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Pathways

LOSARTAN PHARMACOKINETICS PATHWAY (PW:0001463)

View Ontology Report

Description

Losartan is a selective and competitive non-peptide antagonist of angiotensin II receptor type 1 (Agtr1) used in the treatment of hypertension and heart failure. Angiotensin II (AngII) is one of several and probably the most potent peptide generated by the renin-angiotensin cascade. AngII signals through two receptor types to elicit distinct responses. The Agtr1 mediated pathway is involved in vasoconstriction, proliferation, hormone release and fluid homeostasis. The powerful but potentially h

Pathway Diagram:

Ariadne Genomics Inc. ABCB1 CYP3A4 CYP2C9 other losartan metabolites losartan ---> losartan-N-gluc UGT1A3 UGT1A1 losartan ---> E3179 losartan ---> other losartan metabolites E3179 ---> E3174 losartan-N-gluc ---> losartan/E3174 elimination E3174 ---> losartan/E3174 elimination losartan-N-gluc losartan/E3174 elimination E3174 CYP2C8 E3179 losartan UGT2B7
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Genes in Pathway:


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losartan pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO RGD PMID:10725273 RGD:7364967 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 ISO RGD PMID:23118328 RGD:7364964
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO RGD PMID:21666702 RGD:7364965 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 ISO RGD PMID:18674515 RGD:7364966 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 ISO RGD PMID:18674515 RGD:7364966 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 ISO RGD PMID:18674515 RGD:7364966 NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451
JBrowse link

