Htr2b (5-hydroxytryptamine receptor 2B) - Rat Genome Database

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Gene: Htr2b (5-hydroxytryptamine receptor 2B) Rattus norvegicus
Analyze
Symbol: Htr2b
Name: 5-hydroxytryptamine receptor 2B
RGD ID: 61801
Description: Enables serotonin binding activity. Involved in several processes, including cellular response to organonitrogen compound; hepatic stellate cell activation; and inositol phosphate metabolic process. Located in dendrite; neuronal cell body; and plasma membrane. Used to study heart valve disease. Biomarker of brain infarction and congestive heart failure. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (R)-noradrenaline; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-HT-2B; 5-HT-2F; 5-HT2B; 5-hydroxytryptamine (serotonin) receptor 2B; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; serotonin receptor 2B; stomach fundus serotonin receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8994,184,442 - 94,206,851 (-)NCBIGRCr8
mRatBN7.2986,735,793 - 86,756,638 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl986,742,102 - 86,755,108 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx995,160,066 - 95,174,072 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09100,288,563 - 100,302,570 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0998,670,337 - 98,684,343 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0993,112,781 - 93,130,135 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,112,805 - 93,125,014 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0992,836,402 - 92,856,220 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4984,840,026 - 84,852,984 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1985,023,439 - 85,036,403 (-)NCBI
Celera984,162,612 - 84,175,882 (-)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide  (ISO)
(R)-noradrenaline  (EXP)
17beta-estradiol  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
butanal  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chlorpyrifos  (EXP)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
ergotamine  (ISO)
fenfluramine  (ISO)
fluoxetine  (ISO)
furan  (EXP)
genistein  (ISO)
glycogen  (ISO)
hexadecanoic acid  (ISO)
indometacin  (ISO)
lipopolysaccharide  (ISO)
lysergic acid diethylamide  (ISO)
mercaptopurine  (EXP)
mesulergine  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
Methylergonovine Maleate  (ISO)
mifepristone  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
pentanal  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
purine-6-thiol  (EXP)
rac-lactic acid  (ISO)
ritanserin  (ISO)
SB 206553  (EXP)
serotonin  (EXP,ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (ISO)
trichloroethene  (EXP)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium-mediated signaling  (IEA,ISO,ISS)
cardiac muscle hypertrophy  (IEA,ISO,ISS)
cellular response to amine stimulus  (IDA)
cellular response to serotonin  (IDA)
cellular response to temperature stimulus  (IEA,ISO,ISS)
cGMP-mediated signaling  (IEA,ISO,ISS)
chemical synaptic transmission  (IBA)
embryonic morphogenesis  (IEA,ISO,ISS)
ERK1 and ERK2 cascade  (IEA,ISO,ISS)
G protein-coupled receptor internalization  (IEA,ISO)
G protein-coupled receptor signaling pathway  (ISO,ISS)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA)
G protein-coupled serotonin receptor signaling pathway  (ISO,ISS)
heart development  (ISO)
heart morphogenesis  (IEA,ISO,ISS)
hepatic stellate cell activation  (IEP)
inositol phosphate metabolic process  (IEP)
intestine smooth muscle contraction  (IEA,ISO,ISS)
intracellular calcium ion homeostasis  (IEA,ISO)
monoatomic ion transmembrane transport  (IDA)
negative regulation of apoptotic process  (IEA,ISO,ISS)
neural crest cell differentiation  (ISO,ISS)
neural crest cell migration  (IEA,ISO,ISS)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO,ISS)
phospholipase C-activating serotonin receptor signaling pathway  (IBA,IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO,ISS)
positive regulation of cell division  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of cytokine production  (IEA,ISO,ISS)
positive regulation of endothelial cell proliferation  (IEA,ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
positive regulation of phosphatidylinositol biosynthetic process  (IEA,ISO,ISS)
protein kinase C signaling  (IEA,ISO,ISS)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO,ISS)
regulation of behavior  (IEA,ISO,ISS)
release of sequestered calcium ion into cytosol  (IBA,IEA,ISO,ISS)
response to xenobiotic stimulus  (IEA,ISO)
serotonin receptor signaling pathway  (IBA)
vasoconstriction  (IEA,ISO,ISS)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
dendrite  (IBA,IDA)
G protein-coupled serotonin receptor complex  (IEA,ISO)
neuronal cell body  (IDA)
nucleoplasm  (IEA,ISO)
plasma membrane  (IBA,IDA,IEA,ISO,ISS)
synapse  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD. Binetti J, etal., Life (Basel). 2020 Oct 16;10(10):245. doi: 10.3390/life10100245.
2. Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. Brattelid T, etal., J Mol Cell Cardiol. 2007 Dec;43(6):767-79. Epub 2007 Sep 5.
3. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
4. Cyproheptadine prevents pergolide-induced valvulopathy in rats: an echocardiographic and histopathological study. Droogmans S, etal., Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1940-8. doi: 10.1152/ajpheart.01177.2008. Epub 2009 Apr 3.
5. Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system. Duxon MS, etal., Neuroscience. 1997 Jan;76(2):323-9.
6. Cloning and functional characterization of the rat stomach fundus serotonin receptor. Foguet M, etal., EMBO J 1992 Sep;11(9):3481-7.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Jaffre F, etal., Circ Res. 2009 Jan 2;104(1):113-23. doi: 10.1161/CIRCRESAHA.108.180976. Epub 2008 Nov 20.
10. Molecular cloning, functional expression, and pharmacological characterization of a novel serotonin receptor (5-hydroxytryptamine2F) from rat stomach fundus. Kursar JD, etal., Mol Pharmacol. 1992 Oct;42(4):549-57.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. Ruddell RG, etal., Am J Pathol. 2006 Sep;169(3):861-76.
18. 5-Hydroxytryptamine2B receptors stimulate Ca2+ increases in cultured astrocytes from three different brain regions. Sanden N, etal., Neurochem Int. 2000 Apr;36(4-5):427-34.
Additional References at PubMed
PMID:7582481   PMID:7599919   PMID:7926008   PMID:8621713   PMID:8882600   PMID:9165122   PMID:9186750   PMID:10944220   PMID:12761501   PMID:12970106   PMID:15625277   PMID:15831837  
PMID:15862800   PMID:15925089   PMID:16517693   PMID:16758492   PMID:17325130   PMID:17584957   PMID:17609583   PMID:18439428   PMID:18566482   PMID:18604238   PMID:18703043   PMID:19057895  
PMID:19307114   PMID:19308295   PMID:19615378   PMID:20099302   PMID:20374255   PMID:20450948   PMID:20980537   PMID:21179162   PMID:21789169   PMID:22106156   PMID:22476011   PMID:22525520  
PMID:25544272   PMID:26106048   PMID:26804134   PMID:29384698   PMID:32504811   PMID:37747614   PMID:38596485  


