Bp334 QTL Report (Rattus norvegicus) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
QTL Registration

QTL: Bp334 (Blood pressure QTL 334) Rattus norvegicus

Symbol: Bp334
Name: Blood pressure QTL 334
RGD ID: 2303178
Previously known as: S x SHR QTL Region 2; BP QTL 2
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: diastolic blood pressure   (CMO:0000005)    
mean arterial blood pressure   (CMO:0000009)    
systolic blood pressure   (CMO:0000004)    
LOD Score: 3.7
P Value: 0.01
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8986,720,043 - 121,768,150RGD_MAPPER_PIPELINE
mRatBN7.2979,271,511 - 91,616,855RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0983,686,153 - 98,164,303RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0983,451,810 - 97,845,437RGDRnor5.0
RGSC_v3.4977,170,797 - 90,249,887RGDRGSC3.4
Cross Type: intercross
Strains Crossed: SS.SHR-(D9Rat7-D9Mco93)/Mco 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp334Ratdecreased mean systemic arterial blood pressure  IAGP 2302803on 2% NaCl dietRGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp334Ratdiastolic blood pressure  IDA 2302803 RGD 
Bp334Ratmean arterial blood pressure  IDA 2302803 RGD 
Bp334Ratsystolic blood pressure  IDA 2302803 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp334Ratcontrolled sodium content diet  IDA 2302803 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp334Ratintra-aortic abdominal radiotelemetry  IDA 2302803 RGD 
Bp334Rattail cuff photoplethysmography  IDA 2302803 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp334RatSS.SHR-(D9Rat7-D9Mco93)/Mco  IEA 2302803 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp334Ratarterial blood pressure trait  IDA 2302803 RGD 


#
Reference Title
Reference Citation
1. Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models. Kumarasamy S, etal., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4.
2. Blood pressure and proteinuria effects of multiple quantitative trait loci on rat chromosome 9 that differentiate the spontaneously hypertensive rat from the Dahl salt-sensitive rat. Toland EJ, etal., J Hypertens. 2008 Nov;26(11):2134-41.

Related QTL Description Reference
Bp108 interacts with RGD:2302803
Bp34 interacts with RGD:2302803
Pur31 sub_region RGD:6903249



1 to 20 of 172 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
41022835LOC120094905U1 spliceosomal RNA97935164579351807Rat
40973822LOC120094851uncharacterized LOC12009485197937539879380326Rat
9346176LOC103690559uncharacterized LOC10369055997939681379426093Rat
620431Pax3paired box 397956745579664042Rat
11455030LOC108351956RING finger protein 223-like97968147879684988Rat
40952464LOC120094975U6 spliceosomal RNA97975781579757917Rat
1565739Sgpp2sphingosine-1-phosphate phosphatase 297976265879884665Rat
1303210Farsbphenylalanyl-tRNA synthetase subunit beta97988785279947082Rat
1311644Mogat1monoacylglycerol O-acyltransferase 197998096379988513Rat
70552Acsl3acyl-CoA synthetase long-chain family member 398011516480164636Rat
7514331LOC102551819U3 small nucleolar RNA-associated protein 14 homolog B-like98012062280129166Rat
1302957Kcne4potassium voltage-gated channel subfamily E regulatory subunit 498024342980251533Rat
41018431Trnat-agu20transfer RNA threonine (anticodon AGU) 2098033471680334790Rat
619975Hdac1lhistone deacetylase 1-like98045261580454615Rat
41241510LOC120094717uncharacterized LOC12009471798064940180677567Rat
3626Scg2secretogranin II98080307480808646Rat
6499336Eef1a1-ps8eukaryotic translation elongation factor 1 alpha 1, pseudogene 898086618480867575Rat
40949615LOC120094936small nucleolar RNA SNORA1798087056180870674Rat
1566037Rpsa-ps11ribosomal protein SA, pseudogene 1198091006880912886Rat
1311772Ap1s3adaptor related protein complex 1 subunit sigma 398095040281009889Rat

1 to 20 of 172 rows
1 to 20 of 233 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10359D9Got10923298788122287881453Ratregion
10965D9Arb526398700863587008898Ratregion
34088D9Mgh211098636963186369743Ratregion
33688D9Mit717598920003589200212Ratregion
36009D9Rat5414998131436481314513Ratregion
37216D9Rat6720998838794388388152Ratregion
36838D9Rat5116998451486184515030Ratregion
37002D9Rat5312898119923881199366Ratregion
37052D9Rat615798850705588507212Ratregion
37190D9Rat9921998921570589215924Ratregion
37724D9Rat8420898519398285194188Ratregion
37932D9Rat6820798907535889075565Ratregion
35691D9Rat510898707346887073594Ratregion
39654D9Rat11123098910172889101958Ratregion
39658D9Rat14220198988242189882624Ratregion
39970D9Rat14110099154551291545612Ratregion
38270D9Rat9720599109075891090963Ratregion
38388D9Rat7424198369287683693117Ratregion
40080D9Rat14412798385153183851658Ratregion
39384D9Rat14523398329093383291164Ratregion
1 to 20 of 233 rows

Flank 1: (D9Uia6)
Rat AssemblyChrPosition (strand)Source
GRCr8986,720,043 - 86,720,295 (+)Marker Load Pipeline
mRatBN7.2979,271,511 - 79,271,759 (+)MAPPER
Rnor_6.0983,686,153 - 83,686,404NCBI
Rnor_5.0983,451,810 - 83,452,061UniSTS
RGSC_v3.4977,170,797 - 77,171,049RGD
RGSC_v3.4977,170,798 - 77,171,049UniSTS
RGSC_v3.1977,354,082 - 77,354,334RGD
Celera976,786,573 - 76,786,824UniSTS
Cytogenetic Map9 RGD
Peak: (D9Got111)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2990,719,946 - 90,720,113 (+)MAPPER
Rnor_6.0997,276,144 - 97,276,310NCBI
Rnor_5.0996,967,774 - 96,967,940UniSTS
RGSC_v3.4989,249,726 - 89,249,893RGD
RGSC_v3.4989,249,727 - 89,249,893UniSTS
RGSC_v3.1989,454,495 - 89,454,662RGD
Celera988,267,055 - 88,267,221UniSTS
RH 2.0 Map9927.4RGD
Cytogenetic Map9q35UniSTS
Flank 2: (D9Mco93)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2991,616,614 - 91,616,855 (+)MAPPER
Rnor_6.0998,164,065 - 98,164,303NCBI
Rnor_5.0997,845,199 - 97,845,437UniSTS
RGSC_v3.4990,249,649 - 90,249,887UniSTS
Celera989,159,614 - 89,159,852UniSTS
Cytogenetic Map9 RGD


1 to 10 of 29 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat

1 to 10 of 29 rows


Note Type Note Reference
qtl_cross_type intercross  
qtl_general number of animals used: 20 2302803
qtl_general measurement method: animals were on 0.3% NaCl diet, at 40-42 of age they were on 2% NaCl diet; systolic blood pressure was measured by tail-cuff method on days 24-28 of high salt regimen 2302803