Pathway Gene Annotations

Disease Annotations Associated with Genes in the losartan pharmacokinetics pathway
Disease TermsGene Symbols
acquired immunodeficiency syndromeAbcb1a
acute kidney failureUgt1a1
Acute Liver FailureUgt1a1
acute lymphoblastic leukemiaAbcb1a , Cyp2c79
adrenocortical carcinomaAbcb1a
alcohol dependenceCyp3a2
Alcoholic Liver DiseasesCyp3a2
allergic rhinitisAbcb1a
Alzheimer's diseaseAbcb1a
Anthracycline-induced CardiotoxicityAbcb1a
antisocial personality disorderAbcb1a
anxiety disorderCyp3a2
asthmaAbcb1a
Audiogenic EpilepsyAbcb1a
autism spectrum disorderAbcb1a , Cyp2c79 , Ugt1a1 , Ugt2b7
Behcet's diseaseAbcb1a
bilirubin metabolic disorderUgt1a1 , Ugt1a2
breast cancerCyp3a2 , Ugt1a1
Breast NeoplasmsAbcb1a , Cyp3a2
cannabis abuseAbcb1a
cannabis dependenceAbcb1a
carcinomaAbcb1a
cardiomyopathyAbcb1a
Chemical and Drug Induced Liver InjuryAbcb1a , Cyp3a2 , Ugt1a1
cholecystolithiasisUgt1a1
cholelithiasisUgt1a1
cholestasisCyp3a2 , Ugt1a1
Chronic Hepatitis CAbcb1a
chronic myeloid leukemiaAbcb1a
chronic obstructive pulmonary diseaseCyp2c79
colorectal adenocarcinomaAbcb1a
Colorectal NeoplasmsAbcb1a
congenital heart diseaseAbcb1a
contact dermatitisUgt1a1
COVID-19Abcb1a
Crigler Najjar Syndrome, Type 1Ugt1a1 , Ugt1a2
Crigler Najjar Syndrome, Type 2Ugt1a1 , Ugt1a2
Crigler-Najjar syndromeUgt1a1 , Ugt1a2
Critical IllnessAbcb1a
Crohn's diseaseAbcb1a , Ugt1a1
cryoglobulinemiaAbcb1a
diarrheaAbcb1a
diffuse large B-cell lymphomaAbcb1a
disease of cellular proliferationAbcb1a
disease of mental healthAbcb1a
Disease ProgressionAbcb1a
drug dependenceAbcb1a
Drug OverdoseAbcb1a
Drug-Induced LeukopeniaCyp2c79
Drug-induced NeutropeniaAbcb1a , Cyp2c79 , Ugt1a1
Drug-Related Side Effects and Adverse ReactionsAbcb1a , Cyp2c79 , Ugt1a1
encephalitisAbcb1a
ENCEPHALOPATHY, ACUTE TRANSIENTAbcb1a
end stage renal diseaseAbcb1a , Cyp2c79 , Cyp3a2
endometrial cancerUgt1a1
EndotoxemiaAbcb1a
EosinophiliaAbcb1a
epilepsyAbcb1a
Escherichia Coli InfectionsAbcb1a
Esophageal NeoplasmsAbcb1a
Experimental ArthritisAbcb1a
Experimental Diabetes MellitusAbcb1a
Experimental Liver CirrhosisAbcb1a
Experimental Mammary NeoplasmsAbcb1a
familial adenomatous polyposisAbcb1a
familial hyperlipidemiaAbcb1a
familial Mediterranean feverAbcb1a , Cyp3a2
Familial Prostate CancerCyp3a2
familial temporal lobe epilepsy 3Abcb1a
Femur Head NecrosisAbcb1a
Fetal Growth RetardationAbcb1a
GallstonesUgt1a1
genetic diseaseUgt1a1 , Ugt1a2
Genetic Predisposition to DiseaseAbcb1a
Genetic TranslocationAbcb1a
Germ Cell and Embryonal NeoplasmsAbcb1a
Gilbert syndromeUgt1a1 , Ugt1a2
Gram-Negative Bacterial InfectionsUgt1a1
head and neck squamous cell carcinomaAbcb1a
heart diseaseAbcb1a
Helicobacter InfectionsAbcb1a
Hematologic NeoplasmsAbcb1a
hematopoietic system diseaseUgt1a1
hepatitis BUgt1a1
hepatitis CCyp3a2
hepatocellular carcinomaAbcb1a , Cyp2c79
hereditary breast ovarian cancer syndromeAbcb1a
Hereditary HyperbilirubinemiaUgt1a1
heroin dependenceAbcb1a
Hodgkin's lymphomaUgt1a1
human immunodeficiency virus infectious diseaseAbcb1a
Hyperbilirubinemia, Transient Familial NeonatalUgt1a1 , Ugt1a2
hyperthyroidismUgt1a1
Idiopathic Generalized EpilepsyAbcb1a
InflammationAbcb1a , Cyp3a2 , Ugt1a1
inflammatory bowel disease 13Abcb1a
invasive ductal carcinomaAbcb1a
JaundiceUgt1a1
Joubert syndrome 22Ugt1a1 , Ugt1a2
kernicterusUgt1a1
kidney diseaseAbcb1a , Cyp2c79
Kidney NeoplasmsAbcb1a
Latent TuberculosisAbcb1a
