Acsl3 (acyl-CoA synthetase long-chain family member 3) - Rat Genome Database

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Gene: Acsl3 (acyl-CoA synthetase long-chain family member 3) Rattus norvegicus
Analyze
Symbol: Acsl3
Name: acyl-CoA synthetase long-chain family member 3
RGD ID: 70552
Description: Enables arachidonate-CoA ligase activity. Involved in fatty acid metabolic process; response to nutrient; and response to organic cyclic compound. Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Human ortholog(s) of this gene implicated in asthma; breast cancer; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3); PARTICIPATES IN fatty acid beta degradation pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH 1-benzylpiperazine; 1-naphthyl isothiocyanate; 1-nitropropane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acs3; arachidonate--CoA ligase; arachidonate--CoA ligase Acsl3; brain acyl-CoA synthetase II; Facl3; fatty acid CoA ligase Acsl3; fatty acid Coenzyme A ligase, long chain 3; LACS 3; long-chain acyl-CoA synthetase 3; long-chain-fatty-acid--CoA ligase 3; medium-chain acyl-CoA ligase Acsl3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8987,563,601 - 87,613,078 (+)NCBIGRCr8
mRatBN7.2980,115,164 - 80,164,636 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl980,115,112 - 80,164,627 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx988,544,917 - 88,594,391 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0993,660,348 - 93,709,510 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0992,056,362 - 92,105,840 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0984,569,601 - 84,593,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl984,569,597 - 84,593,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0984,301,912 - 84,351,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4978,083,239 - 78,106,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1978,266,656 - 78,290,352 (+)NCBI
Celera977,647,726 - 77,671,370 (+)NCBICelera
Cytogenetic Map9q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
difenoconazole  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
flavonoids  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
glycitein  (ISO)
glycitin  (ISO)
graphene oxide  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
haloperidol  (ISO)
indole-3-methanol  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
isoflavones  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP,ISO)
topotecan  (ISO)
Trapidil  (EXP)
triadimefon  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent peripheral local inflammation. Benani A, etal., Eur J Neurosci. 2003 Oct;18(7):1904-14.
2. Elevated expression of liver X receptor alpha (LXRα) in myocardium of streptozotocin-induced diabetic rats. Cheng Y, etal., Inflammation. 2011 Dec;34(6):698-706. doi: 10.1007/s10753-010-9281-5.
3. Molecular characterization and expression of rat acyl-CoA synthetase 3. Fujino T, etal., J Biol Chem 1996 Jul 12;271(28):16748-52.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Targeted exome sequencing of Korean triple-negative breast cancer reveals homozygous deletions associated with poor prognosis of adjuvant chemotherapy-treated patients. Jeong HM, etal., Oncotarget. 2017 Jun 27;8(37):61538-61550. doi: 10.18632/oncotarget.18618. eCollection 2017 Sep 22.
6. Common variation in fatty acid genes and resuscitation from sudden cardiac arrest. Johnson CO, etal., Circ Cardiovasc Genet. 2012 Aug 1;5(4):422-9. doi: 10.1161/CIRCGENETICS.111.961912. Epub 2012 Jun 1.
7. Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids. Klett EL, etal., J Lipid Res. 2017 May;58(5):884-894. doi: 10.1194/jlr.M072512. Epub 2017 Feb 16.
8. Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate. Legg RL, etal., Reprod Biol Endocrinol. 2008 Nov 24;6:57.
9. Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet. Mashek DG, etal., J Lipid Res. 2006 Sep;47(9):2004-10. Epub 2006 Jun 13.
10. Gene Data Set MGD Curation, June 12, 2002
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Targeting Oct1 genomic function inhibits androgen receptor signaling and castration-resistant prostate cancer growth. Obinata D, etal., Oncogene. 2016 Dec 8;35(49):6350-6358. doi: 10.1038/onc.2016.171. Epub 2016 Jun 6.
14. [Long-term results of prolonged dicoumarol anticoagulant therapy in 327 peipheral arteriopathic subjects] Papadia F, etal., Chir Ital 1976 Dec;28(6):817-30.
15. Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer. Pei Z, etal., PLoS One. 2013 Jul 23;8(7):e69392. doi: 10.1371/journal.pone.0069392. Print 2013.
16. Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. Perera F, etal., PLoS One. 2009;4(2):e4488. doi: 10.1371/journal.pone.0004488. Epub 2009 Feb 16.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Epigenetic alterations by DNA methylation in house dust mite-induced airway hyperresponsiveness. Shang Y, etal., Am J Respir Cell Mol Biol. 2013 Aug;49(2):279-87. doi: 10.1165/rcmb.2012-0403OC.
