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Gene: Mpp4 (MAGUK p55 scaffold protein 4) Rattus norvegicus

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Symbol:

Mpp4

Name:

MAGUK p55 scaffold protein 4

RGD ID:

620016

Description:

Enables signaling receptor binding activity. Predicted to act upstream of or within protein localization to synapse. Predicted to be located in several cellular components, including cone cell pedicle; lateral plasma membrane; and rod spherule. Predicted to be part of protein-containing complex. Predicted to be active in adherens junction and plasma membrane. Orthologous to human MPP4 (MAGUK p55 scaffold protein 4); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

discs large homolog 6; DLG6; MAGUK p55 subfamily member 4; membrane palmitoylated protein 4; membrane protein, palmitoylated 4; membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4); rDLG6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	68,063,867 - 68,103,050 (-)	NCBI		GRCr8
mRatBN7.2	9	60,569,734 - 60,613,035 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	60,569,734 - 60,611,797 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	69,064,652 - 69,104,142 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	74,180,615 - 74,220,109 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	72,498,892 - 72,538,384 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	65,917,917 - 65,961,274 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	65,917,917 - 65,957,101 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	65,725,150 - 65,767,400 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	57,696,943 - 57,736,126 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	57,843,928 - 57,877,524 (-)	NCBI
Celera	9	58,007,768 - 58,046,959 (-)	NCBI		Celera
Cytogenetic Map	9	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune lymphoproliferative syndrome type 2B (ISO)

Autoimmune Lymphoproliferative Syndrome, Type V (ISO)

common variable immunodeficiency 1 (ISO)

Developmental Disabilities (ISO)

Hereditary Spastic Paralysis, Infantile Onset Ascending (ISO)

Joubert syndrome 14 (ISO)

Neurodevelopmental Disorders (ISO)

Pulmonary Arterial Hypertension (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cobalt dichloride (ISO)

Cuprizon (EXP)

cypermethrin (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

dioxygen (ISO)

diquat (ISO)

epoxiconazole (ISO)

ethanol (ISO)

formaldehyde (ISO)

graphite (EXP)

N-nitrosodiethylamine (EXP)

paraquat (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

propanal (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein localization to synapse (ISO)

Cellular Component

actin cytoskeleton (IEA,ISO)

adherens junction (IBA,IEA,ISO)

basal part of cell (ISO)

cone cell pedicle (ISO)

cytoplasm (IEA)

cytosol (IEA,ISO)

Golgi membrane (ISO)

lateral plasma membrane (ISO)

membrane (IEA)

plasma membrane (IBA)

presynaptic membrane (ISO)

protein-containing complex (IEA,ISO)

rod spherule (ISO)

Molecular Function

protein binding (ISO)

signaling receptor binding (IPI)

References

References - curated

#	Reference Title	Reference Citation
1.	Characterization of MPP4, a gene highly expressed in photoreceptor cells, and mutation analysis in retinitis pigmentosa.	Conte I, etal., Gene 2002 Sep 4;297(1-2):33-8.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	rDLG6: a novel homolog of Drosophila DLG expressed in rat brain.	Inagaki H, etal., Biochem Biophys Res Commun 1999 Nov 19;265(2):462-8.
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:15914641	PMID:16520334

Genomics

Comparative Map Data

Mpp4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	68,063,867 - 68,103,050 (-)	NCBI		GRCr8
mRatBN7.2	9	60,569,734 - 60,613,035 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	60,569,734 - 60,611,797 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	69,064,652 - 69,104,142 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	74,180,615 - 74,220,109 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	72,498,892 - 72,538,384 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	65,917,917 - 65,961,274 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	65,917,917 - 65,957,101 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	65,725,150 - 65,767,400 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	57,696,943 - 57,736,126 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	57,843,928 - 57,877,524 (-)	NCBI
Celera	9	58,007,768 - 58,046,959 (-)	NCBI		Celera
Cytogenetic Map	9	q31	NCBI

