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Losartan is a selective and competitive non-peptide antagonist of angiotensin II receptor type 1 (Agtr1) used in the treatment of hypertension and heart failure. Angiotensin II (AngII) is one of several and probably the most potent peptide generated by the renin-angiotensin cascade. AngII signals through two receptor types to elicit distinct responses. The Agtr1 mediated pathway is involved in vasoconstriction, proliferation, hormone release and fluid homeostasis. The powerful but potentially h

Pathway Diagram:

Ariadne Genomics Inc. ABCB1 CYP3A4 CYP2C9 other losartan metabolites losartan ---> losartan-N-gluc UGT1A3 UGT1A1 losartan ---> E3179 losartan ---> other losartan metabolites E3179 ---> E3174 losartan-N-gluc ---> losartan/E3174 elimination E3174 ---> losartan/E3174 elimination losartan-N-gluc losartan/E3174 elimination E3174 CYP2C8 E3179 losartan UGT2B7

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Pathway Gene Annotations

References Associated with the losartan pharmacokinetics pathway:

Ontology Path Diagram:

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