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Gene: Dis3l2 (DIS3-like 3'-5' exoribonuclease 2) Rattus norvegicus
Symbol: Dis3l2
Name: DIS3-like 3'-5' exoribonuclease 2
Description: Predicted to have 3'-5'-exoribonuclease activity; magnesium ion binding activity; and poly(U) RNA binding activity. Predicted to be involved in several processes, including RNA catabolic process; mitotic sister chromatid separation; and stem cell population maintenance. Predicted to localize to the P-body and exosome (RNase complex). Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2); INTERACTS WITH bisphenol A; cisplatin; cobalt dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DIS3 mitotic control homolog (S. cerevisiae)-like 2; DIS3 mitotic control homolog-like 2; DIS3-like exonuclease 2; LOC367307; RGD1560168; similar to RIKEN cDNA 4930429A22
Homo sapiens (human) : DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)  HGNC  Alliance
Mus musculus (house mouse) : Dis3l2 (DIS3 like 3'-5' exoribonuclease 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dis3l2 (DIS3 like 3'-5' exoribonuclease 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)
Canis lupus familiaris (dog) : DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dis3l2 (DIS3 like 3'-5' exoribonuclease 2)
Sus scrofa (pig) : DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0993,767,837 - 94,161,106 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0993,495,138 - 93,886,547 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,470,810 - 85,855,679 (+)NCBIRGSC3.4rn4RGSC3.4
Celera984,770,512 - 85,150,470 (+)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Dis3l2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1560168
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.