Cxcr2 (C-X-C motif chemokine receptor 2) - Rat Genome Database

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Gene: Cxcr2 (C-X-C motif chemokine receptor 2) Rattus norvegicus
Symbol: Cxcr2
Name: C-X-C motif chemokine receptor 2
RGD ID: 2906
Description: Predicted to enable chemokine binding activity and chemokine receptor activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of neutrophil chemotaxis; and regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Used to study colitis; demyelinating disease; and nephritis. Biomarker of periapical periodontitis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal disease; and urinary bladder cancer. Orthologous to human CXCR2 (C-X-C motif chemokine receptor 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: C-X-C chemokine receptor type 2; chemokine (C-X-C motif) receptor 2; chemokine (C-X-C) receptor 2; Cmkar2; CXC-R2; CXCR-2; GRO/MGSA receptor; high affinity interleukin-8 receptor B; IL-8R B; Il8rb; Interleukin 8 receptor beta; interleukin 8 receptor, beta
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2975,729,493 - 75,735,868 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl975,729,115 - 75,739,425 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,182,990 - 84,189,368 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0989,311,908 - 89,318,286 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0987,698,116 - 87,704,494 (+)NCBIRnor_WKY
Rnor_6.0981,427,275 - 81,435,065 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,427,730 - 81,434,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,193,442 - 81,199,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,470,943 - 73,477,315 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1973,617,924 - 73,624,297 (+)NCBI
Celera973,306,852 - 73,313,224 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-naphthylamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aminoguanidine  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
asperentin  (ISO)
atrazine  (ISO)
benzamide  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
ceric oxide  (EXP)
CGP 52608  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (ISO)
cytochalasin D  (ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (EXP)
dioxygen  (EXP)
doramapimod  (ISO)
dorsomorphin  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (EXP)
excitatory amino acid agonist  (ISO)
fenvalerate  (EXP)
formaldehyde  (ISO)
furan  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
isoprenaline  (ISO)
lipoarabinomannan  (ISO)
lipopolysaccharide  (ISO)
lipoteichoic acid  (ISO)
mechlorethamine  (ISO)
methacholine chloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Monobutylphthalate  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
nickel atom  (ISO)
Nicotinamide N-oxide  (ISO)
nicotine  (ISO)
oleandrin  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
reparixin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium chloride  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
tungsten  (ISO)
vinclozolin  (EXP)
wortmannin  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component


References - curated
# Reference Title Reference Citation
1. CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration. Abu Nabah YN, etal., Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2370-6. Epub 2007 Aug 23.
2. Contrasting roles for CXCR2 during experimental colitis. Ajuebor MN, etal., Exp Mol Pathol. 2004 Feb;76(1):1-8.
3. Bladder cancer SNP panel predicts susceptibility and survival. Andrew AS, etal., Hum Genet. 2009 Jun;125(5-6):527-39. Epub 2009 Mar 1.
4. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Bhatia M and Hegde A, Regul Pept. 2007 Jan 10;138(1):40-8. Epub 2006 Oct 2.
5. Susceptibility to experimental Lyme arthritis correlates with KC and monocyte chemoattractant protein-1 production in joints and requires neutrophil recruitment via CXCR2. Brown CR, etal., J Immunol. 2003 Jul 15;171(2):893-901.
6. Inhibition of the chemokine receptor CXCR2 prevents kidney graft function deterioration due to ischemia/reperfusion. Cugini D, etal., Kidney Int. 2005 May;67(5):1753-61.
7. Identification of two rat genes orthologous to the human interleukin-8 receptors. Dunstan CA, etal., J Biol Chem 1996 Dec 20;271(51):32770-6.
8. Alpha-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres. Edman LC, etal., Stem Cells. 2008 Jul;26(7):1891-900. Epub 2008 Apr 24.
9. Chemokine receptor CXCR2 mediates bacterial clearance rather than neutrophil recruitment in a murine model of pneumonic plague. Eisele NA, etal., Am J Pathol. 2011 Mar;178(3):1190-200.
10. Abnormal expression of chemokine receptors on T-cells from patients with systemic lupus erythematosus. Eriksson C, etal., Lupus. 2003;12(10):766-74.
