Htr2b (5-hydroxytryptamine receptor 2B) - Rat Genome Database

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Gene: Htr2b (5-hydroxytryptamine receptor 2B) Chinchilla lanigera
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Symbol: Htr2b
Name: 5-hydroxytryptamine receptor 2B
RGD ID: 8999023
Description: ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); G-protein alpha-subunit binding (ortholog); Gq/11-coupled serotonin receptor activity (ortholog); INVOLVED IN activation of phospholipase C activity (ortholog); calcium-mediated signaling (ortholog); cardiac muscle hypertrophy (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Cardiomegaly (ortholog); congestive heart failure (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); G protein-coupled serotonin receptor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554534,351,668 - 4,367,807 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554534,352,278 - 4,367,807 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of phospholipase C activity  (ISO)
calcium-mediated signaling  (ISO)
cardiac muscle hypertrophy  (ISO)
cellular calcium ion homeostasis  (ISO)
cellular response to amine stimulus  (ISO)
cellular response to serotonin  (ISO)
cellular response to temperature stimulus  (ISO)
cGMP-mediated signaling  (ISO)
embryonic morphogenesis  (ISO)
ERK1 and ERK2 cascade  (ISO)
G protein-coupled receptor internalization  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
G protein-coupled serotonin receptor signaling pathway  (ISO)
heart development  (ISO)
heart morphogenesis  (ISO)
hepatic stellate cell activation  (ISO)
inositol phosphate metabolic process  (ISO)
intestine smooth muscle contraction  (ISO)
ion transmembrane transport  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of cell death  (ISO)
neural crest cell differentiation  (ISO)
neural crest cell migration  (ISO)
phosphatidylinositol 3-kinase signaling  (ISO)
phospholipase C-activating serotonin receptor signaling pathway  (ISO)
phosphorylation  (ISO)
positive regulation of cell division  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phosphatidylinositol biosynthetic process  (ISO)
protein kinase C signaling  (ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
regulation of behavior  (ISO)
release of sequestered calcium ion into cytosol  (ISO)
response to xenobiotic stimulus  (ISO)
vasoconstriction  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Htr2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554534,351,668 - 4,367,807 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554534,352,278 - 4,367,807 (+)NCBIChiLan1.0ChiLan1.0
HTR2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2231,108,230 - 231,125,042 (-)EnsemblGRCh38hg38GRCh38
GRCh382231,108,230 - 231,126,172 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372231,972,944 - 231,989,756 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,681,199 - 231,698,068 (-)NCBINCBI36hg18NCBI36
Build 342231,798,459 - 231,815,329NCBI
Celera2225,748,458 - 225,765,335 (-)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2223,815,006 - 223,831,883 (-)NCBIHuRef
CHM1_12231,978,806 - 231,995,681 (-)NCBICHM1_1
Htr2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,025,268 - 86,043,960 (-)NCBIGRCm39mm39
GRCm39 Ensembl186,026,748 - 86,039,692 (-)Ensembl
GRCm38186,097,546 - 86,116,231 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,099,026 - 86,111,970 (-)EnsemblGRCm38mm10GRCm38
MGSCv37187,995,612 - 88,008,545 (-)NCBIGRCm37mm9NCBIm37
MGSCv36187,930,442 - 87,942,088 (-)NCBImm8
Celera189,064,379 - 89,077,312 (-)NCBICelera
Cytogenetic Map1C5NCBI
Htr2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2986,735,793 - 86,756,640 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl993,112,805 - 93,125,014 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0993,112,781 - 93,130,135 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0992,836,402 - 92,856,220 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4984,840,026 - 84,852,984 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1985,023,439 - 85,036,403 (-)NCBI
Celera984,162,612 - 84,175,882 (-)NCBICelera
Cytogenetic Map9q35NCBI
HTR2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B237,153,709 - 237,174,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B237,153,709 - 237,170,591 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B118,362,719 - 118,381,253 (-)NCBIMhudiblu_PPA_v0panPan3
HTR2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12543,042,306 - 43,056,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2543,042,173 - 43,056,612 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2543,602,608 - 43,616,665 (-)NCBI
ROS_Cfam_1.02543,299,319 - 43,313,380 (-)NCBI
UMICH_Zoey_3.12543,227,978 - 43,242,026 (-)NCBI
UNSW_CanFamBas_1.02543,070,901 - 43,084,964 (-)NCBI
UU_Cfam_GSD_1.02543,226,286 - 43,240,447 (-)NCBI
Htr2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303185,210,647 - 185,227,546 (-)NCBI
SpeTri2.0NW_0049365255,711,894 - 5,729,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15131,844,928 - 131,860,392 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115131,844,578 - 131,860,417 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215145,561,472 - 145,577,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HTR2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110117,132,919 - 117,152,132 (-)NCBI
ChlSab1.1 Ensembl10117,133,195 - 117,149,681 (-)Ensembl
Vero_WHO_p1.0NW_02366604082,292,351 - 82,310,254 (+)NCBI
Htr2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248434,407,055 - 4,424,585 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000017209   ⟹   ENSCLAP00000017042
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554534,351,668 - 4,367,807 (+)Ensembl
RefSeq Acc Id: XM_005395400   ⟹   XP_005395457
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554534,352,388 - 4,367,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005395401   ⟹   XP_005395458
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554534,352,406 - 4,367,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005395402   ⟹   XP_005395459
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554534,352,386 - 4,367,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013519961   ⟹   XP_013375415
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554534,352,278 - 4,367,807 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005395457 (Get FASTA)   NCBI Sequence Viewer  
  XP_005395458 (Get FASTA)   NCBI Sequence Viewer  
  XP_005395459 (Get FASTA)   NCBI Sequence Viewer  
  XP_013375415 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005395459   ⟸   XM_005395402
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005395457   ⟸   XM_005395400
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005395458   ⟸   XM_005395401
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013375415   ⟸   XM_013519961
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000017042   ⟸   ENSCLAT00000017209


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011693 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000017042 ENTREZGENE
Ensembl Transcript ENSCLAT00000017209 ENTREZGENE
NCBI Gene Htr2b ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Htr2b  5-hydroxytryptamine receptor 2B    5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled  Symbol and/or name change 5135510 APPROVED