Prlh (prolactin releasing hormone) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Prlh (prolactin releasing hormone) Rattus norvegicus
Analyze
Symbol: Prlh
Name: prolactin releasing hormone
RGD ID: 628634
Description: Enables neuropeptide hormone activity and prolactin-releasing peptide receptor binding activity. Involved in G protein-coupled receptor signaling pathway and feeding behavior. Acts upstream of or within reduction of food intake in response to dietary excess. Located in cytoplasm. Used to study obesity. Orthologous to human PRLH (prolactin releasing hormone); PARTICIPATES IN obesity pathway; INTERACTS WITH ammonium chloride; bisphenol A; diethylstilbestrol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: preproprolactin-releasing peptide; Prh; prolactin-releasing hormone; prolactin-releasing peptide; prrp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Mcs31
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8998,991,628 - 98,996,515 (+)NCBIGRCr8
mRatBN7.2991,543,128 - 91,549,022 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,547,901 - 91,548,818 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx999,974,701 - 99,975,603 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,110,459 - 105,111,361 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,475,767 - 103,476,669 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,111,391 - 98,114,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,113,346 - 98,114,248 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0997,792,576 - 97,795,938 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,154,031 - 90,154,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1990,358,799 - 90,359,702 (+)NCBI
Celera989,092,213 - 89,093,115 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Quantification of prolactin-releasing peptide (PrRP) mRNA expression in specific brain regions of the rat during the oestrous cycle and in lactation. Anderson ST, etal., Brain Res 2003 May 23;973(1):64-73.
2. Repeated administration of the anorectic factor prolactin-releasing peptide leads to tolerance to its effects on energy homeostasis. Ellacott KL, etal., Am J Physiol Regul Integr Comp Physiol 2003 Nov;285(5):R1005-10.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A prolactin-releasing peptide in the brain. Hinuma S, etal., Nature 1998 May 21;393(6682):272-6.
6. Expression of neuropeptide FF, prolactin-releasing peptide, and the receptor UHR1/GPR10 genes during embryogenesis in the rat. Nieminen ML, etal., Dev Dyn 2003 Mar;226(3):561-9.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Prolactin-releasing peptide and its homolog RFRP-1 act in hypothalamus but not in anterior pituitary gland to stimulate stress hormone secretion. Samson WK, etal., Endocrine 2003 Feb-Mar;20(1-2):59-66.
9. Endogenous prolactin-releasing peptide regulates food intake in rodents. Takayanagi Y, etal., J Clin Invest. 2008 Dec;118(12):4014-24. doi: 10.1172/JCI34682. Epub 2008 Nov 3.
10. Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat. Watanabe TK, etal., Clin Exp Pharmacol Physiol. 2005 May-Jun;32(5-6):355-66.
Additional References at PubMed
PMID:10498338   PMID:11178959   PMID:14512273   PMID:14960341   PMID:15862908   PMID:15929743   PMID:17949829   PMID:19033672   PMID:21056089   PMID:24877622   PMID:25217033   PMID:32200401  
PMID:32890590  


Genomics

Comparative Map Data
Prlh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8998,991,628 - 98,996,515 (+)NCBIGRCr8
mRatBN7.2991,543,128 - 91,549,022 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,547,901 - 91,548,818 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx999,974,701 - 99,975,603 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,110,459 - 105,111,361 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,475,767 - 103,476,669 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,111,391 - 98,114,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,113,346 - 98,114,248 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0997,792,576 - 97,795,938 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,154,031 - 90,154,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1990,358,799 - 90,359,702 (+)NCBI
Celera989,092,213 - 89,093,115 (+)NCBICelera
Cytogenetic Map9q36NCBI
PRLH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,566,574 - 237,567,175 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,566,574 - 237,567,175 (+)EnsemblGRCh38hg38GRCh38
GRCh372238,475,217 - 238,475,818 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,139,956 - 238,140,557 (+)NCBINCBI36Build 36hg18NCBI36
Build 342238,257,216 - 238,257,818NCBI
Celera2232,189,067 - 232,189,668 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,265,422 - 230,266,023 (+)NCBIHuRef
CHM1_12238,480,284 - 238,480,885 (+)NCBICHM1_1
T2T-CHM13v2.02238,056,486 - 238,057,087 (+)NCBIT2T-CHM13v2.0
Prlh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39190,879,545 - 90,881,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl190,880,830 - 90,881,749 (+)EnsemblGRCm39 Ensembl
GRCm38190,951,709 - 90,954,121 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl190,953,108 - 90,954,027 (+)EnsemblGRCm38mm10GRCm38
MGSCv37192,849,685 - 92,850,589 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36192,783,514 - 92,784,418 (+)NCBIMGSCv36mm8
Celera193,898,334 - 93,899,238 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map145.81NCBI
Prlh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555422,765,566 - 2,766,371 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555422,765,578 - 2,768,057 (-)NCBIChiLan1.0ChiLan1.0
PRLH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213140,195,064 - 140,195,667 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B140,210,031 - 140,210,634 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B124,795,504 - 124,796,107 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B243,646,264 - 243,646,867 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B243,642,958 - 243,646,867 (+)Ensemblpanpan1.1panPan2
PRLH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12548,180,216 - 48,181,105 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2548,178,598 - 48,181,155 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2548,677,054 - 48,677,829 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02548,565,268 - 48,566,043 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2548,563,863 - 48,566,138 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,441,177 - 48,441,952 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,229,703 - 48,230,478 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,461,481 - 48,462,257 (+)NCBIUU_Cfam_GSD_1.0
Prlh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303190,167,449 - 190,169,613 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525770,177 - 770,863 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
PRLH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15137,230,247 - 137,230,954 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115137,230,209 - 137,232,178 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PRLH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604075,831,696 - 75,832,476 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prlh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248472,960,750 - 2,961,324 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248472,960,750 - 2,961,324 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prlh
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:98
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000026912
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 3 2 1 1 1 2 10 9 4
Below cutoff 2 1 2 1 5 17 11 2

