Htr2b (5-hydroxytryptamine receptor 2B) - Rat Genome Database

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Gene: Htr2b (5-hydroxytryptamine receptor 2B) Rattus norvegicus
Analyze
Symbol: Htr2b
Name: 5-hydroxytryptamine receptor 2B
RGD ID: 61801
Description: Exhibits serotonin binding activity. Involved in several processes, including cellular response to organonitrogen compound; hepatic stellate cell activation; and inositol phosphate metabolic process. Localizes to several cellular components, including dendrite; neuronal cell body; and plasma membrane. Used to study heart valve disease. Biomarker of congestive heart failure. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (R)-noradrenaline; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5-HT-2B; 5-HT-2F; 5-HT2B; 5-hydroxytryptamine (serotonin) receptor 2B; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; serotonin receptor 2B; stomach fundus serotonin receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2986,735,793 - 86,756,640 (-)NCBI
Rnor_6.0 Ensembl993,112,805 - 93,125,014 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0993,112,781 - 93,130,135 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0992,836,402 - 92,856,220 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4984,840,026 - 84,852,984 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1985,023,439 - 85,036,403 (-)NCBI
Celera984,162,612 - 84,175,882 (-)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of phospholipase C activity  (IEA,ISO)
calcium-mediated signaling  (IEA,ISO,ISS)
cardiac muscle hypertrophy  (IEA,ISO,ISS)
cellular calcium ion homeostasis  (ISO)
cellular response to amine stimulus  (IDA)
cellular response to serotonin  (IDA)
cellular response to temperature stimulus  (IEA,ISO,ISS)
cGMP-mediated signaling  (IEA,ISO,ISS)
chemical synaptic transmission  (IBA)
embryonic morphogenesis  (IEA,ISO,ISS)
ERK1 and ERK2 cascade  (IEA,ISO,ISS)
G protein-coupled receptor internalization  (IEA,ISO)
G protein-coupled receptor signaling pathway  (ISO,ISS)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA)
G protein-coupled serotonin receptor signaling pathway  (ISO,ISS)
heart development  (ISO)
heart morphogenesis  (IEA,ISO,ISS)
hepatic stellate cell activation  (IEP)
inositol phosphate metabolic process  (IEP)
intestine smooth muscle contraction  (IEA,ISO,ISS)
ion transmembrane transport  (IDA)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of autophagy  (IEA,ISO,ISS)
negative regulation of cell death  (ISO,ISS)
neural crest cell differentiation  (ISO,ISS)
neural crest cell migration  (IEA,ISO,ISS)
phosphatidylinositol 3-kinase signaling  (IEA,ISO,ISS)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA)
phospholipase C-activating serotonin receptor signaling pathway  (IEA,ISO)
phosphorylation  (IEA,ISO,ISS)
positive regulation of cell division  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of cytokine production  (IEA,ISO,ISS)
positive regulation of endothelial cell proliferation  (IEA,ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA,ISO,ISS)
positive regulation of MAP kinase activity  (IEA,ISO)
positive regulation of nitric-oxide synthase activity  (IEA,ISO,ISS)
positive regulation of phosphatidylinositol biosynthetic process  (IEA,ISO,ISS)
protein kinase C signaling  (IEA,ISO,ISS)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO,ISS)
regulation of behavior  (IEA,ISO,ISS)
release of sequestered calcium ion into cytosol  (IBA,IEA,ISO,ISS)
response to drug  (IBA,IEA,ISO)
vasoconstriction  (IEA,ISO,ISS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7582481   PMID:7599919   PMID:7926008   PMID:8621713   PMID:8882600   PMID:9165122   PMID:9186750   PMID:10944220   PMID:12761501   PMID:12970106   PMID:15625277   PMID:15831837  
PMID:15862800   PMID:15925089   PMID:16517693   PMID:16758492   PMID:17325130   PMID:17584957   PMID:17609583   PMID:18439428   PMID:18566482   PMID:18604238   PMID:18703043   PMID:19057895  
PMID:19307114   PMID:19308295   PMID:19615378   PMID:20099302   PMID:20374255   PMID:20450948   PMID:20980537   PMID:21179162   PMID:21789169   PMID:22106156   PMID:22476011   PMID:22525520  
PMID:25544272   PMID:26106048   PMID:26804134   PMID:29384698  