MPP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	201,644,874 - 201,698,644 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	201,644,870 - 201,698,694 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	202,509,597 - 202,563,367 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	202,217,865 - 202,271,662 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	202,335,125 - 202,388,923	NCBI
Celera	2	196,261,499 - 196,315,217 (-)	NCBI		Celera
Cytogenetic Map	2	q33.1	NCBI
HuRef	2	194,357,715 - 194,411,441 (-)	NCBI		HuRef
CHM1_1	2	202,516,116 - 202,569,904 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	202,125,526 - 202,180,790 (-)	NCBI		T2T-CHM13v2.0

Mpp4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	59,160,094 - 59,202,548 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	59,160,094 - 59,202,548 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	59,120,935 - 59,163,389 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	59,120,935 - 59,163,389 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	59,177,779 - 59,220,233 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	59,065,481 - 59,103,214 (-)	NCBI		MGSCv36	mm8
Celera	1	59,637,173 - 59,679,621 (-)	NCBI		Celera
Cytogenetic Map	1	C1.3	NCBI
cM Map	1	29.2	NCBI

Mpp4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	109,353 - 147,035 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	109,353 - 147,442 (+)	NCBI	ChiLan1.0	ChiLan1.0

MPP4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	104,267,619 - 104,321,027 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	104,282,562 - 104,331,984 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	88,898,091 - 88,951,597 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	207,052,927 - 207,102,360 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	207,053,077 - 207,102,360 (-)	Ensembl	panpan1.1		panPan2

MPP4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	10,711,324 - 10,751,329 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	10,711,597 - 10,748,889 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	11,594,977 - 11,627,348 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	10,616,177 - 10,648,792 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	10,616,726 - 10,654,080 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	10,597,389 - 10,629,733 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	10,575,945 - 10,608,447 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	10,569,383 - 10,601,998 (-)	NCBI		UU_Cfam_GSD_1.0

Mpp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	158,923,119 - 158,968,572 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936726	892,550 - 938,969 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936726	893,411 - 938,876 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MPP4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	105,277,073 - 105,323,578 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	105,277,295 - 105,319,936 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MPP4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	87,328,555 - 87,382,894 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	87,328,962 - 87,382,232 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	112,029,187 - 112,082,022 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mpp4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624899	175,920 - 205,398 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mpp4
300 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	58
Count of miRNA genes:	54
Interacting mature miRNAs:	56
Transcripts:	ENSRNOT00000014094, ENSRNOT00000038132
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	32535505	77535505	Rat
1300180	Bw14	Body weight QTL 14	3.776		body mass (VT:0001259)	body weight (CMO:0000012)	9	23754024	61381613	Rat
11353957	Bmd92	Bone mineral density QTL 92		0.01	tibia mineral mass (VT:1000283)	volumetric bone mineral density (CMO:0001553)	9	46114199	91114199	Rat
631680	Cm11	Cardiac mass QTL 11	3.1	0.00089	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	9	20430519	65430519	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	25268044	79271759	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	56771635	101771635	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	22071200	67071200	Rat
12879506	Pur33	Proteinuria QTL 33			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	44649921	89649921	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
1598849	Memor17	Memory QTL 17	2.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	49968546	71098346	Rat
10058949	Gmadr5	Adrenal mass QTL 5	2	0.014	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	9	42791513	87976209	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	48598251	93598251	Rat
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	55847841	77026453	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	42495343	79271511	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	58163035	100929646	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	36962359	77814038	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	22071169	86369743	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	23754144	83851531	Rat
6903941	Pur31	Proteinuria QTL 31		0.036	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	9	40194188	85194188	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56627713	78595166	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
11353949	Bp393	Blood pressure QTL 393			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	40194188	85194188	Rat
11353951	Bp394	Blood pressure QTL 394			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	44649921	89649921	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	32535505	77535505	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	27468639	72468639	Rat

