Gene: Pnkd (PNKD metallo-beta-lactamase domain containing) Rattus norvegicus
Analyze
Symbol:
Pnkd
Name:
PNKD metallo-beta-lactamase domain containing
Description:
Predicted to have hydroxyacylglutathione hydrolase activity. Predicted to be involved in modulation of chemical synaptic transmission; neuromuscular process controlling posture; and regulation of dopamine metabolic process. Predicted to localize to the membrane and mitochondrion. Human ortholog(s) of this gene implicated in paroxysmal nonkinesigenic dyskinesia 1. Orthologous to human PNKD (PNKD metallo-beta-lactamase domain containing); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; bisphenol A.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
MGC188259; Mr-1; myofibrillogenesis regulator 1; paroxysmal nonkinesigenic dyskinesia; paroxysmal nonkinesiogenic dyskinesia; PNKD, MBL domain containing; probable hydrolase PNKD
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PNKD (PNKD metallo-beta-lactamase domain containing) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):
Pnkd (paroxysmal nonkinesiogenic dyskinesia) HGNC
EggNOG, NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Pnkd (PNKD metallo-beta-lactamase domain containing) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PNKD (PNKD metallo-beta-lactamase domain containing) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PNKD (PNKD metallo-beta-lactamase domain containing) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Pnkd (PNKD metallo-beta-lactamase domain containing) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PNKD (PNKD metallo-beta-lactamase domain containing) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
PNKD (PNKD metallo-beta-lactamase domain containing)
Alliance
DIOPT (Ensembl Compara, HGNC, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Mus musculus (house mouse):
Pnkd (paroxysmal nonkinesiogenic dyskinesia)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Danio rerio (zebrafish):
pnkd (PNKD metallo-beta-lactamase domain containing)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Saccharomyces cerevisiae (baker's yeast):
GLO2
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoInspector, PANTHER)
Saccharomyces cerevisiae (baker's yeast):
GLO4
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoInspector, PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 9 81,566,074 - 81,634,531 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 81,566,074 - 81,634,534 (+) Ensembl Rnor_5.0 9 81,332,155 - 81,400,726 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 9 73,611,610 - 73,697,690 (+) NCBI RGSC3.4 rn4 RGSC3.4 Celera 9 73,445,105 - 73,513,517 (+) NCBI Celera Cytogenetic Map 9 q33 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
paroxysmal nonkinesigenic dyskinesia 1 ISO RGD:1346850 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21487022 renal cell carcinoma ISO RGD:1346850 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25401301
Imported Annotations - OMIM
paroxysmal nonkinesigenic dyskinesia 1 ISO RGD:1346850 7240710 OMIM
Gene-Chemical Interaction Annotations
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PNKD mRNA] CTD PMID:31150632 1,1-dichloroethene decreases expression ISO RGD:1618392 6480464 vinylidene chloride results in decreased expression of PNKD mRNA CTD PMID:26682919 17beta-estradiol increases expression ISO RGD:1346850 6480464 Estradiol results in increased expression of PNKD mRNA CTD PMID:23019147 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1346850 6480464 Dihydrotestosterone results in increased expression of PNKD mRNA CTD PMID:29581250 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1618392 6480464 Tetrachlorodibenzodioxin affects the expression of PNKD mRNA CTD PMID:21570461 , PMID:28922406 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1618392 6480464 Tetrachlorodibenzodioxin results in increased expression of PNKD mRNA CTD PMID:29935226 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1618392 6480464 Tetrachlorodibenzodioxin results in decreased expression of PNKD mRNA CTD PMID:19465110 more ... 