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Gene: Alpi (alkaline phosphatase, intestinal) Rattus norvegicus
Symbol: Alpi
Name: alkaline phosphatase, intestinal
Description: Exhibits alkaline phosphatase activity; metal ion binding activity; and protein homodimerization activity. Involved in dephosphorylation. Localizes to external side of plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to several human genes including ALPI (alkaline phosphatase, intestinal); PARTICIPATES IN folate metabolic pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 3,7-dihydropurine-6-thione; actinomycin D.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Alkaline phosphatase 1, intestinal, defined by SSR; Alp1; IAP-1; IAP-I; intestinal alkaline phosphatase; intestinal alkaline phosphatase 1; intestinal alkaline phosphatase I IAP-I; intestinal alkaline phosphatase I, IAP-I; intestinal-type alkaline phosphatase 1; S51097
Homo sapiens (human) : ALPI (alkaline phosphatase, intestinal)  HGNC  Alliance
Mus musculus (house mouse) : Alpi (alkaline phosphatase, intestinal)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : ALPI (alkaline phosphatase, intestinal)
Canis lupus familiaris (dog) : ALPI (alkaline phosphatase, intestinal)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alpi (alkaline phosphatase, intestinal)
Chlorocebus sabaeus (African green monkey) : ALPI (alkaline phosphatase, intestinal)
Heterocephalus glaber (naked mole-rat) : Alpi (alkaline phosphatase, intestinal)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0994,197,616 - 94,201,910 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,197,618 - 94,201,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,922,817 - 93,926,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,892,887 - 85,896,353 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1986,076,305 - 86,079,772 (-)NCBI
Celera985,187,115 - 85,190,581 (-)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Alpi
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2099
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.