Gene: Pnkd (PNKD metallo-beta-lactamase domain containing) Rattus norvegicus
Analyze
Symbol:
Pnkd
Name:
PNKD metallo-beta-lactamase domain containing
RGD ID:
2300155
Description:
Predicted to have hydroxyacylglutathione hydrolase activity and metal ion binding activity. Predicted to be involved in modulation of chemical synaptic transmission; neuromuscular process controlling posture; and regulation of dopamine metabolic process. Predicted to localize to membrane and mitochondrion. Human ortholog(s) of this gene implicated in paroxysmal nonkinesigenic dyskinesia 1. Orthologous to human PNKD (PNKD metallo-beta-lactamase domain containing); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
MGC188259; Mr-1; myofibrillogenesis regulator 1; paroxysmal nonkinesigenic dyskinesia; paroxysmal nonkinesiogenic dyskinesia; PNKD, MBL domain containing; probable hydrolase PNKD
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PNKD (PNKD metallo-beta-lactamase domain containing) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):
Pnkd (paroxysmal nonkinesiogenic dyskinesia) HGNC
EggNOG, NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Pnkd (PNKD metallo-beta-lactamase domain containing) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PNKD (PNKD metallo-beta-lactamase domain containing) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PNKD (PNKD metallo-beta-lactamase domain containing) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Pnkd (PNKD metallo-beta-lactamase domain containing) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PNKD (PNKD metallo-beta-lactamase domain containing) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
PNKD (PNKD metallo-beta-lactamase domain containing) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Pnkd (PNKD metallo-beta-lactamase domain containing) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
PNKD (PNKD metallo-beta-lactamase domain containing)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER)
Mus musculus (house mouse):
Pnkd (paroxysmal nonkinesiogenic dyskinesia)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER)
Danio rerio (zebrafish):
pnkd (PNKD metallo-beta-lactamase domain containing)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER)
Saccharomyces cerevisiae (baker's yeast):
GLO2
Alliance
DIOPT (Ensembl Compara|InParanoid|OrthoInspector|PANTHER)
Saccharomyces cerevisiae (baker's yeast):
GLO4
Alliance
DIOPT (Ensembl Compara|InParanoid|OrthoInspector|PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 9 81,566,074 - 81,634,531 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 81,566,074 - 81,634,534 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 9 81,332,155 - 81,400,726 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 9 73,611,610 - 73,697,690 (+) NCBI RGSC3.4 rn4 RGSC3.4 Celera 9 73,445,105 - 73,513,517 (+) NCBI Celera Cytogenetic Map 9 q33 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
paroxysmal nonkinesigenic dyskinesia 1 ISO RGD:1346850 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21487022 renal cell carcinoma ISO RGD:1346850 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25401301
Imported Annotations - OMIM
paroxysmal nonkinesigenic dyskinesia 1 ISO RGD:1346850 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PNKD mRNA] CTD PMID:31150632 1,1-dichloroethene decreases expression ISO RGD:1618392 6480464 vinylidene chloride results in decreased expression of PNKD mRNA CTD PMID:26682919 1,2-dichloroethane increases expression ISO RGD:1618392 6480464 ethylene dichloride results in increased expression of PNKD mRNA CTD PMID:28960355 1,2-dimethylhydrazine decreases expression ISO RGD:1618392 6480464 1, 2-Dimethylhydrazine results in decreased expression of PNKD mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO RGD:1618392 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PNKD mRNA CTD PMID:22206623 17beta-estradiol increases expression ISO RGD:1346850 6480464 Estradiol results in increased expression of PNKD mRNA CTD PMID:23019147 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1346850 6480464 Dihydrotestosterone results in increased expression of PNKD mRNA CTD PMID:29581250 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1618392 6480464 Tetrachlorodibenzodioxin affects the expression of PNKD mRNA CTD PMID:21570461 , PMID:28922406 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PNKD mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1618392 6480464 Tetrachlorodibenzodioxin results in increased expression of PNKD mRNA CTD PMID:29935226 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1618392 6480464 Tetrachlorodibenzodioxin results in decreased expression of PNKD mRNA CTD PMID:19465110 more ... 