Ugt1a1 (UDP glucuronosyltransferase family 1 member A1) - Rat Genome Database
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Gene: Ugt1a1 (UDP glucuronosyltransferase family 1 member A1) Rattus norvegicus
Analyze
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase family 1 member A1
RGD ID: 3935
Description: Exhibits enzyme binding activity and glucuronosyltransferase activity. Involved in several processes, including biphenyl catabolic process; cellular glucuronidation; and cellular response to lipid. Localizes to cytochrome complex and endoplasmic reticulum. Used to study Crigler-Najjar syndrome and bilirubin metabolic disorder. Biomarker of hyperthyroidism; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; female reproductive organ cancer (multiple); and hepatitis B. Orthologous to human UGT1A1 (UDP glucuronosyltransferase family 1 member A1); PARTICIPATES IN axitinib pharmacokinetics pathway; codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; INTERACTS WITH (+)-alpha-tocopherol; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B1; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1 family member 1; UDP-glucuronosyltransferase 1 family, member 1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1A1; Udpgt; UDPGT 1-1; Ugt1; UGT1*1; UGT1-01; UGT1.1
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Allele / Splice: Ugt1a1j  
Genetic Models: Gunn-Ugt1a1j/BluHsdRrrc Gunn-Ugt1a1j/BluHsd
Is Marker For: Strains:   WIST/Nhg   SD.Gunn-Ugt1a1j/Aon   W.Gunn-Ugt1a1j/Aon  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2988,801,344 - 88,808,465 (+)NCBI
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0995,295,701 - 95,302,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0994,982,916 - 94,990,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4987,091,241 - 87,098,362 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1987,277,121 - 87,284,238 (+)NCBI
Celera986,362,434 - 86,369,556 (+)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
(+)-taxifolin  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(S)-naringenin  (ISO)
(Z)-ligustilide  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2',4,4',6'-tetrahydroxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4,6-Triphenyl-1-hexene  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-hydroxyestrone  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-tert-butylhydroquinone  (EXP)
20-HETE  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-Hydroxybenzo[a]pyrene  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyestrone  (ISO)
4-hydroxyphenytoin  (ISO)
4-methylumbelliferone  (ISO)
4-methylumbelliferone beta-D-glucuronide  (ISO)
4-nitrophenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxypsoralen  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
alizarin  (ISO)
all-trans-retinol  (EXP)
alpha-tocotrienol  (ISO)
amentoflavone  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
androsterone  (ISO)
Anetholtrithion  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthraflavic acid  (ISO)
anthrarobin  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
aristolochic acid  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzamidoxime  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bergomottin  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-tocopherol  (EXP)
beta-tocotrienol  (ISO)
bilirubin IXalpha  (EXP,ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Boldine  (EXP)
Bropirimine  (ISO)
buprenorphine  (ISO)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calycosin  (ISO)
capsaicin  (ISO)
carbamazepine  (EXP,ISO)
carvedilol  (ISO)
chalcones  (EXP)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
chrysen-6-ol  (EXP)
chrysin  (EXP,ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
Clofop  (ISO)
clomipramine  (EXP)
clotrimazole  (ISO)
clozapine  (ISO)
coumarins  (EXP,ISO)
coumestrol  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (EXP)
daidzein  (ISO)
decabromodiphenyl ether  (EXP)
delta-tocopherol  (EXP)
delta-tocotrienol  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
dibenzo[a,l]pyrene  (ISO)
diclofenac  (EXP,ISO)
diethylstilbestrol  (ISO)
diflunisal  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
doxorubicin  (EXP)
emodin  (ISO)
endosulfan  (ISO)
entacapone  (ISO)
epoxiconazole  (EXP)
equol  (ISO)
Estragole  (ISO)
estriol  (ISO)
estrone  (ISO)
ethoxyquin  (EXP,ISO)
etoposide  (ISO)
eugenol  (ISO)
ezetimibe  (ISO)
farnesol  (ISO)
felbamate  (EXP)
fenofibrate  (ISO)
fipronil  (EXP,ISO)
fipronil-sulfone  (EXP)
fisetin  (ISO)
flavanone  (ISO)
flavonoids  (ISO)
flumequine  (ISO)
flunitrazepam  (ISO)
flurbiprofen  (ISO)
formononetin  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (ISO)
fusidic acid  (ISO)
galangin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (EXP,ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
ginsenoside Rg1  (EXP)
glabridin  (ISO)
Grepafloxacin  (ISO)
griseofulvin  (ISO)
hyperforin  (ISO)
ibuprofen  (ISO)
imipramine  (EXP)
imperatorin  (EXP,ISO)
indometacin  (ISO)
indoxyl sulfate  (ISO)
irinotecan  (EXP,ISO)
isoflavones  (ISO)
isoliquiritigenin  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
ketoprofen  (ISO)
L-ethionine  (EXP)
labetalol  (ISO)
lansoprazole  (EXP)
leflunomide  (ISO)
lithocholic acid  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mangiferin  (ISO)
masoprocol  (ISO)
Meclizine  (ISO)
MeIQx  (ISO)
metazachlor  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
MK 571  (ISO)
morin  (ISO)
morphine  (ISO)
moxifloxacin  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (EXP)
naproxen  (ISO)
Niflumic acid  (ISO)
nilotinib  (ISO)
notoginsenoside R1  (ISO)
obeticholic acid  (ISO)
ofloxacin  (ISO)
oltipraz  (ISO)
omeprazole  (EXP,ISO)
ortho-Aminoazotoluene  (ISO)
oxycodone  (EXP)
paclitaxel  (ISO)
pantoprazole  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (EXP)
phenanthrene  (ISO)
phenobarbital  (EXP,ISO)
phenylbutazone  (ISO)
phenytoin  (EXP,ISO)
PhIP  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
plumbagin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (EXP)
progesterone  (EXP,ISO)
propacetamol  (ISO)
propiconazole  (EXP)
prostaglandin B1  (ISO)
prostaglandin E2  (EXP)
prostaglandin F2alpha  (EXP)
pterostilbene  (ISO)
puerarin  (ISO)
pyrene  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quinizarin  (ISO)
rabeprazole  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rifampicin  (ISO)
ritonavir  (ISO)
robinetin  (ISO)
SB 203580  (ISO)
scopoletin  (ISO)
sevoflurane  (EXP)
Shikonin  (EXP,ISO)
silibinin  (EXP,ISO)
Sitafloxacin  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (ISO)
sodium propionate  (ISO)
spironolactone  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
taurine  (EXP)
tebuconazole  (ISO)
tert-butyl ethyl ether  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thyroxine  (EXP)
ticlopidine  (ISO)
tienilic acid  (ISO)
trans-piceid  (ISO)
triadimefon  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclocarban  (ISO)
triclosan  (EXP,ISO)
trifluralin  (EXP)
troglitazone  (ISO)
UDP-alpha-D-glucuronic acid  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
vitamin E  (EXP)
vorinostat  (ISO)
warfarin  (ISO)
xanthohumol  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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Additional References at PubMed
PMID:1898728   PMID:7603447   PMID:7608130   PMID:7986077   PMID:8554318   PMID:8999837   PMID:9271076   PMID:9488689   PMID:11437649   PMID:12475965   PMID:12477932   PMID:12951053  
PMID:16141793   PMID:17179145   PMID:18004212   PMID:18052087   PMID:19996319   PMID:20056724   PMID:20308471   PMID:20610558   PMID:22447239   PMID:22579593   PMID:23230277   PMID:28479355  
PMID:29131354  