11. Suppression of liver regeneration affects hepatic graft survival in small-for-size liver transplantation in rats. Fu WY, etal., Hepatol Res. 2013 Mar;43(3):300-10. doi: 10.1111/j.1872-034X.2012.01071.x. Epub 2012 Aug 6.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability. Gavard J, etal., Mol Cell Biol. 2009 May;29(9):2469-80. doi: 10.1128/MCB.01304-08. Epub 2009 Mar 2.
14. The angiogenic response of the aorta to injury and inflammatory cytokines requires macrophages. Gelati M, etal., J Immunol. 2008 Oct 15;181(8):5711-9.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Molecular cloning and characterization of a cDNA encoding the rat interleukin-8 receptor. Gobl AE, etal., Biochim Biophys Acta 1997 Jun 12;1326(2):171-7.
17. Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Hoth JJ, etal., Shock. 2011 Jun;35(6):604-9.
18. Genetic variations of interleukin-8, CXCR1 and CXCR2 genes and risk of acute pyelonephritis in children. Javor J, etal., Int J Immunogenet. 2012 Aug;39(4):338-45. doi: 10.1111/j.1744-313X.2012.01096.x. Epub 2012 Feb 10.
19. Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration. Kang MK, etal., Am J Physiol Renal Physiol. 2012 Oct;303(7):F1060-9. doi: 10.1152/ajprenal.00106.2012. Epub 2012 Jul 11.
20. Inhibition of CXCR2 signaling promotes recovery in models of multiple sclerosis. Kerstetter AE, etal., Exp Neurol. 2009 Nov;220(1):44-56. doi: 10.1016/j.expneurol.2009.07.010. Epub 2009 Jul 17.
21. ROCK InhibitorPrevents Bleomycin-Induced Injury in Neonatal RatsIndependent of Effects on LungInflammation. Lee AH, etal., Am J Respir Cell Mol Biol. 2013 Aug 15.
22. Electronegative low-density lipoprotein induces cardiomyocyte apoptosis indirectly through endothelial cell-released chemokines. Lee AS, etal., Apoptosis. 2012 Sep;17(9):1009-18. doi: 10.1007/s10495-012-0726-1.
23. ELR+-CXC chemokines and their receptors in early metanephric development. Levashova ZB, etal., J Am Soc Nephrol. 2007 Aug;18(8):2359-70. Epub 2007 Jul 18.
24. IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. Li L, etal., J Clin Invest. 2010 Jan;120(1):331-42. doi: 10.1172/JCI38702. Epub 2009 Dec 14.
25. CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation. Marcos V, etal., Nat Med. 2010 Sep;16(9):1018-23. Epub 2010 Sep 5.
26. Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw. Marotta DM, etal., Biochem Pharmacol. 2009 Apr 1;77(7):1223-35.
27. Interleukin-33 contributes to disease severity in Dengue virus infection in mice. Marques RE, etal., Immunology. 2018 Dec;155(4):477-490. doi: 10.1111/imm.12988. Epub 2018 Sep 10.
28. Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis. Martin-Manso G, etal., PLoS One. 2012;7(11):e48775. doi: 10.1371/journal.pone.0048775. Epub 2012 Nov 7.
29. The role of CXCR2/CXCR2 ligand biological axis in renal cell carcinoma. Mestas J, etal., J Immunol. 2005 Oct 15;175(8):5351-7.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. CXCR2 is required for neutrophilic airway inflammation and hyperresponsiveness in a mouse model of human rhinovirus infection. Nagarkar DR, etal., J Immunol. 2009 Nov 15;183(10):6698-707. Epub 2009 Oct 28.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease. Qiu Y, etal., Am J Respir Crit Care Med. 2003 Oct 15;168(8):968-75. Epub 2003 Jul 11.
34. GOA pipeline RGD automated data pipeline
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Comprehensive gene review and curation RGD comprehensive gene curation
37. A rat model of picornavirus-induced airway infection and inflammation. Rosenthal LA, etal., Virol J. 2009 Aug 11;6:122.
38. Role of the chemokine receptor CXCR2 in bleomycin-induced pulmonary inflammation and fibrosis. Russo RC, etal., Am J Respir Cell Mol Biol. 2009 Apr;40(4):410-21. Epub 2008 Oct 3.