lung non-small cell carcinomaAbcb1a , Ugt1a1
malariaAbcb1a
metabolic dysfunction-associated steatotic liver diseaseAbcb1a
myeloid leukemiaUgt1a1
Nasal PolypsAbcb1a
nasal type extranodal NK/T-cell lymphomaAbcb1a
NauseaAbcb1a
Neonatal HyperbilirubinemiaUgt1a1
Neoplasm MetastasisAbcb1a
nephroblastomaAbcb1a
nervous system diseaseAbcb1a , Cyp2c79
neuroblastomaAbcb1a
neutropeniaAbcb1a , Ugt1a1
obstructive sleep apneaAbcb1a
opiate dependenceAbcb1a
Orthostatic HypotensionAbcb1a
osteosarcomaCyp3a2
ovarian cancerAbcb1a , Ugt1a1
ovarian carcinomaCyp3a2
PainAbcb1a
Parkinson's diseaseAbcb1a
perinatal necrotizing enterocolitisAbcb1a
peripheral nervous system diseaseAbcb1a , Cyp2c79
Perlman syndromeUgt1a1 , Ugt1a2
pleomorphic xanthoastrocytomaAbcb1a , Cyp3a2
PoisoningAbcb1a
PolyuriaUgt1a1
Postoperative PainAbcb1a
Prostatic NeoplasmsCyp3a2
pulmonary tuberculosisAbcb1a
renal cell carcinomaAbcb1a
renal hypertensionCyp2c79
Reperfusion InjuryAbcb1a
RhabdomyolysisCyp2c79
Rhabdomyolysis, Cerivastatin-InducedCyp2c79
rheumatoid arthritisAbcb1a
schizophreniaUgt1a2
secondary Parkinson diseaseAbcb1a
small cell carcinomaUgt1a1
ST Elevation Myocardial InfarctionAbcb1a
StarvationUgt1a1
status epilepticusAbcb1a
Subarachnoid HemorrhageCyp3a2
temporal lobe epilepsyAbcb1a
Torsades de PointesCyp3a2
toxic encephalopathyAbcb1a
type 1 diabetes mellitusUgt1a1
type 2 diabetes mellitusAbcb1a , Cyp3a2 , Ugt1a1
ulcerative colitisAbcb1a
urinary bladder cancerUgt2b7
VITAMIN D-DEPENDENT RICKETS, TYPE 3Cyp3a2
VomitingAbcb1a
Pathway Annotations Associated with Genes in the losartan pharmacokinetics pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayCyp2c79
antipyrine drug pathwayCyp2c79
arachidonic acid metabolic pathwayCyp2c79
artemether pharmacokinetics pathwayCyp3a2 , Ugt2b7
ascorbate and aldarate metabolic pathwayUgt1a1 , Ugt1a2
axitinib pharmacokinetics pathwayAbcb1a , Cyp3a2 , Ugt1a1
bile acid transport pathwayAbcb1a
caffeine pharmacokinetics pathwayCyp2c79 , Cyp3a2
carbamazepine pharmacokinetics pathwayCyp2c79 , Cyp3a2
celecoxib pharmacodynamics pathwayCyp2c79 , Cyp3a2
celecoxib pharmacokinetics pathwayCyp3a2
clomipramine pharmacokinetics pathwayCyp3a2
clopidogrel pharmacodynamics pathwayAbcb1a , Cyp3a2
clopidogrel pharmacokinetics pathwayAbcb1a , Cyp3a2
codeine and morphine pharmacodynamics pathwayCyp3a2 , Ugt1a1 , Ugt1a2 , Ugt2b7
codeine and morphine pharmacokinetics pathwayCyp3a2 , Ugt1a1 , Ugt1a2 , Ugt2b7
cyclophosphamide pharmacodynamics pathwayCyp2c79 , Cyp3a2
cyclophosphamide pharmacokinetics pathwayCyp2c79 , Cyp3a2
diclofenac pharmacodynamics pathwayCyp2c79
diflunisal pharmacodynamics pathwayCyp2c79
docetaxel pharmacodynamics pathwayAbcb1a
doxepin pharmacokinetics pathwayCyp3a2
doxorubicin pharmacokinetics pathwayAbcb1a
erlotinib pharmacodynamics pathwayAbcb1a
etodolac pharmacodynamics pathwayCyp2c79
etoposide pharmacodynamics pathwayAbcb1a , Cyp3a2 , Ugt1a1
etoposide pharmacokinetics pathwayAbcb1a , Cyp3a2 , Ugt1a1
felbamate pharmacokinetics pathwayCyp3a2
fenoprofen pharmacodynamics pathwayCyp2c79
fluoxetine pharmacodynamics pathwayCyp3a2
fluoxetine pharmacokinetics pathwayCyp3a2
flurbiprofen pharmacodynamics pathwayCyp2c79
gefitinib pharmacokinetics pathwayAbcb1a , Cyp3a2
hypoxia inducible factor pathwayAbcb1a
ibuprofen pharmacodynamics pathwayCyp2c79 , Cyp3a2 , Ugt1a1 , Ugt1a2 , Ugt2b7
ibuprofen pharmacokinetics pathwayCyp2c79 , Cyp3a2 , Ugt1a1 , Ugt1a2 , Ugt2b7
ifosfamide pharmacodynamics pathwayCyp2c79 , Cyp3a2