Genomics

Comparative Map Data
Ugt1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2988,801,344 - 88,808,465 (+)NCBI
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0995,295,701 - 95,302,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0994,982,916 - 94,990,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4987,091,241 - 87,098,362 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1987,277,121 - 87,284,238 (+)NCBI
Celera986,362,434 - 86,369,556 (+)NCBICelera
Cytogenetic Map9q35NCBI
UGT1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2233,760,248 - 233,773,299 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2233,760,270 - 233,773,300 (+)EnsemblGRCh38hg38GRCh38
GRCh382233,760,270 - 233,773,300 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372234,668,916 - 234,681,946 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,333,658 - 234,346,684 (+)NCBINCBI36hg18NCBI36
Build 342234,450,918 - 234,463,945NCBI
Celera2228,389,552 - 228,402,577 (+)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2226,468,768 - 226,481,779 (+)NCBIHuRef
CHM1_12234,674,733 - 234,687,806 (+)NCBICHM1_1
Ugt1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39188,139,681 - 88,147,724 (+)NCBIGRCm39mm39
GRCm39 Ensembl188,139,681 - 88,146,719 (+)Ensembl
GRCm38188,211,959 - 88,220,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl188,211,959 - 88,218,997 (+)EnsemblGRCm38mm10GRCm38
MGSCv37190,108,534 - 90,116,577 (+)NCBIGRCm37mm9NCBIm37
MGSCv36190,043,130 - 90,050,148 (+)NCBImm8
Celera191,173,026 - 91,181,062 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map144.55NCBI