39. Virus-infected alveolar epithelial cells direct neutrophil chemotaxis and inhibit their apoptosis. Rzepka JP, etal., Am J Respir Cell Mol Biol. 2012 Jun;46(6):833-41. doi: 10.1165/rcmb.2011-0230OC. Epub 2012 Feb 3.
40. Identification of a common receptor for three types of rat cytokine-induced neutrophil chemoattractants (CINCs). Shibata F, etal., Cytokine. 2000 Sep;12(9):1368-73.
41. Association of chemokine gene variants with end stage renal disease in North Indian population. Singh V, etal., Transpl Immunol. 2013 Jun;28(4):189-92. doi: 10.1016/j.trim.2013.04.004. Epub 2013 Apr 21.
42. Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect. Stevenson CS, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L514-22. Epub 2004 Oct 29.
43. Polymorphisms of CXCL8 and Its Receptor CXCR2 Contribute to the Development and Progression of Childhood IgA Nephropathy. Suh JS, etal., J Interferon Cytokine Res. 2011 Jan 8.
44. Effects of epithelial and neutrophil CXCR2 on innate immunity and resistance to kidney infection. Svensson M, etal., Kidney Int. 2008 Jul;74(1):81-90. doi: 10.1038/ki.2008.105. Epub 2008 Apr 9.
45. Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice. Svensson M, etal., Kidney Int. 2011 Nov;80(10):1064-72. doi: 10.1038/ki.2011.257. Epub 2011 Aug 3.
46. Chemokine-dependent neutrophil recruitment in a murine model of Legionella pneumonia: potential role of neutrophils as immunoregulatory cells. Tateda K, etal., Infect Immun. 2001 Apr;69(4):2017-24.
47. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
48. Expression of angiogenic factors in rat periapical lesions. Yamanaka Y, etal., J Endod. 2012 Mar;38(3):313-7. doi: 10.1016/j.joen.2011.11.009. Epub 2011 Dec 23.
49. Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat. Yi M, etal., Am J Respir Crit Care Med. 2004 Dec 1;170(11):1188-96. Epub 2004 Sep 3.
50. Combinatorial model of chemokine involvement in glomerular monocyte recruitment: role of CXC chemokine receptor 2 in infiltration during nephrotoxic nephritis. Zernecke A, etal., J Immunol. 2001 May 1;166(9):5755-62.
Additional References at PubMed
PMID:1840701   PMID:9725262   PMID:10438939   PMID:10558890   PMID:10725748   PMID:10734056   PMID:10820279   PMID:10878382   PMID:12507773   PMID:12829448   PMID:16472549   PMID:16618742  
PMID:17891165   PMID:18391506   PMID:18462836   PMID:19155217   PMID:20420568   PMID:20877331   PMID:21670971   PMID:22361324   PMID:24496685   PMID:26724371   PMID:27145805   PMID:27879294  
PMID:29117499   PMID:31616413   PMID:31638188   PMID:32812337   PMID:36603746  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2975,729,493 - 75,735,868 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl975,729,115 - 75,739,425 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,182,990 - 84,189,368 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0989,311,908 - 89,318,286 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0987,698,116 - 87,704,494 (+)NCBIRnor_WKY
Rnor_6.0981,427,275 - 81,435,065 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,427,730 - 81,434,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,193,442 - 81,199,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,470,943 - 73,477,315 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1973,617,924 - 73,624,297 (+)NCBI
Celera973,306,852 - 73,313,224 (+)NCBICelera
Cytogenetic Map9q33NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382218,125,294 - 218,137,251 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2218,125,289 - 218,137,251 (+)EnsemblGRCh38hg38GRCh38
GRCh372218,990,017 - 219,001,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,698,991 - 218,710,220 (+)NCBINCBI36Build 36hg18NCBI36
Build 342218,816,251 - 218,827,481NCBI
Celera2212,756,449 - 212,768,411 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2210,842,767 - 210,854,732 (+)NCBIHuRef
CHM1_12218,996,503 - 219,008,469 (+)NCBICHM1_1
T2T-CHM13v2.02218,610,987 - 218,622,946 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39174,193,153 - 74,200,405 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,193,148 - 74,200,405 (+)EnsemblGRCm39 Ensembl
GRCm38174,153,994 - 74,161,246 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,153,989 - 74,161,246 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,200,568 - 74,207,820 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,087,201 - 74,094,453 (+)NCBIMGSCv36mm8
