Ugt1a1 (UDP glucuronosyltransferase family 1 member A1) - Rat Genome Database

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Gene: Ugt1a1 (UDP glucuronosyltransferase family 1 member A1) Rattus norvegicus
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Symbol: Ugt1a1
Name: UDP glucuronosyltransferase family 1 member A1
RGD ID: 3935
Description: Enables enzyme binding activity and glucuronosyltransferase activity. Involved in several processes, including biphenyl catabolic process; cellular glucuronidation; and cellular response to lipid. Located in endoplasmic reticulum. Part of cytochrome complex. Used to study Crigler-Najjar syndrome and bilirubin metabolic disorder. Biomarker of hyperthyroidism; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; female reproductive organ cancer (multiple); and hepatitis B. Orthologous to human UGT1A1 (UDP glucuronosyltransferase family 1 member A1); PARTICIPATES IN axitinib pharmacokinetics pathway; codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B1; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1 family member 1; UDP-glucuronosyltransferase 1 family, member 1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1A1; Udpgt; UDPGT 1-1; Ugt1; UGT1*1; UGT1-01; UGT1.1
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Allele / Splice: Ugt1a1j  
Genetic Models: Gunn-Ugt1a1j/BluHsd Gunn-Ugt1a1j/BluHsdRrrc
Is Marker For: Strains:   WIST/Nhg   SD.Gunn-Ugt1a1j/Aon   W.Gunn-Ugt1a1j/Aon  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2988,801,344 - 88,808,465 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)Ensembl
Rnor_6.0995,295,701 - 95,302,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0994,982,916 - 94,990,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4987,091,241 - 87,098,362 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1987,277,121 - 87,284,238 (+)NCBI
Celera986,362,434 - 86,369,556 (+)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-naringenin  (ISO)
(Z)-ligustilide  (ISO)
1,4-dioxane  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2',4,4',6'-tetrahydroxychalcone  (ISO)
2',5'-Dihydroxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4,6-Triphenyl-1-hexene  (ISO)
2,4-Dihydroxychalcone  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-hydroxyestrone  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-tert-butylhydroquinone  (EXP)
20-HETE  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3-Hydroxybenzo[a]pyrene  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-hydroxyestrone  (ISO)
4-hydroxyphenytoin  (ISO)
4-methylumbelliferone  (ISO)
4-methylumbelliferone beta-D-glucuronide  (ISO)
4-nitrophenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxypsoralen  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
8-Epidiosbulbin E acetate  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
alizarin  (ISO)
all-trans-retinol  (EXP)
alpha-tocotrienol  (ISO)
amentoflavone  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
androsterone  (ISO)
Anetholtrithion  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthraflavic acid  (ISO)
anthrarobin  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
aristolochic acid  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzamidoxime  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bergomottin  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-tocopherol  (EXP)
beta-tocotrienol  (ISO)
bilirubin IXalpha  (EXP,ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Boldine  (EXP)
Bropirimine  (ISO)
buprenorphine  (ISO)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calycosin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (EXP,ISO)
carvedilol  (ISO)
CGP 52608  (ISO)
chalcones  (EXP)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
chrysen-6-ol  (EXP)
chrysin  (EXP,ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
Clofop  (ISO)
clomipramine  (EXP)
clotrimazole  (ISO)
clozapine  (ISO)
coumarins  (EXP,ISO)
coumestrol  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (EXP)