22. Lipid metabolism genes in contralateral unaffected breast and estrogen receptor status of breast cancer. Wang J, etal., Cancer Prev Res (Phila). 2013 Apr;6(4):321-30. doi: 10.1158/1940-6207.CAPR-12-0304. Epub 2013 Mar 19.
23. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.
Additional References at PubMed
PMID:9276691   PMID:14741744   PMID:18003621   PMID:19737935   PMID:19946888   PMID:20219900   PMID:20605918   PMID:21498505   PMID:22633490  


Genomics

Comparative Map Data
Acsl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8987,563,601 - 87,613,078 (+)NCBIGRCr8
mRatBN7.2980,115,164 - 80,164,636 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl980,115,112 - 80,164,627 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx988,544,917 - 88,594,391 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0993,660,348 - 93,709,510 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0992,056,362 - 92,105,840 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0984,569,601 - 84,593,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl984,569,597 - 84,593,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0984,301,912 - 84,351,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4978,083,239 - 78,106,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1978,266,656 - 78,290,352 (+)NCBI
Celera977,647,726 - 77,671,370 (+)NCBICelera
Cytogenetic Map9q34NCBI
ACSL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382222,861,036 - 222,944,639 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2222,860,942 - 222,944,639 (+)EnsemblGRCh38hg38GRCh38
GRCh372223,725,754 - 223,809,357 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,433,976 - 223,516,363 (+)NCBINCBI36Build 36hg18NCBI36
Celera2217,493,969 - 217,573,566 (+)NCBICelera
Cytogenetic Map2q36.1NCBI
HuRef2215,580,012 - 215,659,429 (+)NCBIHuRef
CHM1_12223,732,626 - 223,813,632 (+)NCBICHM1_1
T2T-CHM13v2.02223,346,613 - 223,427,414 (+)NCBIT2T-CHM13v2.0
Acsl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39178,635,600 - 78,685,462 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl178,635,542 - 78,685,460 (+)EnsemblGRCm39 Ensembl
GRCm38178,657,825 - 78,707,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl178,657,825 - 78,707,743 (+)EnsemblGRCm38mm10GRCm38
MGSCv37178,654,400 - 78,704,318 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36178,536,898 - 78,586,011 (+)NCBIMGSCv36mm8
Celera179,126,781 - 79,177,063 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map140.84NCBI
Acsl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545310,913,786 - 10,947,963 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545310,916,423 - 10,963,986 (-)NCBIChiLan1.0ChiLan1.0
ACSL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213125,473,216 - 125,554,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B125,488,197 - 125,569,501 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B110,100,210 - 110,181,277 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B228,706,141 - 228,759,882 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B228,706,142 - 228,759,882 (+)Ensemblpanpan1.1panPan2
ACSL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13728,882,264 - 28,929,451 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3728,864,147 - 28,938,866 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3729,699,888 - 29,765,386 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03728,889,472 - 28,955,180 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3728,888,886 - 28,955,178 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13728,798,984 - 28,864,540 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03728,730,857 - 28,796,337 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03728,744,094 - 28,809,662 (+)NCBIUU_Cfam_GSD_1.0
Acsl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303178,431,793 - 178,500,065 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365694,774,542 - 4,844,494 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365694,774,602 - 4,842,906 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15124,765,854 - 124,816,960 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115124,741,986 - 124,816,955 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215138,663,708 - 138,712,406 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACSL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110108,787,341 - 108,867,523 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10108,787,061 - 108,869,042 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604090,486,570 - 90,576,665 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acsl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248232,324,345 - 2,381,420 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248232,323,939 - 2,387,213 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acsl3
346 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:56
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000020161
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat

Markers in Region
SHGC-36164  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2980,164,446 - 80,164,553 (+)MAPPERmRatBN7.2
