Ugt1a2 (UDP glucuronosyltransferase 1 family, polypeptide A2) - Rat Genome Database

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Gene: Ugt1a2 (UDP glucuronosyltransferase 1 family, polypeptide A2) Rattus norvegicus
Analyze
Symbol: Ugt1a2 (Ensembl: Ugt1a3)
Name: UDP glucuronosyltransferase 1 family, polypeptide A2 (Ensembl:UDP glucuronosyltransferase family 1 member A1)
RGD ID: 1549741
Description: Predicted to enable several functions, including glucuronosyltransferase activity; protein dimerization activity; and retinoic acid binding activity. Involved in animal organ regeneration; liver development; and response to organic cyclic compound. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human UGT1A3 (UDP glucuronosyltransferase family 1 member A3); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; ibuprofen pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B2; bilirubin specific; bilirubin-specific UDPGT; UDP glucuronosyltransferase 1A2; UDP glycosyltransferase 1 family polypeptide A2; UDP-glucuronosyltransferase 1-2; UDP-glucuronosyltransferase 1A2; Udpgt; UDPGT 1-2; Ugt1; UGT1*0; UGT1-02; UGT1.2
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2988,791,216 - 88,808,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx997,215,037 - 97,232,360 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.09102,351,229 - 102,368,552 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.09100,719,413 - 100,736,659 (+)NCBIRnor_WKY
Rnor_6.0995,285,592 - 95,302,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0994,972,807 - 94,990,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4987,081,132 - 87,098,362 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera986,352,508 - 86,369,556 (+)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(S)-nicotine  (ISO)
1-Hydroxypyrene  (ISO)
17beta-estradiol  (EXP,ISO)
1H-indene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid  (ISO)
2-amino-4,6-dinitrotoluene  (EXP)
2-hydroxy-17beta-estradiol  (ISO)
2-hydroxyestrone  (ISO)
2-methoxy-17beta-estradiol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-methylcholanthrene  (ISO)
3-phenylpropionic acid  (ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyestrone  (ISO)
4-methylumbelliferone  (ISO)
4-methylumbelliferone beta-D-glucuronide  (ISO)
4-nitrophenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
Afloqualone  (ISO)
amentoflavone  (ISO)
ammonium chloride  (EXP)
androsterone  (ISO)
anthracene-1,8,9-triol  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benoxaprofen  (ISO)
benzamidoxime  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
betulin  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bropirimine  (ISO)
buta-1,3-diene  (ISO)
C.I. Natural Red 20  (ISO)
calycosin  (ISO)
cefaloridine  (EXP)
chenodeoxycholic acid  (ISO)
chlorogenic acid  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clofibric acid  (ISO)
Cuprizon  (EXP)
decanoic acid  (ISO)
dexamethasone  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
diflunisal  (ISO)
dimethylarsinic acid  (ISO)
diphenylacetic acid  (ISO)
dodecanoic acid  (ISO)
entacapone  (ISO)
estriol  (ISO)
estrone  (ISO)
etodolac  (ISO)
etoposide  (ISO)
ezetimibe  (ISO)
farnesol  (ISO)
fenofibrate  (ISO)
fenoprofen  (ISO)
fenthion  (ISO)
ferulic acid  (ISO)
fipronil  (EXP)
flunitrazepam  (ISO)
flurbiprofen  (ISO)
furosemide  (ISO)
galangin  (ISO)
genistein  (ISO)
glabridin  (ISO)
glutathione  (EXP)
Grepafloxacin  (ISO)
GW 4064  (ISO)
GW 7647  (EXP)
hydratropic acid  (ISO)
ibuprofen  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
indoprofen  (ISO)
isoprenaline  (ISO)
isovaleric acid  (ISO)
kaempferol  (ISO)
ketoprofen  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
lamotrigine  (ISO)
lapatinib  (ISO)
Licochalcone A  (ISO)
lithocholic acid  (ISO)
luteolin  (ISO)
mefenamic acid  (ISO)
MeIQx  (ISO)
methoxychlor  (ISO)
methyl salicylate  (ISO)
methylarsonic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (ISO)
morphine  (ISO)
moxifloxacin  (ISO)
Muraglitazar  (ISO)
myricetin  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naproxen  (ISO)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
obeticholic acid  (ISO)
ofloxacin  (ISO)
omeprazole  (ISO)
ortho-vanillin  (ISO)
osimertinib  (ISO)
paracetamol  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylbutazone  (ISO)
pimecrolimus  (ISO)
pirinixic acid  (EXP,ISO)
ponasterone A  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
probenecid  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (EXP,ISO)
resveratrol  (ISO)
rifampicin  (ISO)
salicylic acid  (ISO)
scopoletin  (ISO)
sevoflurane  (EXP)
Shikonin  (ISO)
Sitafloxacin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
spironolactone  (ISO)
sulindac  (ISO)
sulindac sulfone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
trans-caffeic acid  (ISO)
trans-cinnamic acid  (ISO)
trichloroethene  (EXP)
triclocarban  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanillic acid  (ISO)
vanillin  (ISO)
vitamin E  (EXP)
vorinostat  (ISO)
warfarin  (ISO)
xanthohumol  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver. Kishi M, etal., Biochem Biophys Res Commun. 2008 Dec 19;377(3):815-9. Epub 2008 Oct 18.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats. Tian H, etal., Pharm Res. 2005 Dec;22(12):2007-15. Epub 2005 Oct 21.
9. Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. Vansell NR and Klaassen CD, Drug Metab Dispos. 2002 Mar;30(3):240-6.
10. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, etal., Genome Res 2004 Jan;14(1):79-89. Epub 2003 Dec 12.
Additional References at PubMed
PMID:2112380   PMID:7608130   PMID:16141793   PMID:16169882   PMID:17179145   PMID:18052087   PMID:20056724   PMID:20308471   PMID:20610558   PMID:22579593  