Sequence


RefSeq Acc Id: ENSRNOT00000026912   ⟹   ENSRNOP00000026912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl991,547,901 - 91,548,818 (+)Ensembl
Rnor_6.0 Ensembl998,113,346 - 98,114,248 (+)Ensembl
RefSeq Acc Id: NM_022222   ⟹   NP_071558
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8998,994,163 - 98,996,515 (+)NCBI
mRatBN7.2991,546,581 - 91,548,933 (+)NCBI
Rnor_6.0998,113,346 - 98,114,248 (+)NCBI
Rnor_5.0997,792,576 - 97,795,938 (+)NCBI
RGSC_v3.4990,154,031 - 90,154,933 (+)RGD
Celera989,092,213 - 89,093,115 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245478   ⟹   XP_006245540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8998,991,628 - 98,996,515 (+)NCBI
mRatBN7.2991,543,128 - 91,549,022 (+)NCBI
Rnor_6.0998,111,391 - 98,114,831 (+)NCBI
Rnor_5.0997,792,576 - 97,795,938 (+)NCBI
Sequence:
RefSeq Acc Id: NP_071558   ⟸   NM_022222
- Peptide Label: precursor
- UniProtKB: Q8K3Y0 (UniProtKB/Swiss-Prot),   P81278 (UniProtKB/Swiss-Prot),   A6JQN1 (UniProtKB/TrEMBL),   A0A8L2QFX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245540   ⟸   XM_006245478
- Peptide Label: isoform X1
- UniProtKB: Q8K3Y0 (UniProtKB/Swiss-Prot),   P81278 (UniProtKB/Swiss-Prot),   A6JQN1 (UniProtKB/TrEMBL),   A0A8L2QFX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026912   ⟸   ENSRNOT00000026912

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P81278-F1-model_v2 AlphaFold P81278 1-83 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628634 AgrOrtholog
BioCyc Gene G2FUF-26732 BioCyc
Ensembl Genes ENSRNOG00000019871 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055010438 UniProtKB/Swiss-Prot
  ENSRNOG00060010724 UniProtKB/Swiss-Prot
  ENSRNOG00065020894 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026912.5 UniProtKB/TrEMBL
  ENSRNOT00055017665 UniProtKB/Swiss-Prot
  ENSRNOT00060018176 UniProtKB/Swiss-Prot
  ENSRNOT00065035480 UniProtKB/Swiss-Prot
InterPro PrRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:63850 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 63850 ENTREZGENE
PANTHER PROLACTIN-RELEASING PEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR17206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Prolactin_RP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prlh PhenoGen
RatGTEx ENSRNOG00000019871 RatGTEx
  ENSRNOG00055010438 RatGTEx
  ENSRNOG00060010724 RatGTEx
  ENSRNOG00065020894 RatGTEx
UniProt A0A8L2QFX6 ENTREZGENE, UniProtKB/TrEMBL
  A6JQN1 ENTREZGENE, UniProtKB/TrEMBL
  A6JQN2_RAT UniProtKB/TrEMBL
  P81278 ENTREZGENE, UniProtKB/Swiss-Prot
  Q8K3Y0 ENTREZGENE
UniProt Secondary Q8K3Y0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Prlh  prolactin releasing hormone  Prh  preproprolactin-releasing peptide  Symbol and Name updated 1299863 APPROVED
2003-02-27 Prh  preproprolactin-releasing peptide      Symbol and Name status set to provisional 70820 PROVISIONAL