4-hydroxyphenyl retinamide increases expression ISO RGD:1618392 6480464 Fenretinide results in increased expression of PNKD mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine affects expression ISO RGD:1346850 6480464 Decitabine affects the expression of PNKD mRNA CTD PMID:23300844 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of PNKD mRNA CTD PMID:24780913 aflatoxin B1 increases methylation ISO RGD:1346850 6480464 Aflatoxin B1 results in increased methylation of PNKD gene, Aflatoxin B1 results in increased methylation of PNKD intron CTD PMID:27153756 , PMID:30157460 aflatoxin B2 decreases methylation ISO RGD:1346850 6480464 aflatoxin B2 results in decreased methylation of PNKD intron CTD PMID:30157460 all-trans-retinoic acid increases expression ISO RGD:1346850 6480464 Tretinoin results in increased expression of PNKD mRNA CTD PMID:23830798 antirheumatic drug affects expression ISO RGD:1346850 6480464 Antirheumatic Agents affects the expression of PNKD mRNA CTD PMID:24449571 atrazine increases expression ISO RGD:1346850 6480464 Atrazine results in increased expression of PNKD mRNA CTD PMID:22378314 benzo[a]pyrene decreases expression ISO RGD:1618392 6480464 Benzo(a)pyrene results in decreased expression of PNKD mRNA CTD PMID:19770486 , PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:1346850 6480464 Benzo(a)pyrene affects the methylation of PNKD promoter CTD PMID:27901495 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1618392 6480464 Diethylhexyl Phthalate results in increased expression of PNKD mRNA CTD PMID:19850644 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1618392 6480464 PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PNKD mRNA] CTD PMID:19850644 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of PNKD mRNA CTD PMID:25181051 , PMID:30903817 bisphenol A decreases methylation EXP 6480464 bisphenol A results in decreased methylation of PNKD gene CTD PMID:28505145 cadmium atom decreases expression ISO RGD:1618392 6480464 Cadmium results in decreased expression of PNKD mRNA CTD PMID:24067728 calcitriol decreases expression ISO RGD:1346850 6480464 Calcitriol results in decreased expression of PNKD mRNA CTD PMID:16002434 carbon nanotube decreases expression ISO RGD:1618392 6480464 Nanotubes, Carbon analog results in decreased expression of PNKD mRNA, Nanotubes, Carbon results in decreased expression of PNKD mRNA CTD PMID:25554681 , PMID:25620056 carbon nanotube increases expression ISO RGD:1618392 6480464 Nanotubes, Carbon results in increased expression of PNKD mRNA CTD PMID:25620056 chloroprene decreases expression EXP 6480464 Chloroprene results in decreased expression of PNKD mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:1618392 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PNKD mRNA CTD PMID:20938992 cisplatin affects expression ISO RGD:1346850 6480464 Cisplatin affects the expression of PNKD mRNA CTD PMID:23300844 cisplatin multiple interactions ISO RGD:1346850 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of PNKD mRNA CTD PMID:27392435 copper(II) sulfate decreases expression ISO RGD:1346850 6480464 Copper Sulfate results in decreased expression of PNKD mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:1346850 6480464 Cyclosporine results in decreased expression of PNKD mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO RGD:1618392 6480464 Cyclosporine results in decreased expression of PNKD mRNA CTD PMID:19770486 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of PNKD mRNA CTD PMID:23640034 dibutyl phthalate decreases expression ISO RGD:1618392 6480464 Dibutyl Phthalate results in decreased expression of PNKD mRNA CTD PMID:21266533 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of PNKD mRNA CTD PMID:21266533 