daidzein  (ISO)
decabromodiphenyl ether  (EXP)
delta-tocopherol  (EXP)
delta-tocotrienol  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
dibenzo[a,l]pyrene  (ISO)
diclofenac  (EXP,ISO)
diethylstilbestrol  (ISO)
diflunisal  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
doxorubicin  (EXP)
emodin  (ISO)
endosulfan  (ISO)
entacapone  (ISO)
epoxiconazole  (EXP)
equol  (ISO)
Erucin  (ISO)
Estragole  (ISO)
estriol  (ISO)
estrone  (ISO)
ethoxyquin  (EXP,ISO)
etoposide  (ISO)
eugenol  (ISO)
ezetimibe  (ISO)
farnesol  (ISO)
felbamate  (EXP)
fenofibrate  (ISO)
fenthion  (ISO)
fipronil  (EXP,ISO)
fipronil-sulfone  (EXP)
fisetin  (ISO)
flavanone  (ISO)
flavonoids  (ISO)
flumequine  (ISO)
flunitrazepam  (ISO)
flurbiprofen  (ISO)
formononetin  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (ISO)
fusidic acid  (ISO)
galangin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (EXP,ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
ginsenoside Rg1  (EXP)
glabridin  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
Grepafloxacin  (ISO)
griseofulvin  (ISO)
hyperforin  (ISO)
ibuprofen  (ISO)
imipramine  (EXP)
imperatorin  (EXP,ISO)
indometacin  (ISO)
indoxyl sulfate  (ISO)
irinotecan  (EXP,ISO)
isoflavones  (ISO)
isoliquiritigenin  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
ketoprofen  (ISO)
L-ethionine  (EXP)
labetalol  (ISO)
lansoprazole  (EXP)
leflunomide  (ISO)
Licochalcone A  (ISO)
lithocholic acid  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mangiferin  (ISO)
masoprocol  (ISO)
Meclizine  (ISO)
MeIQx  (ISO)
metazachlor  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
MK 571  (ISO)
morin  (ISO)
morphine  (ISO)
moxifloxacin  (ISO)
Muraglitazar  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (EXP)
naproxen  (ISO)
Niflumic acid  (ISO)
nilotinib  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
notoginsenoside R1  (ISO)
obeticholic acid  (ISO)
ofloxacin  (ISO)
oltipraz  (ISO)
omeprazole  (EXP,ISO)
ortho-Aminoazotoluene  (ISO)
osimertinib  (ISO)
oxycodone  (EXP)
paclitaxel  (ISO)
pantoprazole  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (EXP)
phenanthrene  (ISO)
phenobarbital  (EXP,ISO)
phenylbutazone  (ISO)
phenytoin  (EXP,ISO)
PhIP  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
plumbagin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (EXP)
progesterone  (EXP,ISO)
propacetamol  (ISO)
propiconazole  (EXP)
prostaglandin B1  (ISO)
prostaglandin E2  (EXP)
prostaglandin F2alpha  (EXP)
pterostilbene  (ISO)
puerarin  (ISO)
pyrene  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quinizarin  (ISO)
rabeprazole  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rifampicin  (ISO)
ritonavir  (ISO)
robinetin  (ISO)
SB 203580  (ISO)
scopoletin  (ISO)
sevoflurane  (EXP)
Shikonin  (EXP,ISO)
silibinin  (EXP,ISO)
Sitafloxacin  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (ISO)
sodium propionate  (ISO)
spironolactone  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
taurine  (EXP)
tebuconazole  (ISO)
tert-butyl ethyl ether  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thyroxine  (EXP)
ticlopidine  (ISO)
tienilic acid  (ISO)
trans-piceid  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclocarban  (ISO)
triclosan  (EXP,ISO)
trifluralin  (EXP)
troglitazone  (ISO)
UDP-alpha-D-glucuronic acid  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
warfarin  (ISO)
xanthohumol  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats. Alkharfy KM, etal., Drug Metab Lett. 2008 Dec;2(4):248-55.
2. Thalassemia minor, the Gilbert mutation, and the risk of gallstones. Borgna-Pignatti C, etal., Haematologica. 2003 Oct;88(10):1106-9.
3. Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer. Bortolussi G, etal., FASEB J. 2012 Mar;26(3):1052-63. Epub 2011 Nov 17.
4. Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir. Boyd MA, etal., Pharmacogenet Genomics. 2006 May;16(5):321-9.
5. Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats. Braun L, etal., Biochem J. 1998 Dec 15;336 ( Pt 3):587-92.