Rnor_6.0984,593,376 - 84,593,482NCBIRnor6.0
Rnor_5.0984,351,324 - 84,351,430UniSTSRnor5.0
RGSC_v3.4978,106,744 - 78,106,850UniSTSRGSC3.4
Celera977,671,181 - 77,671,287UniSTS
Cytogenetic Map9q33UniSTS
RH138650  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2980,164,527 - 80,164,648 (+)MAPPERmRatBN7.2
Rnor_6.0984,593,457 - 84,593,577NCBIRnor6.0
Rnor_5.0984,351,405 - 84,351,525UniSTSRnor5.0
RGSC_v3.4978,106,825 - 78,106,945UniSTSRGSC3.4
Celera977,671,262 - 77,671,382UniSTS
RH 3.4 Map9727.2UniSTS
Cytogenetic Map9q33UniSTS
RH80004  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2980,164,414 - 80,164,601 (+)MAPPERmRatBN7.2
Rnor_6.0984,593,344 - 84,593,530NCBIRnor6.0
Rnor_5.0984,351,292 - 84,351,478UniSTSRnor5.0
RGSC_v3.4978,106,712 - 78,106,898UniSTSRGSC3.4
Celera977,671,149 - 77,671,335UniSTS
Cytogenetic Map9q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 29 55 39 17 39 8 10 74 35 41 11 8
Low 14 2 2 2 2 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000020161   ⟹   ENSRNOP00000020161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl980,120,613 - 80,164,616 (+)Ensembl
Rnor_6.0 Ensembl984,569,597 - 84,593,565 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108973   ⟹   ENSRNOP00000091017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl980,115,112 - 80,164,627 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110563   ⟹   ENSRNOP00000078357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl980,115,164 - 80,164,455 (+)Ensembl
RefSeq Acc Id: NM_057107   ⟹   NP_476448
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8987,563,601 - 87,613,075 (+)NCBI
mRatBN7.2980,115,164 - 80,164,636 (+)NCBI
Rnor_6.0984,569,601 - 84,593,565 (+)NCBI
Rnor_5.0984,301,912 - 84,351,516 (+)NCBI
RGSC_v3.4978,083,239 - 78,106,933 (+)RGD
Celera977,647,726 - 77,671,370 (+)RGD
Sequence:
RefSeq Acc Id: XM_063266533   ⟹   XP_063122603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8987,569,058 - 87,613,078 (+)NCBI
RefSeq Acc Id: NP_476448   ⟸   NM_057107
- UniProtKB: Q63151 (UniProtKB/Swiss-Prot),   A6JW67 (UniProtKB/TrEMBL),   A0A8L2UJF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020161   ⟸   ENSRNOT00000020161
RefSeq Acc Id: ENSRNOP00000078357   ⟸   ENSRNOT00000110563
RefSeq Acc Id: ENSRNOP00000091017   ⟸   ENSRNOT00000108973
RefSeq Acc Id: XP_063122603   ⟸   XM_063266533
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63151-F1-model_v2 AlphaFold Q63151 1-720 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70552 AgrOrtholog
BioCyc Gene G2FUF-27021 BioCyc
BioCyc Pathway FAO-PWY [fatty acid beta-oxidation I (generic)] BioCyc
  PWY-5143 [long-chain fatty acid activation] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-6000 [gamma-linolenate biosynthesis II (animals)] BioCyc
  PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)] BioCyc
  PWY-8181 [2-methyl-branched fatty acid beta-oxidation] BioCyc
  PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism] BioCyc
  PWY66-387 [3-methyl-branched fatty acid alpha-oxidation] BioCyc
  PWY66-388 [ceramide degradation by alpha-oxidation] BioCyc
  PWY66-389 [phytol degradation] BioCyc
  PWY66-391 [fatty acid beta-oxidation VI (mammalian peroxisome)] BioCyc
BioCyc Pathway Image FAO-PWY BioCyc
  PWY-5143 BioCyc
  PWY-5972 BioCyc
  PWY-6000 BioCyc
  PWY-7049 BioCyc
  PWY-8181 BioCyc
  PWY3DJ-11470 BioCyc
  PWY66-387 BioCyc
  PWY66-388 BioCyc
  PWY66-389 BioCyc
  PWY66-391 BioCyc
Ensembl Genes ENSRNOG00000014718 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020161.3 UniProtKB/TrEMBL
  ENSRNOT00000108973 ENTREZGENE
  ENSRNOT00000108973.1 UniProtKB/TrEMBL
  ENSRNOT00000110563.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.12780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AMP-binding_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANL_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114024 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 114024 ENTREZGENE
PANTHER LONG-CHAIN-FATTY-ACID--COA LIGASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LONG-CHAIN-FATTY-ACID--COA LIGASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AMP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acsl3 PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014718 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZKP6_RAT UniProtKB/TrEMBL
  A0A8I6AC39_RAT UniProtKB/TrEMBL
  A0A8L2UJF0 ENTREZGENE, UniProtKB/TrEMBL
  A6JW66_RAT UniProtKB/TrEMBL
  A6JW67 ENTREZGENE, UniProtKB/TrEMBL
  ACSL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Acsl3  acyl-CoA synthetase long-chain family member 3  Facl3  fatty acid Coenzyme A ligase, long chain 3  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the first reaction in the acyl-CoA metabolism 70280
gene_function catalyzes the first reaction in the acyl-CoA metabolism 70808
gene_process plays a key role in lipid synthesis and in fatty acid degradation 70280
gene_process plays a key role in lipid synthesis and in fatty acid degradation 70808
gene_product member of the firefly luciferase family 70280
gene_product member of the firefly luciferase family 70808
gene_protein predicted 720 amino acids, 80 kDa 70280
gene_protein predicted 720 amino acids, 80 kDa 70808