Cxcr2 (C-X-C motif chemokine receptor 2) - Rat Genome Database

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Gene: Cxcr2 (C-X-C motif chemokine receptor 2) Rattus norvegicus
Analyze
Symbol: Cxcr2
Name: C-X-C motif chemokine receptor 2
RGD ID: 2906
Description: Predicted to have chemokine binding activity and chemokine receptor activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of neutrophil chemotaxis; and regulation of apoptotic process. Predicted to localize to several cellular components, including external side of plasma membrane; mast cell granule; and mitotic spindle. Used to study colitis; demyelinating disease; and nephritis. Biomarker of periapical periodontitis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal disease; and urinary bladder cancer. Orthologous to human CXCR2 (C-X-C motif chemokine receptor 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C-X-C chemokine receptor type 2; chemokine (C-X-C motif) receptor 2; chemokine (C-X-C) receptor 2; Cmkar2; CXC-R2; CXCR-2; GRO/MGSA receptor; high affinity interleukin-8 receptor B; IL-8R B; Il8rb; Interleukin 8 receptor beta; interleukin 8 receptor, beta
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2975,729,493 - 75,735,868 (+)NCBI
Rnor_6.0 Ensembl981,427,730 - 81,434,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0981,427,275 - 81,435,065 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0981,193,442 - 81,199,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,470,943 - 73,477,315 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1973,617,924 - 73,624,297 (+)NCBI
Celera973,306,852 - 73,313,224 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-naphthylamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
aflatoxin B1  (ISO)
aminoguanidine  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
asperentin  (ISO)
atrazine  (ISO)
benzamide  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
ceric oxide  (EXP)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (ISO)
cytochalasin D  (ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (EXP)
doramapimod  (ISO)
dorsomorphin  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (EXP)
excitatory amino acid agonist  (ISO)
fenvalerate  (EXP)
formaldehyde  (ISO)
furan  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
isoprenaline  (ISO)
lipoarabinomannan  (ISO)
lipopolysaccharide  (ISO)
lipoteichoic acid  (ISO)
mechlorethamine  (ISO)
methacholine chloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Monobutylphthalate  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
nickel atom  (ISO)
Nicotinamide N-oxide  (ISO)
nicotine  (ISO)
oleandrin  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium chloride  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
tungsten  (ISO)
vinclozolin  (EXP)
wortmannin  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Abu Nabah YN, etal., Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2370-6. Epub 2007 Aug 23.
2. Ajuebor MN, etal., Exp Mol Pathol. 2004 Feb;76(1):1-8.
3. Andrew AS, etal., Hum Genet. 2009 Jun;125(5-6):527-39. Epub 2009 Mar 1.
4. Bhatia M and Hegde A, Regul Pept. 2007 Jan 10;138(1):40-8. Epub 2006 Oct 2.
5. Brown CR, etal., J Immunol. 2003 Jul 15;171(2):893-901.
6. Cugini D, etal., Kidney Int. 2005 May;67(5):1753-61.
7. Dunstan CA, etal., J Biol Chem 1996 Dec 20;271(51):32770-6.
8. Edman LC, etal., Stem Cells. 2008 Jul;26(7):1891-900. Epub 2008 Apr 24.
9. Eisele NA, etal., Am J Pathol. 2011 Mar;178(3):1190-200.
10. Eriksson C, etal., Lupus. 2003;12(10):766-74.
11. Fu WY, etal., Hepatol Res. 2013 Mar;43(3):300-10. doi: 10.1111/j.1872-034X.2012.01071.x. Epub 2012 Aug 6.
12. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Gavard J, etal., Mol Cell Biol. 2009 May;29(9):2469-80. doi: 10.1128/MCB.01304-08. Epub 2009 Mar 2.
14. Gelati M, etal., J Immunol. 2008 Oct 15;181(8):5711-9.
15. GOA data from the GO Consortium
16. Gobl AE, etal., Biochim Biophys Acta 1997 Jun 12;1326(2):171-7.
17. Hoth JJ, etal., Shock. 2011 Jun;35(6):604-9.
18. Javor J, etal., Int J Immunogenet. 2012 Aug;39(4):338-45. doi: 10.1111/j.1744-313X.2012.01096.x. Epub 2012 Feb 10.
19. Kang MK, etal., Am J Physiol Renal Physiol. 2012 Oct;303(7):F1060-9. doi: 10.1152/ajprenal.00106.2012. Epub 2012 Jul 11.