dioxygen multiple interactions ISO RGD:1618392 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PNKD mRNA CTD PMID:30529165 disodium selenite increases expression ISO RGD:1346850 6480464 Sodium Selenite results in increased expression of PNKD mRNA CTD PMID:18175754 folic acid multiple interactions ISO RGD:1618392 6480464 [1 more ... CTD PMID:20938992 , PMID:22206623 genistein decreases expression ISO RGD:1346850 6480464 Genistein results in decreased expression of PNKD protein CTD PMID:20884965 genistein multiple interactions ISO RGD:1346850 6480464 ESR1 promotes the reaction [Genistein results in decreased expression of PNKD protein] CTD PMID:20884965 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of PNKD mRNA CTD PMID:24136188 hypochlorous acid decreases expression ISO RGD:1618392 6480464 Hypochlorous Acid results in decreased expression of PNKD mRNA CTD PMID:19376150 L-methionine multiple interactions ISO RGD:1618392 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PNKD mRNA CTD PMID:20938992 mercury dichloride decreases expression EXP 6480464 Mercuric Chloride results in decreased expression of PNKD mRNA CTD PMID:16507785 methyl methanesulfonate decreases expression ISO RGD:1346850 6480464 Methyl Methanesulfonate results in decreased expression of PNKD mRNA CTD PMID:23649840 nickel atom decreases expression ISO RGD:1346850 6480464 Nickel results in decreased expression of PNKD mRNA CTD PMID:24768652 , PMID:25583101 nickel sulfate increases expression ISO RGD:1346850 6480464 nickel sulfate results in increased expression of PNKD mRNA CTD PMID:22714537 paracetamol affects expression ISO RGD:1618392 6480464 Acetaminophen affects the expression of PNKD mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1346850 6480464 Acetaminophen results in decreased expression of PNKD mRNA CTD PMID:22230336 , PMID:29067470 perfluorooctanoic acid decreases expression ISO RGD:1346850 6480464 perfluorooctanoic acid results in decreased expression of PNKD protein CTD PMID:26879310 phenobarbital decreases expression ISO RGD:1618392 6480464 Phenobarbital results in decreased expression of PNKD mRNA CTD PMID:19270015 phenobarbital affects expression ISO RGD:1618392 6480464 Phenobarbital affects the expression of PNKD mRNA CTD PMID:23091169 pirinixic acid increases expression ISO RGD:1618392 6480464 pirinixic acid results in increased expression of PNKD mRNA CTD PMID:18301758 potassium dichromate decreases expression ISO RGD:1618392 6480464 Potassium Dichromate results in decreased expression of PNKD mRNA CTD PMID:23608068 Salinomycin decreases expression ISO RGD:1346850 6480464 salinomycin results in decreased expression of PNKD mRNA CTD PMID:19682730 tamoxifen affects expression ISO RGD:1618392 6480464 Tamoxifen affects the expression of PNKD mRNA CTD PMID:20937368 tetrachloromethane decreases expression ISO RGD:1618392 6480464 Carbon Tetrachloride results in decreased expression of PNKD mRNA CTD PMID:27339419 , PMID:31919559 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of PNKD mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PNKD mRNA] CTD PMID:31150632 tributylstannane decreases expression EXP 6480464 tributyltin results in decreased expression of PNKD mRNA CTD PMID:31129395 triphenyl phosphate decreases expression EXP 6480464 triphenyl phosphate results in decreased expression of PNKD mRNA CTD PMID:30589522 Triptolide decreases expression EXP 6480464 triptolide results in decreased expression of PNKD protein CTD PMID:32519852 valproic acid decreases expression ISO RGD:1346850 6480464 Valproic Acid results in decreased expression of PNKD mRNA CTD PMID:29154799 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of PNKD mRNA CTD PMID:29427782 valproic acid decreases methylation ISO RGD:1346850 6480464 Valproic Acid results in decreased methylation of PNKD gene CTD PMID:29154799 valproic acid increases expression ISO RGD:1346850 6480464 Valproic Acid results in increased expression of PNKD mRNA CTD PMID:23179753 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of PNKD mRNA CTD PMID:23034163 zoledronic acid increases expression ISO RGD:1346850 6480464 zoledronic acid results in increased expression of PNKD mRNA CTD PMID:24714768
Gene-Chemical Interaction Annotations
