Alpg (alkaline phosphatase, germ cell) - Rat Genome Database

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Gene: Alpg (alkaline phosphatase, germ cell) Rattus norvegicus
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Symbol: Alpg
Name: alkaline phosphatase, germ cell
RGD ID: 1565100
Description: Predicted to enable alkaline phosphatase activity. Predicted to be located in myofibril. Predicted to be active in plasma membrane. Orthologous to human ALPG (alkaline phosphatase, germ cell); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 1,2-dimethylhydrazine (ortholog); 17alpha-ethynylestradiol (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alkaline phosphatase, germ cell type-like; alkaline phosphatase, placental-like; alkaline phosphatase, placental-like 2; Alppl2; intestinal-type alkaline phosphatase 1-like; LOC367308; RGD1565100; similar to alkaline phosphatase (EC 3.1.3.1) precursor, placental-like - human
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8995,187,995 - 95,205,127 (+)NCBIGRCr8
mRatBN7.2987,748,721 - 87,761,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,753,648 - 87,757,836 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0994,164,667 - 94,184,972 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,178,221 - 94,181,010 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,902,305 - 93,906,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,873,702 - 85,876,375 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera985,154,031 - 85,171,042 (+)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1939159   PMID:2133555   PMID:19531352  


Genomics

Comparative Map Data
Alpg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8995,187,995 - 95,205,127 (+)NCBIGRCr8
mRatBN7.2987,748,721 - 87,761,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,753,648 - 87,757,836 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0994,164,667 - 94,184,972 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,178,221 - 94,181,010 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,902,305 - 93,906,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,873,702 - 85,876,375 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera985,154,031 - 85,171,042 (+)NCBICelera
Cytogenetic Map9q35NCBI
ALPG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382232,406,844 - 232,410,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2232,406,844 - 232,410,714 (+)EnsemblGRCh38hg38GRCh38
GRCh372233,271,554 - 233,275,424 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362232,979,796 - 232,983,668 (+)NCBINCBI36Build 36hg18NCBI36
Build 342233,097,057 - 233,100,922NCBI
Celera2227,035,760 - 227,039,632 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2225,122,316 - 225,126,186 (+)NCBIHuRef
CHM1_12233,277,726 - 233,281,596 (+)NCBICHM1_1
T2T-CHM13v2.02232,893,640 - 232,897,508 (+)NCBIT2T-CHM13v2.0
Alppl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39187,014,412 - 87,023,656 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl187,014,416 - 87,017,650 (-)EnsemblGRCm39 Ensembl
GRCm38187,086,690 - 87,095,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl187,086,694 - 87,089,928 (-)EnsemblGRCm38mm10GRCm38
MGSCv37188,983,265 - 88,986,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36188,917,861 - 88,921,082 (-)NCBIMGSCv36mm8
Celera190,058,871 - 90,062,109 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map144.05NCBI

Variants

.
Variants in Alpg
81 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:80
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000033487
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 73 72 41 25 41 6 200 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000033487   ⟹   ENSRNOP00000038169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl987,753,648 - 87,757,836 (+)Ensembl
Rnor_6.0 Ensembl994,178,221 - 94,181,010 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083137   ⟹   ENSRNOP00000070046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl987,753,648 - 87,757,836 (+)Ensembl
RefSeq Acc Id: XM_039084682   ⟹   XP_038940610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8995,187,995 - 95,205,127 (+)NCBI
mRatBN7.2987,748,721 - 87,761,500 (+)NCBI
RefSeq Acc Id: XM_039084685   ⟹   XP_038940613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8995,187,995 - 95,205,127 (+)NCBI
mRatBN7.2987,748,721 - 87,761,500 (+)NCBI
RefSeq Acc Id: XM_063268168   ⟹   XP_063124238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8995,187,995 - 95,205,127 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038940610 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940613 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124238 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038169.7
  ENSRNOP00000070046.2
Ensembl Acc Id: ENSRNOP00000038169   ⟸   ENSRNOT00000033487
RefSeq Acc Id: XP_038940610   ⟸   XM_039084682
- Peptide Label: isoform X1
- UniProtKB: F1M8U7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940613   ⟸   XM_039084685
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JWW9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000070046   ⟸   ENSRNOT00000083137
RefSeq Acc Id: XP_063124238   ⟸   XM_063268168
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M8U7-F1-model_v2 AlphaFold F1M8U7 1-438 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696834
Promoter ID:EPDNEW_R7353
Type:single initiation site
Name:Alppl2_1
Description:alkaline phosphatase, placental-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0994,178,232 - 94,178,292EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565100 AgrOrtholog
BioCyc Gene G2FUF-26857 BioCyc
Ensembl Genes ENSRNOG00000042889 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033487.7 UniProtKB/TrEMBL
  ENSRNOT00000083137.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.720.10 UniProtKB/TrEMBL
InterPro Alkaline_phosphatase UniProtKB/TrEMBL
  Alkaline_phosphatase_AS UniProtKB/TrEMBL
  Alkaline_phosphatase_core UniProtKB/TrEMBL
NCBI Gene 367308 ENTREZGENE
PANTHER ALKALINE PHOSPHATASE, GERM CELL TYPE UniProtKB/TrEMBL
  PTHR11596 UniProtKB/TrEMBL
Pfam Alk_phosphatase UniProtKB/TrEMBL
PhenoGen Alpg PhenoGen
PRINTS ALKPHPHTASE UniProtKB/TrEMBL
PROSITE ALKALINE_PHOSPHATASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042889 RatGTEx
SMART alkPPc UniProtKB/TrEMBL
Superfamily-SCOP Alkaline_phosphatase_core UniProtKB/TrEMBL
UniProt A0A0G2JWW9 ENTREZGENE, UniProtKB/TrEMBL
  F1M8U7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-06-11 Alpg  alkaline phosphatase, germ cell  Alppl2  alkaline phosphatase, placental-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-07 Alppl2  alkaline phosphatase, placental-like 2  RGD1565100  similar to alkaline phosphatase (EC 3.1.3.1) precursor, placental-like - human  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565100  similar to alkaline phosphatase (EC 3.1.3.1) precursor, placental-like - human   RGD1565100_predicted  similar to alkaline phosphatase (EC 3.1.3.1) precursor, placental-like - human (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565100_predicted  similar to alkaline phosphatase (EC 3.1.3.1) precursor, placental-like - human (predicted)  LOC367308  similar to alkaline phosphatase (EC 3.1.3.1) precursor, placental-like - human  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC367308  similar to alkaline phosphatase (EC 3.1.3.1) precursor, placental-like - human      Symbol and Name status set to provisional 70820 PROVISIONAL