Gene: Cul3 (cullin 3) Rattus norvegicus
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Symbol:
Cul3
Name:
cullin 3
Description:
Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including cellular protein metabolic process; embryonic morphogenesis; and positive regulation of cell cycle process. Predicted to localize to several cellular components, including the Cul3-RING ubiquitin ligase complex; microtubule cytoskeleton; and sperm flagellum. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3); PARTICIPATES IN neddylation pathway; nuclear factor, erythroid 2 like 2 signaling pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
cullin-3; LOC301555; MGC189292
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
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Orthologs 1
Homo sapiens (human):
CUL3 (cullin 3) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Cul3 (cullin 3) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cul3 (cullin 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CUL3 (cullin 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CUL3 (cullin 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cul3 (cullin 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CUL3 (cullin 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
CUL3 (cullin 3)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Cul3 (cullin 3)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
cul3a (cullin 3a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
cul3b (cullin 3b)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
CUL3
Alliance
DIOPT (Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Cul3
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
cul-3
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 9 86,044,485 - 86,129,066 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 86,044,485 - 86,129,329 (-) Ensembl Rnor_5.0 9 85,794,367 - 85,853,471 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 9 79,574,062 - 79,634,396 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 9 79,757,935 - 79,837,198 (-) NCBI Celera 9 79,070,793 - 79,129,030 (-) NCBI Celera Cytogenetic Map 9 q34 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
autosomal dominant pseudohypoaldosteronism type 1 ISO RGD:1317824 8554872 ClinVar Annotator: match by term: Pseudohypoaldosteronism, Type I, Dominant ClinVar autosomal dominant pseudohypoaldosteronism type 1 ISO RGD:1317824 8554872 ClinVar Annotator: match by term: Pseudohypoaldosteronism, Type I, Dominant ClinVar PMID:28492532 autosomal dominant pseudohypoaldosteronism type 1 ISO RGD:1317824 8554872 ClinVar Annotator: match by term: Pseudohypoaldosteronism, Type I, Dominant ClinVar PMID:25741868 genetic disease ISO RGD:1317824 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10500095 more ... Neurodevelopmental Disorders ISO RGD:1317824 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868 pseudohypoaldosteronism ISO RGD:1317824 8554872 ClinVar Annotator: match by term: HYPERTENSIVE HYPERKALEMIA, FAMILIAL, UMLS MESH term: Familial Hypertensive Hyperkalemia ClinVar pseudohypoaldosteronism ISO RGD:1317824 8554872 ClinVar Annotator: match by term: HYPERTENSIVE HYPERKALEMIA, FAMILIAL, UMLS MESH term: Familial Hypertensive Hyperkalemia ClinVar PMID:22266938 Pseudohypoaldosteronism, Type IIE ISO RGD:1317824 8554872 ClinVar Annotator: match by term: Pseudohypoaldosteronism type 2E ClinVar PMID:22266938
Imported Annotations - CTD
melanoma ISO RGD:1317824 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22535842 Neurodevelopmental Disorders ISO RGD:1317824 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28191889 Prostatic Neoplasms ISO RGD:1317824 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29610475
Imported Annotations - OMIM
Pseudohypoaldosteronism, Type IIE ISO RGD:1317824 7240710 OMIM