20. Kerstetter AE, etal., Exp Neurol. 2009 Nov;220(1):44-56. doi: 10.1016/j.expneurol.2009.07.010. Epub 2009 Jul 17.
21. Lee AH, etal., Am J Respir Cell Mol Biol. 2013 Aug 15.
22. Lee AS, etal., Apoptosis. 2012 Sep;17(9):1009-18. doi: 10.1007/s10495-012-0726-1.
23. Levashova ZB, etal., J Am Soc Nephrol. 2007 Aug;18(8):2359-70. Epub 2007 Jul 18.
24. Li L, etal., J Clin Invest. 2010 Jan;120(1):331-42. doi: 10.1172/JCI38702. Epub 2009 Dec 14.
25. Marcos V, etal., Nat Med. 2010 Sep;16(9):1018-23. Epub 2010 Sep 5.
26. Marotta DM, etal., Biochem Pharmacol. 2009 Apr 1;77(7):1223-35.
27. Marques RE, etal., Immunology. 2018 Dec;155(4):477-490. doi: 10.1111/imm.12988. Epub 2018 Sep 10.
28. Martin-Manso G, etal., PLoS One. 2012;7(11):e48775. doi: 10.1371/journal.pone.0048775. Epub 2012 Nov 7.
29. Mestas J, etal., J Immunol. 2005 Oct 15;175(8):5351-7.
30. MGD data from the GO Consortium
31. Nagarkar DR, etal., J Immunol. 2009 Nov 15;183(10):6698-707. Epub 2009 Oct 28.
32. NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Qiu Y, etal., Am J Respir Crit Care Med. 2003 Oct 15;168(8):968-75. Epub 2003 Jul 11.
34. RGD automated data pipeline
35. RGD automated import pipeline for gene-chemical interactions
36. RGD comprehensive gene curation
37. Rosenthal LA, etal., Virol J. 2009 Aug 11;6:122.
38. Russo RC, etal., Am J Respir Cell Mol Biol. 2009 Apr;40(4):410-21. Epub 2008 Oct 3.
39. Rzepka JP, etal., Am J Respir Cell Mol Biol. 2012 Jun;46(6):833-41. doi: 10.1165/rcmb.2011-0230OC. Epub 2012 Feb 3.
40. Shibata F, etal., Cytokine. 2000 Sep;12(9):1368-73.
41. Singh V, etal., Transpl Immunol. 2013 Jun;28(4):189-92. doi: 10.1016/j.trim.2013.04.004. Epub 2013 Apr 21.
42. Stevenson CS, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L514-22. Epub 2004 Oct 29.
43. Suh JS, etal., J Interferon Cytokine Res. 2011 Jan 8.
44. Svensson M, etal., Kidney Int. 2008 Jul;74(1):81-90. doi: 10.1038/ki.2008.105. Epub 2008 Apr 9.
45. Svensson M, etal., Kidney Int. 2011 Nov;80(10):1064-72. doi: 10.1038/ki.2011.257. Epub 2011 Aug 3.
46. Tateda K, etal., Infect Immun. 2001 Apr;69(4):2017-24.
47. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
48. Yamanaka Y, etal., J Endod. 2012 Mar;38(3):313-7. doi: 10.1016/j.joen.2011.11.009. Epub 2011 Dec 23.
49. Yi M, etal., Am J Respir Crit Care Med. 2004 Dec 1;170(11):1188-96. Epub 2004 Sep 3.
50. Zernecke A, etal., J Immunol. 2001 May 1;166(9):5755-62.
Additional References at PubMed
PMID:1840701   PMID:9725262   PMID:10438939   PMID:10558890   PMID:10725748   PMID:10734056   PMID:10820279   PMID:10878382   PMID:12507773   PMID:12829448   PMID:16472549   PMID:16618742  
PMID:17891165   PMID:18391506   PMID:18462836   PMID:19155217   PMID:20420568   PMID:20877331   PMID:21670971   PMID:22361324   PMID:24496685   PMID:26724371   PMID:27145805   PMID:27879294  
PMID:29117499   PMID:31616413   PMID:31638188  


Genomics

Comparative Map Data
Cxcr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2975,729,493 - 75,735,868 (+)NCBI
Rnor_6.0 Ensembl981,427,730 - 81,434,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0981,427,275 - 81,435,065 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0981,193,442 - 81,199,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,470,943 - 73,477,315 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1973,617,924 - 73,624,297 (+)NCBI
Celera973,306,852 - 73,313,224 (+)NCBICelera
Cytogenetic Map9q33NCBI
CXCR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2218,125,289 - 218,137,251 (+)EnsemblGRCh38hg38GRCh38
GRCh382218,125,294 - 218,137,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372218,990,017 - 219,001,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,698,991 - 218,710,220 (+)NCBINCBI36hg18NCBI36
Build 342218,816,251 - 218,827,481NCBI
Celera2212,756,449 - 212,768,411 (+)NCBI
Cytogenetic Map2q35NCBI
HuRef2210,842,767 - 210,854,732 (+)NCBIHuRef
CHM1_12218,996,503 - 219,008,469 (+)NCBICHM1_1
Cxcr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,193,153 - 74,200,405 (+)NCBIGRCm39mm39
GRCm39 Ensembl174,193,148 - 74,200,405 (+)Ensembl
GRCm38174,153,994 - 74,161,246 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,153,989 - 74,161,246 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,200,568 - 74,207,820 (+)NCBIGRCm37mm9NCBIm37
MGSCv36174,087,201 - 74,094,453 (+)NCBImm8
Celera174,715,354 - 74,722,423 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map138.41NCBI
CXCR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B223,987,556 - 223,999,511 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B223,997,066 - 223,998,148 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B105,387,198 - 105,400,533 (+)NCBIMhudiblu_PPA_v0panPan3
CXCR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13724,831,351 - 24,846,387 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3724,843,171 - 24,844,247 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3725,659,341 - 25,664,768 (+)NCBI
ROS_Cfam_1.03724,847,511 - 24,862,398 (+)NCBI
UMICH_Zoey_3.13724,760,631 - 24,766,058 (+)NCBI
UNSW_CanFamBas_1.03724,694,995 - 24,700,420 (+)NCBI
UU_Cfam_GSD_1.03724,714,358 - 24,719,785 (+)NCBI
CXCR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.115120,219,657 - 120,230,203 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,275,203 - 133,286,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103217855
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,012,906 - 104,025,599 (+)NCBI