6. Evolution of the activity of UGT1A1 throughout the development and adult life in a rat. Bustamante N, etal., Life Sci. 2006 Mar 6;78(15):1688-95. Epub 2005 Nov 28.
7. The urinary concentrating defect in the Gunn strain of rat. Role of bilirubin. Call NB and Tisher CC, J Clin Invest 1975 Feb;55(2):319-29.
8. Hereditary Acholuric Jaundice In The Rat Canadian Medical Association Journal
9. UGT1A1*28 polymorphism in ovarian cancer patients. Cecchin E, etal., Oncol Rep. 2004 Aug;12(2):457-62.
10. Risk of hyperbilirubinemia in breast-fed infants. Chang PF, etal., J Pediatr. 2011 Oct;159(4):561-5. doi: 10.1016/j.jpeds.2011.03.042. Epub 2011 May 18.
11. Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide. D'Andrea V, etal., Life Sci. 2005 Jun 24;77(6):683-92. Epub 2005 Feb 25.
12. UDP-glucuronosyltransferase isoforms catalyzing glucuronidation of hydroxy-polychlorinated biphenyls in rat. Daidoji T, etal., Drug Metab Dispos. 2005 Oct;33(10):1466-76. Epub 2005 Jul 8.
13. A functional polymorphism in UGT1A1 related to hyperbilirubinemia is associated with a decreased risk for Crohn's disease. de Vries HS, etal., J Crohns Colitis. 2011 Dec 16.
14. Coinheritance of Gilbert syndrome increases the risk for developing gallstones in patients with hereditary spherocytosis. del Giudice EM, etal., Blood. 1999 Oct 1;94(7):2259-62.
15. UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk. Deming SL, etal., Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):563-70.
16. Induction of UDP-glucuronosyltransferase 1 (UDP-GT1) gene complex by green tea in male F344 rats. Embola CW, etal., Food Chem Toxicol 2002 Jun;40(6):841-4.
17. Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes. Emi Y, etal., Arch Biochem Biophys 2002 Sep 15;405(2):163-9.
18. Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex. Emi Y, etal., J Biol Chem. 1996 Feb 16;271(7):3952-8.
19. Co-inherited Gilbert's syndrome: a factor determining hyperbilirubinemia in homozygous beta-thalassemia. Galanello R, etal., Haematologica. 1999 Feb;84(2):103-5.
20. Splice-site mutations: a novel genetic mechanism of Crigler-Najjar syndrome type 1. Gantla S, etal., Am J Hum Genet. 1998 Mar;62(3):585-92.
21. Associations between UGT1A1*6/*28 polymorphisms and irinotecan-induced severe toxicity in Chinese gastric or esophageal cancer patients. Gao J, etal., Med Oncol. 2013;30(3):630. doi: 10.1007/s12032-013-0630-8. Epub 2013 Jun 20.
22. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
23. Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer. Glimelius B, etal., Pharmacogenomics J. 2011 Feb;11(1):61-71. doi: 10.1038/tpj.2010.10. Epub 2010 Feb 23.
24. Influence of vitamin A status on the regulation of uridine (5'-)diphosphate-glucuronosyltransferase (UGT) 1A1 and UGT1A6 expression by L-triiodothyronine. Haberkorn V, etal., Br J Nutr. 2001 Mar;85(3):289-97.
25. Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyltransferase expression and activity in rat liver. Haberkorn V, etal., Mol Cell Endocrinol 2002 Apr 25;190(1-2):167-75.
26. 9-cis-Retinoic acid regulation of four UGT isoforms in hepatocytes from rats with various thyroid states. Haberkorn V, etal., Pharm Res. 2003 Oct;20(10):1568-73.
27. Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. Han JY, etal., J Clin Oncol. 2006 May 20;24(15):2237-44. Epub 2006 Apr 24.
28. UGT1A1 variation and gallstone formation in sickle cell disease. Haverfield EV, etal., Blood. 2005 Feb 1;105(3):968-72. Epub 2004 Sep 23.
29. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. Innocenti F, etal., J Clin Oncol. 2004 Apr 15;22(8):1382-8. Epub 2004 Mar 8.
30. Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex. Ishii Y, etal., Drug Metab Pharmacokinet. 2007 Oct;22(5):367-76.
31. Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat). Iyanagi T J Biol Chem 1991 Dec 15;266(35):24048-52.
32. The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation. Iyanagi T, etal., J Biol Chem 1989 Dec 15;264(35):21302-7.
33. In vitro induction of bilirubin conjugation in primary rat hepatocyte culture. Jemnitz K, etal., Biochem Biophys Res Commun 2002 Feb 15;291(1):29-33.
34. Long-term correction of hyperbilirubinemia in the Gunn rat by repeated intravenous delivery of naked plasmid DNA into muscle. Jia Z and Danko I, Mol Ther. 2005 Nov;12(5):860-6. Epub 2005 Jul 12.
35. Ethanol-dependent induction of bilirubin UDP-glucuronosyl-transferase in rat liver is mediated by Kupffer cells. Kardon T, etal., Life Sci. 2002 Jan 25;70(10):1205-12.
36. Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases. Kessler FK, etal., Drug Metab Dispos 2002 Mar;30(3):324-30.
37. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
38. The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1. King CD, etal., Arch Biochem Biophys. 1996 Aug 1;332(1):92-100.
39. Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver. Kishi M, etal., Biochem Biophys Res Commun. 2008 Dec 19;377(3):815-9. Epub 2008 Oct 18.
40. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Li Y, etal., Zhonghua Gan Zang Bing Za Zhi. 2001 Jun;9(3):172-4.
41. The effect of hormones on the expression of five isoforms of UDP-glucuronosyltransferase in primary cultures of rat hepatocytes. Li YQ, etal., Pharm Res. 1999 Feb;16(2):191-7.
42. Follicle-stimulating hormone, testosterone, and hypoxia differentially regulate UDP-glucuronosyltransferase 1 isoforms expression in rat sertoli and peritubular myoid cells. Magnanti M, etal., J Steroid Biochem Mol Biol. 2000 Oct;74(3):149-55.
43. Early modification of sickle cell disease clinical course by UDP-glucuronosyltransferase 1A1 gene promoter polymorphism. Martins R, etal., J Hum Genet. 2008;53(6):524-8. doi: 10.1007/s10038-008-0281-3. Epub 2008 Apr 5.
44. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
45. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
46. In the rat liver, Adenoviral gene transfer efficiency is comparable to AAV. Montenegro-Miranda PS, etal., Gene Ther. 2014 Feb;21(2):168-74. doi: 10.1038/gt.2013.69. Epub 2013 Nov 28.
47. Tocilizumab-induced hyperbilirubinemia in Japanese patients with rheumatoid arthritis: its association with UDP glucuronosyltransferase 1A1 gene polymorphisms. Mori S, etal., Mod Rheumatol. 2011 Oct 13.
48. Association between the low-dose irinotecan regimen-induced occurrence of grade 4 neutropenia and genetic variants of in patients with gynecological cancers. Moriya H, etal., Oncol Lett. 2014 Jun;7(6):2035-2040. Epub 2014 Apr 8.
49. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
50. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
51. Phase II clinical trial of metronomic chemotherapy with combined irinotecan and tegafur-gimeracil-oteracil potassium in metastatic and recurrent breast cancer. Otsuka H, etal., Breast Cancer. 2015 Jul;22(4):335-42. doi: 10.1007/s12282-013-0483-1. Epub 2013 Jul 5.
52. Sustained reduction of hyperbilirubinemia in Gunn rats after adeno-associated virus-mediated gene transfer of bilirubin UDP-glucuronosyltransferase isozyme 1A1 to skeletal muscle. Pastore N, etal., Hum Gene Ther. 2012 Oct;23(10):1082-9. doi: 10.1089/hum.2012.018. Epub 2012 Aug 27.
53. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
54. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
55. Glucuronidation of retinoids by rat recombinant UDP: glucuronosyltransferase 1.1 (bilirubin UGT). Radominska A, etal., Drug Metab Dispos. 1997 Jul;25(7):889-92.
56. GOA pipeline RGD automated data pipeline
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. Expression of UDP-glucuronosyltransferase isoform mRNAs during inflammation and infection in mouse liver and kidney. Richardson TA, etal., Drug Metab Dispos. 2006 Mar;34(3):351-3. Epub 2005 Dec 8.
60. [Association of polymorphisms in SULT1A1 and UGT1A1 Genes with breast cancer risk and phenotypes in Russian women]. Shatalova EG, etal., Mol Biol (Mosk). 2006 Mar-Apr;40(2):263-70.
61. Association between severe toxicity of nilotinib and UGT1A1 polymorphisms in Japanese patients with chronic myelogenous leukemia. Shibata T, etal., Int J Clin Oncol. 2014 Apr;19(2):391-6. doi: 10.1007/s10147-013-0562-5. Epub 2013 Apr 23.
62. Regulation of uridine diphosphate glucuronosyltransferase during the acute-phase response. Strasser SI, etal., J Gastroenterol Hepatol. 1998 Jan;13(1):88-94.
63. Sex hormones differentially regulate isoforms of UDP-glucuronosyltransferase. Strasser SI, etal., Pharm Res. 1997 Sep;14(9):1115-21.
64. Genetic Polymorphisms of SLCO1B1, CYP2E1 and UGT1A1 and Susceptibility to Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Chinese Population-Based Prospective Case-Control Study. Sun Q, etal., Clin Drug Investig. 2017 Dec;37(12):1125-1136. doi: 10.1007/s40261-017-0572-6.
65. Clinical significance of UDP-glucuronosyltransferase 1A1*6 for toxicities of combination chemotherapy with irinotecan and cisplatin in gynecologic cancers: a prospective multi-institutional study. Takano M, etal., Oncology. 2009;76(5):315-21. Epub 2009 Mar 20.
66. Association between promoter and coding region mutations of UDP-glucuronosyltransferase 1A1 and beta-thalassemia/Hb E with cholelithiasis. Tankanitlert J, etal., Eur J Haematol. 2008 Apr;80(4):351-5. Epub 2007 Dec 10.
67. Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats. Tian H, etal., Pharm Res. 2005 Dec;22(12):2007-15. Epub 2005 Oct 21.
68. Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector. Toietta G, etal., Proc Natl Acad Sci U S A 2005 Mar 15;102(11):3930-5. Epub 2005 Mar 7.
69. Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice. Tsai MS, etal., Toxicol Lett. 2018 Jun 15;290:97-109. doi: 10.1016/j.toxlet.2018.03.024. Epub 2018 Mar 21.
70. Successful treatment of UGT1A1 deficiency in a rat model of Crigler-Najjar disease by intravenous administration of a liver-specific lentiviral vector. van der Wegen P, etal., Mol Ther. 2006 Feb;13(2):374-81. Epub 2005 Dec 5.
71. Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. Vansell NR and Klaassen CD, Drug Metab Dispos. 2002 Mar;30(3):240-6.
72. The linear effects of alpha-thalassaemia, the UGT1A1 and HMOX1 polymorphisms on cholelithiasis in sickle cell disease. Vasavda N, etal., Br J Haematol. 2007 Jul;138(2):263-70.
73. Long-term reduction of jaundice in Gunn rats by nonviral liver-targeted delivery of Sleeping Beauty transposon. Wang X, etal., Hepatology. 2009 Sep;50(3):815-24. doi: 10.1002/hep.23060.
74. Dysregulations of intestinal and colonic UDP-glucuronosyltransferases in rats with type 2 diabetes. Xie H, etal., Drug Metab Pharmacokinet. 2013;28(5):427-34. Epub 2013 Apr 2.
