000189336.2 UniProtKB/TrEMBL
  ENSMUST00000189347.7 UniProtKB/TrEMBL
  ENSMUST00000191435.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.3310 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT1_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT1_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT1_TAZ2-bd_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_linker UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20846 UniProtKB/TrEMBL
MGD MGI:103063 ENTREZGENE
NCBI Gene 20846 ENTREZGENE
PANTHER PTHR11801 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT1_TAZ2bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_linker UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB STAT1 RGD
PhenoGen Stat1 PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48092 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WRI1_MOUSE UniProtKB/TrEMBL
  A0A087WSP5 ENTREZGENE, UniProtKB/TrEMBL
  A0A087WSQ5_MOUSE UniProtKB/TrEMBL
  E9QK78 ENTREZGENE
  P42225 ENTREZGENE
  Q3TW11 ENTREZGENE, UniProtKB/TrEMBL
  Q8C3V4 ENTREZGENE, UniProtKB/TrEMBL
  Q8C497 ENTREZGENE, UniProtKB/TrEMBL
  Q8C8M3 ENTREZGENE, UniProtKB/TrEMBL
  Q8CFQ1_MOUSE UniProtKB/TrEMBL
  Q91Y52_MOUSE UniProtKB/TrEMBL
  Q99K94 ENTREZGENE, UniProtKB/TrEMBL
  Q9D323 ENTREZGENE, UniProtKB/TrEMBL
  STAT1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary E9QK78 UniProtKB/TrEMBL