Genomics

Comparative Map Data
Ugt1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2988,791,216 - 88,808,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx997,215,037 - 97,232,360 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.09102,351,229 - 102,368,552 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.09100,719,413 - 100,736,659 (+)NCBIRnor_WKY
Rnor_6.0995,285,592 - 95,302,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0994,972,807 - 94,990,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4987,081,132 - 87,098,362 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera986,352,508 - 86,369,556 (+)NCBICelera
Cytogenetic Map9q35NCBI
UGT1A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,729,042 - 233,773,300 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2233,729,042 - 233,773,300 (+)EnsemblGRCh38hg38GRCh38
GRCh372234,637,688 - 234,681,946 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,302,512 - 234,346,684 (+)NCBINCBI36Build 36hg18NCBI36
Build 342234,419,772 - 234,463,945NCBI
Celera2228,358,392 - 228,402,577 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2226,437,616 - 226,481,779 (+)NCBIHuRef
CHM1_12234,643,587 - 234,682,899 (+)NCBICHM1_1
T2T-CHM13v2.02234,217,673 - 234,261,929 (+)NCBIT2T-CHM13v2.0
Ugt1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39188,128,333 - 88,147,724 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl188,128,323 - 88,146,719 (+)EnsemblGRCm39 Ensembl
GRCm38188,200,611 - 88,220,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl188,200,601 - 88,218,997 (+)EnsemblGRCm38mm10GRCm38
MGSCv37190,097,186 - 90,116,577 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36190,031,782 - 90,050,168 (+)NCBIMGSCv36mm8
Celera191,161,681 - 91,181,062 (+)NCBICelera
Cytogenetic Map1DNCBI

Variants

.
Variants in Ugt1a2
75 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat

Markers in Region
RH130767  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,795,599 - 88,795,779 (+)MAPPERmRatBN7.2
Rnor_6.0995,289,976 - 95,290,155NCBIRnor6.0
Rnor_5.0994,977,191 - 94,977,370UniSTSRnor5.0
RGSC_v3.4987,085,516 - 87,085,695UniSTSRGSC3.4
Celera986,356,892 - 86,357,071UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS
RH94830  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,808,140 - 88,808,341 (+)MAPPERmRatBN7.2
Rnor_6.0995,302,498 - 95,302,698NCBIRnor6.0
Rnor_5.0994,989,713 - 94,989,913UniSTSRnor5.0
RGSC_v3.4987,098,038 - 87,098,238UniSTSRGSC3.4
Celera986,369,232 - 86,369,432UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_201423   ⟹   NP_958826
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2988,791,216 - 88,808,465 (+)NCBI
Rnor_6.0995,285,592 - 95,302,822 (+)NCBI
Rnor_5.0994,972,807 - 94,990,037 (+)NCBI
RGSC_v3.4987,081,132 - 87,098,362 (+)RGD
Celera986,352,508 - 86,369,556 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_958826 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42312 (Get FASTA)   NCBI Sequence Viewer  
  AAR95631 (Get FASTA)   NCBI Sequence Viewer  
  BAA07261 (Get FASTA)   NCBI Sequence Viewer  
  EDL92103 (Get FASTA)   NCBI Sequence Viewer  
  P20720 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_958826   ⟸   NM_201423
- Peptide Label: precursor
- UniProtKB: Q6T5F2 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
UDPGT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20720-F1-model_v2 AlphaFold P20720 1-533 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696845
Promoter ID:EPDNEW_R7368
Type:multiple initiation site
Name:Ugt1a7c_4
Description:UDP glucuronosyltransferase 1 family, polypeptide A7C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7366  EPDNEW_R7367  EPDNEW_R7370  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0995,285,570 - 95,285,630EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1549741 AgrOrtholog
BioCyc Gene G2FUF-26818 BioCyc
BioCyc Pathway PWY-5874 [heme degradation I] BioCyc
  PWY-6261 [thyroid hormone metabolism II (via conjugation and/or degradation)] BioCyc
  PWY-6313 [serotonin degradation] BioCyc
  PWY-6398 [melatonin degradation I] BioCyc
Ensembl Genes ENSRNOG00000018740 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000062958 ENTREZGENE
  ENSRNOP00000062958.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000063853 ENTREZGENE
  ENSRNOT00000063853.5 UniProtKB/TrEMBL
InterPro UDP_glucos_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:396527 UniProtKB/TrEMBL
NCBI Gene 396527 ENTREZGENE
Pfam UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB UGT1A3 RGD
PhenoGen Ugt1a2 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P20720 ENTREZGENE
  Q6T5F2 ENTREZGENE, UniProtKB/TrEMBL
  UD12_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q64636 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Ugt1a2  UDP glucuronosyltransferase 1 family, polypeptide A2  Ugt1a2  UDP glycosyltransferase 1 family polypeptide A2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-15 Ugt1a2  UDP glycosyltransferase 1 family polypeptide A2      Symbol and Name status set to provisional 70820 PROVISIONAL