Markers in Region

AI105082

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	60,569,412 - 60,569,513 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	65,917,596 - 65,917,696	NCBI	Rnor6.0
Rnor_5.0	9	65,724,829 - 65,724,929	UniSTS	Rnor5.0
RGSC_v3.4	9	57,696,622 - 57,696,722	UniSTS	RGSC3.4
Celera	9	58,007,447 - 58,007,547	UniSTS
RH 3.4 Map	9	475.59	UniSTS
Cytogenetic Map	9	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	10	47	112	82	82	51	25	51	6	204	92	93	44	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_021265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006245011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767130	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB030499	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB030500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB030501	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BF399374	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB795928	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000014094 ⟹ ENSRNOP00000014094

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	60,569,734 - 60,608,936 (-)	Ensembl
Rnor_6.0 Ensembl	9	65,917,917 - 65,957,101 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000038132 ⟹ ENSRNOP00000032344

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	60,569,734 - 60,608,936 (-)	Ensembl
Rnor_6.0 Ensembl	9	65,917,933 - 65,951,516 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095010 ⟹ ENSRNOP00000097232

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	60,569,734 - 60,608,922 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105582 ⟹ ENSRNOP00000084543

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	60,569,734 - 60,611,797 (-)	Ensembl

RefSeq Acc Id:

NM_021265 ⟹ NP_067088

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	68,063,867 - 68,103,050 (-)	NCBI
mRatBN7.2	9	60,569,734 - 60,608,922 (-)	NCBI
Rnor_6.0	9	65,917,917 - 65,957,101 (-)	NCBI
Rnor_5.0	9	65,725,150 - 65,767,400 (-)	NCBI
RGSC_v3.4	9	57,696,943 - 57,736,126 (-)	RGD
Celera	9	58,007,768 - 58,046,959 (-)	RGD

Sequence:

show sequence

ATGAGGCAGTCTGACAGAGGAGCAGAGCTGACCGACGAGGACAGGGCTCTTTCCACAGCACCCA
ATCCTGAGAACGGTCTCTCTGGGATCCTGAGGCTCCTACTGCAGGAACTGAGTCTTTTCTACAG
CCGGGATGTGCATGGTCTGTGTCTCTTATATGACCTCCTCCATTCACCGTGGCTACAGGCTCTG
CTAAAAGTCTATGACTGCCTCCAGAAGTTTAAAGAGAAGAAGCTAGTTCCTGCTACAACTCATG
CACAGATCTTATCCTGTGAGGTCTTGGAGCTGTTACCCAAAGCCTCCAGTTCCCCTGAGATCCA
AGAGCTAAGGCAAGTCCTCCAGGCTCCGCACTGCAAGGCTTTGCTGAGGGCCCATGACACAGTG
GCTCAGAAAGACTTTGAACCCCTTCTCCCTCCACTGCCAGACAATATCCCCGACAGTGAAGAAG
CAATGAGGACTGTCTGTCTGGTGAAAAACCAACAGCCCCTGGGAGCTACCATCAAGCGTCACGA
GATAACAGGGGATATCCTGGTGGCCAGAGTCATCCACGGTGGGCTGGTGGAGAGGAGCGGGTTG
CTCTATGCTGGAGATAAACTGGTGGAAGTTAATGGAGTTCCCGTAGAGGGTCTGGACCCTGAGC
AAGTGATCCATATTCTGGCTATGTCGTGTGGTACGATCATGTTCAAGGTGATTCCGGTCTCTGC
ACCGCCTGTGAGCAGCCAGACGACAGTTTATGTTCGTGCCATGATTGATTACTGGCCCCAAGAG
GACCCTGACATCCCCTGCATGGATGCCGGATTGCCTTTCCTGAAAGGGGATATTCTCCAGATTG
TGGACCAGAGTGATGCCCTCTGGTGGCAGGCCCGGAAAATCTCAGACCTTGCAATCTGTGCTGG
GCTAATCCCTTCTAACCACCTTCTGAAGAGGAAACAGCGGGAATTCTGGTGGTCTCAGCCGTAC
CAGCCTCATACCTGCCTCAAATCCACCCGATCACTGTCTGTGGAAGAAGAAGATAGCATGAAGA
TTGACGAGAAGTGTGTGGAAGCAGATGAAGAAACTTTTGAATCTGAGGAACTCGCAGAAGCTAA
AGAGGAATTTGTCGGCGATGGGCAGCAGTTTTTTATCGCTGGCTTCCGCCGCAGCATGCGCCTG
TGTCGCAGGAAGTCTCACTTCAGCCAGCTGCATGCCAACATGCGTTGCACCTGCAGCTGTTACA
GTGCTGTGGGTGCCCCTTACGAGGAGGTAGTGAGGTACCAGCGTCAGCCGGCAGACAAACACCG
CCTCATAGTGCTTGTGGGACCTTCTGGTGTTGGAGTCAATGAACTGAGAAGACAACTCATTGGA
TGTAACCCCAGCTGTTTTCAAAGTGCTGTGCCACATACCACCCGTTCCCCGAAGAGTTATGAAA
TGGACGGGCGTGAGTATCACTACGTGTCAAGGGAAACATTTGAAAGCCTCATGTATGGACACAG
GATGCTGGAGTTCGGCGAGTACAAAGGCCACCTGTATGGAACCAGTGTGAATGCTGTACTTGCA
GTCCTTGACGAAGGGAAGATCTGTGTCATGGACTTGGAGCCTCAGGATATTCAGTTGGCTCGAA
CCCGTGAACTGAAGCCCTATGTCATATTTATTAAGCCACCTAGCATGAGCTCCATGAGACACTC
TAGGAGGAATGCTAAGATTATTACTGACTACTTTGTGGACATGAAGTTCAAGGATGAAGACCTA
CAAGAGATGGAGGAGCTAGCCCAGAAAATGGAGAGTCAGTTTGGCCAGTTTTTTGATCACGTGA
TTGTGAATGACAACTTGCAAGATGCCCGTGCCCAGCTGTTGTCTGCCATACAGAAGGCTGAGGA
AGAACTGCAGTGGGTACCAGAGGCATGGGTTTCCCCTGGCGCTGAATCTTAAAAGATCCAGACT
AACAGCTGCCATTGAGAGCACGACAACTGCAACTACGAAGGGCTGCAGCTTATGGAACGGCTTT
AACTAGCATCTAACTAGCATCGTATACTTATAGGGAGCTACTCGTTTGGCTCTCAGGCATTTCC
CCGCTGTTTCCCCATATAAGCTAAAGGTAGGGATGTGAACAATGGTGTCTCTGTATGTGAGAAT
ATTACAGATTTCATATGTTGTAAGACGGCTTTCAAAAATCTTCTAAATAAATCAGACTAATGAC
AGAAGCTGTATTTTACTTTGTAAAA