Genomics

Comparative Map Data
Htr2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2986,735,793 - 86,756,640 (-)NCBI
Rnor_6.0 Ensembl993,112,805 - 93,125,014 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0993,112,781 - 93,130,135 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0992,836,402 - 92,856,220 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4984,840,026 - 84,852,984 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1985,023,439 - 85,036,403 (-)NCBI
Celera984,162,612 - 84,175,882 (-)NCBICelera
Cytogenetic Map9q35NCBI
HTR2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2231,108,230 - 231,125,042 (-)EnsemblGRCh38hg38GRCh38
GRCh382231,108,230 - 231,126,172 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372231,972,944 - 231,989,756 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,681,199 - 231,698,068 (-)NCBINCBI36hg18NCBI36
Build 342231,798,459 - 231,815,329NCBI
Celera2225,748,458 - 225,765,335 (-)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2223,815,006 - 223,831,883 (-)NCBIHuRef
CHM1_12231,978,806 - 231,995,681 (-)NCBICHM1_1
Htr2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,025,268 - 86,043,960 (-)NCBIGRCm39mm39
GRCm39 Ensembl186,026,748 - 86,039,692 (-)Ensembl
GRCm38186,097,546 - 86,116,231 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,099,026 - 86,111,970 (-)EnsemblGRCm38mm10GRCm38
MGSCv37187,995,612 - 88,008,545 (-)NCBIGRCm37mm9NCBIm37
MGSCv36187,930,442 - 87,942,088 (-)NCBImm8
Celera189,064,379 - 89,077,312 (-)NCBICelera
Cytogenetic Map1C5NCBI
Htr2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554534,351,668 - 4,367,807 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554534,352,278 - 4,367,807 (+)NCBIChiLan1.0ChiLan1.0
HTR2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B237,153,709 - 237,174,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B237,153,709 - 237,170,591 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B118,362,719 - 118,381,253 (-)NCBIMhudiblu_PPA_v0panPan3
HTR2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12543,042,306 - 43,056,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2543,042,173 - 43,056,612 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2543,602,608 - 43,616,665 (-)NCBI
ROS_Cfam_1.02543,299,319 - 43,313,380 (-)NCBI
UMICH_Zoey_3.12543,227,978 - 43,242,026 (-)NCBI
UNSW_CanFamBas_1.02543,070,901 - 43,084,964 (-)NCBI
UU_Cfam_GSD_1.02543,226,286 - 43,240,447 (-)NCBI
Htr2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303185,210,647 - 185,227,546 (-)NCBI
SpeTri2.0NW_0049365255,711,894 - 5,729,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15131,844,928 - 131,860,392 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115131,844,578 - 131,860,417 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215145,561,472 - 145,577,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HTR2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110117,132,919 - 117,152,132 (-)NCBI
ChlSab1.1 Ensembl10117,133,195 - 117,149,681 (-)Ensembl
Vero_WHO_p1.0NW_02366604082,292,351 - 82,310,254 (+)NCBI
Htr2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248434,407,055 - 4,424,585 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9105522293442944Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)929075079122095297Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)929466970107878528Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94126103498606834Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)941261034102531865Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94724896594124663Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95417754299177542Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)961186278106186278Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)963270073107878387Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)966757444112943287Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96745166499920892Rat
1578757Pur6Proteinuria QTL 63.30.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96745166499920892Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)970241351115241351Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)970942881115942881Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)981411073119983851Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)98368615398164303Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)98368615398164303Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)98368615398164303Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)983686153111609081Rat
4889852Pur26Proteinuria QTL 26150.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)990024661107199079Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)990024661119983851Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)99274129798606834Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:45
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000023829
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 13 25 9 18 9 8 9 9 19 20 11 8
Below cutoff 18 16 16 1 16 2 26 16 20

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023829   ⟹   ENSRNOP00000023829
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl993,112,805 - 93,125,014 (-)Ensembl
RefSeq Acc Id: NM_017250   ⟹   NP_058946
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2986,742,076 - 86,755,108 (-)NCBI
Rnor_6.0993,112,781 - 93,125,014 (-)NCBI
Rnor_5.0992,836,402 - 92,856,220 (-)NCBI
RGSC_v3.4984,840,026 - 84,852,984 (-)RGD
Celera984,162,612 - 84,175,882 (-)RGD
Sequence:
RefSeq Acc Id: XM_017596306   ⟹   XP_017451795
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2986,741,974 - 86,756,640 (-)NCBI
Rnor_6.0993,112,781 - 93,130,135 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083116   ⟹   XP_038939044
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2986,735,793 - 86,756,638 (-)NCBI
Protein Sequences
Protein RefSeqs NP_058946 (Get FASTA)   NCBI Sequence Viewer  
  XP_017451795 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939044 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA47318 (Get FASTA)   NCBI Sequence Viewer  
  EDL75569 (Get FASTA)   NCBI Sequence Viewer  
  P30994 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058946   ⟸   NM_017250
- Sequence:
RefSeq Acc Id: XP_017451795   ⟸   XM_017596306
- Peptide Label: isoform X1
- UniProtKB: G3V8A0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023829   ⟸   ENSRNOT00000023829
RefSeq Acc Id: XP_038939044   ⟸   XM_039083116
- Peptide Label: isoform X2
Protein Domains
G_PROTEIN_RECEP_F1_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61801 AgrOrtholog
Ensembl Genes ENSRNOG00000017625 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023829 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023829 ENTREZGENE, UniProtKB/TrEMBL
InterPro 5HT2B_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5HT_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29581 UniProtKB/Swiss-Prot
NCBI Gene 29581 ENTREZGENE
PANTHER PTHR24247:SF31 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Htr2b PhenoGen
PRINTS 5HT2BRECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5HTRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 5HT2B_RAT UniProtKB/Swiss-Prot
  G3V8A0 ENTREZGENE, UniProtKB/TrEMBL
  P30994 ENTREZGENE
UniProt Secondary Q9QW44 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr2b  5-hydroxytryptamine receptor 2B  Htr2b  5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr2b  5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled  Htr2b  5-hydroxytryptamine (serotonin) receptor 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Htr2b  5-hydroxytryptamine (serotonin) receptor 2B      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function activation triggered the typical chloride current 61633