17beta-estradiol decreases expression ISO RGD:1317825 6480464 Estradiol results in decreased expression of CUL3 mRNA CTD PMID:30077407 17beta-estradiol multiple interactions ISO RGD:1317825 6480464 [Polyphenols co-treated with Estradiol] results in increased expression of CUL3 mRNA CTD PMID:30077407 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1317825 6480464 Tetrachlorodibenzodioxin results in decreased expression of CUL3 mRNA CTD PMID:18691609 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1317825 6480464 Tetrachlorodibenzodioxin affects the expression of CUL3 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of CUL3 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of CUL3 mRNA CTD PMID:21346803 2-tert-butylhydroquinone multiple interactions ISO RGD:1317824 6480464 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein] CTD PMID:18417180 2-tert-butylhydroquinone multiple interactions ISO RGD:1317825 6480464 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein] CTD PMID:30261176 4-hydroxyphenyl retinamide decreases expression ISO RGD:1317825 6480464 Fenretinide results in decreased expression of CUL3 mRNA CTD PMID:28973697 aflatoxin B1 increases expression ISO RGD:1317825 6480464 Aflatoxin B1 results in increased expression of CUL3 mRNA CTD PMID:19770486 Aroclor 1254 decreases expression ISO RGD:1317825 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of CUL3 mRNA CTD PMID:23650126 auramine O increases expression ISO RGD:1317824 6480464 Benzophenoneidum results in increased expression of CUL3 protein CTD PMID:28722353 benzo[a]pyrene increases expression ISO RGD:1317825 6480464 Benzo(a)pyrene results in increased expression of CUL3 mRNA CTD PMID:20504355 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1317824 6480464 7 more ... CTD PMID:19150397 bisphenol A increases expression ISO RGD:1317824 6480464 bisphenol A results in increased expression of CUL3 mRNA CTD PMID:25047013 bisphenol A decreases methylation ISO RGD:1317824 6480464 bisphenol A results in decreased methylation of CUL3 gene CTD PMID:28582417 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CUL3 mRNA CTD PMID:30816183 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CUL3 mRNA CTD PMID:25181051 bortezomib decreases expression ISO RGD:1317824 6480464 Bortezomib results in decreased expression of CUL3 mRNA CTD PMID:17659339 calcitriol increases expression ISO RGD:1317824 6480464 Calcitriol results in increased expression of CUL3 mRNA CTD PMID:16002434 carbamazepine affects expression ISO RGD:1317824 6480464 Carbamazepine affects the expression of CUL3 mRNA CTD PMID:24752500 diallyl trisulfide decreases expression EXP 6480464 diallyl trisulfide results in decreased expression of CUL3 protein CTD PMID:23453443 diazinon affects expression EXP 6480464 Diazinon affects the expression of CUL3 mRNA CTD PMID:22546817 diclofenac affects expression ISO RGD:1317824 6480464 Diclofenac affects the expression of CUL3 mRNA CTD PMID:24752500 dorsomorphin multiple interactions ISO RGD:1317824 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 elemental selenium decreases expression ISO RGD:1317824 6480464 Selenium results in decreased expression of CUL3 mRNA CTD PMID:19244175 entinostat multiple interactions ISO RGD:1317824 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA CTD PMID:27188386 entinostat decreases expression ISO RGD:1317824 6480464 entinostat results in decreased expression of CUL3 mRNA CTD PMID:26272509 ethanol affects splicing ISO RGD:1317825 6480464 Ethanol affects the splicing of CUL3 mRNA CTD PMID:30319688 furan decreases methylation EXP 6480464 furan results in decreased methylation of CUL3 gene CTD PMID:22079235 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of CUL3 mRNA CTD PMID:22061828 leflunomide decreases expression ISO RGD:1317824 6480464 leflunomide results in decreased expression of CUL3 mRNA CTD PMID:28988120 melphalan increases expression ISO RGD:1317824 6480464 Melphalan results in increased expression of CUL3 mRNA CTD PMID:22363485 mercury dibromide multiple interactions ISO RGD:1317824 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA CTD PMID:27188386 methylmercury chloride decreases expression ISO RGD:1317824 6480464 methylmercuric chloride results in decreased expression of CUL3 mRNA CTD PMID:28001369 motexafin gadolinium multiple interactions ISO RGD:1317824 6480464 [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CUL3 mRNA CTD PMID:16357179 motexafin gadolinium decreases expression ISO RGD:1317824 6480464 motexafin gadolinium results in decreased expression of CUL3 mRNA CTD PMID:16357179 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CUL3 mRNA CTD PMID:25729387 panobinostat decreases expression ISO RGD:1317824 6480464 panobinostat results in decreased expression of CUL3 mRNA CTD PMID:26272509 panobinostat multiple interactions ISO RGD:1317824 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA CTD PMID:27188386 paracetamol affects expression ISO RGD:1317825 6480464 Acetaminophen affects the expression of CUL3 mRNA CTD PMID:17562736 phenylmercury acetate decreases expression ISO RGD:1317824 6480464 Phenylmercuric Acetate results in decreased expression of CUL3 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1317824 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA CTD PMID:27188386 pyrogallol increases expression ISO RGD:1317825 6480464 Pyrogallol results in increased expression of CUL3 mRNA CTD PMID:20362636 SB 431542 multiple interactions ISO RGD:1317824 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 selenium atom decreases expression ISO RGD:1317824 6480464 Selenium results in decreased expression of CUL3 mRNA CTD PMID:19244175 silicon dioxide decreases expression ISO RGD:1317825 6480464 Silicon Dioxide results in decreased expression of CUL3 mRNA CTD PMID:19073995 silicon dioxide increases expression ISO RGD:1317824 6480464 Silicon Dioxide results in increased expression of CUL3 mRNA CTD PMID:25351596 sodium arsenite multiple interactions ISO RGD:1317824 6480464 sodium arsenite promotes the reaction [KEAP1 protein binds to CUL3 protein] CTD PMID:18417180 sodium arsenite multiple interactions ISO RGD:1317825 6480464 sodium arsenite inhibits the reaction [[CUL3 protein binds to KEAP1 protein] which binds to and results in increased ubiquitination of NFE2L2 protein] CTD PMID:16785233 sodium dichromate increases expression ISO RGD:1317825 6480464 sodium bichromate results in increased expression of CUL3 mRNA CTD PMID:22155349 sodium fluoride increases expression ISO RGD:1317825 6480464 Sodium Fluoride results in increased expression of CUL3 protein CTD PMID:28918527 solanesol multiple interactions ISO RGD:1317824 6480464 solanesol inhibits the reaction [KEAP1 protein binds to CUL3 protein binds to RBX1 protein] CTD PMID:25645596 succimer multiple interactions ISO RGD:1317825 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CUL3 mRNA CTD PMID:21641980 sulforaphane multiple interactions ISO RGD:1317824 6480464 sulforafan inhibits the reaction [KEAP1 protein binds to CUL3 protein] CTD PMID:18417180 sulforaphane multiple interactions ISO RGD:1317825 6480464 sulforafan inhibits the reaction [KEAP1 protein binds to CUL3 protein] CTD PMID:30261176 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of CUL3 mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CUL3 mRNA CTD PMID:25729387 trichloroethene decreases methylation EXP 6480464 Trichloroethylene results in decreased methylation of CUL3 gene CTD PMID:27618143 trichostatin A decreases expression ISO RGD:1317824 6480464 trichostatin A results in decreased expression of CUL3 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:1317824 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA CTD PMID:27188386 troglitazone decreases expression ISO RGD:1317825 6480464 troglitazone results in decreased expression of CUL3 mRNA CTD PMID:28973697 valproic acid decreases expression ISO RGD:1317824 6480464 Valproic Acid results in decreased expression of CUL3 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:1317824 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA CTD PMID:27188386 vancomycin increases expression ISO RGD:1317825 6480464 Vancomycin results in increased expression of CUL3 mRNA CTD PMID:18930951 vitamin E decreases expression ISO RGD:1317824 6480464 Vitamin E results in decreased expression of CUL3 mRNA CTD PMID:19244175 zinc acetate multiple interactions ISO RGD:1317824 6480464 [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CUL3 mRNA CTD PMID:16357179 zinc acetate decreases expression ISO RGD:1317824 6480464 Zinc Acetate results in decreased expression of CUL3 mRNA CTD PMID:16357179
Biological Process anaphase-promoting complex-dependent catabolic process ISO RGD:1317824 1624291 (PMID:10500095) RGD PMID:10500095 anaphase-promoting complex-dependent catabolic process IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 biological_process ND 1598407 10/2008: no relevant rat data RGD cell migration ISO RGD:1317824 1624291 (PMID:19782033) RGD PMID:19782033 cell migration IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell morphogenesis ISO RGD:1317825 1624291 MGI:MGI:2651546 (MGI:MGI:1345775 , PMID:10500095) RGD MGI:MGI:1345775 , PMID:10500095 cell projection organization IEA UniProtKB-KW:KW-0970 1600115 GO_REF:0000037 UniProt GO_REF:0000037 COPII vesicle coating ISO RGD:1317824 1624291 (PMID:22358839) RGD PMID:22358839 COPII vesicle coating ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 COPII vesicle coating IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic cleavage ISO RGD:1317825 1624291 (MGI:MGI:5312166, PMID:22358839) RGD MGI:MGI:5312166 , PMID:22358839 embryonic cleavage ISS UniProtKB:Q9JLV5 1600115 GO_REF:0000024 UniProt GO_REF:0000024 embryonic cleavage IEA UniProtKB:Q9JLV5 , ensembl:ENSMUSP000001307381600115 GO_REF:0000107 Ensembl GO_REF:0000107 endoplasmic reticulum to Golgi vesicle-mediated transport ISO RGD:1317824 1624291 (PMID:22358839) RGD PMID:22358839 endoplasmic reticulum to Golgi vesicle-mediated transport ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 fibroblast apoptotic process ISO RGD:1317825 1624291 MGI:MGI:3714267 (MGI:MGI:3713609 , PMID:17339333) RGD MGI:MGI:3713609 , PMID:17339333 fibroblast apoptotic process IEA UniProtKB:Q9JLV5 , ensembl:ENSMUSP000001307381600115 GO_REF:0000107 Ensembl GO_REF:0000107 gastrulation ISO RGD:1317825 1624291 MGI:MGI:2651546 (MGI:MGI:1345775 , PMID:10500095) RGD MGI:MGI:1345775 , PMID:10500095 gastrulation IEA UniProtKB:Q9JLV5 , ensembl:ENSMUSP000001307381600115 GO_REF:0000107 Ensembl GO_REF:0000107 in utero embryonic development ISO RGD:1317825 1624291 MGI:MGI:2651546 (MGI:MGI:1345775 , PMID:10500095) RGD MGI:MGI:1345775 , PMID:10500095 integrin-mediated signaling pathway ISO RGD:1317825 1624291 (MGI:MGI:5312166, PMID:22358839) RGD MGI:MGI:5312166 , PMID:22358839 integrin-mediated signaling pathway ISS UniProtKB:Q9JLV5 1600115 GO_REF:0000024 UniProt GO_REF:0000024 integrin-mediated signaling pathway IEA UniProtKB:Q9JLV5 , ensembl:ENSMUSP000001307381600115 GO_REF:0000107 Ensembl GO_REF:0000107 liver morphogenesis ISO RGD:1317825 1624291 MGI:MGI:3714267 (MGI:MGI:3713609 , PMID:17339333) RGD MGI:MGI:3713609 , PMID:17339333 liver morphogenesis IEA UniProtKB:Q9JLV5 , ensembl:ENSMUSP000001307381600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitotic cell cycle ISO RGD:1317825 1624291 MGI:MGI:3714267 (MGI:MGI:3713609 , PMID:17339333) RGD MGI:MGI:3713609 , PMID:17339333 mitotic metaphase plate congression ISO RGD:1317824 1624291 (PMID:17543862), (PMID:19995937) RGD PMID:17543862 , PMID:19995937 mitotic metaphase plate congression IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of Rho protein signal transduction ISO RGD:1317824 1624291 (PMID:19782033) RGD PMID:19782033 negative regulation of Rho protein signal transduction IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II ISO RGD:1317825 1624291 MGI:MGI:3714267 (MGI:MGI:3713609 , PMID:17339333) RGD MGI:MGI:3713609 , PMID:17339333 negative regulation of transcription by RNA polymerase II IEA UniProtKB:Q9JLV5 , ensembl:ENSMUSP000001307381600115 GO_REF:0000107 Ensembl GO_REF:0000107 nuclear protein quality control by the ubiquitin-proteasome system ISO RGD:1317824 1624291 (PMID:27561354) RGD PMID:27561354 nuclear protein quality control by the ubiquitin-proteasome system ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nuclear protein quality control by the ubiquitin-proteasome system IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cytokinesis ISO RGD:1317824 1624291 (PMID:19261606) RGD PMID:19261606 positive regulation of cytokinesis ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of cytokinesis IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of mitotic cell cycle phase transition ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of mitotic cell cycle phase transition ISO RGD:1317824 1624291 (PMID:23213400) RGD PMID:23213400 positive regulation of mitotic metaphase/anaphase transition ISO RGD:1317824 1624291 (PMID:17543862) RGD PMID:17543862 positive regulation of mitotic metaphase/anaphase transition IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of protein ubiquitination IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of protein ubiquitination ISO RGD:1317824 1624291 RNAcentral:URS00001230A0_9606 (PMID:24844779) RGD PMID:24844779 proteasome-mediated ubiquitin-dependent protein catabolic process ISO RGD:1317825 1624291 MGI:MGI:1343085 (MGI:MGI:4836774 , PMID:20811152) RGD MGI:MGI:4836774 , PMID:20811152 proteasome-mediated ubiquitin-dependent protein catabolic process ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 proteasome-mediated ubiquitin-dependent protein catabolic process ISO RGD:1317824 1624291 (PMID:19261606), (PMID:19782033), (PMID:20389280) RGD PMID:19261606 more ... protein destabilization IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein destabilization ISO RGD:1317824 1624291 RNAcentral:URS00001230A0_9606 (PMID:24844779) RGD PMID:24844779 protein monoubiquitination ISO RGD:1317824 1624291 (PMID:22358839) RGD PMID:22358839 protein monoubiquitination ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein monoubiquitination IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein polyubiquitination ISO RGD:1317824 1624291 (PMID:19261606) RGD PMID:19261606 protein polyubiquitination IEA UniProtKB:Q9JLV5 , ensembl:ENSMUSP000001307381600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein polyubiquitination ISO RGD:1317825 1624291 (MGI:MGI:5806303, PMID:27708159) RGD MGI:MGI:5806303 , PMID:27708159 protein polyubiquitination ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein polyubiquitination IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein ubiquitination ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein ubiquitination ISO RGD:1317824 1624291 (PMID:17543862), (PMID:19782033), (PMID:19995937), (PMID:20389280), (PMID:23213400) RGD PMID:17543862 more ... regulation of transcription by RNA polymerase II ISO RGD:1317825 1624291 MGI:MGI:107187 (MGI:MGI:5588735 , PMID:24863065) RGD MGI:MGI:5588735 , PMID:24863065 stem cell division ISO RGD:1317825 1624291 (MGI:MGI:5312166, PMID:22358839) RGD MGI:MGI:5312166 , PMID:22358839 stem cell division ISS UniProtKB:Q9JLV5 1600115 GO_REF:0000024 UniProt GO_REF:0000024 stem cell division IEA UniProtKB:Q9JLV5 , ensembl:ENSMUSP000001307381600115 GO_REF:0000107 Ensembl GO_REF:0000107 stress fiber assembly ISO RGD:1317824 1624291 (PMID:19782033) RGD PMID:19782033 stress fiber assembly IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 trophectodermal cellular morphogenesis ISO RGD:1317825 1624291 MGI:MGI:2651546 (MGI:MGI:1345775 , PMID:10500095) RGD MGI:MGI:1345775 , PMID:10500095 trophectodermal cellular morphogenesis IEA UniProtKB:Q9JLV5 , ensembl:ENSMUSP000001307381600115 GO_REF:0000107 Ensembl GO_REF:0000107 ubiquitin-dependent protein catabolic process ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ubiquitin-dependent protein catabolic process ISO RGD:1317824 1624291 (PMID:25401743), (PMID:27561354) RGD PMID:25401743 , PMID:27561354 Wnt signaling pathway ISO RGD:1317825 1624291 (MGI:MGI:3820325, PMID:19056892) RGD MGI:MGI:3820325 , PMID:19056892 Wnt signaling pathway IEA UniProtKB:Q9JLV5 , ensembl:ENSMUSP000001307381600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cell IEA GO:0007080 1600115 