ifosfamide pharmacokinetics pathwayCyp2c79 , Cyp3a2
imipramine pharmacodynamics pathwayCyp3a2
imipramine pharmacokinetics pathwayCyp3a2
indometacin pharmacodynamics pathwayCyp2c79
indometacin pharmacodynamics pathwayCyp2c79
irinotecan pharmacodynamics pathwayAbcb1a , Cyp3a2 , Ugt1a1
irinotecan pharmacokinetics pathwayAbcb1a , Cyp3a2 , Ugt1a1
ketoprofen pharmacodynamics pathwayCyp2c79
ketorolac pharmacodynamics pathwayCyp2c79
lamivudine pharmacokinetics pathwayAbcb1a
leukotriene C4 synthase deficiency pathwayCyp2c79
lidocaine pharmacodynamics pathwayCyp3a2
lidocaine pharmacokinetics pathwayCyp3a2
linoleic acid metabolic pathwayCyp3a2
lornoxicam pharmacodynamics pathwayCyp2c79
losartan pharmacokinetics pathwayAbcb1a , Cyp2c79 , Cyp3a2 , Ugt1a1 , Ugt1a2 , Ugt2b7
magnesium salicylate pharmacodynamics pathwayCyp2c79
mefenamic acid pharmacodynamics pathwayCyp2c79
meloxicam pharmacodynamics pathwayCyp2c79
methadone pharmacodynamics pathwayCyp2c79 , Cyp3a2
methadone pharmacokinetics pathwayCyp2c79 , Cyp3a2
mycophenolic acid pharmacokinetics pathwayAbcb1a , Cyp2c79 , Cyp3a2 , Ugt2b7
nabumetone pharmacodynamics pathwayCyp2c79
naproxen pharmacodynamics pathwayCyp2c79
nateglinide pharmacokinetics pathwayCyp3a2
neviparine pharmacokinetics pathwayCyp3a2
O-linked glycan biosynthetic pathwayUgt1a1 , Ugt1a2
paracetamol drug pathwayCyp2c79
paracetamol pharmacokinetics pathwayAbcb1a , Cyp3a2 , Ugt1a1
pentose and glucuronate interconversion pathwayUgt1a1 , Ugt1a2
phase I biotransformation pathway via cytochrome P450Cyp3a2 , Ugt1a1 , Ugt1a2
phenytoin pharmacodynamics pathwayCyp3a2 , Ugt1a1
piroxicam pharmacodynamics pathwayCyp2c79
porphyrin and chlorophyll metabolic pathwayUgt1a1 , Ugt1a2
prednisone pharmacodynamics pathwayCyp3a2
prednisone pharmacokinetics pathwayCyp3a2
repaglinide pharmacokinetics pathwayCyp2c79 , Cyp3a2
retinol metabolic pathwayCyp3a2 , Ugt1a1 , Ugt1a2
rosiglitazone pharmacokinetics pathwayCyp2c79
salicylic acid pharmacodynamics pathwayCyp2c79
sodium salicylate pharmacodynamics pathwayCyp2c79
sorafenib pharmacokinetics pathwayCyp2c79 , Cyp3a2 , Ugt1a1
starch and sucrose metabolic pathwayUgt1a1 , Ugt1a2
statin pharmacokinetics pathwayAbcb1a , Cyp2c79 , Cyp3a2 , Ugt1a1 , Ugt1a2
steroid hormone biosynthetic pathwayCyp3a2 , Ugt1a1 , Ugt1a2
sulindac pharmacodynamics pathwayCyp2c79
tamoxifen pharmacodynamics pathwayCyp3a2
tamoxifen pharmacokinetics pathwayAbcb1a , Cyp2c79 , Cyp3a2 , Ugt1a1 , Ugt1a2 , Ugt2b7
teniposide pharmacodynamics pathwayCyp3a2
teniposide pharmacokinetics pathwayCyp3a2
tenoxicam pharmacodynamics pathwayCyp2c79
tiaprofenic acid pharmacodynamics pathwayCyp2c79
tolmetin pharmacodynamics pathwayCyp2c79
tramadol pharmacokinetics pathwayCyp3a2 , Ugt2b7
tyrosinemia type III pathwayAbcb1a
valdecoxib pharmacodynamics pathwayCyp2c79
valproic acid pharmacokinetics pathwayUgt1a2
venlafaxine pharmacokinetics pathwayAbcb1a , Cyp3a2
vinblastine pharmacodynamics pathwayAbcb1a , Cyp3a2
vincristine pharmacodynamics pathwayAbcb1a
vindesine pharmacodynamics pathwayAbcb1a
vinorelbine pharmacodynamics pathwayAbcb1a , Cyp3a2
vitamin A deficiency pathwayCyp3a2 , Ugt1a1
warfarin pharmacokinetics pathwayCyp2c79 , Cyp3a2 , Ugt1a1
Phenotype Annotations Associated with Genes in the losartan pharmacokinetics pathway

References Associated with the losartan pharmacokinetics pathway:

Ontology Path Diagram:

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