STAT1 (signal transducer and activator of transcription 1) - Rat Genome Database

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Gene: STAT1 (signal transducer and activator of transcription 1) Pan paniscus
Analyze
Symbol: STAT1
Name: signal transducer and activator of transcription 1
RGD ID: 12041039
Description: ENCODES a protein that exhibits CCR5 chemokine receptor binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN blood circulation (ortholog); cell population proliferation (ortholog); cell surface receptor signaling pathway via JAK-STAT (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH angiomyolipoma (ortholog); Brain Injuries (ortholog); breast cancer (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: signal transducer and activator of transcription 1-alpha/beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21393,651,032 - 93,700,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B93,666,016 - 93,711,687 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B78,270,642 - 78,316,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B196,186,906 - 196,232,280 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,186,906 - 196,232,280 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
angiomyolipoma  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
bronchiectasis  (ISO)
chronic mucocutaneous candidiasis  (ISO)
Cognitive Dysfunction  (ISO)
colon adenocarcinoma  (ISO)
combined immunodeficiency  (ISO)
combined T cell and B cell immunodeficiency  (ISO)
COVID-19  (ISO)
Cytomegalovirus Infections  (ISO)
Diarrhea 9  (ISO)
disease by infectious agent  (ISO)
Disease Progression  (ISO)
Dwarfism  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Failure to Thrive  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
Hearing Loss  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Human Influenza  (ISO)
hypothyroidism  (ISO)
immunodeficiency 31A  (ISO)
immunodeficiency 31B  (ISO)
immunodeficiency 31C  (ISO)
Liver Abscess  (ISO)
liver cirrhosis  (ISO)
lupus nephritis  (ISO)
lymphangioleiomyomatosis  (ISO)
lymphocytic choriomeningitis  (ISO)
Mycobacterium Infections  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
Nervous System Trauma  (ISO)
Neurodevelopmental Disorders  (ISO)
Nontuberculous Mycobacterium Infections  (ISO)
pancreatic adenocarcinoma  (ISO)
periodontitis  (ISO)
primary immunodeficiency disease  (ISO)
prostate adenocarcinoma  (ISO)
pulmonary fibrosis  (ISO)
Reoviridae Infections  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
scrapie  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood circulation  (ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (IEA,ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interferon-beta  (IEA)
cellular response to lipopolysaccharide  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to type II interferon  (IEA)
cytokine-mediated signaling pathway  (IEA,ISO)
defense response to virus  (IEA)
DNA-templated transcription  (ISO)
endothelial cell migration  (ISO)
interleukin-27-mediated signaling pathway  (IEA)
interleukin-7-mediated signaling pathway  (IEA)
interleukin-9-mediated signaling pathway  (IEA)
lipopolysaccharide-mediated signaling pathway  (ISO)
negative regulation by virus of viral protein levels in host cell  (IEA)
negative regulation of angiogenesis  (IEA)
negative regulation of canonical NF-kappaB signal transduction  (IEA)
negative regulation of endothelial cell proliferation  (IEA)
negative regulation of macrophage fusion  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of defense response to virus by host  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of erythrocyte differentiation  (IEA)
positive regulation of interferon-alpha production  (IEA)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (IEA,ISO)
renal tubule development  (IEA)
response to bacterium  (ISO)
response to cAMP  (ISO)
response to cytokine  (ISO)
response to exogenous dsRNA  (ISO)
response to hydrogen peroxide  (ISO)
response to interferon-beta  (IEA)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to type I interferon  (ISO)
response to type II interferon  (IEA)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
tumor necrosis factor-mediated signaling pathway  (IEA)
type I interferon-mediated signaling pathway  (IEA)
type II interferon-mediated signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
STAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21393,651,032 - 93,700,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B93,666,016 - 93,711,687 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B78,270,642 - 78,316,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B196,186,906 - 196,232,280 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,186,906 - 196,232,280 (-)Ensemblpanpan1.1panPan2
STAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,969,149 - 191,014,171 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2190,908,460 - 191,020,960 (-)EnsemblGRCh38hg38GRCh38
GRCh372191,833,875 - 191,878,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,542,121 - 191,587,181 (-)NCBINCBI36Build 36hg18NCBI36
Build 342191,665,769 - 191,704,442NCBI
Celera2185,428,361 - 185,473,577 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2183,693,413 - 183,738,626 (-)NCBIHuRef
CHM1_12191,839,599 - 191,884,801 (-)NCBICHM1_1
T2T-CHM13v2.02191,458,256 - 191,503,284 (-)NCBIT2T-CHM13v2.0
Stat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,158,588 - 52,201,024 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,158,599 - 52,201,024 (+)EnsemblGRCm39 Ensembl
GRCm38152,119,438 - 52,161,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl152,119,440 - 52,161,865 (+)EnsemblGRCm38mm10GRCm38
MGSCv37152,176,282 - 52,218,707 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36152,064,002 - 52,105,508 (+)NCBIMGSCv36mm8
Celera152,657,880 - 52,700,334 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.81NCBI
Stat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,911,522 - 56,951,926 (-)NCBIGRCr8
