Bp284 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Bp284 (Blood pressure QTL 284) Rattus norvegicus

Symbol: Bp284
Name: Blood pressure QTL 284
RGD ID: 1581517
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: systolic blood pressure   (CMO:0000004)    
LOD Score: Not Available
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,650,629 - 76,771,824RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0982,356,030 - 82,477,136RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0982,125,291 - 82,246,695RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4974,436,883 - 74,558,151RGDRGSC3.4
RGSC_v3.1929,705,133 - 74,705,133RGD
Cross Type: Not Available
Strains Crossed: SS.SR-(D9Rat69-D9Mco14)/Mco SS.SR-(D9Mco95-Resp18)/Mco 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Resp18 is a candidate Gene for Bp284

Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
systolic blood pressure  IDA 1334447 RGD 

Experimental Condition
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
controlled sodium content diet  IDA 1334447 RGD 

Measurement Method
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
intravascular electromagnetic flow sensor  IDA 1334447 RGD 
radiotelemetry  IDA 1334447 RGD 

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
SS.SR-(D9Mco95-Resp18)/Mco  IEA 1334447 RGD 
SS.SR-(D9Rat69-D9Mco14)/Mco  IEA 1334447 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
arterial blood pressure trait  IDA 1334447 RGD 

Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Locating a Blood Pressure Quantitative Trait Locus Within 117 kb on the Rat Genome. Substitution Mapping and Renal Expression Analysis. Garrett MR, etal., Hypertension 2005 Jan 17;.
2. Blood pressure and proteinuria effects of multiple quantitative trait loci on rat chromosome 9 that differentiate the spontaneously hypertensive rat from the Dahl salt-sensitive rat. Toland EJ, etal., J Hypertens. 2008 Nov;26(11):2134-41.
Related QTLs

Related QTL Description Reference
Bp333 maps to same region RGD:2302803


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
3555Resp18regulated endocrine-specific protein 1897676517976771824Rat
629474Stk16serine/threonine kinase 1697670559176708859Rat
620777Ptprnprotein tyrosine phosphatase, receptor type, N97674101076756704Rat
71077Abcb6ATP binding cassette subfamily B member 697666855476677263Rat
1306260Zfand2bzinc finger AN1-type containing 2B97666546676668447Rat
1310450Atg9aautophagy related 9A97667740376688035Rat
1309474Glb1lgalactosidase, beta 1-like97669332576705548Rat
1359242Ankzf1ankyrin repeat and zinc finger peptidyl tRNA hydrolase 197668822376695141Rat
1359623Tuba4atubulin, alpha 4A97670961776714327Rat
1591035Dnajb2DnaJ heat shock protein family (Hsp40) member B297673106076739278Rat
7695235LOC102554903uncharacterized LOC10255490397671474776730584Rat
40942445LOC120094712uncharacterized LOC12009471297674560976750739Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
60671D9Got9513397665161876651753Ratregion
1358016D9Mco4316297676389676764058Ratregion
1578935D9Mco1425797665062976650886Ratregion
1626791D9Mco6818897674235176742539Ratregion
1626811D9Mco6418197666240876662591Ratregion
1627032D9Mco4418897675782276758010Ratregion
1627114D9Mco6518997668508676685275Ratregion
1627155D9Mco6620097669929976699501Ratregion
1627472D9Mco6718597672089476721079Ratregion
7193085AA955828127297669351476694786Ratregion
5025562RH12879918097673902876739208Ratregion
5054467RH14324115697673127376731429Ratregion
5046530RH13180619397674115676741349Ratregion
5048066RH13268818497670963176709815Ratregion
5043722RH13018919197670863976708830Ratregion
5070313X744389697674101676741112Ratregion
5060632BE09874921897666863476668974Ratregion
5063056AA95582816997669336776693536Ratregion
5087348BQ19398416297667698176677143Ratregion
5506567PTPRN_135056897674102276741590Ratregion
5502190MARC_8095-8096:996688286:168797674565076746337Ratregion
Position Markers

Flank 1: (D9Mco14)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2976,650,629 - 76,650,886 (+)MAPPER
Rnor_6.0982,356,030 - 82,356,286NCBI
Rnor_5.0982,125,291 - 82,125,547UniSTS
RGSC_v3.4974,436,883 - 74,437,140UniSTS
Celera974,221,096 - 74,221,352UniSTS
Cytogenetic Map9 RGD
Flank 2: (Resp18)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2976,765,179 - 76,771,824 (-)NCBI
mRatBN7.2 Ensembl976,764,590 - 76,778,722 (-)Ensembl
Rnor_6.0982,470,794 - 82,477,136 (-)NCBI
Rnor_6.0 Ensembl982,470,759 - 82,477,181 (-)Ensembl
Rnor_5.0982,240,055 - 82,246,695 (-)NCBI
RGSC_v3.4974,551,809 - 74,558,151 (-)NCBI
RGSC_v3.1974,698,790 - 74,705,133 (-)NCBI
Celera974,335,568 - 74,341,910 (-)NCBI
Cytogenetic Map9q33NCBI


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97665062976771824Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
1578757Pur6Proteinuria QTL 63.30.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
6903941Pur31Proteinuria QTL 310.036total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
12879506Pur33Proteinuria QTL 33total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_statistics_details QTL flanking region determined by congenic strain analyis; initial mapping included Resp18 as a candidate, however the smallest flanking region defined by further congenic strain mapping contains a BP QTL independent of Resp18, based on loss of differential Resp18 expression and analysis of Resp18 nucleotide variants 1334447