Genomics

Comparative Map Data
Htr2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8994,184,442 - 94,206,851 (-)NCBIGRCr8
mRatBN7.2986,735,793 - 86,756,638 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl986,742,102 - 86,755,108 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx995,160,066 - 95,174,072 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09100,288,563 - 100,302,570 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0998,670,337 - 98,684,343 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0993,112,781 - 93,130,135 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,112,805 - 93,125,014 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0992,836,402 - 92,856,220 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4984,840,026 - 84,852,984 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1985,023,439 - 85,036,403 (-)NCBI
Celera984,162,612 - 84,175,882 (-)NCBICelera
Cytogenetic Map9q35NCBI
HTR2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,108,230 - 231,125,042 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2231,108,230 - 231,125,042 (-)EnsemblGRCh38hg38GRCh38
GRCh372231,972,944 - 231,989,756 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,681,199 - 231,698,068 (-)NCBINCBI36Build 36hg18NCBI36
Build 342231,798,459 - 231,815,329NCBI
Celera2225,748,458 - 225,765,335 (-)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2223,815,006 - 223,831,883 (-)NCBIHuRef
CHM1_12231,978,806 - 231,995,681 (-)NCBICHM1_1
T2T-CHM13v2.02231,592,736 - 231,609,548 (-)NCBIT2T-CHM13v2.0
Htr2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,025,268 - 86,043,960 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl186,026,748 - 86,039,692 (-)EnsemblGRCm39 Ensembl
GRCm38186,097,546 - 86,116,231 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,099,026 - 86,111,970 (-)EnsemblGRCm38mm10GRCm38
MGSCv37187,995,612 - 88,008,545 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36187,930,442 - 87,942,088 (-)NCBIMGSCv36mm8
Celera189,064,379 - 89,077,312 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map143.94NCBI
Htr2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554534,351,668 - 4,367,807 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554534,352,278 - 4,367,807 (+)NCBIChiLan1.0ChiLan1.0
HTR2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213133,720,071 - 133,758,758 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B133,735,036 - 133,773,723 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B118,362,719 - 118,381,253 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B237,153,709 - 237,174,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B237,153,709 - 237,170,591 (-)Ensemblpanpan1.1panPan2
HTR2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12543,042,306 - 43,056,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2543,042,173 - 43,056,612 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2543,602,608 - 43,616,665 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02543,299,319 - 43,313,380 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2543,299,186 - 43,314,350 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12543,227,978 - 43,242,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02543,070,901 - 43,084,964 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02543,226,286 - 43,240,447 (-)NCBIUU_Cfam_GSD_1.0
Htr2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303185,210,647 - 185,227,546 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365255,712,329 - 5,729,831 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365255,711,894 - 5,729,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15131,844,992 - 131,859,277 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115131,844,578 - 131,860,417 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215145,561,472 - 145,577,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HTR2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110117,132,919 - 117,152,132 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10117,133,195 - 117,149,681 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604082,292,351 - 82,310,254 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248434,408,424 - 4,424,168 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248434,407,055 - 4,424,585 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Htr2b
94 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:45
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000023829
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 13 25 9 18 9 8 9 9 19 20 11 8
Below cutoff 18 16 16 1 16 2 26 16 20