Position Markers
RH94830  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0995,302,498 - 95,302,698NCBIRnor6.0
Rnor_5.0994,989,713 - 94,989,913UniSTSRnor5.0
RGSC_v3.4987,098,038 - 87,098,238UniSTSRGSC3.4
Celera986,369,232 - 86,369,432UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)929466970107878528Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95417754299177542Rat
4889852Pur26Proteinuria QTL 26150.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)990024661107199079Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)99274129798606834Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)990024661119983851Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94126103498606834Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)966757444112943287Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)981411073119983851Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96745166499920892Rat
1578757Pur6Proteinuria QTL 63.30.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96745166499920892Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)970241351115241351Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)941261034102531865Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)963270073107878387Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)929075079122095297Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)98368615398164303Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)98368615398164303Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)98368615398164303Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)970942881115942881Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)983686153111609081Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)961186278106186278Rat


Related Rat Strains
The following Strains have been annotated to Ugt1a1


Genetic Models
This gene Ugt1a1 is modified in the following models/strains

Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025045   ⟹   ENSRNOP00000025045
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,295,701 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000025291   ⟹   ENSRNOP00000025292
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,256,627 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000025652   ⟹   ENSRNOP00000025652
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,202,632 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000032634   ⟹   ENSRNOP00000030374
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,241,609 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000045163   ⟹   ENSRNOP00000046507
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,274,707 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000063853   ⟹   ENSRNOP00000062958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,285,592 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000066839   ⟹   ENSRNOP00000063634
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,221,474 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000071003   ⟹   ENSRNOP00000075547
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,233,957 - 95,302,810 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000071200   ⟹   ENSRNOP00000066773
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077416   ⟹   ENSRNOP00000070501
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,241,626 - 95,302,816 (+)Ensembl
RefSeq Acc Id: NM_012683   ⟹   NP_036815
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2988,801,344 - 88,808,465 (+)NCBI
Rnor_6.0995,295,701 - 95,302,822 (+)NCBI
Rnor_5.0994,982,916 - 94,990,037 (+)NCBI
RGSC_v3.4987,091,241 - 87,098,362 (+)RGD
Celera986,362,434 - 86,369,556 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036815   ⟸   NM_012683
- Peptide Label: precursor
- UniProtKB: Q64550 (UniProtKB/Swiss-Prot),   Q5DT04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000046507   ⟸   ENSRNOT00000045163
RefSeq Acc Id: ENSRNOP00000062958   ⟸   ENSRNOT00000063853
RefSeq Acc Id: ENSRNOP00000075547   ⟸   ENSRNOT00000071003
RefSeq Acc Id: ENSRNOP00000070501   ⟸   ENSRNOT00000077416
RefSeq Acc Id: ENSRNOP00000030374   ⟸   ENSRNOT00000032634
RefSeq Acc Id: ENSRNOP00000066773   ⟸   ENSRNOT00000071200
RefSeq Acc Id: ENSRNOP00000025292   ⟸   ENSRNOT00000025291
RefSeq Acc Id: ENSRNOP00000025652   ⟸   ENSRNOT00000025652
RefSeq Acc Id: ENSRNOP00000063634   ⟸   ENSRNOT00000066839
RefSeq Acc Id: ENSRNOP00000025045   ⟸   ENSRNOT00000025045
Protein Domains
UDPGT

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696846
Promoter ID:EPDNEW_R7370
Type:multiple initiation site
Name:Ugt1a7c_3
Description:UDP glucuronosyltransferase 1 family, polypeptide A7C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7366  EPDNEW_R7367  EPDNEW_R7368  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0995,295,686 - 95,295,746EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 95295888 95295889 G A snv CDR


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3935 AgrOrtholog
Ensembl Genes ENSRNOG00000018740 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000025045 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025045 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro UDP_glucos_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24861 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24861 ENTREZGENE
Pfam UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB UGT1A1 RGD
PhenoGen Ugt1a1 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q5DT04 ENTREZGENE, UniProtKB/TrEMBL
  Q64550 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q64635 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ugt1a1  UDP glucuronosyltransferase family 1 member A1  Ugt1a1  UDP glucuronosyltransferase 1 family, polypeptide A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Ugt1a1  UDP glucuronosyltransferase 1 family, polypeptide A1  Ugt1a1  UDP glycosyltransferase 1 family, polypeptide A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ugt1a1  UDP glycosyltransferase 1 family, polypeptide A1  Ugt1  UDP-glucuronosyltransferase 1 family, member 1  Symbol and Name updated 629477 APPROVED
2002-06-10 Ugt1  UDP-glucuronosyltransferase 1 family, member 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver hepatocytes 70480
gene_process functions in glucuronidation and excretion of bilirubin 70480
gene_transcript each variable exon is preceded by a promoter region which may be used for tissue specific gene expression 1302827