Nmur1 (neuromedin U receptor 1) - Rat Genome Database

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Gene: Nmur1 (neuromedin U receptor 1) Rattus norvegicus
Analyze
Symbol: Nmur1
Name: neuromedin U receptor 1
RGD ID: 619867
Description: Predicted to enable neuromedin U binding activity and neuromedin U receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; activation of phospholipase C activity; and second-messenger-mediated signaling. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human NMUR1 (neuromedin U receptor 1); INTERACTS WITH amitriptyline; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 66; G protein-coupled receptor FM-3; G-protein coupled receptor 66; G-protein coupled receptor FM-3; Gpr66; neuromedin-U receptor 1; NMU-R1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2987,033,231 - 87,038,070 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,033,279 - 87,036,684 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx995,450,336 - 95,453,852 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.09100,579,513 - 100,582,978 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0998,961,616 - 98,965,029 (-)NCBIRnor_WKY
Rnor_6.0993,402,871 - 93,407,264 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,403,314 - 93,404,883 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,131,707 - 93,133,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,146,808 - 85,148,380 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1985,330,226 - 85,331,797 (-)NCBI
Celera984,448,712 - 84,452,127 (-)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (ISO)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Highly differential expression of SN1, a bidirectional glutamine transporter, in astroglia and endothelium in the developing rat brain. Boulland JL, etal., Glia 2003 Feb;41(3):260-75.
2. Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. Fujii R, etal., J Biol Chem 2000 Jul 14;275(28):21068-74.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Identification of receptors for neuromedin U and its role in feeding. Howard AD, etal., Nature 2000 Jul 6;406(6791):70-4.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. Mori K, etal., EMBO J 2005 Jan 26;24(2):325-35. Epub 2005 Jan 6.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10899166   PMID:11027493   PMID:17016626   PMID:18180374   PMID:18506360   PMID:23212943   PMID:24270810  


Genomics

Comparative Map Data
Nmur1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2987,033,231 - 87,038,070 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,033,279 - 87,036,684 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx995,450,336 - 95,453,852 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.09100,579,513 - 100,582,978 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0998,961,616 - 98,965,029 (-)NCBIRnor_WKY
Rnor_6.0993,402,871 - 93,407,264 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,403,314 - 93,404,883 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,131,707 - 93,133,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,146,808 - 85,148,380 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1985,330,226 - 85,331,797 (-)NCBI
Celera984,448,712 - 84,452,127 (-)NCBICelera
Cytogenetic Map9q35NCBI
NMUR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,518,455 - 231,530,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2231,523,187 - 231,530,445 (-)EnsemblGRCh38hg38GRCh38
GRCh372232,387,898 - 232,395,156 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362232,096,116 - 232,103,452 (-)NCBINCBI36Build 36hg18NCBI36
Build 342232,213,375 - 232,220,707NCBI
Celera2226,164,278 - 226,171,589 (-)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2224,229,326 - 224,236,645 (-)NCBIHuRef
CHM1_12232,393,685 - 232,400,994 (-)NCBICHM1_1
T2T-CHM13v2.02232,007,626 - 232,014,884 (-)NCBIT2T-CHM13v2.0
Nmur1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,313,964 - 86,317,083 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl186,314,025 - 86,353,950 (-)EnsemblGRCm39 Ensembl
GRCm38186,386,242 - 86,389,361 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,386,303 - 86,426,228 (-)EnsemblGRCm38mm10GRCm38
MGSCv37188,282,900 - 88,284,716 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36188,217,496 - 88,219,312 (-)NCBIMGSCv36mm8
Celera189,354,761 - 89,356,568 (-)NCBICelera
Cytogenetic Map1C5NCBI
Nmur1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554534,120,110 - 4,124,927 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554534,118,532 - 4,126,143 (+)NCBIChiLan1.0ChiLan1.0
NMUR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B237,556,920 - 237,564,268 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B237,556,920 - 237,564,268 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B118,773,713 - 118,854,590 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NMUR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12543,395,711 - 43,400,670 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2543,399,597 - 43,411,087 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2543,954,267 - 43,963,017 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02543,653,048 - 43,661,799 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2543,654,204 - 43,663,250 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12543,580,573 - 43,589,297 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02543,422,295 - 43,432,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02543,578,790 - 43,587,539 (-)NCBIUU_Cfam_GSD_1.0
Nmur1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303185,553,423 - 185,559,248 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365255,382,372 - 5,385,788 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365255,355,570 - 5,386,284 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NMUR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15132,217,223 - 132,228,645 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115132,217,236 - 132,228,645 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215145,991,968 - 146,016,042 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NMUR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110117,547,123 - 117,557,405 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604081,893,793 - 81,900,968 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nmur1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248434,655,198 - 4,659,942 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nmur1
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:42
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000025024
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 2 8 14 20 9 7 10
Below cutoff 1 15 24 17 5 17 6 9 51 20 17 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025024   ⟹   ENSRNOP00000025024
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl987,033,279 - 87,036,684 (-)Ensembl
Rnor_6.0 Ensembl993,403,314 - 93,404,883 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119948   ⟹   ENSRNOP00000085073
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl987,033,279 - 87,035,320 (-)Ensembl
RefSeq Acc Id: NM_023100   ⟹   NP_075588
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2987,033,269 - 87,036,684 (-)NCBI
Rnor_6.0993,402,871 - 93,406,286 (-)NCBI
Rnor_5.0993,131,707 - 93,133,277 (-)NCBI
RGSC_v3.4985,146,808 - 85,148,380 (-)RGD
Celera984,448,712 - 84,452,127 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596633   ⟹   XP_017452122
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2987,033,231 - 87,038,070 (-)NCBI
Rnor_6.0993,402,879 - 93,407,264 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_075588 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452122 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF82754 (Get FASTA)   NCBI Sequence Viewer  
  BAA99387 (Get FASTA)   NCBI Sequence Viewer  
  EDL75586 (Get FASTA)   NCBI Sequence Viewer  
  Q9JJI5 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_075588   ⟸   NM_023100
- UniProtKB: A0A1P0PI13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452122   ⟸   XM_017596633
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000025024   ⟸   ENSRNOT00000025024
RefSeq Acc Id: ENSRNOP00000085073   ⟸   ENSRNOT00000119948
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJI5-F1-model_v2 AlphaFold Q9JJI5 1-425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619867 AgrOrtholog
BioCyc Gene G2FUF-26884 BioCyc
Ensembl Genes ENSRNOG00000018521 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025024 ENTREZGENE
  ENSRNOP00000025024.5 UniProtKB/TrEMBL
  ENSRNOP00000085073.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025024 ENTREZGENE
  ENSRNOT00000025024.6 UniProtKB/TrEMBL
  ENSRNOT00000119948.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125834 IMAGE-MGC_LOAD
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NeuromedU_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NeuromedU_rcpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93418 IMAGE-MGC_LOAD
NCBI Gene 65276 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nmur1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROMEDINUR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROMEDNU1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1P0PI13 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0W8_RAT UniProtKB/TrEMBL
  NMUR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1LQC9 UniProtKB/Swiss-Prot
  Q9JIB2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Nmur1  neuromedin U receptor 1  Gpr66  G protein-coupled receptor 66  Symbol and Name updated 1299863 APPROVED
2004-12-14 Gpr66  G protein-coupled receptor 66    G protein-coupled receptor FM-3  Name updated 1299863 APPROVED
2002-08-07 Gpr66  G protein-coupled receptor FM-3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression displays high mRNA expression in small intestine and lung 632946