Sequence


RefSeq Acc Id: ENSRNOT00000023829   ⟹   ENSRNOP00000023829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl986,742,102 - 86,755,108 (-)Ensembl
Rnor_6.0 Ensembl993,112,805 - 93,125,014 (-)Ensembl
RefSeq Acc Id: NM_017250   ⟹   NP_058946
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8994,190,083 - 94,204,087 (-)NCBI
mRatBN7.2986,742,076 - 86,756,081 (-)NCBI
Rnor_6.0993,112,781 - 93,125,014 (-)NCBI
Rnor_5.0992,836,402 - 92,856,220 (-)NCBI
RGSC_v3.4984,840,026 - 84,852,984 (-)RGD
Celera984,162,612 - 84,175,882 (-)RGD
Sequence:
RefSeq Acc Id: XM_039083116   ⟹   XP_038939044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8994,184,442 - 94,206,851 (-)NCBI
mRatBN7.2986,735,793 - 86,756,638 (-)NCBI
RefSeq Acc Id: XM_063266817   ⟹   XP_063122887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8994,184,555 - 94,206,851 (-)NCBI
Protein Sequences
Protein RefSeqs NP_058946 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939044 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122887 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA47318 (Get FASTA)   NCBI Sequence Viewer  
  EDL75569 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023829
  ENSRNOP00000023829.3
  ENSRNOP00065027794
GenBank Protein P30994 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058946   ⟸   NM_017250
- UniProtKB: Q9QW44 (UniProtKB/Swiss-Prot),   P30994 (UniProtKB/Swiss-Prot),   G3V8A0 (UniProtKB/TrEMBL),   A6JWG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023829   ⟸   ENSRNOT00000023829
RefSeq Acc Id: XP_038939044   ⟸   XM_039083116
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063122887   ⟸   XM_063266817
- Peptide Label: isoform X1
- UniProtKB: Q9QW44 (UniProtKB/Swiss-Prot),   P30994 (UniProtKB/Swiss-Prot),   A6JWG0 (UniProtKB/TrEMBL),   G3V8A0 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30994-F1-model_v2 AlphaFold P30994 1-479 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61801 AgrOrtholog
BioCyc Gene G2FUF-26905 BioCyc
Ensembl Genes ENSRNOG00000017625 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00065020494 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023829 ENTREZGENE
  ENSRNOT00000023829.5 UniProtKB/TrEMBL
  ENSRNOT00065034649 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 5HT2B_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5HT_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29581 UniProtKB/Swiss-Prot
NCBI Gene 29581 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24247:SF31 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Htr2b PhenoGen
PRINTS 5HT2BRECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5HTRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017625 RatGTEx
  ENSRNOG00065020494 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 5HT2B_RAT UniProtKB/Swiss-Prot
  A6JWG0 ENTREZGENE, UniProtKB/TrEMBL
  G3V8A0 ENTREZGENE, UniProtKB/TrEMBL
  P30994 ENTREZGENE
  Q9QW44 ENTREZGENE
UniProt Secondary Q9QW44 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr2b  5-hydroxytryptamine receptor 2B  Htr2b  5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr2b  5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled  Htr2b  5-hydroxytryptamine (serotonin) receptor 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Htr2b  5-hydroxytryptamine (serotonin) receptor 2B      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function activation triggered the typical chloride current 61633