Celera174,715,354 - 74,722,423 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map138.41NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12B120,776,837 - 120,788,338 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B105,387,198 - 105,400,533 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B223,987,556 - 223,999,511 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B223,997,066 - 223,998,148 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13724,831,351 - 24,846,387 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3724,843,171 - 24,844,247 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3725,659,341 - 25,664,768 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03724,847,511 - 24,862,398 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3724,855,136 - 24,860,563 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13724,760,631 - 24,766,058 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03724,694,995 - 24,700,420 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03724,714,358 - 24,719,785 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.115120,219,657 - 120,230,203 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,275,203 - 133,286,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.110104,012,906 - 104,025,599 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,022,811 - 104,023,893 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604095,376,101 - 95,386,709 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Cxcr2
35 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:31
Interacting mature miRNAs:33
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2975,735,803 - 75,735,937 (+)MAPPERmRatBN7.2
Rnor_6.0981,434,038 - 81,434,171NCBIRnor6.0
Rnor_5.0981,199,750 - 81,199,883UniSTSRnor5.0
RGSC_v3.4973,477,251 - 73,477,384UniSTSRGSC3.4
Celera973,313,160 - 73,313,293UniSTS
Cytogenetic Map9q33UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 1
Low 25 10 17 10 9 10
Below cutoff 3 28 27 26 26 5 8 34 29 17 5


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019109   ⟹   ENSRNOP00000019109
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl981,427,730 - 81,434,102 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081711   ⟹   ENSRNOP00000071417
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl981,427,754 - 81,434,028 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101059   ⟹   ENSRNOP00000093296
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl975,729,115 - 75,739,425 (+)Ensembl
RefSeq Acc Id: NM_017183   ⟹   NP_058879
Rat AssemblyChrPosition (strand)Source
mRatBN7.2975,729,493 - 75,735,868 (+)NCBI
Rnor_6.0981,427,730 - 81,434,102 (+)NCBI
Rnor_5.0981,193,442 - 81,199,814 (+)NCBI
RGSC_v3.4973,470,943 - 73,477,315 (+)RGD
Celera973,306,852 - 73,313,224 (+)RGD
Protein Sequences
Protein RefSeqs NP_058879 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52961 (Get FASTA)   NCBI Sequence Viewer  
  BAA09797 (Get FASTA)   NCBI Sequence Viewer  
  CAA54824 (Get FASTA)   NCBI Sequence Viewer  
  EDL75335 (Get FASTA)   NCBI Sequence Viewer  
  P35407 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058879   ⟸   NM_017183
- UniProtKB: P35407 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071417   ⟸   ENSRNOT00000081711
RefSeq Acc Id: ENSRNOP00000019109   ⟸   ENSRNOT00000019109
RefSeq Acc Id: ENSRNOP00000093296   ⟸   ENSRNOT00000101059

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35407-F1-model_v2 AlphaFold P35407 1-359 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2906 AgrOrtholog
BioCyc Gene G2FUF-27149 BioCyc
Ensembl Genes ENSRNOG00000014269 Ensembl
  ENSRNOG00000063618 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000093296 ENTREZGENE
  ENSRNOP00000093296.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000101059 ENTREZGENE
  ENSRNOT00000101059.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Chemokine_CXCR2 UniProtKB/Swiss-Prot
  Chemokine_CXCR_1/2 UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:29385 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Cxcr2 PhenoGen
  INTRLEUKIN8R UniProtKB/Swiss-Prot
  INTRLEUKN8BR UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC207804
UniProt CXCR2_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Cxcr2  C-X-C motif chemokine receptor 2  Cxcr2  chemokine (C-X-C motif) receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-06 Cxcr2  chemokine (C-X-C motif) receptor 2  Il8rb  interleukin 8 receptor, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Il8rb  interleukin 8 receptor, beta      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in spleen, heart, lung, liver, skeletal muscle and kidney but not found in brain and testis 729076
gene_product members of the rhodopsin G-protein coupled receptor (GCR) superfamily 69860