mRatBN7.2949,419,561 - 49,459,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,419,340 - 49,588,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx957,969,129 - 58,009,299 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,091,965 - 63,132,135 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,387,952 - 61,428,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,287,540 - 54,327,958 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,287,541 - 54,484,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0953,998,204 - 54,038,463 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,455,635 - 46,497,560 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,458,584 - 46,495,612 (-)NCBI
Celera947,082,882 - 47,123,002 (-)NCBICelera
Cytogenetic Map9q22NCBI
Stat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,156,660 - 8,194,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,156,660 - 8,192,018 (+)NCBIChiLan1.0ChiLan1.0
STAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,513,438 - 1,549,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,507,219 - 1,550,178 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,461,622 - 2,502,035 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0371,400,933 - 1,441,368 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,395,727 - 1,441,301 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1371,410,525 - 1,450,952 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,378,532 - 1,418,954 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,407,084 - 1,447,502 (-)NCBIUU_Cfam_GSD_1.0
Stat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303149,602,218 - 149,641,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,196,797 - 7,233,756 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,196,860 - 7,235,854 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1595,593,211 - 95,646,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11595,593,201 - 95,646,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
STAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11076,492,859 - 76,537,689 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1076,492,533 - 76,533,393 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040122,939,721 - 122,984,472 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,067,535 - 5,102,106 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248545,067,578 - 5,106,052 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000056672   ⟹   ENSPPAP00000033795
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B196,186,906 - 196,232,280 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000056731   ⟹   ENSPPAP00000033852
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B196,191,429 - 196,228,040 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000056733   ⟹   ENSPPAP00000033854
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B196,192,511 - 196,228,040 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000056740   ⟹   ENSPPAP00000033861
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B196,192,511 - 196,200,852 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000056758   ⟹   ENSPPAP00000033879
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B196,193,563 - 196,228,406 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000056763   ⟹   ENSPPAP00000033883
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B196,216,072 - 196,228,040 (-)Ensembl
RefSeq Acc Id: XM_003825284   ⟹   XP_003825332
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21393,651,032 - 93,696,678 (-)NCBI
NHGRI_mPanPan12B93,666,016 - 93,711,662 (-)NCBI
Mhudiblu_PPA_v02B78,270,759 - 78,316,074 (-)NCBI
PanPan1.12B196,186,906 - 196,232,280 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008950622   ⟹   XP_008948870
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21393,651,032 - 93,696,568 (-)NCBI
NHGRI_mPanPan12B93,666,016 - 93,711,550 (-)NCBI
Mhudiblu_PPA_v02B78,270,642 - 78,315,996 (-)NCBI
PanPan1.12B196,186,906 - 196,232,258 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014344032   ⟹   XP_014199518
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21393,651,032 - 93,700,280 (-)NCBI
NHGRI_mPanPan12B93,666,016 - 93,711,687 (-)NCBI
Mhudiblu_PPA_v02B78,270,642 - 78,316,003 (-)NCBI
PanPan1.12B196,186,906 - 196,232,258 (-)NCBI
Sequence:
RefSeq Acc Id: XP_003825332   ⟸   XM_003825284
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BVY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008948870   ⟸   XM_008950622
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BVY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_014199518   ⟸   XM_014344032
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BVY7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000033861   ⟸   ENSPPAT00000056740
Ensembl Acc Id: ENSPPAP00000033879   ⟸   ENSPPAT00000056758
Ensembl Acc Id: ENSPPAP00000033883   ⟸   ENSPPAT00000056763
Ensembl Acc Id: ENSPPAP00000033854   ⟸   ENSPPAT00000056733
Ensembl Acc Id: ENSPPAP00000033852   ⟸   ENSPPAT00000056731
Ensembl Acc Id: ENSPPAP00000033795   ⟸   ENSPPAT00000056672
Protein Domains
SH2   STAT transcription factor protein interaction


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039583 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000056672.1 UniProtKB/TrEMBL
  ENSPPAT00000056731.1 UniProtKB/TrEMBL
  ENSPPAT00000056733.1 UniProtKB/TrEMBL
  ENSPPAT00000056740.1 UniProtKB/TrEMBL
  ENSPPAT00000056758.1 UniProtKB/TrEMBL
  ENSPPAT00000056763.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  6.10.250.3310 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
  STAT1_C_sf UniProtKB/TrEMBL
  STAT1_SH2 UniProtKB/TrEMBL
  STAT1_TAZ2-bd_C UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/TrEMBL
NCBI Gene STAT1 ENTREZGENE
PANTHER PTHR11801 UniProtKB/TrEMBL
  SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  STAT1_TAZ2bind UniProtKB/TrEMBL
  STAT_alpha UniProtKB/TrEMBL
  STAT_bind UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART STAT_int UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/TrEMBL
  SSF48092 UniProtKB/TrEMBL
  SSF49417 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A2R9BVY7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BW31_PANPA UniProtKB/TrEMBL
  A0A2R9BWM9_PANPA UniProtKB/TrEMBL
  A0A2R9BZ81_PANPA UniProtKB/TrEMBL
  A0A2R9C5N8_PANPA UniProtKB/TrEMBL
  A0A2R9C5R1_PANPA UniProtKB/TrEMBL