hide sequence

RefSeq Acc Id:

XM_063267659 ⟹ XP_063123729

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	68,063,867 - 68,097,317 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_067088	(Get FASTA)	NCBI Sequence Viewer
	XP_063123729	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA88229	(Get FASTA)	NCBI Sequence Viewer
	BAA88230	(Get FASTA)	NCBI Sequence Viewer
	BAA88231	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000014094
	ENSRNOP00000101708
GenBank Protein	Q9QYH1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_067088 ⟸ NM_021265

- UniProtKB:

A6IPA0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRQSDRGAELTDEDRALSTAPNPENGLSGILRLLLQELSLFYSRDVHGLCLLYDLLHSPWLQAL
LKVYDCLQKFKEKKLVPATTHAQILSCEVLELLPKASSSPEIQELRQVLQAPHCKALLRAHDTV
AQKDFEPLLPPLPDNIPDSEEAMRTVCLVKNQQPLGATIKRHEITGDILVARVIHGGLVERSGL
LYAGDKLVEVNGVPVEGLDPEQVIHILAMSCGTIMFKVIPVSAPPVSSQTTVYVRAMIDYWPQE
DPDIPCMDAGLPFLKGDILQIVDQSDALWWQARKISDLAICAGLIPSNHLLKRKQREFWWSQPY
QPHTCLKSTRSLSVEEEDSMKIDEKCVEADEETFESEELAEAKEEFVGDGQQFFIAGFRRSMRL
CRRKSHFSQLHANMRCTCSCYSAVGAPYEEVVRYQRQPADKHRLIVLVGPSGVGVNELRRQLIG
CNPSCFQSAVPHTTRSPKSYEMDGREYHYVSRETFESLMYGHRMLEFGEYKGHLYGTSVNAVLA
VLDEGKICVMDLEPQDIQLARTRELKPYVIFIKPPSMSSMRHSRRNAKIITDYFVDMKFKDEDL
QEMEELAQKMESQFGQFFDHVIVNDNLQDARAQLLSAIQKAEEELQWVPEAWVSPGAES

hide sequence

Ensembl Acc Id:

ENSRNOP00000014094 ⟸ ENSRNOT00000014094

Ensembl Acc Id:

ENSRNOP00000032344 ⟸ ENSRNOT00000038132

Ensembl Acc Id:

ENSRNOP00000084543 ⟸ ENSRNOT00000105582

Ensembl Acc Id:

ENSRNOP00000097232 ⟸ ENSRNOT00000095010

RefSeq Acc Id:	XP_063123729 ⟸ XM_063267659
- Peptide Label:	isoform X1
- UniProtKB:	Q9QYH1 (UniProtKB/Swiss-Prot), Q9QYH0 (UniProtKB/Swiss-Prot), Q9QYG9 (UniProtKB/Swiss-Prot)

Protein Domains

Guanylate kinase-like L27 PDZ SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9QYH1-F1-model_v2	AlphaFold	Q9QYH1	1-441	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620016	AgrOrtholog
BioCyc Gene	G2FUF-27418	BioCyc
Ensembl Genes	ENSRNOG00000010486	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000014094	ENTREZGENE
	ENSRNOT00000148378	ENTREZGENE
Gene3D-CATH	2.30.42.10	UniProtKB/Swiss-Prot
	3.40.50.300	UniProtKB/Swiss-Prot
	SH3 Domains	UniProtKB/Swiss-Prot
InterPro	GK/Ca_channel_bsu	UniProtKB/Swiss-Prot
	Guanylate_kin-like_dom	UniProtKB/Swiss-Prot
	Guanylate_kinase_CS	UniProtKB/Swiss-Prot
	MAGUK	UniProtKB/Swiss-Prot
	MPP4_SH3	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	PDZ_sf	UniProtKB/Swiss-Prot
	SH3-like_dom_sf	UniProtKB/Swiss-Prot
	SH3_domain	UniProtKB/Swiss-Prot
NCBI Gene	58808	ENTREZGENE
PANTHER	MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK	UniProtKB/Swiss-Prot
Pfam	Guanylate_kin	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
PhenoGen	Mpp4	PhenoGen
PROSITE	GUANYLATE_KINASE_1	UniProtKB/Swiss-Prot
	GUANYLATE_KINASE_2	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	SH3	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000010486	RatGTEx
SMART	GuKc	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	SH3	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50044	UniProtKB/Swiss-Prot
	SSF50156	UniProtKB/Swiss-Prot
	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZZC2_RAT	UniProtKB/TrEMBL
	A0A8I6ASJ9_RAT	UniProtKB/TrEMBL
	A6IPA0	ENTREZGENE, UniProtKB/TrEMBL
	D3ZUC7_RAT	UniProtKB/TrEMBL
	F1MA44_RAT	UniProtKB/TrEMBL
	MPP4_RAT	UniProtKB/Swiss-Prot
	Q9QYG9	ENTREZGENE
	Q9QYH0	ENTREZGENE
	Q9QYH1	ENTREZGENE
UniProt Secondary	Q9QYG9	UniProtKB/Swiss-Prot
	Q9QYH0	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-09-23	Mpp4	MAGUK p55 scaffold protein 4	Mpp4	membrane palmitoylated protein 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-04-14	Mpp4	membrane palmitoylated protein 4	Mpp4	membrane protein, palmitoylated 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-12-10	Mpp4	membrane protein, palmitoylated 4	Mpp4	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Mpp4	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Mpp4	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA predominantly expressed in brain	633183
gene_physical_interaction	GST pulldown assay shows protein binding to AMPA receptor GluR2 subunit	633183

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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