Gene: Alpi (alkaline phosphatase, intestinal) Rattus norvegicus
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Symbol: Alpi
Name: alkaline phosphatase, intestinal
Description: ENCODES a protein that exhibits alkaline phosphatase activity; magnesium ion binding; protein homodimerization activity; INVOLVED IN dephosphorylation; phosphorus metabolic process; cellular response to BMP stimulus (ortholog); PARTICIPATES IN folate metabolic pathway; ASSOCIATED WITH Dysbiosis; Crohn's disease (ortholog); inflammatory bowel disease (ortholog); FOUND IN external side of plasma membrane; plasma membrane (ortholog); INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID; 3,7-dihydropurine-6-thione
AGR Description: Exhibits alkaline phosphatase activity, metal ion binding activity, and protein homodimerization activity; involved in dephosphorylation; localizes to the external side of plasma membrane; orthologous to several human genes including ALPI (alkaline phosphatase, intestinal).
Merged Description: Exhibits alkaline phosphatase activity, metal ion binding activity, and protein homodimerization activity; involved in dephosphorylation; localizes to the external side of plasma membrane; orthologous to several human genes including ALPI (alkaline phosphatase, intestinal); PARTICIPATES IN folate metabolic pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Alkaline phosphatase 1, intestinal, defined by SSR; Alp1; IAP-1; IAP-I; intestinal alkaline phosphatase; intestinal alkaline phosphatase 1; intestinal alkaline phosphatase I IAP-I; intestinal alkaline phosphatase I, IAP-I; intestinal-type alkaline phosphatase 1; S51097
Orthologs:
Homo sapiens (human) : ALPI (alkaline phosphatase, intestinal)  HGNC  Alliance
Mus musculus (house mouse) : Alpi (alkaline phosphatase, intestinal)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : ALPI (alkaline phosphatase, intestinal)
Canis lupus familiaris (dog) : ALPI (alkaline phosphatase, intestinal)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alpi (alkaline phosphatase, intestinal)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0994,197,616 - 94,201,910 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0993,922,817 - 93,926,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,892,887 - 85,896,353 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1986,076,305 - 86,079,772 (-)NCBI
Celera985,187,115 - 85,190,581 (-)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Alpi
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2099
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.