4-hydroxyphenyl retinamide increases expression ISO RGD:1618392 6480464 Fenretinide results in increased expression of PNKD mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine affects expression ISO RGD:1346850 6480464 Decitabine affects the expression of PNKD mRNA CTD PMID:23300844 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of PNKD mRNA CTD PMID:24780913 aflatoxin B1 increases methylation ISO RGD:1346850 6480464 Aflatoxin B1 results in increased methylation of PNKD gene, Aflatoxin B1 results in increased methylation of PNKD intron CTD PMID:27153756 , PMID:30157460 aflatoxin B2 decreases methylation ISO RGD:1346850 6480464 aflatoxin B2 results in decreased methylation of PNKD intron CTD PMID:30157460 all-trans-retinoic acid increases expression ISO RGD:1346850 6480464 Tretinoin results in increased expression of PNKD mRNA CTD PMID:23830798 antirheumatic drug affects expression ISO RGD:1346850 6480464 Antirheumatic Agents affects the expression of PNKD mRNA CTD PMID:24449571 atrazine increases expression ISO RGD:1346850 6480464 Atrazine results in increased expression of PNKD mRNA CTD PMID:22378314 benzo[a]pyrene decreases expression ISO RGD:1618392 6480464 Benzo(a)pyrene results in decreased expression of PNKD mRNA CTD PMID:19770486 , PMID:22228805 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1618392 6480464 Diethylhexyl Phthalate results in increased expression of PNKD mRNA CTD PMID:19850644 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1618392 6480464 PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PNKD mRNA] CTD PMID:19850644 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of PNKD mRNA CTD PMID:25181051 , PMID:30903817 bisphenol A decreases methylation EXP 6480464 bisphenol A results in decreased methylation of PNKD gene CTD PMID:28505145 cadmium atom decreases expression ISO RGD:1618392 6480464 Cadmium results in decreased expression of PNKD mRNA CTD PMID:24067728 calcitriol decreases expression ISO RGD:1346850 6480464 Calcitriol results in decreased expression of PNKD mRNA CTD PMID:16002434 carbon nanotube decreases expression ISO RGD:1618392 6480464 Nanotubes, Carbon analog results in decreased expression of PNKD mRNA, Nanotubes, Carbon results in decreased expression of PNKD mRNA CTD PMID:25554681 , PMID:25620056 carbon nanotube increases expression ISO RGD:1618392 6480464 Nanotubes, Carbon results in increased expression of PNKD mRNA CTD PMID:25620056 chloroprene decreases expression EXP 6480464 Chloroprene results in decreased expression of PNKD mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:1618392 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PNKD mRNA CTD PMID:20938992 cisplatin affects expression ISO RGD:1346850 6480464 Cisplatin affects the expression of PNKD mRNA CTD PMID:23300844 cisplatin multiple interactions ISO RGD:1346850 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of PNKD mRNA CTD PMID:27392435 copper(II) sulfate decreases expression ISO RGD:1346850 6480464 Copper Sulfate results in decreased expression of PNKD mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:1346850 6480464 Cyclosporine results in decreased expression of PNKD mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO RGD:1618392 6480464 Cyclosporine results in decreased expression of PNKD mRNA CTD PMID:19770486 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of PNKD mRNA CTD PMID:23640034 dibutyl phthalate decreases expression ISO RGD:1618392 6480464 Dibutyl Phthalate results in decreased expression of PNKD mRNA CTD PMID:21266533 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of PNKD mRNA CTD PMID:21266533 dioxygen multiple interactions ISO RGD:1618392 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PNKD mRNA CTD PMID:30529165 disodium selenite increases expression ISO RGD:1346850 6480464 Sodium Selenite results in increased expression of PNKD mRNA CTD PMID:18175754 folic acid multiple interactions ISO RGD:1618392 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PNKD mRNA CTD PMID:20938992 genistein decreases expression ISO RGD:1346850 6480464 Genistein results in decreased expression of PNKD protein CTD PMID:20884965 genistein multiple interactions ISO RGD:1346850 6480464 ESR1 promotes the reaction [Genistein results in decreased expression of PNKD protein] CTD PMID:20884965 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of PNKD mRNA CTD PMID:24136188 hypochlorous acid decreases expression ISO RGD:1618392 6480464 Hypochlorous Acid results in decreased expression of PNKD mRNA CTD PMID:19376150 L-methionine multiple interactions ISO RGD:1618392 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PNKD mRNA CTD PMID:20938992 mercury dichloride decreases expression EXP 6480464 Mercuric Chloride results in decreased expression of PNKD mRNA CTD PMID:16507785 methyl