Cdk15 (cyclin-dependent kinase 15) - Rat Genome Database

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Gene: Cdk15 (cyclin-dependent kinase 15) Rattus norvegicus
Analyze
Symbol: Cdk15
Name: cyclin-dependent kinase 15
RGD ID: 1306205
Description: Predicted to enable cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle phase transition. Predicted to be active in cytosol and nucleus. Orthologous to human CDK15 (cyclin dependent kinase 15); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH vinclozolin; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: frizzled family receptor 7; Fzd7; LOC301440
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8968,205,759 - 68,299,218 (+)NCBIGRCr8
mRatBN7.2960,710,787 - 60,803,638 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,711,715 - 60,802,777 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0966,059,765 - 66,153,729 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl966,058,047 - 66,148,087 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,865,897 - 65,958,276 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,840,625 - 57,930,096 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1958,185,126 - 58,214,016 (+)NCBI
Celera958,148,588 - 58,242,444 (+)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IBA)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The p53 transcriptional target gene wnt7b contributes to NGF-inducible neurite outgrowth in neuronal PC12 cells. Brynczka C and Merrick BA, Differentiation. 2008 Jan 2;.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition. Li CM, etal., Am J Pathol. 2002 Jun;160(6):2181-90.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
11. Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes. Yu H, etal., Development. 2012 Dec 1;139(23):4383-94. doi: 10.1242/dev.083352. Epub 2012 Oct 24.
Additional References at PubMed
PMID:24866247  


Genomics

Comparative Map Data
Cdk15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8968,205,759 - 68,299,218 (+)NCBIGRCr8
mRatBN7.2960,710,787 - 60,803,638 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,711,715 - 60,802,777 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0966,059,765 - 66,153,729 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl966,058,047 - 66,148,087 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,865,897 - 65,958,276 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,840,625 - 57,930,096 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1958,185,126 - 58,214,016 (+)NCBI
Celera958,148,588 - 58,242,444 (+)NCBICelera
Cytogenetic Map9q31NCBI
CDK15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382201,806,429 - 201,895,550 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2201,790,461 - 201,895,550 (+)EnsemblGRCh38hg38GRCh38
GRCh372202,671,152 - 202,760,273 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362202,379,443 - 202,466,511 (+)NCBINCBI36Build 36hg18NCBI36
Build 342202,496,703 - 202,583,769NCBI
Celera2196,423,311 - 196,510,043 (+)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2194,519,358 - 194,609,045 (+)NCBIHuRef
CHM1_12202,677,626 - 202,766,857 (+)NCBICHM1_1
T2T-CHM13v2.02202,287,333 - 202,376,437 (+)NCBIT2T-CHM13v2.0
Cdk15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,296,029 - 59,391,656 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl159,296,065 - 59,392,152 (+)EnsemblGRCm39 Ensembl
GRCm38159,256,861 - 59,352,497 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,256,906 - 59,352,993 (+)EnsemblGRCm38mm10GRCm38
MGSCv37159,313,751 - 59,409,213 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36159,201,452 - 59,297,158 (+)NCBIMGSCv36mm8
Celera159,774,052 - 59,869,619 (+)NCBICelera
Cytogenetic Map1C1.3- C2NCBI
cM Map129.47NCBI
Cdk15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545712,880,959 - 12,966,410 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545712,878,736 - 12,966,434 (-)NCBIChiLan1.0ChiLan1.0
CDK15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213104,429,756 - 104,519,360 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B104,444,798 - 104,534,360 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B89,060,334 - 89,149,106 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B207,198,906 - 207,304,029 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B207,215,058 - 207,304,029 (+)Ensemblpanpan1.1panPan2
CDK15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13710,848,789 - 10,929,818 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3710,849,003 - 10,926,856 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3711,732,588 - 11,814,581 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03710,784,792 - 10,867,012 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3710,785,070 - 10,866,645 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13710,735,784 - 10,818,006 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03710,714,305 - 10,796,498 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03710,706,802 - 10,789,638 (+)NCBIUU_Cfam_GSD_1.0
Cdk15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303159,067,332 - 159,160,261 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367261,037,636 - 1,130,571 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367261,037,614 - 1,129,961 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15105,401,165 - 105,506,114 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115105,401,170 - 105,506,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,938,476 - 116,997,821 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDK15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11087,499,225 - 87,592,748 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1087,499,808 - 87,589,730 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040111,820,757 - 111,914,138 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476514,555,207 - 14,641,545 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476514,550,267 - 14,641,749 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:36
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000033707, ENSRNOT00000071819, ENSRNOT00000074635
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 11 6 97 44 46 22 13 22 6 103 35 84 30 59 24

Sequence


Ensembl Acc Id: ENSRNOT00000071819   ⟹   ENSRNOP00000065356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl960,711,715 - 60,802,777 (+)Ensembl
Rnor_6.0 Ensembl966,058,047 - 66,148,087 (+)Ensembl
RefSeq Acc Id: XM_039084845   ⟹   XP_038940773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,205,842 - 68,299,218 (+)NCBI
mRatBN7.2960,710,787 - 60,803,638 (+)NCBI
RefSeq Acc Id: XM_039084847   ⟹   XP_038940775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,205,842 - 68,299,218 (+)NCBI
mRatBN7.2960,710,787 - 60,803,638 (+)NCBI
RefSeq Acc Id: XM_039084848   ⟹   XP_038940776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,205,759 - 68,250,364 (+)NCBI
mRatBN7.2960,710,787 - 60,755,763 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001418168 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418169 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940773 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940775 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940776 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98954 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065356.3
Ensembl Acc Id: ENSRNOP00000065356   ⟸   ENSRNOT00000071819
RefSeq Acc Id: XP_038940773   ⟸   XM_039084845
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038940775   ⟸   XM_039084847
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038940776   ⟸   XM_039084848
- Peptide Label: isoform X2
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7D0-F1-model_v2 AlphaFold M0R7D0 1-432 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306205 AgrOrtholog
BioCyc Gene G2FUF-27414 BioCyc
Ensembl Genes ENSRNOG00000022899 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071819.4 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CDK UniProtKB/TrEMBL
  CDK15_STKc UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene 301440 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE 15 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Cdk15 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022899 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt M0R7D0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-05 Cdk15  cyclin-dependent kinase 15  Fzd7  frizzled family receptor 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Fzd7  frizzled family receptor 7  Fzd7  frizzled homolog 7 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Fzd7  frizzled homolog 7 (Drosophila)   Fzd7_predicted  frizzled homolog 7 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fzd7_predicted  frizzled homolog 7 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED