Alppl2 (alkaline phosphatase, placental-like 2) - Rat Genome Database

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Gene: Alppl2 (alkaline phosphatase, placental-like 2) Mus musculus
Analyze
Symbol: Alppl2
Name: alkaline phosphatase, placental-like 2
RGD ID: 1314396
MGI Page MGI
Description: Enables alkaline phosphatase activity. Located in myofibril. Is expressed in early conceptus; intestine; and testis. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell) and ALPI (alkaline phosphatase, intestinal).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ak; Akp5; alkaline phosphatase 5; alkaline phosphatase, germ cell type; alkaline phosphatase, placental-like; Alpg; C77216; D1Ertd816; D1Ertd816e; EAP; embryonic alkaline phosphatase; embryonic-type alkaline phosphatase
RGD Orthologs
Human
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39187,014,412 - 87,023,656 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl187,014,416 - 87,017,650 (-)EnsemblGRCm39 Ensembl
GRCm38187,086,690 - 87,095,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl187,086,694 - 87,089,928 (-)EnsemblGRCm38mm10GRCm38
MGSCv37188,983,265 - 88,986,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36188,917,861 - 88,921,082 (-)NCBIMGSCv36mm8
Celera190,058,871 - 90,062,109 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map144.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
myofibril  (IDA)
plasma membrane  (IBA,IEA,ISO)
side of membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2133555   PMID:2286375   PMID:9056646   PMID:9061447   PMID:9291464   PMID:10349636   PMID:10767088   PMID:10878613   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:11722850   PMID:12477932   PMID:14681479   PMID:14691545   PMID:16141072   PMID:16141073   PMID:16537572   PMID:17901166   PMID:19531352   PMID:21873635   PMID:22675556   PMID:26902285  
PMID:31289197  


Genomics

Comparative Map Data
Alppl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39187,014,412 - 87,023,656 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl187,014,416 - 87,017,650 (-)EnsemblGRCm39 Ensembl
GRCm38187,086,690 - 87,095,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl187,086,694 - 87,089,928 (-)EnsemblGRCm38mm10GRCm38
MGSCv37188,983,265 - 88,986,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36188,917,861 - 88,921,082 (-)NCBIMGSCv36mm8
Celera190,058,871 - 90,062,109 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map144.05NCBI
ALPG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382232,406,844 - 232,410,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2232,406,844 - 232,410,714 (+)EnsemblGRCh38hg38GRCh38
GRCh372233,271,554 - 233,275,424 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362232,979,796 - 232,983,668 (+)NCBINCBI36Build 36hg18NCBI36
Build 342233,097,057 - 233,100,922NCBI
Celera2227,035,760 - 227,039,632 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2225,122,316 - 225,126,186 (+)NCBIHuRef
CHM1_12233,277,726 - 233,281,596 (+)NCBICHM1_1
T2T-CHM13v2.02232,893,640 - 232,897,508 (+)NCBIT2T-CHM13v2.0
Alpg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8995,187,995 - 95,205,127 (+)NCBIGRCr8
mRatBN7.2987,748,721 - 87,761,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,753,648 - 87,757,836 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0994,164,667 - 94,184,972 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,178,221 - 94,181,010 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,902,305 - 93,906,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,873,702 - 85,876,375 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera985,154,031 - 85,171,042 (+)NCBICelera
Cytogenetic Map9q35NCBI

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:135
Interacting mature miRNAs:137
Transcripts:ENSMUST00000027455
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
25394563Skmw48_mskeletal muscle weight 48, EDL (mouse)18547800687323158Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
25394564Skmw49_mskeletal muscle weight 49, TA (mouse)18342011988552630Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186483929120483929Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
14696691Malq1_mmean attack latency QTL 1 (mouse)17797663787927722Mouse
14696692Tavq1_mtotal attack value QTL 1 (mouse)18197771588427722Mouse
14696693Avd2q1_mattack value day 2 QTL 1 (mouse)17897771790927722Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1302029Sst1_msusceptibility to tuberculosis 1 (mouse)Not determined18165211487130822Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182832635116832635Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179858683113858791Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179858683113858791Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
11667074Led2_mlate embryonic death 2 (mouse)185696027117195081Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse
1300821Lore1_mloss of righting induced by ethanol 1 (mouse)Not determined17554919192941077Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182832635116832635Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16588900688496101Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse

Markers in Region
RH136468  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38187,086,766 - 87,086,967UniSTSGRCm38
MGSCv37188,983,341 - 88,983,542UniSTSGRCm37
Celera190,058,947 - 90,059,148UniSTS
Cytogenetic Map1DUniSTS
cM Map154.0UniSTS
C77216  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38187,086,844 - 87,086,969UniSTSGRCm38
MGSCv37188,983,419 - 88,983,544UniSTSGRCm37
Celera190,059,025 - 90,059,150UniSTS
Cytogenetic Map1DUniSTS
cM Map154.0UniSTS
Whitehead/MRC_RH11258.21UniSTS
D1Ertd816e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38187,086,745 - 87,086,958UniSTSGRCm38
MGSCv37188,983,320 - 88,983,533UniSTSGRCm37
Celera190,058,926 - 90,059,139UniSTS
Cytogenetic Map1DUniSTS
cM Map154.0UniSTS
Akp5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1DUniSTS
cM Map154.0UniSTS
cM Map1 UniSTS
cM MapUN UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000027455   ⟹   ENSMUSP00000027455
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl187,014,416 - 87,017,633 (-)Ensembl
GRCm38.p6 Ensembl187,086,694 - 87,089,911 (-)Ensembl
Ensembl Acc Id: ENSMUST00000188310   ⟹   ENSMUSP00000139887
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl187,014,417 - 87,017,650 (-)Ensembl
GRCm38.p6 Ensembl187,086,695 - 87,089,928 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190082
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl187,016,502 - 87,017,527 (-)Ensembl
GRCm38.p6 Ensembl187,088,780 - 87,089,805 (-)Ensembl
RefSeq Acc Id: NM_007433   ⟹   NP_031459
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39187,014,412 - 87,017,650 (-)NCBI
GRCm38187,086,690 - 87,089,928 (-)NCBI
MGSCv37188,983,265 - 88,986,503 (-)RGD
Celera190,058,871 - 90,062,109 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006529082   ⟹   XP_006529145
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39187,014,417 - 87,023,656 (-)NCBI
GRCm38187,086,695 - 87,095,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011247904   ⟹   XP_011246206
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39187,014,417 - 87,023,649 (-)NCBI
GRCm38187,086,695 - 87,095,927 (-)NCBI
Sequence:
RefSeq Acc Id: NP_031459   ⟸   NM_007433
- Peptide Label: precursor
- UniProtKB: Q3ULC9 (UniProtKB/Swiss-Prot),   P24823 (UniProtKB/Swiss-Prot),   Q7TPW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006529145   ⟸   XM_006529082
- Peptide Label: isoform X1
- UniProtKB: Q3ULC9 (UniProtKB/Swiss-Prot),   P24823 (UniProtKB/Swiss-Prot),   Q7TPW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011246206   ⟸   XM_011247904
- Peptide Label: isoform X1
- UniProtKB: Q3ULC9 (UniProtKB/Swiss-Prot),   P24823 (UniProtKB/Swiss-Prot),   Q7TPW4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000027455   ⟸   ENSMUST00000027455
Ensembl Acc Id: ENSMUSP00000139887   ⟸   ENSMUST00000188310

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24823-F1-model_v2 AlphaFold P24823 1-529 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108009 AgrOrtholog
Ensembl Genes ENSMUSG00000026246 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027455 ENTREZGENE
  ENSMUST00000027455.13 UniProtKB/Swiss-Prot
  ENSMUST00000188310.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.720.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Alkaline_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alkaline_phosphatase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11650 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108009 ENTREZGENE
NCBI Gene 11650 ENTREZGENE
PANTHER ALKALINE PHOSPHATASE, GERM CELL TYPE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11596 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Alk_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Alppl2 PhenoGen
PRINTS ALKPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALKALINE_PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART alkPPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P24823 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3ULC9 ENTREZGENE
  Q7TPW4 ENTREZGENE, UniProtKB/TrEMBL
  Q91Z87_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3ULC9 UniProtKB/Swiss-Prot