Gpr55 (G protein-coupled receptor 55) - Rat Genome Database

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Gene: Gpr55 (G protein-coupled receptor 55) Rattus norvegicus
Analyze
Symbol: Gpr55
Name: G protein-coupled receptor 55
RGD ID: 1559828
Description: Predicted to enable cannabinoid receptor activity. Predicted to be involved in several processes, including bone resorption; negative regulation of osteoclast differentiation; and positive regulation of intracellular signal transduction. Predicted to be active in plasma membrane. Orthologous to human GPR55 (G protein-coupled receptor 55); INTERACTS WITH ammonium chloride; bisphenol A; Cannabidivarin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G-protein coupled receptor 55
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8994,037,748 - 94,081,426 (-)NCBIGRCr8
mRatBN7.2986,584,906 - 86,640,601 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl986,590,885 - 86,640,613 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0992,961,431 - 93,011,157 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl992,962,738 - 92,963,697 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0992,690,726 - 92,740,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4984,657,975 - 84,658,934 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera984,012,133 - 84,061,885 (-)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9931487   PMID:18757503   PMID:19723626   PMID:19805329   PMID:21497900   PMID:21726355   PMID:21885477   PMID:23472002   PMID:23814062   PMID:23992544   PMID:24378736   PMID:26292188  
PMID:32121640   PMID:32197469   PMID:32360768   PMID:32519268   PMID:32967746   PMID:35612493   PMID:35831708   PMID:36099968   PMID:38374108  


Genomics

Comparative Map Data
Gpr55
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8994,037,748 - 94,081,426 (-)NCBIGRCr8
mRatBN7.2986,584,906 - 86,640,601 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl986,590,885 - 86,640,613 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0992,961,431 - 93,011,157 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl992,962,738 - 92,963,697 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0992,690,726 - 92,740,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4984,657,975 - 84,658,934 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera984,012,133 - 84,061,885 (-)NCBICelera
Cytogenetic Map9q35NCBI
GPR55
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,907,328 - 230,961,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,907,318 - 230,961,066 (-)EnsemblGRCh38hg38GRCh38
GRCh372231,772,043 - 231,789,957 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,480,287 - 231,498,185 (-)NCBINCBI36Build 36hg18NCBI36
Build 342231,597,538 - 231,615,446NCBI
Celera2225,548,449 - 225,566,348 (-)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2223,614,400 - 223,632,298 (-)NCBIHuRef
CHM1_12231,777,847 - 231,795,746 (-)NCBICHM1_1
T2T-CHM13v2.02231,390,497 - 231,444,798 (-)NCBIT2T-CHM13v2.0
Gpr55
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39185,860,927 - 85,924,781 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl185,866,039 - 85,888,729 (-)EnsemblGRCm39 Ensembl
GRCm38185,933,221 - 85,991,583 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl185,938,318 - 85,961,007 (-)EnsemblGRCm38mm10GRCm38
MGSCv37187,836,112 - 87,857,630 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36187,770,708 - 87,792,178 (-)NCBIMGSCv36mm8
Celera188,904,892 - 88,926,362 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map143.94NCBI
Gpr55
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554534,470,602 - 4,520,036 (+)NCBIChiLan1.0ChiLan1.0
GPR55
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213133,530,894 - 133,585,350 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B133,545,859 - 133,600,315 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B118,159,511 - 118,163,334 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B236,955,534 - 236,973,443 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B236,958,210 - 236,959,169 (-)Ensemblpanpan1.1panPan2
GPR55
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12542,864,869 - 42,931,786 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2542,866,416 - 42,908,332 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2543,423,433 - 43,492,124 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02543,119,993 - 43,188,752 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2543,125,851 - 43,137,553 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12543,048,843 - 43,117,310 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02542,891,570 - 42,960,149 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02543,046,922 - 43,115,784 (-)NCBIUU_Cfam_GSD_1.0
Gpr55
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303185,053,427 - 185,098,555 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365255,869,416 - 5,888,789 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365255,869,416 - 5,888,789 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR55
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15131,655,663 - 131,673,693 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115131,655,655 - 131,674,816 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215145,334,233 - 145,406,104 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR55
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110116,945,216 - 116,967,559 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10116,947,905 - 116,948,864 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604082,498,705 - 82,516,906 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr55
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248434,263,659 - 4,282,131 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248434,263,818 - 4,311,348 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr55
262 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:79
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000023546
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 5 27 46 83 82 51 25 51 6 172 72 26 35 51 31

Sequence


Ensembl Acc Id: ENSRNOT00000023546   ⟹   ENSRNOP00000023548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl986,590,885 - 86,609,655 (-)Ensembl
Rnor_6.0 Ensembl992,962,738 - 92,963,697 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104980   ⟹   ENSRNOP00000076429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl986,591,007 - 86,604,337 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110974   ⟹   ENSRNOP00000080034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl986,591,007 - 86,640,613 (-)Ensembl
RefSeq Acc Id: NM_001427436   ⟹   NP_001414365
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8994,037,748 - 94,060,757 (-)NCBI
RefSeq Acc Id: XM_006245495   ⟹   XP_006245557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8994,037,749 - 94,081,426 (-)NCBI
mRatBN7.2986,590,961 - 86,610,258 (-)NCBI
Rnor_6.0992,961,431 - 92,983,579 (-)NCBI
Rnor_5.0992,690,726 - 92,740,360 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063267633   ⟹   XP_063123703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8994,037,749 - 94,081,426 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414365 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245557 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123703 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD22411 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023548.4
  ENSRNOP00000076429.1
  ENSRNOP00000080034.1
RefSeq Acc Id: XP_006245557   ⟸   XM_006245495
- Peptide Label: isoform X1
- UniProtKB: F1MAK4 (UniProtKB/TrEMBL),   Q9WU09 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023548   ⟸   ENSRNOT00000023546
Ensembl Acc Id: ENSRNOP00000080034   ⟸   ENSRNOT00000110974
Ensembl Acc Id: ENSRNOP00000076429   ⟸   ENSRNOT00000104980
RefSeq Acc Id: NP_001414365   ⟸   NM_001427436
- UniProtKB: A0A8I5Y6K3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123703   ⟸   XM_063267633
- Peptide Label: isoform X2
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAK4-F1-model_v2 AlphaFold F1MAK4 1-319 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559828 AgrOrtholog
BioCyc Gene G2FUF-26919 BioCyc
Ensembl Genes ENSRNOG00000017521 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023546.4 UniProtKB/TrEMBL
  ENSRNOT00000104980.1 UniProtKB/TrEMBL
  ENSRNOT00000110974.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
KEGG Report rno:501177 UniProtKB/TrEMBL
NCBI Gene 501177 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PTHR24232:SF56 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Gpr55 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017521 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I5Y6K3 ENTREZGENE, UniProtKB/TrEMBL
  F1MAK4 ENTREZGENE, UniProtKB/TrEMBL
  Q9WU09 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Gpr55  G protein-coupled receptor 55   Gpr55_predicted  G protein-coupled receptor 55 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 Gpr55_predicted  G protein-coupled receptor 55 (predicted)  Gpr55  G protein-coupled receptor 55  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Gpr55  G protein-coupled receptor 55      Symbol and Name status set to provisional 70820 PROVISIONAL