GO_REF:0000108 GOC GO_REF:0000108 cellular_component ND 1598407 10/2008: no relevant rat data RGD centrosome ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 centrosome IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 centrosome ISO RGD:1317824 1624291 (PMID:23213400) RGD PMID:23213400 Cul3-RING ubiquitin ligase complex ISO RGD:1317824 1624291 (PMID:15983046), (PMID:17543862), (PMID:19158078), (PMID:19261606), (PMID:19782033), (PMID:19995937), (PMID:20389280), (PMID:22358839), (PMID:22578813), (PMID:23453970), (PMID:23455478), (PMID:23576762), (PMID:24768539), (PMID:26399832) RGD PMID:15983046 more ... Cul3-RING ubiquitin ligase complex ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 Cul3-RING ubiquitin ligase complex IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoplasm ISO RGD:1317825 1624291 (MGI:MGI:5588735, PMID:24863065) RGD MGI:MGI:5588735 , PMID:24863065 cytoplasm ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cytoplasm ISO RGD:1317824 1624291 (PMID:28395323) RGD PMID:28395323 Golgi apparatus ISO RGD:1317825 1624291 (MGI:MGI:1345775, PMID:10500095) RGD MGI:MGI:1345775 , PMID:10500095 Golgi membrane IEA GO:0048208 1600115 GO_REF:0000108 GOC GO_REF:0000108 mitotic spindle ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 mitotic spindle ISO RGD:1317824 1624291 (PMID:23213400) RGD PMID:23213400 mitotic spindle IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:1317825 1624291 (MGI:MGI:1345775 more ... RGD MGI:MGI:1345775 more ... nucleus IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:1317824 1624291 (PMID:23213400) RGD PMID:23213400 nucleus ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nucleus IEA UniProtKB:Q9JLV5 , ensembl:ENSMUSP000001307381600115 GO_REF:0000107 Ensembl GO_REF:0000107 polar microtubule ISO RGD:1317824 1624291 (PMID:19995937) RGD PMID:19995937 polar microtubule IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 sperm flagellum IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 sperm flagellum ISO RGD:1317824 1624291 (PMID:28395323) RGD PMID:28395323 sperm flagellum ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 spindle pole ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 spindle pole ISO RGD:1317824 1624291 (PMID:23213400) RGD PMID:23213400 Molecular Function cyclin binding ISO RGD:1317825 1624291 UniProtKB:Q61457 (MGI:MGI:1345775 , PMID:10500095) RGD MGI:MGI:1345775 , PMID:10500095 cyclin binding IEA UniProtKB:Q9JLV5 , ensembl:ENSMUSP000001307381600115 GO_REF:0000107 Ensembl GO_REF:0000107 molecular_function ND 1598407 10/2008: no relevant rat data RGD Notch binding IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 Notch binding ISO RGD:1317824 1624291 UniProtKB:P46531 (PMID:25401743) RGD PMID:25401743 POZ domain binding ISO RGD:1317824 1624291 (PMID:19261606) RGD PMID:19261606 POZ domain binding ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 POZ domain binding IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding IPI UniProtKB:Q8K430 8553595 PMID:17062563 UniProt protein binding ISO RGD:1317824 1624291 UniProtKB:O14965 more ... RGD PMID:12609982 more ... protein binding ISO RGD:1317825 1624291 UniProtKB:E9Q9D5 more ... RGD MGI:MGI:5468889 more ... protein heterodimerization activity ISO RGD:1317825 1624291 UniProtKB:Q9D5V5 (MGI:MGI:5499695 , PMID:22709582) RGD MGI:MGI:5499695 , PMID:22709582 protein homodimerization activity ISO RGD:1317825 1624291 (MGI:MGI:5499695, PMID:22709582) RGD MGI:MGI:5499695 , PMID:22709582 ubiquitin protein ligase binding IEA InterPro:IPR001373 , InterPro:IPR016157 1600115 GO_REF:0000002 InterPro GO_REF:0000002 ubiquitin-protein transferase activity contributes_to ISO RGD:1317824 1624291 (PMID:15983046), (PMID:19261606), (PMID:19782033), (PMID:20389280) RGD PMID:15983046 more ... ubiquitin-protein transferase activity contributes_to ISS UniProtKB:Q13618 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ubiquitin-protein transferase activity IEA UniProtKB:Q13618 , ensembl:ENSP000002644141600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