methanesulfonate decreases expression ISO RGD:1346850 6480464 Methyl Methanesulfonate results in decreased expression of PNKD mRNA CTD PMID:23649840 nickel atom decreases expression ISO RGD:1346850 6480464 Nickel results in decreased expression of PNKD mRNA CTD PMID:24768652 , PMID:25583101 nickel sulfate increases expression ISO RGD:1346850 6480464 nickel sulfate results in increased expression of PNKD mRNA CTD PMID:22714537 paracetamol affects expression ISO RGD:1618392 6480464 Acetaminophen affects the expression of PNKD mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1346850 6480464 Acetaminophen results in decreased expression of PNKD mRNA CTD PMID:22230336 , PMID:29067470 perfluorooctanoic acid decreases expression ISO RGD:1346850 6480464 perfluorooctanoic acid results in decreased expression of PNKD protein CTD PMID:26879310 phenobarbital decreases expression ISO RGD:1618392 6480464 Phenobarbital results in decreased expression of PNKD mRNA CTD PMID:19270015 phenobarbital affects expression ISO RGD:1618392 6480464 Phenobarbital affects the expression of PNKD mRNA CTD PMID:23091169 pirinixic acid increases expression ISO RGD:1618392 6480464 pirinixic acid results in increased expression of PNKD mRNA CTD PMID:18301758 potassium dichromate decreases expression ISO RGD:1618392 6480464 Potassium Dichromate results in decreased expression of PNKD mRNA CTD PMID:23608068 Salinomycin decreases expression ISO RGD:1346850 6480464 salinomycin results in decreased expression of PNKD mRNA CTD PMID:19682730 tamoxifen affects expression ISO RGD:1618392 6480464 Tamoxifen affects the expression of PNKD mRNA CTD PMID:20937368 tetrachloromethane decreases expression ISO RGD:1618392 6480464 Carbon Tetrachloride results in decreased expression of PNKD mRNA CTD PMID:27339419 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of PNKD mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PNKD mRNA] CTD PMID:31150632 tributylstannane decreases expression EXP 6480464 tributyltin results in decreased expression of PNKD mRNA CTD PMID:31129395 valproic acid decreases expression ISO RGD:1346850 6480464 Valproic Acid results in decreased expression of PNKD mRNA CTD PMID:29154799 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of PNKD mRNA CTD PMID:29427782 valproic acid decreases methylation ISO RGD:1346850 6480464 Valproic Acid results in decreased methylation of PNKD gene CTD PMID:29154799 valproic acid increases expression ISO RGD:1346850 6480464 Valproic Acid results in increased expression of PNKD mRNA CTD PMID:23179753 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of PNKD mRNA CTD PMID:23034163 zoledronic acid increases expression ISO RGD:1346850 6480464 zoledronic acid results in increased expression of PNKD mRNA CTD PMID:24714768
Gene Ontology Annotations
Biological Process methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IEA InterPro:IPR017782 1600115 GO_REF:0000002 InterPro GO_REF:0000002 negative regulation of neurotransmitter secretion ISO RGD:1346850 1624291 (PMID:25730884) RGD PMID:25730884 negative regulation of neurotransmitter secretion IEA UniProtKB:Q8N490 , ensembl:ENSP000002730771600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of neurotransmitter secretion IEA UniProtKB:Q69ZP3 , ensembl:ENSMUSP000000273701600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of neurotransmitter secretion ISO RGD:1618392 1624291 MGI:MGI:2152971 more ... RGD MGI:MGI:5634213 , PMID:25730884 neuromuscular process controlling posture ISO RGD:1618392 1624291 MGI:MGI:5006973 (MGI:MGI:5466578 , PMID:22214848) RGD MGI:MGI:5466578 , PMID:22214848 neuromuscular process controlling posture IEA UniProtKB:Q69ZP3 , ensembl:ENSMUSP000000273701600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of dopamine metabolic process ISO RGD:1618392 1624291 MGI:MGI:5006973 (MGI:MGI:5466578 , PMID:22214848) RGD MGI:MGI:5466578 , PMID:22214848 regulation of dopamine metabolic process IEA UniProtKB:Q69ZP3 , ensembl:ENSMUSP000000273701600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of synaptic transmission, dopaminergic ISO RGD:1618392 1624291 MGI:MGI:5006973 (MGI:MGI:5466578 , PMID:22214848) RGD MGI:MGI:5466578 , PMID:22214848 regulation of synaptic transmission, dopaminergic IEA UniProtKB:Q69ZP3 , ensembl:ENSMUSP000000273701600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000038 UniProt GO_REF:0000038 membrane ISO RGD:1346850 1624291 (PMID:22214848) RGD PMID:22214848 membrane IEA UniProtKB:Q8N490 , ensembl:ENSP000002730771600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitochondrion ISO RGD:1346850 1624291 RGD GO_REF:0000052 mitochondrion IEA UniProtKB:Q8N490 , ensembl:ENSP000002730771600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitochondrion IEA UniProtKB:A0A024R415 , ensembl:ENSP000002730771600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function hydroxyacylglutathione hydrolase activity IEA InterPro:IPR017782 1600115 GO_REF:0000002 InterPro GO_REF:0000002 protein binding ISO RGD:1346850 1624291 UniProtKB:G5E962 more ... RGD PMID:25066297 more ... protein binding ISO RGD:1618392 1624291 UniProtKB:Q99NE5 more ... RGD MGI:MGI:5634213 , PMID:25730884
10054125 Srcrt7 Stress Responsive Cort QTL 7 3.33 0.0011 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 9 1055222 93442944 Rat 70186 Niddm26 Non-insulin dependent diabetes mellitus QTL 26 3.87 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 9 25692342 92741406 Rat 7207814 Bmd91 Bone mineral density QTL 91 3.5 femur size trait (VT:1000369) femoral neck cross-sectional area (CMO:0001697) 9 27486155 88333183 Rat 70218 Cm28 Cardiac mass QTL 28 8.3 0.0001 heart mass (VT:0007028) heart wet weight (CMO:0000069) 9 29075079 83686404 Rat 724544 Uae9 Urinary albumin excretion QTL 9 4.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 9 29075079 122095297 Rat 731164 Uae25 Urinary albumin excretion QTL 25 3.5 0.0001 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 9 29466970 107878528 Rat 7411571 Bw138 Body weight QTL 138 14.3 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 9 37642351 82642351 Rat 7411656 Foco26 Food consumption QTL 26 9.8 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 9 37642351 82642351 Rat 1598834 Memor11 Memory QTL 11 2.5 exploratory behavior trait (VT:0010471) average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674) 9 41261034 90024806 Rat 8662828 Vetf6 Vascular elastic tissue fragility QTL 6 3.9 artery integrity trait (VT:0010639) patent ductus arteriosus score (CMO:0002566) 9 41261034 98606834 Rat 2290450 Scl57 Serum cholesterol level QTL 57 4.15 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 9 41261034 102531865 Rat 6903941 Pur31 Proteinuria QTL 31 0.036 total urine protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) 9 46579769 91579769 Rat 11353949 Bp393 Blood pressure QTL 393 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 46579769 91579769 Rat 61352 Bp34 Blood pressure QTL 34 5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 46952427 83686153 Rat 10058949 Gmadr5 Adrenal mass QTL 5 2 0.014 adrenal gland mass (VT:0010420) both adrenal glands wet weight to body weight ratio (CMO:0002411) 9 47248965 94124663 Rat 631656 Bp108 Blood pressure QTL 108 5.97 0.0001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 54177542 99177542 Rat 2303170 Bp332 Blood pressure QTL 332 3.73 0.027 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 9 60810298 82732466 Rat 1578760 Cm53 Cardiac mass QTL 53 3.3 0.0001 heart mass (VT:0007028) heart wet weight (CMO:0000069) 9 61186278 106186278 Rat 2303180 Bp333 Blood pressure QTL 333 0.001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 61730923 82890620 Rat 2303180 Bp333 Blood pressure QTL 333 0.001 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 9 61730923 82890620 Rat 2303180 Bp333 Blood pressure QTL 333 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 9 61730923 82890620 Rat 724515 Uae16 Urinary albumin excretion QTL 16 8 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 9 63270073 107878387 Rat 1300134 Bp185 Blood pressure QTL 185 3.73 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 9 66757444 112943287 Rat 1581580 Uae34 Urinary albumin excretion QTL 34 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 9 67451664 99920892 Rat 1578757 Pur6 Proteinuria QTL 6 3.3 0.005 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 9 67451664 99920892 Rat 731171 Glom6 Glomerulus QTL 6 2.8 0.0003 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) 9 70942881 115942881 Rat 1354626 Bvd1 Brain ventricular dilatation QTL 1 3.73 0.001 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) 9 81411073 119983851 Rat
Predicted Target Of
Count of predictions: 1205 Count of miRNA genes: 252 Interacting mature miRNAs: 307 Transcripts: ENSRNOT00000020049, ENSRNOT00000046229, ENSRNOT00000074131 Prediction methods: Microtar, Miranda, Rnahybrid Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