75. Yinchenhao Decoction Ameliorates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis in Rats by Regulating Phase II Metabolic Enzymes and Transporters. Yi YX, etal., Front Pharmacol. 2018 May 15;9:510. doi: 10.3389/fphar.2018.00510. eCollection 2018.
76. Effects on extrahepatic UDP-glucuronosyltransferases in hypophysectomized rat. Yokota H, etal., J Biochem (Tokyo) 2002 Aug;132(2):265-70.
77. Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism. Yu WG, etal., Environ Toxicol Chem. 2009 May;28(5):990-6.
78. Correlations between polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A and C-C motif chemokine receptor 5 genes and infection with the hepatitis B virus in three ethnic groups in China. Zhang C, etal., J Int Med Res. 2018 Feb;46(2):739-751. doi: 10.1177/0300060517730174. Epub 2017 Sep 20.
79. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, etal., Genome Res 2004 Jan;14(1):79-89. Epub 2003 Dec 12.
Additional References at PubMed
PMID:1898728   PMID:7603447   PMID:7608130   PMID:7986077   PMID:8554318   PMID:8999837   PMID:9271076   PMID:9488689   PMID:11437649   PMID:12475965   PMID:12477932   PMID:12951053  
PMID:16141793   PMID:17179145   PMID:18004212   PMID:18052087   PMID:19996319   PMID:20056724   PMID:20308471   PMID:20610558   PMID:22447239   PMID:22579593   PMID:23230277   PMID:28479355  
PMID:29131354  


Genomics

Comparative Map Data
Ugt1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2988,801,344 - 88,808,465 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)Ensembl
Rnor_6.0995,295,701 - 95,302,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0994,982,916 - 94,990,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4987,091,241 - 87,098,362 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1987,277,121 - 87,284,238 (+)NCBI
Celera986,362,434 - 86,369,556 (+)NCBICelera
Cytogenetic Map9q35NCBI
UGT1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,760,270 - 233,773,300 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2233,760,270 - 233,773,300 (+)EnsemblGRCh38hg38GRCh38
GRCh372234,668,916 - 234,681,946 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,333,658 - 234,346,684 (+)NCBINCBI36hg18NCBI36
Build 342234,450,918 - 234,463,945NCBI
Celera2228,389,552 - 228,402,577 (+)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2226,468,768 - 226,481,779 (+)NCBIHuRef
CHM1_12234,674,733 - 234,682,899 (+)NCBICHM1_1
T2T-CHM13v2.02234,248,901 - 234,261,929 (+)NCBI
Ugt1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39188,139,681 - 88,147,724 (+)NCBIGRCm39mm39
GRCm39 Ensembl188,139,681 - 88,146,719 (+)Ensembl
GRCm38188,211,959 - 88,220,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl188,211,959 - 88,218,997 (+)EnsemblGRCm38mm10GRCm38
MGSCv37190,108,534 - 90,116,577 (+)NCBIGRCm37mm9NCBIm37
MGSCv36190,043,130 - 90,050,148 (+)NCBImm8
Celera191,173,026 - 91,181,062 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map144.55NCBI

Position Markers
RH94830  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,808,140 - 88,808,341 (+)MAPPERmRatBN7.2
Rnor_6.0995,302,498 - 95,302,698NCBIRnor6.0
Rnor_5.0994,989,713 - 94,989,913UniSTSRnor5.0
RGSC_v3.4987,098,038 - 87,098,238UniSTSRGSC3.4
Celera986,369,232 - 86,369,432UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat


Related Rat Strains
The following Strains have been annotated to Ugt1a1


Genetic Models
This gene Ugt1a1 is modified in the following models/strains

Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025045   ⟹   ENSRNOP00000025045
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,801,339 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,295,701 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000025291   ⟹   ENSRNOP00000025292
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,762,249 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,256,627 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000025652   ⟹   ENSRNOP00000025652
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,739,577 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,202,632 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000032634   ⟹   ENSRNOP00000030374
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,747,213 - 88,808,463 (+)Ensembl
Rnor_6.0 Ensembl995,241,609 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000045163   ⟹   ENSRNOP00000046507
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,780,328 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,274,707 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000063853   ⟹   ENSRNOP00000062958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,791,216 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,285,592 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000066839   ⟹   ENSRNOP00000063634
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,221,474 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000071003   ⟹   ENSRNOP00000075547
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,233,957 - 95,302,810 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000071200   ⟹   ENSRNOP00000066773
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,727,092 - 88,808,453 (+)Ensembl
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077416   ⟹   ENSRNOP00000070501
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,241,626 - 95,302,816 (+)Ensembl
RefSeq Acc Id: NM_012683   ⟹   NP_036815
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2988,801,344 - 88,808,465 (+)NCBI
Rnor_6.0995,295,701 - 95,302,822 (+)NCBI
Rnor_5.0994,982,916 - 94,990,037 (+)NCBI
RGSC_v3.4987,091,241 - 87,098,362 (+)RGD
Celera986,362,434 - 86,369,556 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036815   ⟸   NM_012683
- Peptide Label: precursor
- UniProtKB: Q64550 (UniProtKB/Swiss-Prot),   Q5DT04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000046507   ⟸   ENSRNOT00000045163
RefSeq Acc Id: ENSRNOP00000062958   ⟸   ENSRNOT00000063853
RefSeq Acc Id: ENSRNOP00000075547   ⟸   ENSRNOT00000071003
RefSeq Acc Id: ENSRNOP00000070501   ⟸   ENSRNOT00000077416
RefSeq Acc Id: ENSRNOP00000030374   ⟸   ENSRNOT00000032634
RefSeq Acc Id: ENSRNOP00000066773   ⟸   ENSRNOT00000071200
RefSeq Acc Id: ENSRNOP00000025292   ⟸   ENSRNOT00000025291
RefSeq Acc Id: ENSRNOP00000025652   ⟸   ENSRNOT00000025652
RefSeq Acc Id: ENSRNOP00000063634   ⟸   ENSRNOT00000066839
RefSeq Acc Id: ENSRNOP00000025045   ⟸   ENSRNOT00000025045
Protein Domains
UDPGT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64550-F1-model_v2 AlphaFold Q64550 1-535 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696846
Promoter ID:EPDNEW_R7370
Type:multiple initiation site
Name:Ugt1a7c_3
Description:UDP glucuronosyltransferase 1 family, polypeptide A7C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7366  EPDNEW_R7367  EPDNEW_R7368  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0995,295,686 - 95,295,746EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 95295888 95295889 G A snv CDR


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3935 AgrOrtholog
BioCyc Gene G2FUF-26816 BioCyc
Ensembl Genes ENSRNOG00000018740 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000025045 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025045 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro UDP_glucos_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24861 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24861 ENTREZGENE
Pfam UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB UGT1A1 RGD
PhenoGen Ugt1a1 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q5DT04 ENTREZGENE, UniProtKB/TrEMBL
  Q64550 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q64635 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ugt1a1  UDP glucuronosyltransferase family 1 member A1  Ugt1a1  UDP glucuronosyltransferase 1 family, polypeptide A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Ugt1a1  UDP glucuronosyltransferase 1 family, polypeptide A1  Ugt1a1  UDP glycosyltransferase 1 family, polypeptide A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ugt1a1  UDP glycosyltransferase 1 family, polypeptide A1  Ugt1  UDP-glucuronosyltransferase 1 family, member 1  Symbol and Name updated 629477 APPROVED
2002-06-10 Ugt1  UDP-glucuronosyltransferase 1 family, member 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver hepatocytes 70480
gene_process functions in glucuronidation and excretion of bilirubin 70480
gene_transcript each variable exon is preceded by a promoter region which may be used for tissue specific gene expression 1302827