ChlSab1.1 Ensembl10104,022,811 - 104,023,893 (+)Ensembl

Position Markers
L23637  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0981,434,038 - 81,434,171NCBIRnor6.0
Rnor_5.0981,199,750 - 81,199,883UniSTSRnor5.0
RGSC_v3.4973,477,251 - 73,477,384UniSTSRGSC3.4
Celera973,313,160 - 73,313,293UniSTS
Cytogenetic Map9q33UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9105522293442944Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92569234292741406Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92748615588333183Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92907507983686404Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)929075079122095297Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)929466970107878528Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93764235182642351Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93764235182642351Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)94126103490024806Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94126103498606834Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)941261034102531865Rat
6903941Pur31Proteinuria QTL 310.036total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94657976991579769Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94657976991579769Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94695242783686153Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94724896594124663Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95417754299177542Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)96081029882732466Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)961186278106186278Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)96173092382890620Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)96173092382890620Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)96173092382890620Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)963270073107878387Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)966757444112943287Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96745166499920892Rat
1578757Pur6Proteinuria QTL 63.30.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96745166499920892Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)970241351115241351Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)970942881115942881Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)981411073119983851Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:31
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000019109
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 1
Low 25 10 17 10 9 10
Below cutoff 3 28 27 26 26 5 8 34 29 17 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019109   ⟹   ENSRNOP00000019109
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl981,427,730 - 81,434,102 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081711   ⟹   ENSRNOP00000071417
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl981,427,754 - 81,434,028 (+)Ensembl
RefSeq Acc Id: NM_017183   ⟹   NP_058879
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2975,729,493 - 75,735,868 (+)NCBI
Rnor_6.0981,427,730 - 81,434,102 (+)NCBI
Rnor_5.0981,193,442 - 81,199,814 (+)NCBI
RGSC_v3.4973,470,943 - 73,477,315 (+)RGD
Celera973,306,852 - 73,313,224 (+)RGD
Sequence:
RefSeq Acc Id: XM_008767213   ⟹   XP_008765435
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0981,427,275 - 81,435,065 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058879 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52961 (Get FASTA)   NCBI Sequence Viewer  
  BAA09797 (Get FASTA)   NCBI Sequence Viewer  
  CAA54824 (Get FASTA)   NCBI Sequence Viewer  
  EDL75335 (Get FASTA)   NCBI Sequence Viewer  
  P35407 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058879   ⟸   NM_017183
- UniProtKB: P35407 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008765435   ⟸   XM_008767213
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000071417   ⟸   ENSRNOT00000081711
RefSeq Acc Id: ENSRNOP00000019109   ⟸   ENSRNOT00000019109
Protein Domains
G_PROTEIN_RECEP_F1_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2906 AgrOrtholog
Ensembl Genes ENSRNOG00000014269 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019109 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071417 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019109 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000081711 UniProtKB/TrEMBL
InterPro Chemokine_CXCR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXCR_1/2 UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29385 UniProtKB/Swiss-Prot
NCBI Gene 29385 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cxcr2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLEUKIN8R UniProtKB/Swiss-Prot
  INTRLEUKN8BR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC207804
UniProt A0A0G2K0F0_RAT UniProtKB/TrEMBL
  CXCR2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Cxcr2  C-X-C motif chemokine receptor 2  Cxcr2  chemokine (C-X-C motif) receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-06 Cxcr2  chemokine (C-X-C motif) receptor 2  Il8rb  interleukin 8 receptor, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Il8rb  interleukin 8 receptor, beta      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in spleen, heart, lung, liver, skeletal muscle and kidney but not found in brain and testis 729076
gene_product members of the rhodopsin G-protein coupled receptor (GCR) superfamily 69860